Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cells

Toxicology Letters

Volumn 209, Issue 1, 2012, Pages 43-50

  Kocbach Bølling, Anette ^a   Ovrevik, Johan ^a   Samuelsen, Jan Tore ^b   Holme, Jørn A ^a   Rakkestad, Kirsten E ^c   Mathisen, Gro H ^c   Paulsen, Ragnhild E ^c   Suárez Korsnes, Mónica ^a   Becher, Rune ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b Nordisk Institutt for Odontologiske Materialer   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Asthma; Inflammation; Intracellular signalling; Macrophage differentiation; Phthalates

Indexed keywords

CD163 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME PHOSPHORYLATION; INTRACELLULAR SIGNALING; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; DIETHYLHEXYL PHTHALATE; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICROSCOPY, FLUORESCENCE; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PPAR ALPHA; PPAR GAMMA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 84155176931     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.11.016     Document Type: Article

References (60)

1. Adibi J.J., Whyatt R.M., Williams P.L., Calafat A.M., Camann D., Herrick R., Nelson H., Bhat H.K., Perera F.P., Silva M.J., Hauser R. Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples. Environ. Health Perspect. 2008, 116:467-473.
2. Albro P.W., Thomas R.O. Enzymatic hydrolysis of di-(2-ethylhexyl) phthalate by lipases. Biochim. Biophys. Acta 1973, 306:380-390.
3. Auten R.L., Davis J.M. Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatr. Res. 2009, 66:121-127.
4. Bergh C., Torgrip R., Emenius G., Ostman C. Organophosphate and phthalate esters in air and settled dust-a multi-location indoor study. Indoor Air 2011, 21:67-76.
5. Berry M., Brightling C., Pavord I., Wardlaw A. TNF-alpha in asthma. Curr. Opin. Pharmacol. 2007, 7:279-282.
6. Bornehag C.G., Nanberg E. Phthalate exposure and asthma in children. Int. J. Androl. 2010, 33:333-345.
7. Bornehag C.G., Sundell J., Weschler C.J., Sigsgaard T., Lundgren B., Hasselgren M., Hagerhed-Engman L. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ. Health Perspect. 2004, 112:1393-1397.
8. Bouhlel M.A., Brozek J., Derudas B., Zawadzki C., Jude B., Staels B., Chinetti-Gbaguidi G. Unlike PPARgamma, PPARalpha or PPARbeta/delta activation does not promote human monocyte differentiation toward alternative macrophages. Biochem. Biophys. Res. Commun. 2009, 386:459-462.
9. Byers D.E., Holtzman M.J. Alternatively activated macrophages as cause or effect in airway disease. Am. J. Respir. Cell Mol. Biol. 2010, 43:1-4.
10. Cho M.K., Jang Y.P., Kim Y.C., Kim S.G. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition. Int. Immunopharmacol. 2004, 4:1419-1429.
11. Coonrod J.D., Karathanasis P., Lin R. Lipoprotein lipase: a source of free fatty acids in bronchoalveolar lining fluid. J. Lab. Clin. Med. 1989, 113:449-457.
12. Dietert R.R. Maternal and childhood asthma: Risk factors, interactions, and ramifications. Reprod. Toxicol. 2011, 32:198-204.
13. European Chemicals Agency, 2009. Background document for bis(2-ethylhexyl) phthalate (DEHP). http://echa.europa.eu/doc/authorisation/annex_xiv_rec/subs_spec_background_docs/dehp.pdf.
14. Feige J.N., Gelman L., Rossi D., Zoete V., Metivier R., Tudor C., Anghel S.I., Grosdidier A., Lathion C., Engelborghs Y., Michielin O., Wahli W., Desvergne B. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J. Biol. Chem. 2007, 282:19152-19166.
15. Hamid Q., Tulic' M.K., Liu M.C., Moqbel R. Inflammatory cells in asthma: mechanisms and implications for therapy. J. Allergy Clin. Immunol. 2003, 111:S5-S12.
