Model-based process challenge of an industrial ion-exchange chromatography step

Chemical Engineering and Technology

Volumn 35, Issue 1, 2012, Pages 183-190

  Westerberg, K ^a   Broberg Hansen, E ^b   Degerman, M ^b   Budde Hansen, T ^b   Nilsson, B ^a  

^a LUND UNIVERSITY   (Sweden)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Chromatography; Process modeling; Quality by design; Robustness; Sensitivity analysis

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; CRITICAL PROCESS PARAMETERS; CRITICAL QUALITY; EXPERIMENTAL STUDIES; FACTOR ANALYSIS; INTERACTION EFFECT; ION-EXCHANGE CHROMATOGRAPHY; MECHANISTIC MODELS; PH DEPENDENCE; PROCESS MODELING; PROCESS PARAMETERS; PRODUCT PURITY; PROTEIN CONCENTRATIONS; QUALITY BY DESIGN; ROBUSTNESS ANALYSIS; SAMPLING-BASED; THERAPEUTIC PROTEIN;

CHROMATOGRAPHY; ION EXCHANGE; LIQUID CHROMATOGRAPHY; PH EFFECTS; ROBUSTNESS (CONTROL SYSTEMS); SENSITIVITY ANALYSIS; SEPARATION;

QUALITY CONTROL;

EID: 84855180189     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.201000560     Document Type: Article

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