Application of chromatographic theory for process characterization towards validation of an ion-exchange operation

Biotechnology and Bioengineering

Volumn 98, Issue 1, 2007, Pages 201-210

  Kaltenbrunner, O ^a   Giaverini, O ^b   Woehle, D ^a   Asenjo, J A ^b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

Chromatographic theory; Ion exchange chromatography; Process characterization; Protein

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; IONIC STRENGTH; LIGANDS; PROTEINS;

ELUTION FLOW RATE; RESIN LIGAND DENSITY;

ION EXCHANGE;

PROTEIN;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ELUTION; EMPIRICAL RESEARCH; EXPERIMENTAL DESIGN; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; IONIC STRENGTH; PH; PROTEIN ANALYSIS; PROTEIN PURIFICATION; VALIDATION PROCESS;

CHROMATOGRAPHY, ION EXCHANGE; COMPUTER SIMULATION; ELECTROCHEMISTRY; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEINS;

EID: 34548230655     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21358     Document Type: Article

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