Signal-transduction pathways that regulate visceral smooth muscle function III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 288, Issue 5 51-5, 2005, Pages

  Gerthoffer, William T ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Heat shock protein 27; Mitogen activated protein kinase; Mitogen activated protein kinase activated protein kinase; Phosphatidylinositol 3 kinase; Src

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE; CATION CHANNEL; CELL PROTEIN; DIACYLGLYCEROL; EFFECTOR PROTEIN; HEAT SHOCK PROTEIN 27; INOSITOL 1,4,5 TRISPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; MYOSIN LIGHT CHAIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE; PROTEIN KINASE; PROTEIN TYROSINE KINASE; RHO KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EXCITATION CONTRACTION COUPLING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR UPREGULATION; REVIEW; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GASTROINTESTINAL TRACT; GENE EXPRESSION; HUMANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 17744377218     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00530.2004     Document Type: Review

References (25)

1. Bitar KN, Kaminski MS, Hailat N, Cease KB, and Strahler JR. Hsp27 is a mediator of sustained smooth muscle contraction in response to bombesin. Biochem Biophys Res Commun 181: 1192-1200, 1991.
2. Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, and Felder CC. Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life Sci 68: 2473-2479, 2001.
3. Callaghan B, Koh SD, and Keef KD. Muscarinic M2 receptor stimulation of Cav1.2b requires phosphatidylinositol 3-kinase, protein kinase C, and c-Src. Circ Res 94: 626-633, 2004.
4. Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, and Harnett KM. MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol 285: G86-G95, 2003.
5. Cook AK, Carty M, Singer CA, Yamboliev IA, and Gerthoffer WT. Coupling of M(2) muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 278: G429-G437, 2000.
6. Eglen RM. Muscarinic receptors and gastrointestinal tract smooth muscle function. Life Sci 68: 2573-2578, 2001.
7. Gerthoffer WT and Gunst SJ. Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol 91: 963-972, 2001.
8. Gerthoffer WT, Yamboliev IA, Shearer M, Pohl J, Haynes R, Dang S, Sato K, and Sellers JR. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. J Physiol 495: 597-609, 1996.
9. Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA, and Gerthoffer WT. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274: 24211-24219, 1999.
10. Hedges JC, Oxhorn BC, Carty M, Adam LP, Yamboliev IA, and Gerthoffer WT. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 278: C718-C726, 2000.
11. Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, and Gerthoffer WT. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol Cell Physiol 275: C527-C534, 1998.
12. Jin X, Morsy N, Shoeb F, Zavzavadjian J, and Akbarali HI. Coupling of M2 muscarinic receptor to L-type Ca channel via c-src kinase in rabbit colonic circular smooth muscle. Gastroenterology 123: 827-834, 2002.
13. Meloche S, Landry J, Huot J, Houle F, Marceau F, and Giasson E. p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle. Am J Physiol Heart Circ Physiol 279: H741-H751, 2000.
14. Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, and Makhlouf GM. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/ Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. Biochem J 374: 145-155, 2003.
15. Patil SB, Pawar MD, and Bitar KN. Phosphorylated HSP27 essential for acetylcholine-induced association of RhoA with PKCα. Am J Physiol Gastrointest Liver Physiol 286: G635-G644, 2004.
16. Patil SB, Tsunoda Y, Pawar MD, and Bitar KN. Translocation and association of ROCK-II with RhoA and HSP27 during contraction of rabbit colon smooth muscle cells. Biochem Biophys Res Commun 319: 95-102, 2004.
17. Shi XZ and Sarna SK. G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammation. Am J Physiol Gastrointest Liver Physiol 286: G899-G905, 2004.
18. Singer CA, Vang S, and Gerthoffer WT. Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 282: G61-G68, 2002.
19. Somara S and Bitar KN. Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle. Am J Physiol Cell Physiol 286: C1290-C1301, 2004.
20. Somlyo AP and Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
21. Yamboliev IA, Hedges JC, Mutnick JL, Adam LP, and Gerthoffer WT. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol 278: H1899-H1907, 2000.
22. Yamboliev IA, Wiesmann KM, Singer CA, Hedges JC, and Gerthoffer WT. Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle. Am J Physiol Cell Physiol 279: C352-C360, 2000.
23. Zhang LB and Buxton IL. Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. Mol Pharmacol 40: 952-959, 1991.
24. Zhang LB, Horowitz B, and Buxton IL. Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes. Mol Pharmacol 40: 943-951, 1991.
25. Zhou H, Das S, and Murthy KS. Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. Am J Physiol Gastrointest Liver Physiol 284: G472-G480, 2003.