SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: Viral mRNAs are resistant to nsp1-induced RNA cleavage

PLoS Pathogens

Volumn 7, Issue 12, 2011, Pages

  Huang, Cheng ^a   Lokugamage, Kumari G ^a   Rozovics, Janet M ^b   Narayanan, Krishna ^a   Semler, Bert L ^b   Makino, Shinji ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; NSP1 PROTEIN, SARS CORONAVIRUS; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; IN VITRO STUDY; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PESTIVIRUS; PROTEIN SYNTHESIS; RNA CLEAVAGE; RNA TRANSLATION; SARS CORONAVIRUS; VIRUS INFECTION; VIRUS REPLICATION; DNA TEMPLATE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA STABILITY;

CLASSICAL SWINE FEVER VIRUS; CRICKET PARALYSIS VIRUS; ENCEPHALOMYOCARDITIS VIRUS; HEPATITIS C VIRUS; PICORNAVIRIDAE; SARS CORONAVIRUS;

GENE EXPRESSION REGULATION, VIRAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA REPLICASE; RNA STABILITY; RNA, MESSENGER; RNA, VIRAL; SARS VIRUS; TEMPLATES, GENETIC; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84855288589     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002433     Document Type: Article

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