The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover

Osteoarthritis and Cartilage

Volumn 14, Issue 6, 2006, Pages 597-608

  Jones, S W ^a   Brockbank, S M V ^a   Mobbs, M L ^a   Le Good, N J ^a   Soma Haddrick, S ^a   Heuze, A J ^a   Langham, C J ^a   Timms, D ^a   Newham, P ^a   Needham, M R C ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Angiogenesis; Cartilage; Chondrocytes; Metalloproteinases; Orphan GPCR; Osteoarthritis; RDC1

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MATRIX METALLOPROTEINASE; PROTEIN RDC1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; EXPLANT; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

CALCIUM; CARTILAGE, ARTICULAR; CELL LINE; CHONDROCYTES; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; NEOVASCULARIZATION, PATHOLOGIC; OSTEOARTHRITIS, KNEE; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 33646881816     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2006.01.007     Document Type: Article

References (36)

1. Shimizu N., Soda Y., Kanbe K., Liu H.Y., Mukai R., Kitamura T., et al. A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. J Virol 74 (2000) 619-626
2. Zhou J., Jin Y., Gao Y., Wang H., Hu G., Huang Y., et al. Genomic-scale analysis of gene expression profiles in TNF-alpha treated human umbilical vein endothelial cells. Inflamm Res 51 (2002) 332-341
3. Okada H., Nakajima T., Yoshimura T., Yasuda K., and Kanzaki H. Microarray analysis of genes controlled by progesterone in human endometrial stromal cells in vitro. Gynecol Endocrinol 17 (2003) 271-280
4. Kapas S., and Clark A.J. Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor. Biochem Biophys Res Commun 217 (1995) 832-838
5. Ladoux A., and Frelin C. Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier. J Biol Chem 275 (2000) 39914-39919
6. Qing X., Svaren J., and Keith I.M. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am J Physiol Lung Cell Mol Physiol 280 (2001) L547-L554
7. Chakravarty P., Suthar T.P., Coppock H.A., Nicholl C.G., Bloom S.R., Legon S., et al. CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues. Br J Pharmacol 130 (2000) 189-195
8. McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J., Thompson N., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393 (1998) 333-339
9. Martinez A., Kapas S., Miller M.J., Ward Y., and Cuttitta F. Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology 141 (2000) 406-411
10. Qing X., and Keith I.M. Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats. Am J Physiol Lung Cell Mol Physiol 285 (2003) L86-L96
11. Madden S.L., Cook B.P., Nacht M., Weber W.D., Callahan M.R., Jiang Y., et al. Vascular gene expression in nonneoplastic and malignant brain. Am J Pathol 165 (2004) 601-608
12. Poole L.J., Yu Y., Kim P.S., Zheng Q.Z., Pevsner J., and Hayward G.S. Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol 76 (2002) 3395-3420
13. Raggo C., Ruhl R., McAllister S., Koon H., Dezube B.J., Fruh K., et al. Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Cancer Res 65 (2005) 5084-5095
14. Gershengorn M.C., Geras-Raaka E., Varma A., and Clark-Lewis I. Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest 102 (1998) 1469-1472
15. Bissantz C., Bernard P., Hibert M., and Rognan D. Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?. Proteins 50 (2003) 5-25
16. Lohmander L.S., Ionescu M., Jugessur H., and Poole A.R. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 42 (1999) 534-544
17. Lohmander L.S., Hoerrner L.A., Dahlberg L., Roos H., Bjornsson S., and Lark M.W. Stromelysin, tissue inhibitor of metalloproteinases and proteoglycan fragments in human knee joint fluid after injury. J Rheumatol 20 (1993) 1362-1368
18. Tetlow L.C., and Woolley D.E. Effect of histamine on the production of matrix metalloproteinases-1, -3, -8 and -13, and TNFalpha and PGE(2) by human articular chondrocytes and synovial fibroblasts in vitro: a comparative study. Virchows Arch 445 (2004) 485-490
19. Tetlow L.C., and Woolley D.E. Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro. Ann Rheum Dis 61 (2002) 737-740
20. Brama P.A., van den B.R., DeGroott J., Kiers G.H., and van Weeren P.R. Collagenase-1 (MMP-1) activity in equine synovial fluid: influence of age, joint pathology, exercise and repeated arthrocentesis. Equine Vet J 36 (2004) 34-40
21. Jo H., Park J.S., Kim E.M., Jung M.Y., Lee S.H., Seong S.C., et al. The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes. Osteoarthritis Cartilage 11 (2003) 585-594
22. Jo H., Ahn H.J., Kim E.M., Kim H.J., Seong S.C., Lee I., et al. Effects of dehydroepiandrosterone on articular cartilage during the development of osteoarthritis. Arthritis Rheum 50 (2004) 2531-2538
23. Lin P.M., Chen C.T., and Torzilli P.A. Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage. Osteoarthritis Cartilage 12 (2004) 485-496
24. Flannelly J., Chambers M.G., Dudhia J., Hembry R.M., Murphy G., Mason R.M., et al. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthritis Cartilage 10 (2002) 722-733
25. Bluteau G., Conrozier T., Mathieu P., Vignon E., Herbage D., and Mallein-Gerin F. Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis. Biochim Biophys Acta 1526 (2001) 147-158
26. Wu W., Billinghurst R.C., Pidoux I., Antoniou J., Zukor D., Tanzer M., et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 46 (2002) 2087-2094
27. Mitchell P.G., Magna H.A., Reeves L.M., Lopresti-Morrow L.L., Yocum S.A., Rosner P.J., et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 97 (1996) 761-768
28. Knauper V., Lopez-Otin C., Smith B., Knight G., and Murphy G. Biochemical characterization of human collagenase-3. J Biol Chem 271 (1996) 1544-1550
29. Dahlberg L., Billinghurst R.C., Manner P., Nelson F., Webb G., Ionescu M., et al. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1). Arthritis Rheum 43 (2000) 673-682
30. Pratta M.A., Yao W., Decicco C., Tortorella M.D., Liu R.Q., Copeland R.A., et al. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 278 (2003) 45539-45545
31. Gerber H.P., and Ferrara N. Angiogenesis and bone growth. Trends Cardiovasc Med 10 (2000) 223-228
32. Hashimoto S., Creighton-Achermann L., Takahashi K., Amiel D., Coutts R.D., and Lotz M. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 10 (2002) 180-187
33. Tanaka E., Aoyama J., Miyauchi M., Takata T., Hanaoka K., Iwabe T., et al. Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis. Histochem Cell Biol 123 (2005) 275-281
34. Tardif G., Hum D., Pelletier J.P., Boileau C., Ranger P., and Martel-Pelletier J. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum 50 (2004) 2521-2530
35. Nakase T., Miyaji T., Tomita T., Kaneko M., Kuriyama K., Myoui A., et al. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage 11 (2003) 278-284
36. Balabanian K., Lagane B., Infantino S., Chow K.Y., Harriague J., Moepps B., et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem (2005)