The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy

Journal of Nuclear Medicine

Volumn 46, Issue 12, 2005, Pages 2068-2075

  Buursma, Anne Rixt ^a   Beerens, Antoine M J ^b   De Vries, Erik F J ^a   Van Waarde, Aren ^a   Rots, Marianne G ^b   Hospers, Geke A P ^a   Vaalburg, Willem ^a   Haisma, Hidde J ^a,b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

11C m hydroxyephedrine; Gene therapy; Human norepinephrine transporter; PET; Reporter gene

Indexed keywords

3 HYDROXYEPHEDRINE C 11; ADENOVIRUS VECTOR; CARBON 11; DESIPRAMINE; GREEN FLUORESCENT PROTEIN; NORADRENALIN TRANSPORTER; UNCLASSIFIED DRUG; 3 HYDROXYEPHEDRINE; 3-HYDROXYEPHEDRINE; CARBON; CONTRAST MEDIUM; DRUG DERIVATIVE; EPHEDRINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; ADENOVIRUS; ANIMAL; CANCER TRANSPLANTATION; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL MODEL; GENETICS; METABOLISM; METHODOLOGY; RAT; SENSITIVITY AND SPECIFICITY; TIME; TUMOR CELL LINE;

ADENOVIRIDAE; ANIMALS; CARBON RADIOISOTOPES; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CONTRAST MEDIA; COS CELLS; DESIPRAMINE; EPHEDRINE; GENE THERAPY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; MODELS, CHEMICAL; NEOPLASM TRANSPLANTATION; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; POSITRON-EMISSION TOMOGRAPHY; RATS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TRANSFECTION;

EID: 33644875886     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Gambhir SS, Herschman HR, Cherry SR, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia. 2000;2:118-138.
2. de Vries EFJ, Buursma AR, Hospers GAP, Mulder NH, Vaalburg W. Scintigraphic imaging of HSVtk gene therapy. Curr Pharm Des. 2002;8:1435-1450.
3. Jacobs A, Voges J, Reszka R, et al. Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet. 2001;358:727-729.
4. 18F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med. 2001;42:1225-1234.
5. Haberkorn U, Khazaie K, Morr I, Altmann A, Muller M, van Kaick G. Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase. Nucl Med Biol. 1998;25:367-373.
6. 18F]FHPG as PET tracer for HSVtk gene expression. Nucl Med Biol. 2003;30:651-660.
7. Tjuvajev JG, Doubrovin M, Akhurst T, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med. 2002;43:1072-1083.
8. Penuelas I, Boan J, Marti-Climent JM, et al. Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging. Mol Imaging Biol. 2004;6:225-238.
9. Groot-Wassink T, Aboagye EO, Wang Y, Lemoine NR, Reader AJ, Vassaux G. Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal. Mol Ther. 2004;9:436-442.
10. Shin JH, Chung JK, Kang JH, et al. Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk. Eur J Nucl Med Mol Imaging. 2004;31:425-432.
11. Haberkorn U, Beuter P, Kubler W, et al. Iodide kinetics and dosimetry in vivo after transfer of the human sodium iodide symporter gene in rat thyroid carcinoma cells. J Nucl Med. 2004;45:827-833.
12. Zhao Y, Sun L. Perinatal cocaine exposure reduces myocardial norepinephrine transporter function in the neonatal rat. Neurotoxicol Teratol. 2004;26:443-450.
13. Eisenhofer G. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther. 2001;91:35-62.
14. 18F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart. Nucl Med Biol. 2000;27:233-238.
15. Allman KC, Wieland DM, Muzik O, DeGrado TR, Wolfe ER Jr, Schwaiger M. Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol. 1993;22:368-375.
16. Schwaiger M, Kalff V, Rosenspire K, et al. Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation. 1990;82:457-464.
17. 11C]hydroxyephedrine and positron emission tomography. Circulation. 2000;101:516-523.
18. 11C hydroxyephedrine PET. Radiology. 2004;230:423-428.
19. Shulkin BL, Wieland DM, Schwaiger M, et al. PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med. 1992;33:1125-1131.
20. Melikian HE, McDonald JK, Gu H, Rudnick G, Moore KR, Blakely RD. Human norepinephrine transporter: biosynthetic studies using a site-directed polyclonal antibody. J Biol Chem. 1994;269:12290-12297.
21. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA. 1998;95:2509-2514.
22. Larsen P, Ulin J, Dahlstrom K, Jensen M. Synthesis of [C-11]iodomethane by iodination of [C-11]methane. Appl Radiat Isot. 1997;48:153-157.
23. 11C]methyl triflate. Nucl Med Biol. 1995;22:235-239.
24. Anton M, Wagner B, Haubner R, et al. Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells. J Gene Med. 2004;6:119-126.
25. De Kraker J, Hoefnagel CA, Caron H, et al. First line targeted radiotherapy, a new concept in the treatment of advanced stage neuroblastoma. Eur J Cancer. 1995;31A:600-602.
26. 131I-meta- iodobenzylguanidine: a case report. Radiother Oncol. 1990;17:103-108.
27. 131I meta-iodobenzylguanidine. Gene Ther. 1999;6:1147-1152.
28. 131I]MIBG and clonogenic cell kill. Oncogene. 2001;20:7804-7808.
29. 131I]meta- iodobenzylguanidine. J Gene Med. 2001;3:165-172.
30. Altmann A, Kissel M, Zitzmann S, et al. Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma. J Nucl Med. 2003;44:973-980.
31. Vaidyanathan G, Affleck DJ, Zalutsky MR. Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG. J Nucl Med. 1995;36:644-650.
32. Glaser M, Luthra SK, Brady F. Applications of positron-emitting halogens in PET oncology. Int J Oncol. 2003;22:253-267.
33. 18F]fluoroalkyl)benzylguanidines. Bioconjug Chem. 2004;15:104-111.
34. Shulkin BL, Wieland DM, Baro ME, et al. PET hydroxyephedrine imaging of neuroblastoma. J Nucl Med. 1996;37:16-21.
35. Kim M, Zinn KR, Barnett BG, et al. The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells. Eur J Cancer. 2002;38:1917-1926.
36. Bruning A, Runnebaum IB. The coxsackie adenovirus receptor inhibits cancer cell migration. Exp Cell Res. 2004;298:624-631.