High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients

Transplantation

Volumn 84, Issue 12, 2007, Pages 1625-1630

  Van Timmeren, Mirjan M ^a   Vaidya, Vishal S ^b   Van Ree, Rutger M ^a   Oterdoom, Leendert H ^a   De Vries, Aiko P J ^a   Gans, Reinold O B ^a   Van Goor, Harry ^a   Stegeman, Coen A ^a   Bonventre, Joseph V ^b   Bakker, Stephan J L ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Biomarker; Chronic transplant dysfunction; Kidney injury molecule 1; Renal transplantation

Indexed keywords

BIOLOGICAL MARKER; KIDNEY INJURY MOLECULE 1; MEMBRANE PROTEIN; MICROSPHERE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CREATININE CLEARANCE; DISEASE ASSOCIATION; DONOR; FEMALE; FOLLOW UP; GRAFT FAILURE; HAZARD RATIO; HUMAN; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; PROTEIN FUNCTION; PROTEINURIA; QUANTITATIVE ANALYSIS; RECIPIENT; RISK FACTOR; STATISTICAL ANALYSIS; URINALYSIS; URINARY EXCRETION;

ADULT; BIOLOGICAL MARKERS; CREATININE; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PROTEINURIA; RECEPTORS, VIRUS; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT FAILURE;

EID: 37549009988     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000295982.78039.ef     Document Type: Article

References (38)

1. Tantravahi J, Womer KL, Kaplan B. Why hasn't eliminating acute rejection improved graft survival? Annu Rev Med 2007; 58: 369.
2. Kreis HA, Ponticelli C. Causes of late renal allograft loss: Chronic allograft dysfunction, death, and other factors. Transplantation 2001; 71: SS5-SS9.
3. Massy ZA, Guijarro C, Wiederkehr MR, et al. Chronic renal allograft rejection: Immunologic and nonimmunologic risk factors. Kidney Int 1996; 49: 518.
4. Joosten SA, Sijpkens YW, van Kooten C, Paul LC. Chronic renal allograft rejection: Pathophysiologic considerations. Kidney Int 2005; 68: 1.
5. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
6. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
7. Solez K, Axelsen RA, Benediktsson H, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411.
8. Lachenbruch PA, Rosenberg AS, Bonvini E, et al. Biomarkers and surrogate endpoints in renal transplantation: Present status and considerations for clinical trial design. Am J Transplant 2004; 4: 451.
9. Kaplan B, Schold J, Meier-Kriesche HU. Poor predictive value of serum creatinine for renal allograft loss. Am J Transplant 2003; 3: 1560.
10. Kasiske BL, Andany MA, Danielson B. A thirty percent chronic decline in inverse serum creatinine is an excellent predictor of late renal allograft failure. Am J Kidney Dis 2002; 39: 762.
11. Roodnat JI, Mulder PG, Rischen-Vos J, et al. Proteinuria after renal transplantation affects not only graft survival but also patient survival. Transplantation 2001; 72: 438.
12. Merville P. Combating chronic renal allograft dysfunction: Optimal immunosuppressive regimens. Drugs 2005; 65: 615.
13. Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol 2005; 16: 3015.
14. Marsden PA. Predicting outcomes after renal transplantation - new tools and old tools. N Engl J Med 2003; 349: 182.
15. Ichimura T, Hung CC, Yang SA, et al. Kidney Injury Molecule -1 (Kim-1): A tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol 2003; 286: F552.
16. Han WK, Bailly V, Abichandani R, et al. Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 2002; 62: 237.
17. Ichimura T, Bonventre JV, Bailly V, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998; 273: 4135.
18. Kuehn EW, Park KM, Somlo S, Bonventre JV. Kidney injury molecule-1 expression in murine polycystic kidney disease.AmJ Physiol Renal Physiol 2002; 283: F1326.
19. Van Timmeren MM, Bakker SJ, Vaidya VS, et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol 2006; 291: F456.
20. Vaidya VS, Ramirez V, Ichimura T, et al. Urinary kidney injury molecule-1:A sensitive quantitative biomarker for early detection of kidney tubular injury. AmJ Physiol Renal Physiol 2006; 290: F517.
21. Van Timmeren MM, van den Heuvel MC, Bailly V, et al. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol 2007; 212: 209.
22. de Vries AP, Bakker SJ, van Son WJ, et al. Metabolic syndrome is associated with impaired long-term renal allograft function; Not all component criteria contribute equally. Am J Transplant 2004; 4: 1675.
23. van Ree RM, Oterdoom LH, de Vries AP, et al. Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients. Nephrol Dial Transplant 2007; 22: 246.
24. de Vries AP, van Son WJ, van der Heide JJ, et al. The predictive value of renal vascular resistance for late renal allograft loss. Am J Transplant 2006; 6: 364.
25. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461.
26. Liangos O, Perianayagam MC, Vaidya VS, et al. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 2007; 18: 904.
27. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics 1988; 44: 837.
28. Han WK, Alinani A, Wu CL, et al. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol 2005; 16: 1126.
29. Lin F, Zhang PL, Yang XJ, et al. Human kidney injury molecule-1 (hKIM-1): A useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am J Surg Pathol 2007; 31: 371.
30. Bailly V, Zhang Z, Meier W, et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem 2002; 277: 39739.
31. Muramatsu M, Miyagi M, Ishikawa Y, et al. Estimation of damaged tubular epithelium in renal allografts by determination of vimentin expression. Int J Urol 2004; 11: 954.
32. Grimm PC, Nickerson P, Gough J, et al. Quantitation of allograft fibrosis and chronic allograft nephropathy. Pediatr Transplant 1999; 3: 257.
33. Meyers JH, Chakravarti S, Schlesinger D, et al. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 2005; 6: 455.
34. De Borst MH, Van Timmeren MM, Vaidya VS, et al. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol 2007; 292: F313.
35. Kramer AB, Van Timmeren MM, Schuurs TA, et al. De novo induction of Kidney Injury Molecule-1 (Kim-1) in proteinuria-induced tubular injury is attenuated by RAS blockade [abstract]. J AmSoc Nephrol 2005; 16: 430A.
36. Oien CM, Reisaeter AV, Leivestad T, et al. Living donor kidney transplantation: The effects of donor age and gender on short- and longterm outcomes. Transplantation 2007; 83: 600.
37. Pessione F, Cohen S, Durand D, et al. Multivariate analysis of donor risk factors for graft survival in kidney transplantation. Transplantation 2003; 75: 361.
38. Cosio FG, Henry M, Pesavento TE, et al. The relationship between donor age and cadaveric renal allograft survival is modified by the recipient's blood pressure. Am J Transplant 2003; 3: 340.