New insights into the metabolism of organomercury compounds: Mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase

Archives of Biochemistry and Biophysics

Volumn 517, Issue 1, 2012, Pages 20-29

  Bridges, Christy C ^a   Krasnikov, Boris F ^b   Joshee, Lucy ^a   Pinto, John T ^b   Hallen, André ^c   Li, Jianyong ^d   Zalups, Rudolfs K ^a   Cooper, Arthur J L ^b  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c MACQUARIE UNIVERSITY   (Australia)

^d VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Cystathionine lyase; Glutamine transaminase K; Kynurenine aminotransferase isozyme I; Mercury cysteine S conjugate; Methylmercury cysteine S conjugate; Sulfur containing amino acids

Indexed keywords

CYSTATHIONINE; CYSTATHIONINE GAMMA LYASE; CYSTEINE CONJUGATE; CYSTINE; GLUTAMINE PHENYLPYRUVATE AMINOTRANSFERASE; HOMOCYSTEINE; MERCURY; MERCURY CHLORIDE; METHIONINE; METHYLMERCURY DERIVATIVE; ORGANOMERCURY COMPOUND; RECOMBINANT ENZYME; SULFUR AMINO ACID;

ANIMAL TISSUE; ARTICLE; BIOCATALYSIS; BIOCHEMISTRY; BIOTRANSFORMATION; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACIDS, SULFUR; ANIMALS; CATTLE; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; CYSTINE; HUMANS; LYASES; MERCURIC CHLORIDE; METHYLMERCURY COMPOUNDS; MODELS, MOLECULAR; ORGANOMERCURY COMPOUNDS; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; TRANSAMINASES;

BOVINAE; RATTUS;

EID: 84155172720     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2011.11.002     Document Type: Article

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