Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women

Cytokine

Volumn 57, Issue 1, 2012, Pages 32-36

  Gupta, Vani ^a   Gupta, Abhishek ^a   Jafar, Tabrez ^a   Gupta, Vandana ^a   Agrawal, Suraksha ^b   Srivastava, Nidhi ^a   Kumar, Sandeep ^a   Singh, Arun K ^a   Natu, S M ^a   Agarwal, C G ^a   Agarwal, G G ^c  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^c UNIVERSITY OF LUCKNOW   (India)

Author keywords

HOMA index; Leptin; Metabolic syndrome; PCR; TNF alpha

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERTENSION; INDIAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR NECROSIS FACTOR ALPHA GENE; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADULT; ANTHROPOMETRY; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDIA; INSULIN RESISTANCE; LEPTIN; METABOLIC SYNDROME X; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84155168053     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.04.012     Document Type: Article

References (39)

1. Koh K.K., Han S.H., Quon M.J. Inflammatory markers and the metabolic syndrome; insight from therapeutic interventions. J Am Coll Cardiol 2005, 46:1978-1985.
2. Ritche S.A., Connell J.M. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 2006.
3. Ferrario C.M., Strawn W.B. Role of rennin-angiotensin-Aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol 2006, 98:121-128.
4. Semenkovich C.F. Insulin resistance and atherosclerosis. J Clin Invest 2006, 116:1813-1822.
5. Wilson A.G., di Giovine F.S., Blakemore A.I., Duff G.W. Single base polymorphism in the human tumour necrosis factor a (TNF-a) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1992, 1:353.
6. Aguillón J.C., Cruzat A., Aravena O., Salazar L., Llanos C., Cuchacovich M. Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?. Immunobiology 2006, 211(1-2):75-84.
7. Abraham L.J., Kroeger K.M. Impact of the 2308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukocyte Biol 1999, 66:562-566.
8. Jéquier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002, 967:379-388.
9. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med Nov 1995, 1(11):1155-1161.
10. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 1(334):292-295.
11. Trujillo M.E., Lee M.J., Sullivan S., Feng J., Schneider S.H., Greenberg A.S., et al. Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase. J Clin Endocrinol Metab 2006, 91(4):1484-1490.
12. Sookoian S.C., González C., Pirola C.J. Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome. Obes Res 2005, 13(12):2122-2131.
13. Sookoian S., García S.I., Gianotti T.F., Dieuzeide G., González C.D., Pirola C.J., et al. The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome. Am J Hypertens 2005, 18(10):1271-1275.
14. Fernandez-Real J.M., Gutierrez C., Ricart W., Casamitjana R., Fernandez-Castaner M., Vendrell J., et al. The TNF-α gene NCO I polymorphism influences the relationship among insulin resistance, percent body fat and increased serum leptin levels. Diabetes 1997, 46:1468-1471.
15. Ranjith N., Pegoraro R.J., Naidoo D.P., Shanmugam R., Rom L. Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction. Metab Syndr Relat Disord 2008, 6(3):209-214.
16. Pyrzak B., Wiśniewska A., Rymkiewicz-Kluczyńska B. Tumor necrosis factor alpha (TNF-α) gene G-308A polymorphism relationship to insulin resistance and lipid abnormalities in children with obesity. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 2006, 12(3):171-174.
17. Lee S.C., Pu Y.B., Thomas G.N., Lee Z.S., Tomlinson B., Cockram C.S., et al. Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. Metabolism 2000, 49(8):1021-1024.
18. Waltson J., Seibert M., Yen C.J., Cheskin L.J., Andersen R.F. Tumor necrosis factor-a -238 and -308 polymorphisms do not associate with traits to obesity and insulin-resistance. Diabetes 1999, 48(10):2096-2098.
19. Gogia Atul, Agarwal P.K. Metabolic syndrome. Ind J Med Sci 2006, 60(2).
20. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
21. Mehmet Keskin, Selim Kurtoglu, Mustafa Kendirci, M. Emre Atabek, Cevat Yazici. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115 (4): e500-e503.
22. John Wass. Software: Statistics, fast and easy. Science 1998; Vol. 282. No. 5394, p. 1652.
23. Wilson A.G., de Vries N., Pociot F., di Giovine F.S., van der Putte L.B., Duff G.W. An allelic polymorphism within the human tumor necrosis factor promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med 1993, 177:557-560.
24. Wilson A.G., Symons J.A., McDowell T.L., McDevitt H.O., Duff G.W. Effects of a polymorphism in the human tumor necrosis factor promoter on transcriptional activation. Proc Natl Acad Sci USA 1993, 94:3195-3199.
25. Kroeger K.M., Carville K.S., Abraham L.J. The 308 tumor necrosis factor- promoter polymorphism effects transcription. Mol Immunol 1997, 34:391-399.
26. Jacob C.O., Fronek Z., Lewis G.D., Koo M., Hansen J.A., McDevitt H.O. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 1990, 87:1233-1237.
27. Wilson A.G., Symons J.A., McDowell T.L., di Giovine F.S., Duff G.W. Effects of the tumour necrosis factor (TNF-α) promoter base transition on transcriptional activity. Br J Rheumatol 1994, 33(1):89.
28. Caro J.F., Kolaczynski J.W., Nyce M.R., et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996, 348(9021):159-161.
29. Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999, 194(1):6-11.
30. Loffreda S., Yang S.Q., Lin H.Z., et al. Leptin regulates proinflammatory immune responses. FASEB J 1998, 12(1):57-65.
31. Mantzoros C.S., Moschos S., Avramopoulos I., et al. Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans. J Clin Endocrinol Metab 1997, 82(10):3408-3413.
32. Bullo M., Garcia-Lorda P., Peinado-Onsurbe J., Hernandez M., Del Castillo D., Argiles J.M., et al. TNFα expression of subcutaneous adipose tissue in obese and morbid obese females:relationship to adipocyte LPL activity and leptin synthesis. Int J Obes Relat Metab Disord 2002, 26:652-658.
33. Hamann A., Mantzoros C., Vidal-Puig A., Flier J.S. Genetic variability in the TNFα promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun 1995, 211:833-839.
34. Rasmussen S.K., Urhammer S.A., Jensen J.N., Hansen T., Borch-Johnsen K., Pedersen O. The TNFα -238 and TNFα -308 G-A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians. J Clin Endocrinol Metab 2000, 85:1731-1734.
35. Herrmann S.M., Ricard S., Nicaud V., et al. Polymorphisms of the tumour necrosis factor- TNFα gene, coronary heart disease and obesity. Eur J Clin Invest 1998, 28:59-66.
36. Hoffstedt J., Eriksson P., Hellstrom L., Rossner S., Ryden M., Arner P. Excessive fat accumulation is associated with the TNF-308 G/A promoter polymorphism in women but not in men. Diabetologia 2000, 43:117-120.
37. Norman R.A., Bogardus C., Ravussin E. Linkage between obesity and marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 1995, 96:158-162.
38. Koch M., Rett K., Volk A., Maerker E., Haist K., Weisser M., et al. The tumor necrosis factor alpha -238 G → A and 308 G → A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of type II diabetic patients. Diabetologia 2000, 43:181-184.
39. Da Sliva B., Gaspur S.M., Achenbach Y.H., Schuh T.S., Kotla T.J., Liu K., et al. Lack of association between the G-308A polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome. J Investig Med 2000, 48(4):236-244.