The human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) is irreversibly inhibited by inorganic (Hg2+) and organic mercury (CH3Hg+): Mechanism and kinetics

FEBS Letters

Volumn 584, Issue 15, 2010, Pages 3366-3369

  Ragunathan, Nilusha ^a   Busi, Florent ^a   Pluvinage, Benjamin ^a   Sanfins, Elodie ^a   Dupret, Jean Marie ^a   Rodrigues Lima, Fernando ^a   Dairou, Julien ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Arylamine N acetyltransferase; Inhibition; Mercury; Xenobiotic metabolism

Indexed keywords

ACYLTRANSFERASE; MERCURY; METHYLMERCURY; N ACETYLTRANSFERASE 1; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL;

ACETYL COENZYME A; ARYLAMINE N-ACETYLTRANSFERASE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GLUTATHIONE; HUMANS; ISOENZYMES; KINETICS; LUNG; MERCURY; METHYLMERCURY COMPOUNDS; XENOBIOTICS;

EID: 77955281589     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.022     Document Type: Article

References (30)

1. Hein D., McQueen C., Grant D., Goodfellow G., Kadlubar F., Weber W. Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber. Drug Metab. Dispos. 2000, 28:1425-1432.
2. Minchin R.F., Hanna P.E., Dupret J.M., Wagner C.R., Rodrigues-Lima F., Butcher N.J. Arylamine N-acetyltransferase I. Int. J. Biochem. Cell Biol. 2007, 39:1999-2005.
3. Hein D.W., et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol. Biomarkers Prev. 2000, 9:29-42.
4. Minchin R.F. Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem. J. 1995, 307:1-3.
5. Wakefield L., Cornish V., Long H., Griffiths W.J., Sim E. Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem. Biophys. Res. Commun. 2007, 364:556-560.
6. Adam P.J., et al. Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Mol. Cancer Res. 2003, 1:826-835.
7. Wakefield L., Robinson J., Long H., Ibbitt J.C., Cooke S., Hurst H.C., Sim E. Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. Genes Chromosomes Cancer 2008, 47:118-126.
8. Tiang J.M., Butcher N.J., Minchin R.F. Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells. Biochem. Biophys. Res. Commun. 2010, 393:95-100.
9. Rodrigues-Lima F., Dairou J., Busi F., Dupret J.M. Human arylamine N-acetyltransferase 1: a drug-metabolizing enzyme and a drug target?. Curr. Drug Targets 2010, 11:759-766.
10. Rodrigues-Lima F., et al. Skeletal muscles express the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase. J. Histochem. Cytochem. 2003, 51:789-796.
11. Dairou J., Malecaze F., Dupret J.M., Rodrigues-Lima F. The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases (NAT) in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol. Pharmacol. 2005, 67:1299-1306.
12. Boukouvala S., Fakis G. Arylamine N-acetyltransferases: what we learn from genes and genomes. Drug Metab. Rev. 2005, 37:511-564.
13. Goyer R., Clarkson T. Toxicology: The Basic Science of Poisons 2001, McGraw-Hill, New-York. C.D. Klaassen (Ed.).
14. Bridges C.C., Zalups R.K. Molecular and ionic mimicry and the transport of toxic metals. Toxicol. Appl. Pharmacol. 2005, 204:274-308.
15. Jacoby S.C., Gagnon E., Caron L., Chang J., Isenring P. Inhibition of Na(+)-K(+)-2Cl(-) cotransport by mercury. Am. J. Physiol. 1999, 277:C684-C692.
16. Bozcaarmutlu A., Arinc E. Mechanism of inhibition of purified leaping mullet (Liza saliens) NADPH-cytochrome P450 reductase by toxic metals: aluminum and thallium. J. Biochem. Mol. Toxicol. 2007, 21:340-347.
17. Draper A.J., Hammock B.D. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol. Sci. 1999, 52:26-32.
18. Nakahama T., Inouye Y., Fukuhara M. Comparative study on the in vitro inhibitory effects of heavy metals on rabbit drug-metabolizing enzymes. J. Health Sci. 2001, 47:14-20.
19. Weber W.W., Cohen S.N. N-Acetylation of drugs: isolation and properties of an N-acetyltransferase from rabbit liver. Mol. Pharmacol. 1967, 3:266-273.
20. Nuttall K.L. Interpreting mercury in blood and urine of individual patients. Ann. Clin. Lab. Sci. 2004, 34:235-250.
21. Dairou J., Atmane N., Dupret J.M., Rodrigues-Lima F. Reversible inhibition of the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 by S-nitrosothiols. Biochem. Biophys. Res. Commun. 2003, 307:1059-1065.
22. Mushtaq A., Payton M., Sim E. The C-terminus of arylamine N-acetyl transferase from Salmonella typhimurium controls enzymic activity. J. Biol. Chem. 2002, 277:12175-12181.
23. Grant D.M., Blum M., Beer M., Meyer U.A. Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes. Mol. Pharmacol. 1991, 39:184-191.
24. Dairou J., Petit E., Ragunathan N., Baeza-Squiban A., Marano F., Dupret J.M., Rodrigues-Lima F. Arylamine N-acetyltransferase activity in bronchial epithelial cells and its inhibition by cellular oxidants. Toxicol. Appl. Pharmacol. 2009, 236:366-371.
25. Ragunathan N., Dairou J., Pluvinage B., Martins M., Petit E., Janel N., Dupret J.M., Rodrigues-Lima F. Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition. Mol. Pharmacol. 2008, 73:1761-1768.
26. Cornish-Bowden A. Fundamentals in Enzyme Kinetics 2001, Portland Press, London, p. 343.
27. Park E.J., Park K. Induction of reactive oxygen species and apoptosis in BEAS-2B cells by mercuric chloride. Toxicol. In Vitro 2007, 21:789-794.
28. Castell J.V., Donato M.T., Gomez-Lechon M.J. Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Exp. Toxicol. Pathol. 2005, 57(Suppl. 1):189-204.
29. Bem E.M., Mailer K., Elson C.M. Influence of mercury (II), cadmium (II), methylmercury, and phenylmercury on the kinetic properties of rat liver glutathione peroxidase. Can. J. Biochem. Cell Biol. 1985, 63:1212-1216.
30. Rahman I., MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic. Biol. Med. 2000, 28:1405-1420.