Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication

Journal of Virology

Volumn 85, Issue 13, 2011, Pages 6381-6389

  Cencic, Regina ^a   Desforges, Marc ^b   Hall, David R ^c   Kozakov, Dima ^c   Du, Yuhong ^d   Min, Jaeki ^d   Dingledine, Raymond ^d   Fu, Haian ^d   Vajda, Sandor ^c   Talbot, Pierre J ^b   Pelletier, Jerry ^a,e  

^a MCGILL UNIVERSITY   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

^c Boston University   (United States)

^d EMORY UNIVERSITY   (United States)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4E2RCAT; INITIATION FACTOR 4E; INITIATION FACTOR 4G; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CAPPED RNA; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CORONAVIRUS; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; VIRUS INFECTION; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; GENETICS; METABOLISM; MOLECULAR LIBRARY; PATHOGENICITY; PHYSIOLOGY; PROTEIN SYNTHESIS;

ANTIVIRAL AGENTS; CELL LINE; CORONAVIRUS 229E, HUMAN; DRUG DISCOVERY; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEIN BIOSYNTHESIS; RNA CAPS; SMALL MOLECULE LIBRARIES; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 80052048025     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00078-11     Document Type: Article

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