메뉴 건너뛰기




Volumn 10, Issue 4, 2011, Pages 328-340

Exploiting tyrosinase expression and activity in melanocytic tumors: Quercetin and the central role of p53

Author keywords

melanoma; neuroblastoma; p53; quercetin; tyrosinase

Indexed keywords

DACARBAZINE; MONOPHENOL MONOOXYGENASE; PROTEIN P53; QUERCETIN; TEMOZOLOMIDE;

EID: 84855218005     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735410391661     Document Type: Article
Times cited : (45)

References (111)
  • 1
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V, Wellbrock C, Marais R. Melanoma biology and new targeted therapy. Nature. 2007 ; 445: 851-857
    • (2007) Nature , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 2
    • 2942688195 scopus 로고    scopus 로고
    • Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: A possible escape mechanism from chemotherapy
    • Lev DC, Ruiz M, Mills L, McGary EC, Price JE, Bar-Eli M. Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy. Mol Cancer Ther. 2003 ; 2: 753-763
    • (2003) Mol Cancer Ther , vol.2 , pp. 753-763
    • Lev, D.C.1    Ruiz, M.2    Mills, L.3    McGary, E.C.4    Price, J.E.5    Bar-Eli, M.6
  • 3
    • 34247609235 scopus 로고    scopus 로고
    • Prognostic relevance of baseline and sequential peripheral blood tyrosinase expression in 200 consecutive advanced metastatic melanoma patients
    • DOI 10.1097/CMR.0b013e328054c667, PII 0000839020070400000002
    • Quaglino P, Osella-Abate S, Cappello N, et al. Prognostic relevance of baseline and sequential peripheral blood tyrosinase expression in 200 consecutive advanced metastatic melanoma patients. Melanoma Res. 2007 ; 17: 75-82 (Pubitemid 46673900)
    • (2007) Melanoma Research , vol.17 , Issue.2 , pp. 75-82
    • Quaglino, P.1    Osella-Abate, S.2    Cappello, N.3    Ortoncelli, M.4    Nardo, T.5    Fierro, M.T.6    Cavallo, F.7    Savoia, P.8    Bernengo, M.G.9
  • 4
    • 0036311384 scopus 로고    scopus 로고
    • Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors: An immunohistochemical study
    • Boyle JL, Haupt HM, Stern JB, Multhaupt HA. Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors. Arch Pathol Lab Med. 2002 ; 126: 816-822 (Pubitemid 34761639)
    • (2002) Archives of Pathology and Laboratory Medicine , vol.126 , Issue.7 , pp. 816-822
    • Boyle, J.L.1    Haupt, H.M.2    Stern, J.B.3    Multhaupt, H.A.B.4
  • 5
    • 0036286708 scopus 로고    scopus 로고
    • Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)
    • DOI 10.1016/S0968-0896(02)00097-4, PII S0968089602000974
    • Jordan AM, Khan TH, Malkin H, Osborn HM. Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). Bioorg Med Chem. 2002 ; 10: 2625-2633 (Pubitemid 34626225)
    • (2002) Bioorganic and Medicinal Chemistry , vol.10 , Issue.8 , pp. 2625-2633
    • Jordan, A.M.1    Khan, T.H.2    Malkin, H.3    Osborn, H.M.I.4
  • 6
    • 0031020020 scopus 로고    scopus 로고
    • Melanogenesis-targeted anti-melanoma pro-drug development: Effect of side-chain variations on the cytotoxicity of tyrosinase-generated ortho-quinones in a model screening system
    • DOI 10.1016/S0959-8049(96)00340-1, PII S0959804996003401
    • Riley PA, Cooksey CJ, Johnson CI, Land EJ, Latter AM, Ramsden CA. Melanogenesis-targeted anti-melanoma pro-drug development: effect of side-chain variations on the cytotoxicity of tyrosinase-generated ortho-quinones in a model screening system. Eur J Cancer. 1997 ; 33: 135-143 (Pubitemid 27099581)
    • (1997) European Journal of Cancer Part A , vol.33 , Issue.1 , pp. 135-143
    • Riley, P.A.1    Cooksey, C.J.2    Johnson, C.I.3    Land, E.J.4    Latter, A.M.5    Ramsden, C.A.6
  • 7
    • 52149089437 scopus 로고    scopus 로고
    • Prodrug cancer gene therapy
    • Altaner C. Prodrug cancer gene therapy. Cancer Lett. 2008 ; 270: 191-201
    • (2008) Cancer Lett , vol.270 , pp. 191-201
    • Altaner, C.1
  • 8
    • 0033215226 scopus 로고    scopus 로고
    • Modified vaccinia virus ankara for delivery of human tyrosinase as melanoma-associated antigen: Induction of tyrosinase- and melanoma-specific human leukocyte antigen A0201-restricted cytotoxic T cells in vitro and in vivo
