The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis

Neurogastroenterology and Motility

Volumn 24, Issue 1, 2012, Pages

  Ihara, E ^a   Chappellaz, M ^a   Turner, S R ^a   Macdonald, J A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Calcium sensitization; Colon; Inflammation; Myosin phosphatase; MYPT1; Smooth muscle

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CARBACHOL; CHELERYTHRINE; DEXTRAN SULFATE; PROTEIN; PROTEIN CPI 17; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; DESCENDING COLON; ENZYME ANALYSIS; ENZYME INHIBITION; FEMALE; INTESTINE CONTRACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; TH2 CELL; WESTERN BLOTTING;

ANIMALS; CARBACHOL; CHOLINERGIC AGONISTS; COLITIS; COLON; FEMALE; ISOENZYMES; MICE; MICE, INBRED BALB C; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 84155195024     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2011.01821.x     Document Type: Article

References (45)

1. von der Ohe MR, Camilleri M, Kvols LK, Thomforde GM. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med 1993; 329: 1073-8.
2. Barbara G, De Giorgio R, Stanghellini V, Cremon C, Salvioli B, Corinaldesi R. New pathophysiological mechanisms in irritable bowel syndrome. Aliment Pharmacol Ther 2004; 20(Suppl. 2): 1-9.
3. Vermillion DL, Huizinga JD, Riddell RH, Collins SM. Altered small intestinal smooth muscle function in Crohn's disease. Gastroenterology 1993; 104: 1692-9.
4. Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Arch Surg 2002; 137: 439-45. discussion 445-436.
5. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996; 111: 1683-99.
6. Ohama T, Hori M, Ozaki H. Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced? J Smooth Muscle Res 2007; 43: 43-54.
7. Murthy KS. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol 2006; 68: 345-74.
8. 2+ sensitivity of smooth muscle and non-muscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003; 83: 1325-58.
9. Gerthoffer WT. Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol 2005; 288: G849-53.
10. Ali I, Sarna SK. Selective modulation of PKC isozymes by inflammation in canine colonic circular muscle cells. Gastroenterology 2002; 122: 483-94.
11. 2+ -sensitization in attenuated carbachol-induced contraction of the colon in a rat model of colitis. Eur J Pharmacol 2008; 579: 365-73.
12. Eto M, Ohmori T, Suzuki M, Furuya K, Morita F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J Biochem 1995; 118: 1104-7.
13. 2+ sensitivity of protein kinase C-induced contraction in rabbit smooth muscle. J Physiol 2001; 535: 553-64.
14. Walsh MP, Susnjar M, Deng J, Sutherland C, Kiss E, Wilson DP. Phosphorylation of the protein phosphatase type 1 inhibitor protein CPI-17 by protein kinase C. Methods Mol Biol 2007; 365: 209-23.
15. MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. FEBS Lett 2001; 493: 91-4.
16. Ihara E, MacDonald JA. The regulation of smooth muscle contractility by zipper-interacting protein kinase. Can J Physiol Pharmacol 2007; 85: 79-87.
17. Koyama M, Ito M, Feng J et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 2000; 475: 197-200.
18. 2+ sensitization in murine experimental colitis. Mol Pharmacol 2009; 75: 1031-41.
19. 2+ sensitization in rat ileal longitudinal smooth muscle. Am J Physiol Gastrointest Liver Physiol 2007; 293: G699-710.
20. Kinoshita E, Kinoshita-Kikuta E, Takiyama K, Koike T. Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol Cell Proteomics 2006; 5: 749-57.
21. Harnett KM, Cao W, Biancani P. Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles. Am J Physiol Gastrointest Liver Physiol 2005; 288: G407-16.
22. Gonzalez-Montelongo MC, Marin R, Gomez T, Marrero-Alonso J, Diaz M. Androgens induce non-genomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17. Mol Endocrinol 2010; 24: 1007-23.
23. Murthy KS, Grider JR, Kuemmerle JF, Makhlouf GM. Sustained muscle contraction induced by agonists, growth factors, and Ca(2+) mediated by distinct PKC isozymes. Am J Physiol Gastrointest Liver Physiol 2000; 279: G201-10.
24. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J 1997; 11: 649-69.
25. Brehmer D, Godl K, Zech B, Wissing J, Daub H. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics 2004; 3: 490-500.
26. Keenan C, Goode N, Pears C. Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. FEBS Lett 1997; 415: 101-8.
27. Ohama T, Hori M, Sato K, Ozaki H, Karaki H. Chronic treatment with interleukin-1beta attenuates contractions by decreasing the activities of CPI-17 and MYPT-1 in intestinal smooth muscle. J Biol Chem 2003; 278: 48794-804.
28. Sato K, Ohkura S, Kitahara Y et al. Involvement of CPI-17 downregulation in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model. Neurogastroenterol Motil 2007; 19: 504-14.
29. Sakai H, Chiba Y, Hirano T, Misawa M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyper-responsive rats. Mol Pharmacol 2005; 68: 145-51.
30. Vermillion DL, Collins SM. Increased responsiveness of jejunal longitudinal muscle in Trichinella-infected rats. Am J Physiol 1988; 254: G124-9.
31. Blennerhassett MG, Vignjevic P, Vermillion DL, Collins SM. Inflammation causes hyperplasia and hypertrophy in smooth muscle of rat small intestine. Am J Physiol 1992; 262: G1041-6.
32. Khan WI, Collins SM. Gut motor function: immunological control in enteric infection and inflammation. Clin Exp Immunol 2006; 143: 389-97.
33. Moreels TG, De Man JG, Dick JM et al. Effect of TNBS-induced morphological changes on pharmacological contractility of the rat ileum. Eur J Pharmacol 2001; 423: 211-22.
34. Ohama T, Hori M, Fujisawa M et al. Downregulation of CPI-17 contributed to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients. J Gastroenterol 2008; 43: 504-14.
35. Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer WT, Ozaki H. IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages. Am J Physiol Gastrointest Liver Physiol 2007; 292: G1315-22.
36. Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins SM. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology 2005; 129: 131-41.
37. Sakai H, Yamamoto M, Kozutsumi Y, Chiba Y, Misawa M. Identification of PKC isoforms expressed in human bronchial smooth muscle cell. J Smooth Muscle Res 2009; 45: 55-62.
38. Zini N, Bavelloni A, Lisignoli G et al. PKC-zeta expression is lower in osteoblasts from arthritic patients: IL1-beta and TNF-alpha induce a similar decrease in non-arthritic human osteoblasts. J Cell Biochem 2008; 103: 547-55.
39. Greene MW, Ruhoff MS, Burrington CM, Garofalo RS, Orena SJ. TNFalpha activation of PKCdelta, mediated by NFkappaB and ER stress, cross-talks with the insulin signaling cascade. Cell Signal 2010; 22: 274-84.
40. Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. J Biol Chem 2001; 276: 29072-8.
41. Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, Makhlouf GM. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Biochem J 2003; 374: 145-55.
42. Ozaki H, Yasuda K, Kim YS et al. Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation. Br J Pharmacol 2003; 140: 1303-12.
43. Gerthoffer WT, Yamboliev IA, Shearer M et al. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. J Physiol 1996; 495 (Pt 3): 597-609.
44. Hu W, Li F, Mahavadi S, Murthy KS. Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway. Am J Physiol Cell Physiol 2009; 296: C1310-20.
45. Ulke-Lemee A, Macdonald JA. Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors. Pharmaceuticals 2010; 3: 1739-60.