Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection

Transplantation

Volumn 89, Issue 9, 2010, Pages 1071-1078

  Ting, Yi Tian ^a   Coates, P Toby ^b   Marti, Hans Peter ^c   Dunn, Amy C ^a   Parker, Richard M ^a   Pickering, John W ^d   Jack, Ralph W ^a   Kemp, Roslyn A ^a   Walker, Robert J ^e   McLellan, Alexander D ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b QUEEN ELIZABETH HOSPITAL   (Australia)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e DUNEDIN HOSPITAL   (New Zealand)

Author keywords

HLA DR; Renal transplant rejection; Soluble MHC

Indexed keywords

HLA DR ANTIGEN;

ACUTE GRAFT REJECTION; ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; FEMALE; HUMAN; KIDNEY GRAFT REJECTION; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; PATIENT MONITORING; PRIORITY JOURNAL; URINALYSIS; WESTERN BLOTTING;

ACUTE DISEASE; ADULT; BIOLOGICAL MARKERS; GRAFT REJECTION; HLA-DR ANTIGENS; HUMANS; INFLAMMATION; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MIDDLE AGED; SOLUBILITY;

EID: 77951859420     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181d15492     Document Type: Article

References (52)

1. Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004; 4: 378.
2. Matas AJ, Gillingham KJ, Payne WD, et al. The impact of an acute rejection episode on long-term renal allograft survival (t1/2). Transplantation 1994; 57: 857.
3. Hariharan S, Johnson CP, Bresnahan BA, et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000; 342: 605.
4. Wu J, Chen J, Wang Y, et al. Impact of acute rejection episodes on long-term renal allograft survival. Chin Med J (Engl) 2003; 116: 1741.
5. Chapman J. Addressing the challenges for improving long-term outcomes in renal transplantation. Transplant Proc 2008; 40: S2.
6. Endre ZH, Westhuyzen J. Early detection of acute kidney injury: Emerging new biomarkers. Nephrology (Carlton) 2008; 13: 91.
7. Coca SG, Yalavarthy R, Concato J, et al. Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review. Kidney Int 2008; 73: 1008.
8. Han WK, Waikar SS, Johnson A, et al. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int 2008; 73: 863.
9. Beckingham IJ, Nicholson ML, Bell PR. Analysis of factors associated with complications following renal transplant needle core biopsy. Br J Urol 1994; 73: 13.
10. Takemoto S, Port FK, Claas FH, et al. HLA matching for kidney transplantation. Hum Immunol 2004; 65: 1489.
11. Claas FH, Roelen DL, Dankers MK, et al. A critical appraisal of HLA matching in today's renal transplantation. Transplant Rev 2004; 18: 96.
12. Trivedi VB, Dave AP, Dave JM, et al. Human leukocyte antigen and its role in transplantation biology. Transplant Proc 2007; 39: 688.
13. Bishop GA, Waugh JA, Hall BM. Expression of HLA antigens on renal tubular cells in culture. II. Effect of increased HLA antigen expression on tubular cell stimulation of lymphocyte activation and on their vulnerability to cell-mediated lysis. Transplantation 1988; 46: 303.
14. Belitsky P, Miller SM, Gupta R, et al. Induction of MHC class II expression in recipient tissues caused by allograft rejection. Transplantation 1990; 49: 472.
15. Koo DD, Welsh KI, McLaren AJ, et al. Cadaver versus living donor kidneys: Impact of donor factors on antigen induction before transplantation. Kidney Int 1999; 56: 1551.
16. Henny FC, Weening JJ, Baldwin WM, et al. Expression of HLA-DR antigens on peripheral blood T lymphocytes and renal graft tubular epithelial cells in association with rejection. Transplantation 1986; 42: 479.
17. Gonzalez-Posada JM, Garcia-Castro MC, Tamajon LP, et al. HLA-DR class II and ICAM-1 expression on tubular cells taken by fine-needle aspiration biopsy in renal allograft dysfunction. Nephrol Dial Transplant 1996; 11: 148.
18. Ozdemir BH, Aksoy PK, Haberal AN, et al. Relationship of HLA-DR expression to rejection and mononuclear cell infiltration in renal allo-graft biopsies. Ren Fail 2004; 26: 247.
19. Roberti I, Panico M, Reisman L. Urine flow cytometry as a tool to differentiate acute allograft rejection from other causes of acute renal graft dysfunction. Transplantation 1997; 64: 731.
20. Schaub S, Mayr M, Honger G, et al. Detection of subclinical tubular injury after renal transplantation: Comparison of urine protein analysis with allograft histopathology. Transplantation 2007; 84: 104.
21. Hayman MW, van Beijnen MT, Stamp LK, et al. Soluble human leukocyte antigen: A diagnostic indicator of rheumatoid arthritis? J Immunol Methods 2006; 315: 19.
