Urinary tubular biomarkers as potential early predictors of renal allograft rejection

Nephrology

Volumn 17, Issue 1, 2012, Pages 11-16

  Ting, Yi Tian ^a   Coates, P Toby ^c   Walker, Robert J ^b   McLellan, Alexander D ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b DUNEDIN HOSPITAL   (New Zealand)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

biological marker; graft rejection; kidney transplantation; kidney tubule; proximal; urine

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; HLA DR ANTIGEN; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; N ACETYL BETA GLUCOSAMINIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

ANTIGEN DETECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GRAFT SURVIVAL; HUMAN; IMMUNOREGULATION; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVIEW; URINALYSIS;

BIOLOGICAL MARKERS; CELL MOVEMENT; CHEMOTACTIC FACTORS; EARLY DIAGNOSIS; EPITHELIAL CELLS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNITY, CELLULAR; KIDNEY TRANSPLANTATION; KIDNEY TUBULES, PROXIMAL; MEMBRANE PROTEINS; PREDICTIVE VALUE OF TESTS;

EID: 84855173585     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2011.01536.x     Document Type: Review

References (66)

1. Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B,. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am. J. Transplant. 2004; 4: 378-83. (Pubitemid 38282293)
2. Hornick P, Lechler R,. Direct and indirect pathways of alloantigen recognition: Relevance to acute and chronic allograft rejection. Nephrol. Dial. Transplant. 1997; 12: 1806-10. (Pubitemid 27379445)
3. Rogers NJ, Lechler RI,. Allorecognition. Am. J. Transplant. 2001; 1: 97-102. (Pubitemid 33674147)
4. Mayer TG, Fuller AA, Fuller TC, Lazarovits AI, Boyle LA, Kurnick JT,. Characterization of in vivo-activated allospecific T lymphocytes propagated from human renal allograft biopsies undergoing rejection. J. Immunol. 1985; 134: 258-64. (Pubitemid 15191506)
5. Li B, Hartono C, Ding R, et al,. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N. Engl. J. Med. 2001; 344: 947-54. (Pubitemid 32240312)
6. Lesko LJ, Atkinson AJ Jr,. Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies. Annu. Rev. Pharmacol. Toxicol. 2001; 41: 347-66. (Pubitemid 32390116)
7. Nickerson P,. Post-transplant monitoring of renal allografts: Are we there yet? Curr. Opin. Immunol. 2009; 21: 563-8.
8. Pisitkun T, Shen RF, Knepper MA,. Identification and proteomic profiling of exosomes in human urine. Proc. Natl Acad. Sci. U. S. A. 2004; 101: 13368-73. (Pubitemid 39209672)
9. Zhou H, Pisitkun T, Aponte A, et al,. Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury. Kidney Int. 2006; 70: 1847-57. (Pubitemid 44684818)
10. Knepper MA, Pisitkun T,. Exosomes in urine: Who would have thought. ? Kidney Int. 2007; 72: 1043-5. (Pubitemid 47609047)
11. Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M,. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 2006; 7: R80.
12. Gonzalez-Buitrago JM, Ferreira L, Lorenzo I,. Urinary proteomics. Clin. Chim. Acta 2007; 375: 49-56. (Pubitemid 44584242)
13. Sigdel TK, Kaushal A, Gritsenko M, et al,. Shotgun proteomics identifies proteins specific for acute renal transplant rejection. Proteomics Clin. Appl. 2010; 4: 32-47.
14. Furness PN, Taub N,. International variation in the interpretation of renal transplant biopsies: Report of the CERTPAP Project. Kidney Int. 2001; 60: 1998-2012. (Pubitemid 33000007)
15. Cervini P, Hesley GK, Thompson RL, Sampathkumar P, Knudsen JM,. Incidence of infectious complications after an ultrasound-guided intervention. AJR Am. J. Roentgenol. 2010; 195: 846-50.
16. Nguan CY, Du C,. Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection. Transplant. Rev. (Orlando) 2009; 23: 129-38.
17. Kirby JA, Rajasekar MR, Lin Y, Proud G, Taylor RM,. Interaction between T lymphocytes and kidney epithelial cells during renal allograft rejection. Kidney Int. Suppl. 1993; 39: S124-8.
18. Woltman AM, de Haij S, Boonstra JG, Gobin SJ, Daha MR, van Kooten C,. Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells. J. Am. Soc. Nephrol. 2000; 11: 2044-55.
