Expression of CPI-17 and myosin phosphatase correlates with Ca2+ sensitivity of protein kinase C-induced contraction in rabbit smooth muscle

Journal of Physiology

Volumn 535, Issue 2, 2001, Pages 553-564

  Woodsome, Terence P ^a   Eto, Masumi ^b   Everett, Allen ^b   Brautigan, David L ^b   Kitazawa, Toshio ^a,c  

^a GEORGETOWN UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; CALCIUM ION; CALPONIN; CPI 17; H CALPONIN; MYOSIN LIGHT CHAIN; PHORBOL ESTER; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; FEMORAL ARTERY; IMMUNOHISTOCHEMISTRY; MALE; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE TONE; STATISTICAL ANALYSIS; VAS DEFERENS; VASCULAR SMOOTH MUSCLE; VISCERA; WESTERN BLOTTING;

ACTINS; ANIMALS; AORTA; CALCIUM; CALCIUM-BINDING PROTEINS; CARCINOGENS; FEMORAL ARTERY; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IMMUNOHISTOCHEMISTRY; MALE; MICROFILAMENT PROTEINS; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHORBOL 12,13-DIBUTYRATE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PORTAL VEIN; PROTEIN KINASE C; RABBITS; TRACHEA; URINARY BLADDER; VAS DEFERENS;

EID: 0035449930     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.t01-1-00553.x     Document Type: Article

References (50)

1. Myosin structure and function
2. The control of protein phosphatase-1 by targeting subunits: The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1
3. Myosin light chains
4. A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch
5. A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes
6. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms
7. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization
8. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: Specific location in smooth muscle
9. Inhibition of myosin/moesin phosphatase by expression of the phosphoinhibitor protein CPI-17 alters microfilament organization and retards cell spreading
10. Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development
11. Actin and tropomyosin variants in smooth muscles. Dependence on tissue type
12. Rho-associated kinase of chicken gizzard smooth muscle
13. 2+ sensitization of rabbit smooth muscle
14. Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle
15. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N
16. Biochemistry of the contractile process in smooth muscle
17. Myosin light chain phosphatase: Subunit composition, interactions and regulation
18. 2+ sensitivities of guinea-pig ileum and rabbit pulmonary artery smooth muscle
19. Cytoplasmic free calcium, myosin light chain phosphorylation, and force in phasic and tonic smooth muscle
20. Mechanism of contracture on cooling of caffeine-treated frog skeletal muscle fibres
21. 2+-independent vasocontraction
22. Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1β in vivo
23. Regulation of smooth muscle contractile elements by second messengers
24. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β
25. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo
26. 2+-independent isoforms of protein kinase-C differentially translocate in smooth muscle
27. Regulation of myosin phosphatase by Rho and Rho-Associated kinase (Rho-kinase)
28. Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility
29. 2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation
30. G protein-mediated inhibition of myosin light chain phosphatase in vascular smooth muscle
31. Reconstitution of protein kinase C-induced contractile calcium sensitization in Triton X-100-demembranated rabbit arterial smooth muscle
32. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
33. GTPγS-dependent regulation of smooth muscle contractile elements
34. Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle
35. A novel mechanism for the calcium sensitizing effect of protein kinase C on vascular smooth muscle: Inhibition of myosin light chain phosphatase
36. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
37. Actin isoform compartments in chicken gizzard smooth muscle cells
38. 2+ sensitivity of contractile elements via protein kinase C in alpha-toxin permeabilized SMA from young spontaneously hypertensive rats
39. Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm
40. Identification of trimeric myosin phosphatase (PP1M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle
41. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
42. Vascular protein kinase C in Wistar-Kyoto and spontaneously hypertensive rats
43. Electromechanical and pharmacomechanical coupling in vascular smooth muscle
44. Signal transduction and regulation in smooth muscle
45. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
46. Inhibition of Rho-associated kinase blocks agonist-induced calcium sensitization of myosin phosphorylation and force in guinea-pig ileum
47. Differences in contractile protein content and isoforms in phasic and tonic smooth muscles
48. The dimensional characteristics of smooth muscle in rat blood vessels. A computer-assisted analysis
49. Thiophosphorylation of the 130 kDa subunit is associated with a decreased activity of myosin light chain phosphatase in alpha-toxin-permeabilized smooth muscle
50. CPI-17 and myosin light chain phosphatase expression in smooth muscle