Selection of microbial mutants tolerant to extreme environmental stress using continuous culture-control design

Biotechnology Progress

Volumn 15, Issue 6, 1999, Pages 1115-1124

  Lane, Paul G ^a   Hutter, Anton ^a   Oliver, Stephen G ^a   Butler, Philip R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL MUTANT; CONTINUOUS CULTURE; MICROORGANISM SCREENING; MODEL; PROCESS CONTROL; SIMULATION; STRESS TOLERANCE;

CONTROL SYSTEM SYNTHESIS; PROCESS CONTROL; STRESS ANALYSIS;

MICROBIAL MUTANTS;

CONTINUOUS CELL CULTURE;

BIOREACTORS; BIOTECHNOLOGY; COMPUTER SIMULATION; EQUIPMENT DESIGN; MUTATION; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS);

EID: 0033231528     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990084j     Document Type: Article

References (11)

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2. Butler, P. R.; Brown, M.; Oliver, S. G. Improvement of antibiotic titers from streptomyces bacteria by interactive continuous selection. Biotechnol. Bioeng. 1996, 49, 185-196.
3. Dykhuizen, D. E.; Hartl, D. L. Selection in Chemostats. Microbiol. Rev. 1983, 47, 150-168.
4. Hutter, A.; Oliver, S. G. Ethanol production using nuclear petite yeast mutants. Appl. Microbiol. Biotechnol. 1998, 49, 511-516.
5. Ignova, M. Design of Control Strategies for Strain Improvement using Feedback Continuous Selection. MSc Thesis, UMIST, Manchester, 1992.
6. Lane, P. G.; Oliver, S. G.; Butler, P. R. Selection of Microbial Mutants Tolerant to Extreme Environmental Stress using Continuous Culture: A Theoretical Framework. Biotechnol. Bioeng. 1999, Submitted for publication.
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8. Markx, G. H.; Kell, D. B. The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture. Biotechnol. Prog. 1995, 11, 64-70.
9. Sinclair, C. G.; Kristiansen, B. Fermentation Kinetics and Modelling; Open University Press: Milton Keynes, 1987.
10. Watson, T. G. Steady-state operation of a continuous culture at maximum growth rate by control of carbon dioxide production. J. Gen. Microbiol. 1969, 59, 63-89.
11. Wellstead, P. E.; Zarrop, M. B. Self-Tuning Systems: Control and Signal Processing; John Wiley & Sons Ltd: Chichester, England, 1991.