PKC-ζ expression is lower in osteoblasts from arthritic patients: IL1-β and TNF-α induce a similar decrease in non-arthritic human osteoblasts

Journal of Cellular Biochemistry

Volumn 103, Issue 2, 2008, Pages 547-555

  Zini, Nicoletta ^a   Bavelloni, Alberto ^b   Lisignoli, Gina ^b   Ghisu, Sonia ^b   Valmori, Aurelio ^a   Martelli, Alberto Maria ^a,c   Facchini, Andrea ^b,c   Maraldi, Nadir Mario ^a,b,c  

^a CNR   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Osteoarthritis; Osteoblast; Protein kinase C; Rheumatoid arthritis

Indexed keywords

INTERLEUKIN 1BETA; ISOENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C BETA2; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C IOTA; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C MU; PROTEIN KINASE C THETA; PROTEIN KINASE C ZETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTHRITIS; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; INFLAMMATION; OSTEOARTHRITIS; OSTEOBLAST; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGED; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; ENZYME INDUCTION; FEMALE; FEMUR HEAD; HIP INJURIES; HUMANS; INTERLEUKIN-1BETA; ISOENZYMES; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; OSTEOARTHRITIS; OSTEOBLASTS; PROTEIN KINASE C; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38649116322     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21424     Document Type: Article

References (39)