16. Hansen J.S., Larsen S.T., Poulsen L.K., Nielsen G.D. Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice. Toxicology 2007, 232:79-88.
17. Hurst C.H., Waxman D.J. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol. Sci. 2003, 74:297-308.
18. Ito K., Caramori G., Adcock I.M. Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J. Pharmacol. Exp. Ther. 2007, 321:1-8.
19. Jepsen K.F., Abildtrup A., Larsen S.T. Monophthalates promote IL-6 and IL-8 production in the human epithelial cell line A549. Toxicol. In Vitro 2004, 18:265-269.
20. Kasahara E., Sato E.F., Miyoshi M., Konaka R., Hiramoto K., Sasaki J., Tokuda M., Nakano Y., Inoue M. Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. Biochem. J 2002, 365:849-856.
21. Kim E.Y., Battaile J.T., Patel A.C., You Y., Agapov E., Grayson M.H., Benoit L.A., Byers D.E., Alevy Y., Tucker J., Swanson S., Tidwell R., Tyner J.W., Morton J.D., Castro M., Polineni D., Patterson G.A., Schwendener R.A., Allard J.D., Peltz G., Holtzman M.J. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat. Med. 2008, 14:633-640.
22. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2063-2078.
23. Kolarik B., Naydenov K., Larsson M., Bornehag C.G., Sundell J. The association between phthalates in dust and allergic diseases among Bulgarian children. Environ. Health Perspect. 2008, 116:98-103.
24. Kuroki M., Noguchi Y., Shimono M., Tomono K., Tashiro T., Obata Y., Nakayama E., Kohno S. Repression of bleomycin-induced pneumopathy by TNF. J. Immunol. 2003, 170:567-574.
25. Larsen S.T., Hansen J.S., Hammer M., Alarie Y., Nielsen G.D. Effects of mono-2-ethylhexyl phthalate on the respiratory tract in BALB/c mice. Hum. Exp. Toxicol. 2004, 23:537-545.
26. Larsen S.T., Hansen J.S., Hansen E.W., Clausen P.A., Nielsen G.D. Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice. Toxicology 2007, 235:119-129.
27. Laskin D.L. Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem. Res. Toxicol. 2009, 22:1376-1385.
28. Lee A.K., Sung S.H., Kim Y.C., Kim S.G. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br. J. Pharmacol. 2003, 139:11-20.
29. Lee K.S., Park S.J., Hwang P.H., Yi H.K., Song C.H., Chai O.H., Kim J.S., Lee M.K., Lee Y.C. PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. FASEB J. 2005, 19:1033-1035.
30. Li L.H., Jester W.F., Orth J.M. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol. Appl. Pharmacol. 1998, 153:258-265.
31. Magliozzi R., Nardacci R., Scarsella G., Di C.V., Stefanini S. Effects of the plasticiser DEHP on lung of newborn rats: catalase immunocytochemistry and morphometric analysis. Histochem. Cell Biol. 2003, 120:41-49.
32. Mahoney E.M., Khoo J.C., Steinberg D. Lipoprotein lipase secretion by human monocytes and rabbit alveolar macrophages in culture. Proc. Natl. Acad. Sci. U. S. A. 1982, 79:1639-1642.
33. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
34. Matheny R.W., Adamo M.L. Current perspectives on Akt Akt-ivation and Akt-ions. Exp. Biol. Med. (Maywood) 2009, 234:1264-1270.
35. Melgert B.N., Oriss T.B., Qi Z., Dixon-McCarthy B., Geerlings M., Hylkema M.N., Ray A. Macrophages: regulators of sex differences in asthma?. Am. J. Respir. Cell Mol. Biol. 2010, 42:595-603.
36. Oh P.S., Lim K., Lim K.T. Phytoglycoprotein (75kDa) inhibits expression of interleukin-1beta stimulated by DEHP in human mast cells. Cell Biochem. Funct. 2010, 28:352-359.
37. Oh P.S., Lim K.T. Modulatory effects of phytoglycoprotein (75kDa) on allergic inflammatory cytokines in Di(2-ethylhexyl) phthalate (DEHP)-stimulated RBL-2H3 cells. J. Cell. Biochem. 2010, 109:124-131.