    • Drexler I, Antunes E, Schmitz M, et al. Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201- restricted cytotoxic T cells in vitro and in vivo. Cancer Res. 1999 ; 59: 4955-4963 (Pubitemid 29472901)
    • (1999) Cancer Research , vol.59 , Issue.19 , pp. 4955-4963
    • Drexler, I.1    Antunes, E.2    Schmitz, M.3    Wolfel, T.4    Huber, C.5    Erfle, V.6    Rieber, P.7    Theobald, M.8    Sutter, G.9
  • 9
    • 0034599497 scopus 로고    scopus 로고
    • Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: Implications for tumor immunotherapy
    • Colella TA, Bullock TN, Russell LB, et al. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. J Exp Med. 2000 ; 191: 1221-1232
    • (2000) J Exp Med , vol.191 , pp. 1221-1232
    • Colella, T.A.1    Bullock, T.N.2    Russell, L.B.3
  • 13
    • 0025492979 scopus 로고
    • 4-S-cysteaminylphenol and its analogues as substrates for tyrosinase and monoamine oxidase
    • Pankovich JM, Jimbow K, Ito S. 4-S-cysteaminylphenol and its analogues as substrates for tyrosinase and monoamine oxidase. Pigment Cell Res. 1990 ; 3: 146-149
    • (1990) Pigment Cell Res , vol.3 , pp. 146-149
    • Pankovich, J.M.1    Jimbow, K.2    Ito, S.3
  • 14
    • 0027439861 scopus 로고
    • Mechanism(s) regulating inhibition of thymidylate synthase and growth by γ-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells
    • DOI 10.1016/0006-2952(93)90085-B
    • Prezioso JA, Damodaran KM, Wang N, Bloomer WD. Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3- iodobenzene, a novel melanin precursor, in melanogenic melanoma cells. Biochem Pharmacol. 1993 ; 45: 473-481 (Pubitemid 23042648)
    • (1993) Biochemical Pharmacology , vol.45 , Issue.2 , pp. 473-481
    • Prezioso, J.A.1    Damodaran, K.M.2    Wang, N.3    Bloomer, W.D.4
  • 19
    • 33144489156 scopus 로고    scopus 로고
    • Melanoma: Etiology, treatment, and dental implications
    • Little JW. Melanoma: etiology, treatment, and dental implications. Gen Dent. 2006 ; 54: 61-66 (Pubitemid 43266259)
    • (2006) General Dentistry , vol.54 , Issue.1 , pp. 61-66
    • Little, J.W.1
  • 20
    • 0034961266 scopus 로고    scopus 로고
    • The early steps of neural crest development
    • DOI 10.1016/S0925-4773(01)00394-X, PII S092547730100394X
    • Nieto MA. The early steps of neural crest development. Mech Dev. 2001 ; 105: 27-35 (Pubitemid 32586757)
    • (2001) Mechanisms of Development , vol.105 , Issue.1-2 , pp. 27-35
    • Nieto M.Angela1
  • 22
    • 0026408937 scopus 로고
    • Pro-opiomelanocortin expression and potential function of pro-opiomelanocortin products during induced hair growth in mice
    • Slominski A, Paus R, Mazurkiewicz J. Pro-opiomelanocortin expression and potential function of pro-opiomelanocortin products during induced hair growth in mice. Ann N Y Acad Sci. 1991 ; 642: 459-461
    • (1991) Ann N y Acad Sci , vol.642 , pp. 459-461
    • Slominski, A.1    Paus, R.2    Mazurkiewicz, J.3
  • 24
    • 0036356231 scopus 로고    scopus 로고
    • Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities
    • Halaban R. Pigmentation in melanomas: changes manifesting underlying oncogenic and metabolic activities. Oncol Res. 2002 ; 13: 3-8 (Pubitemid 38166399)
    • (2002) Oncology Research , vol.13 , Issue.1 , pp. 3-8
    • Halaban, R.1
  • 25
    • 41949092429 scopus 로고    scopus 로고
    • Regulation of melanogenesis-controversies and new concepts
    • DOI 10.1111/j.1600-0625.2007.00675.x
    • Schallreuter KU, Kothari S, Chavan B, Spencer JD. Regulation of melanogenesis-controversies and new concepts. Exp Dermatol. 2008 ; 17: 395-404 (Pubitemid 351513953)
    • (2008) Experimental Dermatology , vol.17 , Issue.5 , pp. 395-404
    • Schallreuter, K.U.1    Kothari, S.2    Chavan, B.3    Spencer, J.D.4
  • 26
    • 0033523009 scopus 로고    scopus 로고
    • Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
    • Park HY, Perez JM, Laursen R, Hara M, Gilchrest BA. Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain. J Biol Chem. 1999 ; 274: 16470-16478
    • (1999) J Biol Chem , vol.274 , pp. 16470-16478