1. Altman R, Asch E, Bloch D. 1986. Development of criteria for the classification of osteoarthritis of the knee. Arthritis Rheum 20:1039-1049.
2. Arner EC, Pratta MA. 1991. Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Arthritis Rheum 34:1006-1013.
3. Arnett FC, Edworth SM, Bloch DA, Mcshane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neusladt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324.
4. Bogoch ER, Moran E. 1998. Abnormal bone remodelling in inflammatory arthritis. Can J Surg 41:264-271.
5. Buchner K. 1995. Protein kinase C in the transduction of signals toward and within the cell nucleus. Eur J Biochem 228:211-221.
6. Buckwalter JA, Brown TD. 2004. Joint injury, repair, and remodeling. Clin Orthop Relat R 423:7-16.
7. Cheung WMW, Ng WW, Kung AWC. 2006. Dimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells. FEBS Letters 580:121-126.
8. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. 2000. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol 279:L429-L438.
9. Geng WD, Boskovic G, Fultz ME, Li C, Niles RM, Ohno S, Wright GL. 2001. Regulation of expression and activity of four isozymes in confluent and mechanically stimulated UMR-108 osteolastic cells. J Cell Physiol 189:216-228.
10. Hug H, Sarre TF. 1993. Protein kinase C isozymes: Divergence in signal transduction? Biochem J 291:329-343.
11. Lajeunesse D, Reboul P. 2003. Subchondral bone in osteoarthritis: A biologic link with articular cartilage leading to abnormal remodeling. Curr Opin Rheumatol 15:628-633.
12. Lampasso JD, Kamer A, Margarone J, III, Dziak R. 2001. Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. Prostaglandins Leukot Essent Fatty Acids 65:139-146.
13. Lampasso JD, Marzec N, Margarone J, III, Dziak R. 2002. Role of protein kinase C α in primary human osteoblast proliferation. J Bone Miner Res 17:1968-1976.
14. Lampasso JD, Chen W, Marzec N. 2006. The expression profile of PKC isoforms during MC3T3-E1 differentiation. Int J Mol Med 17:1125-1131.
15. Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Riccio M, Ferruzzi A, Gualtieri G, Facchini A. 1999. Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 26:791-799.
16. Mansell JP, Bailey AJ. 1998. Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest 101:1596-1603.
17. Marmiroli S, Ognibene A, Bavelloni A, Cinti C, Cocco L, Maraldi NM. 1994. Interleukin 1 α stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. J Biol Chem 269:13-16.
18. Martelli AM, Evangelisti C, Nyakern M, Manzoli FA. 2006. Nuclear protein kinase C. Biochim Biophys Acta 1761:542-551.
19. 2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts. Arthritis Rheum 41:2004-2013.
20. Musashi M, Ota S, Shiroshita N. 2000. The role of protein kinase C isoforms in cell proliferation and apoptosis. Int J hematol 72:12-19.
21. Newton AC. 1997. Regulation of protein kinase C. Curr Opin Cell Biol 9:161-167.
22. Nishizuka Y. 1995. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496.
23. Olson EN, Burgess R, Staudinger J. 1993. Protein kinase C as a transducer of nuclear signals. Cell Growth Differ 4:699-705.
24. Pendaries C, Tronchere H, Plantavid M, Payrastre B. 2003. Phosphoinositide signaling disorders in human diseases. FEBS Lett 546:25-31.
25. Poole DP, Hunne B, Robbins HL, Furness JB. 2003. Protein kinase C isoforms in the enteric nervous system. Histochem Cell Biol 120:51-61.
26. Prestwich GD, Chen R, Feng L, Ozaki S, Ferguson CG, Drees BE, Neklason DA, Mostert MJ, Porter-Gill PA, Kang VH, Shope JC, Neilsen PO, Dewald DB. 2002. In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul 42:19-38.
27. Robey PG, Termine JD. 1985. Human bone cells in vitro. Calcif Tissue Int 37:453-460.
28. Rodan SB, Wesolowski G, Chin J, Limjuco GA, Schmidt JA, Rodan GA. 1990. IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production. J Immunol 145:1231-1237.
29. Sanders JL, Stern PH. 1996. Espression and phorbol ester-induced down-regulation of protein kinase C isozymes in osteoblasts. J Bone Miner Res 11:1862-1872.
30. Satsuma H, Saito N, Hamanishi C, Hashima M, Tanaka S. 1996. Alpha and epsilon isozymes of protein kinase C in the chondrocytes in normal and early osteoarthritic articular cartilage. Calcif Tissue Int 58:192-194.
31. Tanaka S, Hamanishi C, Kikuchi H, Fukuda K. 1998. Factors related to degradation of articular cartilage in osteoarthritis: A review. Sem Arthritis Rheum 27:392-399.
32. Van Lint J, Rykx A, Vantus T, Vandenheede JR. 2002. Getting to know protein Kinase D. Int J Biochem Cell Biol 34:577-581.
33. Westacott CI, Webb GR, Warnock MG, Sims JV, Elson CJ. 1997. Alteration of cartilage metabolism by cells from osteoarthritic bone. Arthritis Rheum 40:1282-1291.
34. Wetsel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A, Hannun YA. 1992. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 117:121-133.
35. Woolley DE, Tetlow LC. 1997. Observations on the microenvironmental nature of cartilage degradation in rheumatoid arthritis. Ann Rheum Dis 56:151-161.
36. Yuan J, Bae D, Cantrell D, Nel AE, Rozengurt E. 2002. Protein kinase D is a downstream target of protein kinase Cθ. Biochem Biophys Res Commun 291:444-452.
37. Zini N, Sabatelli P, Faenza I, Ognibene A, Maraldi NM. 1996. Interleukin-1 α induces variations of the intranuclear amount of phosphatidylinositol 4,5-bisphosphate and phospholipase C β1 in human osteosarcoma Saos-2 cells. Histochem J 28:495-504.
38. Zini N, Lisignoli G, Solimando L, Bavelloni A, Grassi F, Guidotti L, Trimarchi C, Facchini A, Maraldi NM. 2003. IL1-β and TNF-α induce changes in the nuclear polyphosphoinositide signalling system in osteoblasts similar to that occurring in patients with rheumatoid arthritis: An immunochemical and immunocytochemical study. Histochem Cell Biol 120:243-250.
39. Zini N, Lisignoli G, Solimando L, Bavelloni A, Valmori A, Cristino S, Martelli AM, Facchini A, Maraldi NM. 2005. Quantitative immunodetection of key elements of polyphosphoinositide signal transduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation. Histochem Cell Biol 124:131-137.