Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity

Obesity

Volumn 20, Issue 1, 2012, Pages 178-185

  Clark, Stephen J ^a   Falchi, Mario ^a   Olsson, Bob ^b   Jacobson, Peter ^b   Cauchi, Stéphane ^c   Balkau, Beverley ^d,e   Marre, Michel ^f,g   Lantieri, Olivier ^h   Andersson, Johanna C ^a,b   Jernås, Margareta ^b   Aitman, Timothy J ^a   Richardson, Sylvia ⁱ   Sjöström, Lars ^b   Wong, Hang Y ^a,j   Carlsson, Lena M S ^b   Froguel, Philippe ^a,c   Walley, Andrew J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c INSTITUT PASTEUR DE LILLE   (France)

^d CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^e UNIVERSITÉ PARIS SACLAY   (France)

^f BICHAT HOSPITAL   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h IRSA   (France)

ⁱ IMPERIAL COLLEGE LONDON   (United Kingdom)

^j HEALTH SCIENCES AUTHORITY   (Singapore)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADIPOSE TISSUE; ADOLESCENT; ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRENCH CAUCASIAN; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN TISSUE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; OBESITY; RACE; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; SIRTUIN GENE; SWEDEN;

ADOLESCENT; ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; OBESITY, MORBID; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; SIBLINGS; SIRTUIN 1; SWEDEN; UP-REGULATION;

EID: 84655167647     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.200     Document Type: Article

References (42)

1. Cohen HY, Miller C, Bitterman KJ et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004;305:390-392. (Pubitemid 38938153)
2. Yang T, Fu M, Pestell R, Sauve AA. SIRT1 and endocrine signaling. Trends Endocrinol Metab 2006;17:186-191. (Pubitemid 43974972)
3. Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999;13:2570-2580. (Pubitemid 29489648)
4. Picard F, Guarente L. Molecular links between aging and adipose tissue. Int J Obes (Lond) 2005;29 Suppl 1:S36-S39. (Pubitemid 40343170)
5. Cantó C, Gerhart-Hines Z, Feige JN et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009;458:1056-1060.
6. Freyssenet D. Energy sensing and regulation of gene expression in skeletal muscle. J Appl Physiol 2007;102:529-540. (Pubitemid 46220880)
7. Zong H, Ren JM, Young LH et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 2002;99:15983-15987. (Pubitemid 35462735)
8. Picard F, Kurtev M, Chung N et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004;429:771-776. (Pubitemid 38833129)
9. Bäckesjö CM, Li Y, Lindgren U, Haldosén LA. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. J Bone Miner Res 2006;21:993-1002.
10. Lagouge M, Argmann C, Gerhart-Hines Z et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122. (Pubitemid 44894520)
11. Gerhart-Hines Z, Rodgers JT, Bare O et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 2007;26:1913-1923. (Pubitemid 46624046)
12. Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 2006;103:10230-10235. (Pubitemid 44051149)
13. Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem 2006;281:39915-39924. (Pubitemid 46041795)
14. Qiang L, Wang H, Farmer SR. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 2007;27:4698-4707. (Pubitemid 47016124)
15. Trujillo ME, Scherer PE. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005;257:167-175. (Pubitemid 40193966)
16. Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83. (Pubitemid 29299050)
17. Bouatia-Naji N, Meyre D, Lobbens S et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006;55:545-550. (Pubitemid 43343288)
18. Stumvoll M, Tschritter O, Fritsche A et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002;51:37-41. (Pubitemid 34517977)
19. Menzaghi C, Ercolino T, Di Paola R et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002;51:2306-2312. (Pubitemid 34729040)
20. Milne JC, Lambert PD, Schenk S et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007;450: 712-716. (Pubitemid 350207685)
21. Baur JA, Pearson KJ, Price NL et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342. (Pubitemid 44764104)
22. Feige JN, Lagouge M, Canto C et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 2008;8:347-358.
23. Peeters AV, Beckers S, Verrijken A et al. Association of SIRT1 gene variation with visceral obesity. Hum Genet 2008;124:431-436.
24. van den Berg SW, Dollé ME, Imholz S et al. Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study. Int J Obes (Lond) 2009;33:1143-1152.
25. Zillikens MC, van Meurs JB, Rivadeneira F et al. SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes 2009;58:2828-2834.
26. Pedersen SB, Ølholm J, Paulsen SK, Bennetzen MF, Richelsen B. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women. Int J Obes (Lond) 2008;32:1250-1255.
27. Rolland-Cachera MF, Cole TJ, Sempé M et al. Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr 1991;45:13-21.
28. Jaquet D, Collin D, Lévy-Marchal C, Czernichow P. Adult height distribution in subjects born small for gestational age. Horm Res 2004;62:92-96. (Pubitemid 39274259)
29. Jaziri R, Lobbens S, Aubert R et al.; DESIR Study Group. The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Diabetes 2006;55:1157-1162. (Pubitemid 44100195)
30. Jernås M, Olsson B, Arner P et al. Regulation of carboxylesterase 1 (CES1) in human adipose tissue. Biochem Biophys Res Commun 2009;383:63-67.
31. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265. (Pubitemid 40202029)
32. Sauer S, Gut IG. Genotyping single-nucleotide polymorphisms by matrixassisted laser-desorption/ionization time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2002;782:73-87. (Pubitemid 35402020)
33. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101.
34. Brazma A, Hingamp P, Quackenbush J et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 2001;29:365-371. (Pubitemid 34326681)
35. Irizarry RA, Hobbs B, Collin F et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-264.
36. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575. (Pubitemid 47330214)
37. Salyakina D, Seaman SR, Browning BL, Dudbridge F, Muller-Myhsok B. Evaluation of Nyholt's procedure for multiple testing correction. Hum Hered 2005;60:19-25; discussion 61. (Pubitemid 41291516)
38. Gabriel SB, Schaffner SF, Nguyen H et al. The structure of haplotype blocks in the human genome. Science 2002;296:2225-2229. (Pubitemid 34680308)
39. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000;66: 279-292. (Pubitemid 30481489)
40. Meyre D, Delplanque J, Chèvre JC et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-159.
41. Sladek R, Rocheleau G, Rung J et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-885.
42. Saxena R, Voight BF, Lyssenko V et al.; Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336. (Pubitemid 46871653)