    • Park, H.Y.1    Perez, J.M.2    Laursen, R.3    Hara, M.4    Gilchrest, B.A.5
  • 27
    • 0028346248 scopus 로고
    • Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region
    • Ponnazhagan S, Hou L, Kwon BS. Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region. J Invest Dermatol. 1994 ; 102: 744-748 (Pubitemid 24144255)
    • (1994) Journal of Investigative Dermatology , vol.102 , Issue.5 , pp. 744-748
    • Ponnazhagan, S.1    Hou, L.2    Kwon, B.S.3
  • 28
    • 0028051530 scopus 로고
    • Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene
    • Yasumoto K, Yokoyama K, Shibata K, Tomita Y, Shibahara S. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol. 1994 ; 14: 8058-8070 (Pubitemid 24373554)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.12 , pp. 8058-8070
    • Yasumoto, K.-I.1    Yokoyama, K.2    Shibata, K.3    Tomita, Y.4    Shibahara, S.5
  • 30
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • DOI 10.1038/nrc1014
    • Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003 ; 3: 203-216 (Pubitemid 37328872)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.3 , pp. 203-216
    • Brodeur, G.M.1
  • 32
    • 33747357791 scopus 로고    scopus 로고
    • Neuroblastoma incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System project
    • Spix C, Pastore G, Sankila R, Stiller CA, Steliarova-Foucher E. Neuroblastoma incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006 ; 42: 2081-2091
    • (2006) Eur J Cancer , vol.42 , pp. 2081-2091
    • Spix, C.1    Pastore, G.2    Sankila, R.3    Stiller, C.A.4    Steliarova-Foucher, E.5
  • 35
    • 34249295787 scopus 로고    scopus 로고
    • Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma
    • DOI 10.1038/sj.cdd.4402126, PII 4402126
    • Becker K, Marchenko ND, Maurice M, Moll UM. Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ. 2007 ; 14: 1350-1360 (Pubitemid 46965264)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.7 , pp. 1350-1360
    • Becker, K.1    Marchenko, N.D.2    Maurice, M.3    Moll, U.M.4
  • 36
    • 33745150087 scopus 로고    scopus 로고
    • The intricacies of p21 phosphorylation: Protein/protein interactions, subcellular localization and stability
    • Child ES, Mann DJ. The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability. Cell Cycle. 2006 ; 5: 1313-1319 (Pubitemid 43894287)
    • (2006) Cell Cycle , vol.5 , Issue.12 , pp. 1313-1319
    • Child, E.S.1    Mann, D.J.2
  • 38
    • 0033839721 scopus 로고    scopus 로고
    • Rationale for intergroup trial E-3695 comparing concurrent biochemotherapy with cisplatin, vinblastine, and DTIC alone in patients with metastatic melanoma
    • Flaherty LE. Rationale for intergroup trial E-3695 comparing concurrent biochemotherapy with cisplatin, vinblastine, and DTIC alone in patients with metastatic melanoma. Cancer J Sci Am. 2000 ; 6 (suppl 1). S15 - S20
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL. 1
    • Flaherty, L.E.1
  • 40
    • 0037010054 scopus 로고    scopus 로고
    • The treatment of brain metastases from malignant melanoma
    • DOI 10.1053/sonc.2002.35247
    • Douglas JG, Margolin K. The treatment of brain metastases from malignant melanoma. Semin Oncol. 2002 ; 29: 518-524 (Pubitemid 35178291)
    • (2002) Seminars in Oncology , vol.29 , Issue.5 , pp. 518-524
    • Douglas, J.G.1    Margolin, K.2
  • 41
    • 44149116743 scopus 로고    scopus 로고
    • Indirect oxidation of the antitumor agent procarbazine by tyrosinase-Possible application in designing anti-melanoma prodrugs
    • DOI 10.1016/j.bmcl.2008.04.041, PII S0960894X08004319
    • Gasowska-Bajger B, Wojtasek H. Indirect oxidation of the antitumor agent procarbazine by tyrosinase-possible application in designing anti-melanoma prodrugs. Bioorg Med Chem Lett. 2008 ; 18: 3296-3300 (Pubitemid 351718327)
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , Issue.11 , pp. 3296-3300
    • Gasowska-Bajger, B.1    Wojtasek, H.2
  • 42
    • 36849000866 scopus 로고    scopus 로고
    • Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase
