Tumor necrosis factor alpha (TNF-α) gene G-308A polymorphism relationschip to insulin resistance and lipid abnormalities in children with obesity;Wpływ polimorfizmu G-308A genu czynnika martwicy guza alfa (TNF-α) no zaburzenia gospodarki wȩglowodanowej i lipidowej u dzieci z otyłościa̧

Endokrynologia, Diabetologia i Choroby Przemiany Materii Wieku Rozwojowego

Volumn 12, Issue 3, 2006, Pages 171-174

  Pyrzak, Beata ^a   Wiśniewska, Alicja ^a   Rymkiewicz Kluczyńska, Barbara ^a  

^a Medical University of Warsaw Katedra i Klinika Pediatrii Hematologii i Onkologii   (Poland)

Author keywords

Children; Obesity; Polymorphism TNF

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE CONVERSION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYMERASE CHAIN REACTION; SCHOOL CHILD; SINGLE STRAND CONFORMATION POLYMORPHISM; SKINFOLD;

ADOLESCENT; ANTHROPOMETRY; CHILD; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDS; MALE; OBESITY; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33749504425     PISSN: 1234625X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Bastard J.P., Maachi M., Lagathu C. i wsp.: Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine. Netw., 2006, 17, 4-12.
2. Fernandez-Real J.M., Gutierrez C., Ricart W. i wsp.: The TNF-α gene Nco I polymorphism influenes the relationschip among insulin resistance, percent body FAT, and increased serum leptin levels. Diabetes, 1997, 46, 1468-1472.
3. Wanic K., Małecki M., Klupa T. i wsp.: TNF-α PC-1 gene polymorphism and pre-diabetes quantitative features in the Polish population. Przegl. Lek. 2002, 59, 888-891.
4. Bȩc L., Karolczak M.A.: Rola układowej odpowiedzi zapalnej w kra̧żeniu pozaustrojowym. Cytokiny. Nowa Pediatria. 2001, 23, 1-6.
5. Sookoian S.C., Gonzalez C., Pirola C.J.: Meta-analysis on the G-308A tumor necrosis factor alpha variant and phenotypes associated with the metabolic syndrome. Obes. Res., 2005, 13, 2122-2131.
6. Slaughter M.H. i wsp.: Skinfold equations for estimation of body fatness in children and youth. Hum. Biol., 1988, 60, 709-723.
7. Hotamisligil G., Arner P., Caro J. i wsp.: Increased adipose tissue expression of tumor necrosis factor alpha in human obesity and insulin resistance. J. Clin. Invest., 1995, 95, 2409-2415.
8. Gupta A., Ten S., Anhalt H.: Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linker to insulin resistance and glucose intolerane in children. J. Pediatr. Endocrinol. Metab., 2005, 18, 75-82.
9. Hoffstedt J., Eriksson P., Hellstrom L. i wsp.: Excessive FAT accumulation is associated with the TNF-α308G/A promoter polymorphism in women but not in men. Diabetologia, 2000, 43, 117-120.
10. Walstron J., Seibert M., Yen C.-J. i wsp.: Tumor necrosis factor - α-238 and 308 polymorphism do not associate with traits related to obesity and insulin resistance. Diabetes, 1999, 48, 2096-2098.
11. Kubaszek A., Pihlajamaki J., Komarovski V. i wsp.: Promoter polymorphism of the TNF-α (G-308A) and IL (C-174G) genes predict the conversion from impaired glucose tolerancje to type 2 diabetes. Diabetes, 2003, 52, 1872-1875.
12. Lee S., Pu Y., Thomas G. i wsp.: Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. Metanol. Clin. Exp., 2000, 8, 1021-1024.
13. Allen R.: Polymorphism of the human TNF-α promoter - random variation of functional diversity. Molec. Immunol., 1999, 36, 1017-1027.