22. MacKay PA, Leibundgut-Landmann S, Koch N, et al. Circulating, soluble forms of major histocompatibility complex antigens are not exosome-associated. Eur J Immunol 2006; 36: 2875.
23. Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 1996; 183: 1161.
24. McLellan AD. Exosome release by primary B cells. Crit Rev Immunol 2009; 29: 203.
25. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 2004; 101: 13368.
26. Solez K, Axelsen RA, Benediktsson H, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411.
27. Saunderson SC, Schuberth PC, Dunn AC, et al. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. J Immunol 2008; 180: 8146.
28. Stevenson FK, George AJ, Walters MT, et al. Analysis of soluble HLA class II antigenic material in patients with immunological diseases using monoclonal antibodies. J Immunol Methods 1986; 86: 187.
29. Bechtel U, Scheuer R, Landgraf R, et al. Assessment of soluble adhesion molecules (sICAM-1, sVCAM-1, sELAM-1) and complement cleavage products (sC4d, sC5b-9)in urine. Clinical monitoring ofrenal allograft recipients. Transplantation 1994; 58: 905.
30. Lederer SR, FriedrichN,RegenbogenC,etal. Non-invasive monitoring of renal transplant recipients: Urinary excretion of soluble adhesion molecules and of the complement-split product C4d. Nephron Clin Pract 2003; 94: c19.
31. NickeleitV, Mihatsch MJ. Kidney transplants, antibodies and rejection: Is C4d a magic marker? Nephrol Dial Transplant 2003; 18: 2232.
32. Matthews JB, Ramos E, Bluestone JA. Clinical trials of transplant tolerance: Slow but steady progress. Am J Transplant 2003; 3: 794.
33. Claus R, Bittorf T, Walzel H, et al. High concentration of soluble HLA-DR in the synovial fluid: Generation and significance in "rheumatoid- like" inflammatory joint diseases. Cell Immunol 2000; 206: 85.
34. Baer PC, Scherberich JE, Bereiter-Hahn J, et al. Induction of RAN-TES, HLA-DR, and intercellular adhesion molecule-1 on highly purified distal tubular cells from human kidney. Transplantation 2000; 69: 2456.
35. Bricio T, RiveraM, Molina A, et al. Soluble adhesion molecules in renal transplantation. Ren Fail 1996; 18: 75.
36. Adachi J, Kumar C, Zhang Y, et al. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol 2006; 7: R80.
37. Thongboonkerd V, Malasit P. Renal and urinary proteomics: Current applications and challenges. Proteomics 2005; 5: 1033.
38. Borelli SD, Ferreira E, Oliveira AM, et al. Specific sHLA in healthy donors and donor-specific sHLA in renal transplant patients. Hum Immunol 1999; 60: 430.
39. Koelman CA, Vaessen LM, Balk AH, et al. Donor-derived soluble HLA plasma levels can not be used to monitor graft rejection in heart transplant recipients. Transpl Immuno 2000; 8: 57.
40. Adamashvili I, Kelley RE, Pressly T, et al. Soluble HLA: Patterns of expression in normal subjects, autoimmune diseases, and transplant recipients. Rheumatol Int 2005; 25: 491.
41. Nguan CY, Du C. Renal tubular epithelial cells as immunoregulatory cells in renal allograft rejection. Transplant Rev (Orlando) 2009; 23: 129.
42. Halloran PF, Broski AP, Batiuk TD, et al. The molecular immunology of acute rejection: An overview. Transpl Immunol 1993; 1: 3.
43. Dubinski B, Boratynska M, Kopec W, et al. Activated cells in urine and monocyte chemotactic peptide-1 (MCP-1)\Sensitive rejection markers in renal graft recipients. Transpl Immunol 2008; 18: 203.
44. Tatapudi RR, Muthukumar T, Dadhania D, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004; 65: 2390.
45. Hu H, Kwun J, Aizenstein BD, et al. Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation 2009; 87: 1814.
46. Kaden J, Priesterjahn R. Increasing urinary IL-6 levels announce kidney graft rejection. Transpl Int 2000; 13 (suppl 1): S34.
47. Chareandee C, Herman WH, Hricik DE, et al. Elevated endothelin-1 in tubular epithelium is associated with renal allograft rejection. Am J Kidney Dis 2000; 36: 541.
48. van Timmeren MM, Vaidya VS, van Ree RM, et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 2007; 84: 1625.
49. Herlyn M, Lange B, Bennicelli J, et al. Increased levels of circulating HLA-DR antigen in sera of patients with acute lymphoblastoid leukemia. Leuk Res 1984; 8: 323.
50. Adams TE, Bodmer JG, Bodmer WF. Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human Ia alloantigens. Immunology 1983; 50: 613.
51. Fu XT, Karr RW. HLA-DR alpha chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes. Hum Immunol 1994; 39: 253.
52. Gorga JC, Horejsi V, Johnson DR, et al. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J Bioll Chem 1987; 262: 16087.