    • Thangasamy T, Sittadjody S, Lanza-Jacoby S, Wachsberger P, Limesand K, Burd R. Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase. Nutr Cancer. 2007 ; 59: 1-11
    • (2007) Nutr Cancer , vol.59 , pp. 1-11
    • Thangasamy, T.1    Sittadjody, S.2    Lanza-Jacoby, S.3    Wachsberger, P.4    Limesand, K.5    Burd, R.6
  • 43
    • 52449121015 scopus 로고    scopus 로고
    • Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine
    • Thangasamy T, Sittadjody S, Limesand KH, Burd R. Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine. Cell Oncol. 2008 ; 30: 371-387
    • (2008) Cell Oncol , vol.30 , pp. 371-387
    • Thangasamy, T.1    Sittadjody, S.2    Limesand, K.H.3    Burd, R.4
  • 44
    • 0032860282 scopus 로고    scopus 로고
    • Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of a targeted treatment for malignant melanoma
    • DOI 10.1016/S0968-0896(99)00126-1, PII S0968089699001261
    • Jordan AM, Khan TH, Osborn HM, Photiou A, Riley PA. Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma. Bioorg Med Chem. 1999 ; 7: 1775-1780 (Pubitemid 29457673)
    • (1999) Bioorganic and Medicinal Chemistry , vol.7 , Issue.9 , pp. 1775-1780
    • Jordan, A.M.1    Khan, T.H.2    Osborn, H.M.I.3    Photiou, A.4    Riley, P.A.5
  • 45
    • 34848897229 scopus 로고    scopus 로고
    • An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy
    • Ulasov IV, Rivera AA, Nettelbeck DM, et al. An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy. Int J Oncol. 2007 ; 31: 1177-1185
    • (2007) Int J Oncol , vol.31 , pp. 1177-1185
    • Ulasov, I.V.1    Rivera, A.A.2    Nettelbeck, D.M.3
  • 46
    • 77956634425 scopus 로고    scopus 로고
    • Hormesis and synergy: Pathways and mechanisms of quercetin in cancer prevention and management
    • Vargas AJ, Burd R. Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutr Rev. 2010 ; 68: 418-428
    • (2010) Nutr Rev , vol.68 , pp. 418-428
    • Vargas, A.J.1    Burd, R.2
  • 47
    • 0043063961 scopus 로고    scopus 로고
    • Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism
    • DOI 10.1016/S0003-9861(03)00284-4
    • Murota K, Terao J. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys. 2003 ; 417: 12-17 (Pubitemid 36960043)
    • (2003) Archives of Biochemistry and Biophysics , vol.417 , Issue.1 , pp. 12-17
    • Murota, K.1    Terao, J.2
  • 48
    • 32344433333 scopus 로고    scopus 로고
    • Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)
    • DOI 10.1007/s00394-005-0558-7
    • Alia M, Mateos R, Ramos S, Lecumberri E, Bravo L, Goya L. Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur J Nutr. 2006 ; 45: 19-28 (Pubitemid 43221280)
    • (2006) European Journal of Nutrition , vol.45 , Issue.1 , pp. 19-28
    • Alia, M.1    Mateos, R.2    Ramos, S.3    Lecumberri, E.4    Bravo, L.5    Goya, L.6
  • 51
    • 51049095905 scopus 로고    scopus 로고
    • Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans
    • Egert S, Wolffram S, Bosy-Westphal A, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr. 2008 ; 138: 1615-1621
    • (2008) J Nutr , vol.138 , pp. 1615-1621
    • Egert, S.1    Wolffram, S.2    Bosy-Westphal, A.3
  • 52
    • 0033661837 scopus 로고    scopus 로고
    • Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
    • Erlund I, Kosonen T, Alfthan G, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol. 2000 ; 56: 545-553
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 545-553
    • Erlund, I.1    Kosonen, T.2    Alfthan, G.3
  • 55
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
    • DOI 10.1016/j.tiv.2005.06.048, PII S0887233305002080
    • Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro. 2006 ; 20: 187-210 (Pubitemid 43087702)
    • (2006) Toxicology in Vitro , vol.20 , Issue.2 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 56
    • 33645939838 scopus 로고    scopus 로고
    • Potential synergism of natural products in the treatment of cancer
    • Hemaiswarya S, Doble M. Potential synergism of natural products in the treatment of cancer. Phytother Res. 2006 ; 20: 239-249
    • (2006) Phytother Res , vol.20 , pp. 239-249
    • Hemaiswarya, S.1    Doble, M.2
