A Model-based approach to determine the design space of preparative Chromatography

Chemical Engineering and Technology

Volumn 32, Issue 8, 2009, Pages 1195-1202

  Degerman, Marcus ^a   Westerberg, Karin ^a   Nilsson, Bernt ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Design space; Modeling; Optimization; Preparative chromatography; Sensitivity analysis; Uncertainty analysis

Indexed keywords

CHROMATOGRAPHIC PROCESS; CRITICAL PROCESS PARAMETERS; DESIGN SPACE; DESIGN SPACES; DIFFERENT PROCESS; HIGHER YIELD; INTELLIGENT METHOD; LARGE DESIGNS; MODEL BASED APPROACH; MODELING; OBJECTIVE FUNCTIONS; OPERATING POINTS; OPTIMAL OPERATING POINT; PARETO FRONT; PHARMACEUTICAL COMPANY; PREPARATIVE CHROMATOGRAPHY; PROCESS DISTURBANCES; REGULATORY AGENCIES;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DESIGN; OPERATING COSTS; OPTIMIZATION; SENSITIVITY ANALYSIS;

UNCERTAINTY ANALYSIS;

EID: 69649094493     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.200900102     Document Type: Article

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