Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in Urine

Transplantation

Volumn 87, Issue 12, 2009, Pages 1814-1820

  Hu, Huaizhong ^a,b   Kwun, Jean ^b   Aizenstein, Brian D ^a   Knechtle, Stuart J ^a,b,c  

^a Renovar Inc   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Chemokines; Cytokines; Diagnosis; Organ transplantation; Urine

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1; OSTEOPROTEGERIN;

ACUTE GRAFT REJECTION; ARTICLE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DIAGNOSTIC VALUE; HUMAN; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY INJURY; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; URINALYSIS;

BIOLOGICAL MARKERS; BIOPSY, NEEDLE; CHEMOKINE CXCL10; CHEMOKINES; CREATININE; CYTOKINES; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOPROTEGERIN; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; TRANSPLANTATION, HOMOLOGOUS;

EID: 67649635344     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181a66b3e     Document Type: Article

References (32)

1. Gourishankar S, Halloran PF. Late deterioration of organ transplants: A problem in injury and homeostasis. Curr Opin Immunol 2002; 14: 576.
2. Pascual M, Theruvath T, Kawai T, et al. Strategies to improve longterm outcomes after renal transplantation.NEngl J Med 2002; 346: 580.
3. Knight RJ, Burrows L, Bodian C. The influence of acute rejection on long-term renal allograft survival:Acomparison of living and cadaveric donor transplantation. Transplantation 2001; 72: 69.
4. Colvin RB. The renal allograft biopsy. Kidney Int 1996; 50: 1069.
5. Chandraker A. Diagnostic techniques in the work-up of renal allograft dysfunction-An update. Curr Opin Nephrol Hypertens 1999; 8: 723.
6. First MR. Renal function as a predictor of long-term graft survival in renal transplant patients. Nephrol Dial Transplant 2003; 18(suppl 1): i3.
7. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 1987; 34: 571.
8. Bunchman TE, Fryd DS, Sibley RK, et al. Manifestations of renal allograft rejection in small children receiving adult kidneys. Pediatr Nephrol 1990; 4: 255.
9. Birk PE, Stannard KM, Konrad HB, et al. Surveillance biopsies are superior to functional studies for the diagnosis of acute and chronic renal allograft pathology in children. Pediatr Transplant 2004; 8: 29.
10. Isoniemi H, Taskinen E, Hayry P. Histological chronic allograft damage index accurately predicts chronic renal allograft rejection. Transplantation 1994; 58: 1195.
11. Solez K, Axelsen RA, Benediktsson H, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411.
12. Furness PN, Philpott CM, Chorbadjian MT, et al. Protocol biopsy of the stable renal transplant: A multicenter study of methods and complication rates. Transplantation 2003; 76: 969.
13. Mengel M, Gwinner W, Schwarz A, et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007; 7: 356.
14. Budde K, Liefeldt L, Slowinski T, et al. No evidence for a relationship between infiltrates in renal protocol biopsies and outcome.AmJ Transplant 2007; 7: 2637.
15. Moreso F, Lopez M, Vallejos A, et al. Serial protocol biopsies to quantify the progression of chronic transplant nephropathy in stable renal allografts. Am J Transplant 2001; 1: 82.
16. Shapiro R, Randhawa P, Jordan ML, et al. An analysis of early renal transplant protocol biopsies-The high incidence of subclinical tubulitis. Am J Transplant 2001; 1: 47.
17. Isoniemi HM, Krogerus L, von Willebrand E, et al. Histopathological findings in well-functioning, long-term renal allografts. Kidney Int 1992; 41: 155.
18. Kanmaz T, Feng P, Torrealba J, et al. Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine. Transplantation 2004; 78: 1002.
19. Hu H, Aizenstein BD, Puchalski A, et al. Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. Am J Transplant 2004; 4: 432.
20. Tatapudi RR, Muthukumar T, Dadhania D, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004; 65: 2390.
21. Matz M, Beyer J, Wunsch D, et al. Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short- and longterm graft function. Kidney Int 2006; 69: 1683.
22. Racusen LC, Colvin RB, Solez K, et al. Antibody-mediated rejection criteria-An addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708.
23. Vignali DA. Multiplexed particle-based flow cytometric assays. J Immunol Methods 2000; 243: 243.
24. Cozzolino M, Mazzaferro S, Pugliese F, et al. Vascular calcification and uremia: What do we know? Am J Nephrol 2008; 28: 339.
25. Richter R, Forssmann U, Henschler R, et al. Increase of expression and activation of chemokine CCL15 in chronic renal failure. Biochem Biophys Res Commun 2006; 345: 1504.
26. MorenaM,Terrier N, Jaussent I, et al. Plasma osteoprotegerin is associated with mortality in hemodialysis patients. J Am Soc Nephrol 2006; 17: 262.
27. Mazzaferro S, Pasquali M, Pugliese F, et al. Serum levels of calcification inhibition proteins and coronary artery calcium score: Comparison between transplantation and dialysis. Am J Nephrol 2007; 27: 75.
28. Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997; 89: 309.
29. Yasuda H, Shima N, Nakagawa N, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998; 95: 3597.
30. Bucay N, Sarosi I, Dunstan CR, et al. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998; 12: 1260.
31. Lee WH, Kim SH, Jeong EM, et al. A novel chemokine, leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis. Atherosclerosis 2002; 161: 255.
32. Malyankar UM, Scatena M, Suchland KL, et al. Osteoprotegerin is an alpha vbeta 3-induced, NF-kappa B-dependent survival factor for endothelial cells. J Biol Chem 2000; 275: 20959.