38. Oh P.S., Lim K.T. IgE, COX-2, and IL-4 are expressed by DEHP through p38 MAPK and suppressed by plant glycoprotein (75kDa) in ICR mice. Inflammation 2011, 34:326-334.
39. Oie L., Hersoug L.G., Madsen J.O. Residential exposure to plasticizers and its possible role in the pathogenesis of asthma. Environ. Health Perspect. 1997, 105:972-978.
40. Pearce N., Ait-Khaled N., Beasley R., Mallol J., Keil U., Mitchell E., Robertson C. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007, 62:758-766.
41. Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Am. J. Respir. Cell Mol. Biol. 2004, 31:3-7.
42. Rajaram M.V., Ganesan L.P., Parsa K.V., Butchar J.P., Gunn J.S., Tridandapani S. Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice. J. Immunol. 2006, 177:6317-6324.
43. Rakkestad K.E., Dye C.J., Yttri K.E., Holme J.A., Hongslo J.K., Schwarze P.E., Becher R. Phthalate levels in Norwegian indoor air related to particle size fraction. J. Environ. Monit. 2007, 9:1419-1425.
44. Rakkestad K.E., Holme J.A., Paulsen R.E., Schwarze P.E., Becher R. Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha. Inhal. Toxicol. 2010, 22:140-150.
45. Raman M., Chen W., Cobb M.H. Differential regulation and properties of MAPKs. Oncogene 2007, 26:3100-3112.
46. Reddy R.C. Immunomodulatory role of PPAR-gamma in alveolar macrophages. J. Investig. Med. 2008, 56:522-527.
47. Ricote M., Li A.C., Willson T.M., Kelly C.J., Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998, 391:79-82.
48. Rogers R., Ouellet G., Brown C., Moyer B., Rasoulpour T., Hixon M. Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis. Toxicol. Sci. 2008, 106:497-508.
49. Rosicarelli B., Stefanini S. DEHP effects on histology and cell proliferation in lung of newborn rats. Histochem. Cell Biol. 2009, 131:491-500.
50. Saad M.J., Folli F., Araki E., Hashimoto N., Csermely P., Kahn C.R. Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone. Mol. Endocrinol. 1994, 8:545-557.
51. Saklatvala J. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr. Opin. Pharmacol. 2004, 4:372-377.
52. Schettler T. Human exposure to phthalates via consumer products. Int. J. Androl. 2006, 29:134-139.
53. Smythe C.D., Skinner V.O., Bruckdorfer K.R., Haskard D.O., Landis R.C. The state of macrophage differentiation determines the TNF alpha response to nitrated lipoprotein uptake. Atherosclerosis 2003, 170:213-221.
54. van der Plas M.J., van Dissel J.T., Nibbering P.H. Maggot secretions skew monocyte-macrophage differentiation away from a pro-inflammatory to a pro-angiogenic type. PLoS One 2009, 4:e8071.
55. Vetrano A.M., Laskin D.L., Archer F., Syed K., Gray J.P., Laskin J.D., Nwebube N., Weinberger B. Inflammatory effects of phthalates in neonatal neutrophils. Pediatr. Res. 2010, 68:134-139.
56. Wewers M.D., Herzyk D.J. Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay. J. Immunol. 1989, 143:1635-1641.
57. Yagnik D.R., Hillyer P., Marshall D., Smythe C.D., Krausz T., Haskard D.O., Landis R.C. Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in gout. Arthritis Rheum. 2000, 43:1779-1789.
58. Yamashita U., Sugiura T., Yoshida Y., Kuroda E. Effect of endocrine disrupters on macrophage functions in vitro. J. UOEH 2005, 27:1-10.
59. Yao P.L., Lin Y.C., Sawhney P., Richburg J.H. Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury. J. Biol. Chem. 2007, 282:5420-5431.
60. Yessoufou A., Wahli W. Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med. Wkly. 2010, 140:w13071.