Transport of a neurotoxicant by molecular mimicry: The methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2

Biochemical Journal

Volumn 367, Issue 1, 2002, Pages 239-246

  Simmons Willis, Tracey A ^a   Koh, Albert S ^a   Clarkson, Thomas W ^a   Ballatori, Nazzareno ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Amino acid carrier; Amino acid exchanger; L cysteine; Metal ion homoeostasis and toxicity; Methionine

Indexed keywords

AMINO ACIDS; BRAIN; CELL MEMBRANES; DIFFUSION; HYDROPHILICITY; SUBSTRATES; TISSUE; TOXICITY;

METAL ION HOMOEOSTATIS;

BIOCHEMISTRY;

ACETYLCYSTEINE; AMINO ACID TRANSPORTER LAT1; AMINO ACID TRANSPORTER LAT2; CARBON 14; CARRIER PROTEIN; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; LEUCINE; METHIONINE; METHYLMERCURY; NEUROTOXIN; PENICILLAMINE; PHENYLALANINE; UNCLASSIFIED DRUG; AMINO ACID; AMINO ACID TRANSPORTER; CD98 ANTIGEN; COMPLEMENTARY DNA; COMPLEMENTARY RNA; DRUG DERIVATIVE; ION; METHYLMERCURY CYSTEINE; METHYLMERCURY DERIVATIVE; SLC7A8 PROTEIN, HUMAN;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL KINETICS; CELL MEMBRANE TRANSPORT; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION; FEMALE; HEAVY METAL POISONING; HOMEOSTASIS; MOLECULAR MIMICRY; NEUROTOXICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICOKINETICS; XENOPUS LAEVIS; ANALYSIS OF VARIANCE; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMISTRY; DOSE RESPONSE; HUMAN; KINETICS; METABOLISM; PROTEIN BINDING; TIME; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID TRANSPORT SYSTEM Y+; AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD98 LIGHT CHAINS; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; CYSTEINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IONS; KINETICS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; METHIONINE; METHYLMERCURY COMPOUNDS; NEUROTOXINS; OOCYTES; PROTEIN BINDING; RNA, COMPLEMENTARY; TIME FACTORS; XENOPUS LAEVIS;

EID: 0036798145     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020841     Document Type: Article

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