  • 57
    • 0034541169 scopus 로고    scopus 로고
    • Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
    • Simonova M, Wall A, Weissleder R, Bogdanov A. Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res. 2000 ; 60: 6656-6662
    • (2000) Cancer Res , vol.60 , pp. 6656-6662
    • Simonova, M.1    Wall, A.2    Weissleder, R.3    Bogdanov, A.4
  • 58
    • 0842305869 scopus 로고    scopus 로고
    • Synthesis and antimelanoma activity of tertiary amide analogues of N-acetyl-4-S-cysteaminylphenol
    • Pearson VC, Ferguson J, Rogers PM, Kelland LR, Robins DJ. Synthesis and antimelanoma activity of tertiary amide analogues of N-acetyl-4-S- cysteaminylphenol. Oncol Res. 2003 ; 13: 503-512
    • (2003) Oncol Res , vol.13 , pp. 503-512
    • Pearson, V.C.1    Ferguson, J.2    Rogers, P.M.3    Kelland, L.R.4    Robins, D.J.5
  • 59
    • 0033384965 scopus 로고    scopus 로고
    • Selective incorporation and specific cytocidal effect as the cellular basis for the antimelanoma action of sulphur containing tyrosine analogs
    • DOI 10.1046/j.1523-1747.1999.00781.x
    • Thomas PD, Kishi H, Cao H, et al. Selective incorporation and specific cytocidal effect as the cellular basis for the antimelanoma action of sulphur containing tyrosine analogs. J Invest Dermatol. 1999 ; 113: 928-934 (Pubitemid 30013333)
    • (1999) Journal of Investigative Dermatology , vol.113 , Issue.6 , pp. 928-934
    • Thomas, P.D.1    Kishi, H.2    Cao, H.3    Ota, M.4    Yamashita, T.5    Singh, S.6    Jimbow, K.7
  • 60
    • 0034724758 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
    • DOI 10.1016/S0921-8777(99)00074-9, PII S0921877799000749
    • Johnson MK, Loo G. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA. Mutat Res. 2000 ; 459: 211-218 (Pubitemid 30254308)
    • (2000) Mutation Research - DNA Repair , vol.459 , Issue.3 , pp. 211-218
    • Johnson, M.K.1    Loo, G.2
  • 62
    • 0842327291 scopus 로고    scopus 로고
    • Quercetin Enhances Melanogenesis by Increasing the Activity and Synthesis of Tyrosinase in Human Melanoma Cells and in Normal Human Melanocytes
    • DOI 10.1046/j.1600-0749.2003.00113.x
    • Nagata H, Takekoshi S, Takeyama R, Homma T, Yoshiyuki OR. Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Pigment Cell Res. 2004 ; 17: 66-73 (Pubitemid 38166441)
    • (2004) Pigment Cell Research , vol.17 , Issue.1 , pp. 66-73
    • Nagata, H.1    Takekoshi, S.2    Takeyama, R.3    Homma, T.4    Osamura, R.Y.5
  • 63
    • 4944246893 scopus 로고    scopus 로고
    • Quercetin-induced melanogenesis in a reconstituted three-dimensional human epidermal model
    • DOI 10.1023/B:HIJO.0000023388.51625.6c
    • Takeyama R, Takekoshi S, Nagata H, Osamura RY, Kawana S. Quercetin-induced melanogenesis in a reconstituted three-dimensional human epidermal model. J Mol Histol. 2004 ; 35: 157-165 (Pubitemid 40585326)
    • (2004) Journal of Molecular Histology , vol.35 , Issue.2 , pp. 157-165
    • Takeyama, R.1    Takekoshi, S.2    Nagata, H.3    Osamura, R.Y.4    Kawana, S.5
  • 64
    • 0345148810 scopus 로고    scopus 로고
    • Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
    • DOI 10.1016/S0891-5849(98)00167-1, PII S0891584998001671
    • Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med. 1999 ; 26: 107-116 (Pubitemid 29001498)
    • (1998) Free Radical Biology and Medicine , vol.26 , Issue.1-2 , pp. 107-116
    • Metodiewa, D.1    Jaiswal, A.K.2    Cenas, N.3    Dickancaite, E.4    Segura-Aguilar, J.5
  • 65
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • DOI 10.1016/S0092-8674(00)81871-1
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997 ; 88: 323-331 (Pubitemid 27131374)
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 68
  • 69
    • 34547753615 scopus 로고    scopus 로고
    • P63 and p73 in human cancer: Defining the network
    • DOI 10.1038/sj.onc.1210337, PII 1210337
    • DeYoung MP, Ellisen LW. p63 and p73 in human cancer: defining the network. Oncogene. 2007 ; 26: 5169-5183 (Pubitemid 47237632)
    • (2007) Oncogene , vol.26 , Issue.36 , pp. 5169-5183
    • DeYoung, M.P.1    Ellisen, L.W.2