19. Sayegh MH,. Why do we reject a graft? Role of indirect allorecognition in graft rejection. Kidney Int. 1999; 56: 1967-79. (Pubitemid 29518201)
20. Haverty TP, Kelly CJ, Hines WH, et al,. Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J. Cell Biol. 1988; 107: 1359-68.
21. Wuthrich RP, Glimcher LH, Yui MA, Jevnikar AM, Dumas SE, Kelley VE,. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 1990; 37: 783-92. (Pubitemid 20056852)
22. Regele H, Bohmig GA, Habicht A, et al,. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J. Am. Soc. Nephrol. 2002; 13: 2371-80. (Pubitemid 34925248)
23. Donadio C, Puccini R, Lucchesi A, Giordani R, Rizzo G,. Urinary excretion of proteins and tubular enzymes in renal transplant patients. Ren. Fail. 1998; 20: 707-15. (Pubitemid 28413229)
24. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR,. The natural history of chronic allograft nephropathy. N. Engl. J. Med. 2003; 349: 2326-33. (Pubitemid 37509740)
25. Nankivell BJ, Chapman JR,. Chronic allograft nephropathy: Current concepts and future directions. Transplantation 2006; 81: 643-54.
26. Bechtel U, Scheuer R, Landgraf R, Konig A, Feucht HE,. Assessment of soluble adhesion molecules (sICAM-1, sVCAM-1, sELAM-1) and complement cleavage products (sC4d, sC5b-9) in urine. Clinical monitoring of renal allograft recipients. Transplantation 1994; 58: 905-11. (Pubitemid 24333281)
27. Tesch GH,. Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective. Nephrology (Carlton) 2010; 15: 609-16.
28. Waanders F, Navis G, van Goor H,. Urinary tubular biomarkers of kidney damage: Potential value in clinical practice. Am. J. Kidney Dis. 2010; 55: 813-16.
29. van Timmeren MM, Vaidya VS, van Ree RM, et al,. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 2007; 84: 1625-30.
30. Sarvary E, Borka P, Sulyok B, et al,. Diagnostic value of urinary enzyme determination in renal transplantation. Transpl. Int. 1996; 9 (Suppl. 1): S68-72.
31. Kuzniar J, Marchewka Z, Krasnowski R, Boratynska M, Dlugosz A, Klinger M,. Enzymuria and low molecular weight protein excretion as the differentiating marker of complications in the early post kidney transplantation period. Int. Urol. Nephrol. 2006; 38: 753-8. (Pubitemid 46336035)
32. Sundberg AG, Appelkvist EL, Backman L, Dallner G,. Urinary pi-class glutathione transferase as an indicator of tubular damage in the human kidney. Nephron 1994; 67: 308-16.
33. Sureshkumar KK, Marcus RJ,. Urinary biomarkers as predictors of long-term allograft function after renal transplantation. Transplantation 2010; 90: 688-9.
34. Teppo AM, von Willebrand E, Honkanen E, Ahonen J, Gronhagen-Riska C,. Soluble intercellular adhesion molecule-1 (sICAM-1) after kidney transplantation: The origin and role of urinary sICAM-1? Transplantation 2001; 71: 1113-19. (Pubitemid 32448828)
35. Segerer S, Cui Y, Eitner F, et al,. Expression of chemokines and chemokine receptors during human renal transplant rejection. Am. J. Kidney Dis. 2001; 37: 518-31. (Pubitemid 32195291)
36. Matz M, Beyer J, Wunsch D, et al,. Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short- and long-term graft function. Kidney Int. 2006; 69: 1683-90.
37. Hancock WW, Lu B, Gao W, et al,. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 2000; 192: 1515-20.
38. Hancock WW, Gao W, Csizmadia V, Faia KL, Shemmeri N, Luster AD,. Donor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 2001; 193: 975-80. (Pubitemid 32525870)
39. Pattison J, Nelson PJ, Huie P, et al,. RANTES chemokine expression in cell-mediated transplant rejection of the kidney. Lancet 1994; 343 (8891): 209-11. (Pubitemid 24031644)
40. Hu H, Kwun J, Aizenstein BD, Knechtle SJ,. Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation 2009; 87: 1814-20.
41. Gerard C, Rollins BJ,. Chemokines and disease. Nat. Immunol. 2001; 2: 108-15. (Pubitemid 33707927)
42. Kanmaz T, Feng P, Torrealba J, et al,. Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine. Transplantation 2004; 78: 1002-7. (Pubitemid 39391861)
