Homocysteine, system b0,+ and the renal epithelial transport and toxicity of inorganic mercury

American Journal of Pathology

Volumn 165, Issue 4, 2004, Pages 1385-1394

  Bridges, Christy C ^a   Zalups, Rudolfs K ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (2 AMINO 2 CARBOXYETHYLSULFANYLMERCURICSULFANYL)BUTYRIC ACID; 2 AMINO 4 (3 AMINO 3 CARBOXYPROPYLSULFANYLMERCURICSULFANYL)BUTYRIC ACID; AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER SYSTEM B0+; CYSTEINE DERIVATIVE; HOMOCYSTEINE; INORGANIC COMPOUND; MERCURY; MERCURY DERIVATIVE; UNCLASSIFIED DRUG; CYSTEINE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL STRAIN; CELL VIABILITY; CONJUGATE; CONTROLLED STUDY; CYTOPATHOLOGY; ENZYME SPECIFICITY; EPITHELIUM CELL; GENETIC TRANSFECTION; KIDNEY DISEASE; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; MERCURIALISM; MODEL; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SATURATION KINETICS; TEMPERATURE DEPENDENCE; TIME; TRANSPORT KINETICS; ANIMAL; CELL CULTURE; CHEMISTRY; DOG; EPITHELIUM; KIDNEY; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID TRANSPORT SYSTEMS; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYSTEINE; DOGS; EPITHELIUM; HOMOCYSTEINE; KIDNEY; MERCURY;

EID: 4644240505     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63396-2     Document Type: Article

References (29)

1. Refsum H, Ueland PM, Nygard O, Vollset SE: Homocysteine and cardiovascular disease. Annu Rev Med 1998, 49:31-62
2. Selhub J: Homocysteine metabolism. Annu Rev Nutr 1999, 19:217-246
3. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I: Hyperhomocysteineimia: an independent risk factor for vascular disease. N Engl J Med 1991, 324:1149-1155
4. Dudman NP, Guo XW, Gordon RB, Dawson PA, Wilcken DE: Human homocysteine catabolism: three major pathways and their relevance to development of arterial occlusive disease. J Nutr 1996, 126:295S-300S
5. House JD, Brosnan ME, Brosnan JT: Characterization of homocysteine metabolism in the rat kidney. Biochem J 1997, 328:287-292
6. House JD, Brosnan ME, Brosnan JT: Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia. Kidney Int 1998, 54:601-607
7. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J: Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 1995, 116:59-62
8. Friedman AN, Bostom AG, Selhub J, Levey AS, Rosenberg IH: The kidney and homocysteine metabolism. J Am Soc Nephrol 2001, 12:2181-2189
9. 0,+: implications of molecular mimicry. J Am Soc Nephrol 2004, 15:663-673
10. Palacin M, Estevez R, Bertran J, Zorzano A: Molecular biology of plasma membrane amino acid transporters. Physiol Rev 1998, 78:969-1054
11. 0,+ and cystinuria. Mol Membr Biol 2001, 18:21-26
12. Kanai Y, Stelzner MG, Lee WS, Wells RG, Brown D, Hediger MA: Expression of mRNA (D2) encoding a protein involved in amino acid transport in S3 proximal tubule. Am J. Physiol 1992, 263:F1087-F1092
13. Furriols M, Chillaron J, Mora C, Castello A, Bertran J, Camps M, Testar X, Vilaro S, Zorzano A, Palacin M: rBat, related to L-cystine transport, is localized to the microvilli of proximal straight tubules, and its expression is regulated in kidney by development. J Biol Chem 1993, 268:27060-27068
14. Pfeiffer R, Loffing J, Rossier G, Bauch C, Meier C, Eggermann T, Loffing-Cueni D, Kuhn LC, Verrey F: Luminal heterodimeric amino acid transporter defective in cystinuria. Mol Biol Cell 1999, 10:4135-4147
15. Zalups RK, Barfuss DW: Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury. J Am Soc Nephrol 1998, 9:551-561
16. Foreman JW, Wald H, Blumberg G, Pepe LM, Segal S: Homocystine uptake in isolated rat renal cortical tubules. Metabolism 1982, 31:613-619
17. Naggar H, Fei YJ, Ganapathy V, Smith SB: Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells. Exp Eye Res 2003, 77:687-697
18. Bauch C, Verrey F: Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cells. Am J Physiol 2003, 283:F181-F189
19. Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V: Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2000, 42:47-54
20. Bridges CC, Ola S, Prasad PD, El-Sherbeny A, Ganapathy V, Smith SB: Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells. Am J. Physiol 2000, 281:C1825-C1836
21. Zalups RK: Molecular interactions with mercury in the kidney. Pharmacol Rev 2000, 52:113-143
22. Fuhr B, Rabenstein DL: Nuclear magnetic-resonance studies of solution chemistry of metal-complexes. 9. Binding of cadmium, zinc, lead, and mercury by glutathione. J Am Chem Soc 1973, 95:6944-6950
23. Aslamkhan AG, Man YH, Yang XP, Zalups RK, Pritchard JB: Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharmacol 2003, 63:590-596
24. 2+ in the renal proximal tubule. J Am Soc Nephrol 2000, 11:394-402
25. Cannon VT, Zalups RK, Barfuss DW: Amino acid transporters involved in luminal transport of mercuric conjugates of cysteine in rabbit proximal tubule. J Pharmacol Exp Ther 2001, 298:780-789
26. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH: Total homocysteine in plasma or serum. Methods and clinical applications. Clin Chem 1993, 39:1764-1779
27. Rabenstein DL, Fairhurst MT: Nuclear magnetic resonance studies of the solution chemistry of metal complexes XI. The binding of methyl-mercury by sulfhydryl-containing amino acids and by glutathione. J Am Chem Soc 1975, 97:2086-2092
28. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J: Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988, 81:466-474
29. Malinow MR: Hyperhomocysteinemia: a common and easily reversible risk factor of occlusive artherosclerosis. Circulation 1990, 81:2004-2006