  • 71
    • 64549155365 scopus 로고    scopus 로고
    • Different intracellular compartmentalization of TA and DeltaNp73 in non-small cell lung cancer
    • Di VA, Sessa F, Casciano I, et al. Different intracellular compartmentalization of TA and DeltaNp73 in non-small cell lung cancer. Int J Oncol. 2009 ; 34: 449-456
    • (2009) Int J Oncol , vol.34 , pp. 449-456
    • Di, V.A.1    Sessa, F.2    Casciano, I.3
  • 73
    • 0032945080 scopus 로고    scopus 로고
    • Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver
    • DOI 10.1038/sj.bjc.6690465
    • Tannapfel A, Engeland K, Weinans L, et al. Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver. Br J Cancer. 1999 ; 80: 1069-1074 (Pubitemid 29233931)
    • (1999) British Journal of Cancer , vol.80 , Issue.7 , pp. 1069-1074
    • Tannapfel, A.1    Engeland, K.2    Weinans, L.3    Katalinic, A.4    Hauss, J.5    Mossner, J.6    Wittekind, C.7
  • 75
    • 77953296031 scopus 로고    scopus 로고
    • Quercetin abrogates chemoresistance in melanoma cells by modulating DeltaNp73
    • Thangasamy T, Sittadjody S, Mitchell GC, et al. Quercetin abrogates chemoresistance in melanoma cells by modulating DeltaNp73. BMC Cancer. 2010 ; 10: 282
    • (2010) BMC Cancer , vol.10 , pp. 282
    • Thangasamy, T.1    Sittadjody, S.2    Mitchell, G.C.3
  • 77
    • 0032997116 scopus 로고    scopus 로고
    • Antiproliferative and cytotoxic effects of N,N-Diethylaminoethyl ethers of flavanone oximes: A comparison with anthracycline(s), anthraquinone and nitroxides action
    • Metodiewa D, Koceva-Chyla A, Kochman A, Skolimowski J, Jozwiak Z. Antiproliferative and cytotoxic effects of N, N-diethylaminoethyl ethers of flavanone oximes: a comparison with anthracycline(s), anthraquinone and nitroxides action. Anticancer Res. 1999 ; 19: 1255-1260 (Pubitemid 29257568)
    • (1999) Anticancer Research , vol.19 , Issue.A , pp. 1255-1260
    • Metodiewa, D.1    Koceva-Chyla, A.2    Kochman, A.3    Skolimowski, J.4    Jozwiak, Z.5
  • 78
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 2000 ; 29: 323-333
    • (2000) Free Radic Biol Med , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 79
    • 0842303315 scopus 로고    scopus 로고
    • The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX
    • DOI 10.1016/j.dnarep.2003.10.014
    • Ye R, Goodarzi AA, Kurz EU, et al. The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 ; 3: 235-244 (Pubitemid 38177245)
    • (2004) DNA Repair , vol.3 , Issue.3 , pp. 235-244
    • Ye, R.1    Goodarzi, A.A.2    Kurz, E.U.3    Saito, S.4    Higashimoto, Y.5    Lavin, M.F.6    Appella, E.7    Anderson, C.W.8    Lees-Miller, S.P.9
  • 80
    • 3543110350 scopus 로고    scopus 로고
    • P63 and p73: Roles in development and tumor formation
    • Moll UM, Slade N. p63 and p73: roles in development and tumor formation. Mol Cancer Res. 2004 ; 2: 371-386 (Pubitemid 39031071)
    • (2004) Molecular Cancer Research , vol.2 , Issue.7 , pp. 371-386
    • Moll, U.M.1    Slade, N.2
  • 81
    • 0142227023 scopus 로고    scopus 로고
    • No PUMA, no death: Implications for p53-dependent apoptosis
    • DOI 10.1016/S1535-6108(03)00249-6
    • Yu J, Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell. 2003 ; 4: 248-249 (Pubitemid 37329788)
    • (2003) Cancer Cell , vol.4 , Issue.4 , pp. 248-249
    • Yu, J.1    Zhang, L.2
  • 82
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • DOI 10.1016/S1097-2765(01)00214-3
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001 ; 7: 683-694 (Pubitemid 32706359)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 83
    • 43049090780 scopus 로고    scopus 로고
    • Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells
    • Lee DH, Kim C, Zhang L, Lee YJ. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol. 2008 ; 75: 2020-2033
    • (2008) Biochem Pharmacol , vol.75 , pp. 2020-2033
    • Lee, D.H.1    Kim, C.2    Zhang, L.3    Lee, Y.J.4
  • 84
    • 33749472634 scopus 로고    scopus 로고
    • Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival
    • DOI 10.1158/0008-5472.CAN-05-3633