43. Ichimura T, Bonventre JV, Bailly V, et al,. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 1998; 273: 4135-42. (Pubitemid 28103282)
44. Waanders F, van Timmeren MM, Stegeman CA, Bakker SJ, van Goor H,. Kidney injury molecule-1 in renal disease. J. Pathol. 2010; 220: 7-16.
45. Zhang PL, Rothblum LI, Han WK, Blasick TM, Potdar S, Bonventre JV,. Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int. 2008; 73: 608-14. (Pubitemid 351264105)
46. Han WK, Waikar SS, Johnson A, et al,. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int. 2008; 73: 863-9. (Pubitemid 351398278)
47. Nielsen BS, Borregaard N, Bundgaard JR, Timshel S, Sehested M, Kjeldsen L,. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 1996; 38: 414-20.
48. Mishra J, Ma Q, Kelly C, et al,. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr. Nephrol. 2006; 21: 856-63. (Pubitemid 43740956)
49. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P,. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003; 63: 1714-24. (Pubitemid 36513317)
50. Mishra J, Ma Q, Prada A, et al,. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J. Am. Soc. Nephrol. 2003; 14: 2534-43. (Pubitemid 37169339)
51. Parikh CR, Jani A, Mishra J, et al,. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am. J. Transplant. 2006; 6: 1639-45. (Pubitemid 43945804)
52. Endre ZH, Pickering JW, Walker RJ, et al,. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 2011; 79: 1119-30.
53. Gonzalez-Posada JM, Garcia-Castro MC, Tamajon LP, et al,. HLA-DR class II and ICAM-1 expression on tubular cells taken by fine-needle aspiration biopsy in renal allograft dysfunction. Nephrol. Dial. Transplant. 1996; 11: 148-52. (Pubitemid 26038480)
54. Ozdemir BH, Aksoy PK, Haberal AN, Demirhan B, Haberal M,. Relationship of HLA-DR expression to rejection and mononuclear cell infiltration in renal allograft biopsies. Ren. Fail. 2004; 26: 247-51. (Pubitemid 39050665)
55. Manfro RC, Goncalves LF, Rauber M, Moura LA,. Analysis of ICAM-1 and HLA-DR expression on renal allograft aspirates. Clin. Transplant. 1996; 10: 379-83. (Pubitemid 26300750)
56. Dubinski B, Boratynska M, Kopec W, Szyber P, Patrzalek D, Klinger M,. Activated cells in urine and monocyte chemotactic peptide-1 (MCP-1)-Sensitive rejection markers in renal graft recipients. Transpl. Immunol. 2008; 18: 203-7. (Pubitemid 350151854)
57. Ting YT, Coates PT, Marti HP, et al,. Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection. Transplantation 2010; 89: 1071-8.
58. Alachkar N, Rabb H, Jaar BG,. Urinary biomarkers in acute kidney transplant dysfunction. Nephron Clin. Pract. 2010; 118: c173-81.
59. Tatapudi RR, Muthukumar T, Dadhania D, et al,. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int. 2004; 65: 2390-97. (Pubitemid 38670025)
60. Hartono C, Muthukumar T, Suthanthiran M,. Noninvasive diagnosis of acute rejection of renal allografts. Curr. Opin. Organ Transplant. 2010; 15: 35-41.
61. Graziotto R, Del Prete D, Rigotti P, et al,. Perforin, Granzyme B, and fas ligand for molecular diagnosis of acute renal-allograft rejection: Analyses on serial biopsies suggest methodological issues. Transplantation 2006; 81: 1125-32.
62. Muthukumar T, Dadhania D, Ding R, et al,. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N. Engl. J. Med. 2005; 353: 2342-51. (Pubitemid 41713746)
63. Vasconcellos LM, Schachter AD, Zheng XX, et al,. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation 1998; 66: 562-6. (Pubitemid 28433834)
64. Han WK, Wagener G, Zhu Y, Wang S, Lee HT,. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin. J. Am. Soc. Nephrol. 2009; 4: 873-82.
65. McEwan P, Baboolal K, Dixon S, Conway P, Currie CJ,. Patterns of graft and patient survival following renal transplantation and evaluation of serum creatinine as a predictor of survival: A review of data collected from one clinical centre over 34 years. Curr. Med. Res. Opin. 2005; 21: 1793-800. (Pubitemid 41667247)
66. Endre ZH, Westhuyzen J,. Early detection of acute kidney injury: Emerging new biomarkers. Nephrology (Carlton) 2008; 13: 91-8. (Pubitemid 351229631)