Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 47-57

  Shi, Genbin ^a   Shaw, Gary ^a   Liang, Yu He ^a   Subburaman, Priadarsini ^a   Li, Yue ^b   Wu, Yan ^b   Yan, Honggao ^b   Ji, Xinhua ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Michigan State University   (United States)

Author keywords

Antibacterial; Bisubstrate; Folate; HPPK; Pterin

Indexed keywords

2 AMINO 6 [[2 [4 [5 (6 AMINO PURIN 9 YL) 3,4 DIHYDROXY TETRAHYDRO FURAN 2 YLMETHYLSULFANYL]PIPERIDINE 1 YL]ETHYLAMINO]METHYL] 3H PTERIDIN 4 ONE; 2 AMINO 6 [[2 [4 [5 (6 AMINO PURIN 9 YL) 3,4 DIHYDROXY TETRAHYDRO FURAN 2 YLMETHYLSULFANYL]PIPERIDINE 1 YL]ETHYLAMINO]METHYL] 7,7 DIMETHYL 7,8 DIHYDRO 3H PTERIDIN 4 ONE; 2 AMINO 7,7 DIMETHYL 4 OXO 3,4,7,8 TETRAHYDRO PTERIDIN 6 CARBOXYLIC ACID [2 [4 [5 (6 AMINO PURIN 9 YL) 3,4 DIHYDROXY TETRAHYDRO FURAN 2 YLMETHYLSULFANYL]PIPERIDINE 1 YL]ETHYL]AMIDE; 2', 3' ISOPROPYLIDENEADENOSINE; 2,4 DIAMINO 6 (HYDROXYMETHYL)PTERIDINE; 4 ACETYLSULFANYL PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 4 BROMO PIPERIDINE; 6 BROMOMETHYL 7,7 DIMETHYL 7,8 DIHYDROPTERIN; 6 BROMOMETHYLPTERIN; 6 CARBALDEHYDE 7,7 DIMETHYL 7,8 DIHYDROPTERIN; 6 CARBOXY 7,7 DIMETHYL 7,8 DIHYDROPTERIN; 6 CARBOXYLIC ACID ETHYL ESTER 7,7 DIMETHYL 7,8 DIHYDROPTERIN; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE INHIBITOR; 7,8 DIHYDRO 7,7 DIMETHYLPTERIN; ACETIC ACID DERIVATIVE; HYDROBROMIC ACID; PHOSPHATE; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PIPERIDINE; PIPERIDINE DERIVATIVE; POTASSIUM THIOACETATE; SULFIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; IC 50; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHOTRANSFERASES; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; KINETICS; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PTERINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84855189470     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.032     Document Type: Article

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