    • Karst AM, Dai DL, Cheng JQ, Li G. Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer Res. 2006 ; 66: 9221-9226 (Pubitemid 44521143)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9221-9226
    • Karst, A.M.1    Dai, D.L.2    Cheng, J.Q.3    Li, G.4
  • 85
    • 58649083936 scopus 로고    scopus 로고
    • Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
    • Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. 2009 ; 106: 73-82
    • (2009) J Cell Biochem , vol.106 , pp. 73-82
    • Jeong, J.H.1    An, J.Y.2    Kwon, Y.T.3    Rhee, J.G.4    Lee, Y.J.5
  • 88
    • 67749118180 scopus 로고    scopus 로고
    • Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin
    • Tan J, Wang B, Zhu L. Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin. Chem Biodivers. 2009 ; 6: 1101-1110
    • (2009) Chem Biodivers , vol.6 , pp. 1101-1110
    • Tan, J.1    Wang, B.2    Zhu, L.3
  • 89
    • 67649382925 scopus 로고    scopus 로고
    • Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis
    • Zhang Q, Zhao XH, Wang ZJ. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 ; 23: 797-807
    • (2009) Toxicol in Vitro , vol.23 , pp. 797-807
    • Zhang, Q.1    Zhao, X.H.2    Wang, Z.J.3
  • 90
    • 56049123402 scopus 로고    scopus 로고
    • The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
    • Aalinkeel R, Bindukumar B, Reynolds JL, et al. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. Prostate. 2008 ; 68: 1773-1789
    • (2008) Prostate , vol.68 , pp. 1773-1789
    • Aalinkeel, R.1    Bindukumar, B.2    Reynolds, J.L.3
  • 91
    • 48649102539 scopus 로고    scopus 로고
    • The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways
    • Hassan M, Alaoui A, Feyen O, et al. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene. 2008 ; 27: 4557-4568
    • (2008) Oncogene , vol.27 , pp. 4557-4568
    • Hassan, M.1    Alaoui, A.2    Feyen, O.3
  • 93
    • 33750312678 scopus 로고    scopus 로고
    • Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
    • DOI 10.1158/0008-5472.CAN-06-0747
    • Qin JZ, Xin H, Sitailo LA, Denning MF, Nickoloff BJ. Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res. 2006 ; 66: 9636-9645 (Pubitemid 44623663)
    • (2006) Cancer Research , vol.66 , Issue.19 , pp. 9636-9645
    • Qin, J.-Z.1    Xin, H.2    Sitailo, L.A.3    Denning, M.F.4    Nickoloff, B.J.5
  • 94
    • 33646373219 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis: Multiple pathways and activation of p53-UP-regulated modulator of apoptosis (PUMA) and NOXA by p53
    • DOI 10.1074/jbc.M509868200
    • Li J, Lee B, Lee AS. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem. 2006 ; 281: 7260-7270 (Pubitemid 43847494)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.11 , pp. 7260-7270
    • Li, J.1    Lee, B.2    Lee, A.S.3
  • 95
    • 1542305653 scopus 로고    scopus 로고
    • Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis
    • DOI 10.1074/jbc.M312866200
    • Hershko T, Ginsberg D. Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis. J Biol Chem. 2009 ; 279: 8627-8634 (Pubitemid 38295917)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.10 , pp. 8627-8634
    • Hershko, T.1    Ginsberg, D.2
  • 96
    • 33847319601 scopus 로고    scopus 로고
    • Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours
    • Armstrong JL, Veal GJ, Redfern CP, Lovat PE. Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. Apoptosis. 2007 ; 12: 613-622
    • (2007) Apoptosis , vol.12 , pp. 613-622
    • Armstrong, J.L.1    Veal, G.J.2    Redfern, C.P.3    Lovat, P.E.4
  • 97
    • 77954338545 scopus 로고    scopus 로고
    • Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons
    • Fricker M, Papadia S, Hardingham GE, Tolkovsky AM. Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J Neurochem. 2010 ; 114: 772-783
    • (2010) J Neurochem , vol.114 , pp. 772-783
    • Fricker, M.1    Papadia, S.2    Hardingham, G.E.3    Tolkovsky, A.M.4
  • 99
    • 0025681045 scopus 로고
    • Melanocytic differentiation of human neuroblastoma: Expression of a human melanosome-associated antigen
    • Maeda K, Feyles V, McGarry RC, Jerry LM. Melanocytic differentiation of human neuroblastoma: expression of a human melanosome-associated antigen. J Invest Dermatol. 1990 ; 95: 665-670
    • (1990) J Invest Dermatol , vol.95 , pp. 665-670
    • Maeda, K.1    Feyles, V.2    McGarry, R.C.3    Jerry, L.M.4
  • 101
    • 34247626395 scopus 로고    scopus 로고
    • Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines [15]
    • DOI 10.1038/sj.leu.2404610, PII 2404610
    • Russo M, Nigro P, Rosiello R, D'Arienzo R, Russo GL. Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines. Leukemia. 2007 ; 21: 1130-1133 (Pubitemid 46672100)
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 1130-1133
    • Russo, M.1    Nigro, P.2    Rosiello, R.3    D'Arienzo, R.4    Russo, G.L.5
  • 103
    • 0032743986 scopus 로고    scopus 로고
    • Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line
    • Russo M, Palumbo R, Tedesco I, et al. Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line. FEBS Lett. 1999 ; 462: 322-328
    • (1999) FEBS Lett , vol.462 , pp. 322-328
    • Russo, M.1    Palumbo, R.2    Tedesco, I.3
  • 104
    • 0016811010 scopus 로고
    • Disposition of quercetin in man after single oral and intravenous doses
    • Gugler R, Leschik M, Dengler HJ. Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol. 1975 ; 9: 229-234
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 229-234
    • Gugler, R.1    Leschik, M.2    Dengler, H.J.3
  • 105
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three wine-related polyphenols in three different matrices by healthy subjects
    • DOI 10.1016/S0009-9120(02)00397-1
    • Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem. 2003 ; 36: 79-87 (Pubitemid 36126394)
    • (2003) Clinical Biochemistry , vol.36 , Issue.1 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 106
    • 0030949275 scopus 로고    scopus 로고
    • Bioavailability of rutin and quercetin in rats
    • DOI 10.1016/S0014-5793(97)00467-5, PII S0014579397004675
    • Manach C, Morand C, Demigne C, Texier O, Regerat F, Remesy C. Bioavailability of rutin and quercetin in rats. FEBS Lett. 1997 ; 409: 12-16 (Pubitemid 27248557)
    • (1997) FEBS Letters , vol.409 , Issue.1 , pp. 12-16
    • Manach, C.1    Morand, C.2    Demigne, C.3    Texier, O.4    Regerat, F.5    Remesy, C.6
  • 108
    • 26444577469 scopus 로고    scopus 로고
    • Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism
    • DOI 10.1016/j.lfs.2005.03.033, PII S0024320505005874
    • Silberberg M, Morand C, Manach C, Scalbert A, Remesy C. Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life Sci. 2005 ; 77: 3156-3167 (Pubitemid 41433317)
    • (2005) Life Sciences , vol.77 , Issue.25 , pp. 3156-3167
    • Silberberg, M.1    Morand, C.2    Manach, C.3    Scalbert, A.4    Remesy, C.5
  • 109
    • 0345599933 scopus 로고    scopus 로고
    • Anti- and prooxidant effects of chronic quercetin administration in rats
    • DOI 10.1016/j.ejphar.2003.09.067
    • Choi EJ, Chee KM, Lee BH. Anti- and prooxidant effects of chronic quercetin administration in rats. Eur J Pharmacol. 2003 ; 482: 281-285 (Pubitemid 37505954)
    • (2003) European Journal of Pharmacology , vol.482 , Issue.1-3 , pp. 281-285
    • Choi, E.J.1    Chee, K.-M.2    Lee, B.H.3
  • 110
    • 15244352965 scopus 로고    scopus 로고
    • Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses
    • DOI 10.1016/j.fct.2004.12.012
    • Choi EJ, Lee BH, Lee K, Chee KM. Long-term combined administration of quercetin and daidzein inhibits quercetin-induced suppression of glutathione antioxidant defenses. Food Chem Toxicol. 2005 ; 43: 793-798 (Pubitemid 40385120)
    • (2005) Food and Chemical Toxicology , vol.43 , Issue.5 , pp. 793-798
    • Choi, E.J.1    Lee, B.H.2    Lee, K.3    Chee, K.-M.4
  • 111
    • 46649092119 scopus 로고    scopus 로고
    • Evaluation of the potential in vivo genotoxicity of quercetin
    • Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat Res. 2008 ; 654: 38-44
    • (2008) Mutat Res , vol.654 , pp. 38-44
    • Utesch, D.1    Feige, K.2    Dasenbrock, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.