Guanylate cyclase activators, cell volume changes and IOP reduction

Cellular Physiology and Biochemistry

Volumn 28, Issue 6, 2011, Pages 1145-1154

  Ellis, Dorette Z ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Aqueous humor outflow; Cell volume; Glaucoma; Nitric oxide; Protein kinase G; Schlemm's canal; Soluble guanylate cyclase; Trabecular meshwork

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; BENDAZAC; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL;

AQUEOUS HUMOR; CELL VOLUME; CILIARY MUSCLE; EXTRACELLULAR MATRIX; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW; SCHLEMM CANAL; TRABECULAR MESHWORK;

EID: 83755206950     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000335866     Document Type: Review

References (99)

1. Lee WR, Grierson P, McMenamin PG: The Morphological Response of the Primate Outflow System; in Lutjen-Drecoll E (ed): Basic Aspects of Glaucoma Research. Stuttgart, F.K. Schattauer, 1982, pp 123-139.
2. Kaufman PL: Aqueous humor outflow. Curr Top Eye Res 1984;4:97-138.
3. Krupin T, Civan MM: The physiological basis of aqueous humor formation; in Ritch R, Shields MB (eds): The Glaucomas. St. Louis, Mosby, 1995, pp 251-280.
4. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, Wilson MR, Gordon MO: The Ocular Hypertension Treatment Study: A randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120:701-713. (Pubitemid 34620348)
5. Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, Wilson MR, Kass MA: The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 2002;120:714-720. (Pubitemid 34620349)
6. Higginbotham EJ, Gordon MO, Beiser JA, Drake MV, Bennett GR, Wilson MR, Kass MA: The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch Ophthalmol 2004;122:813-820. (Pubitemid 38736239)
7. Al-Aswad LA, Gong H, Lee D, O'Donnell ME, Brandt JD, Ryan WJ, Schroeder A, Erickson KA: Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Invest Ophthalmol Vis Sci 1999;40:1695-1701. (Pubitemid 29297144)
8. Freddo TF, Patterson MM, Scott DR, Epstein DL: Influence of mercurial sulfhydryl agents on aqueous outflow pathways in enucleated eyes. Invest Ophthalmol Vis Sci 1984;25:278-285. (Pubitemid 14164775)
9. Gual A, Llobet A, Gilabert R, Borras M, Pales J, Bergamini MV, Belmonte C: Effects of time of storage, albumin, and osmolality changes on outflow facility (C) of bovine anterior segment in vitro. Invest Ophthalmol Vis Sci 1997;38:2165-2171. (Pubitemid 27407536)
10. O'Donnell ME, Brandt JD, Curry FR: Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol 1995;268:C1067-C1074.
11. Mitchell CH, Fleischhauer JC, Stamer WD, Peterson-Yantorno K, Civan MM: Human trabecular meshwork cell volume regulation. Am J Physiol Cell Physiol 2002;283:C315-C326. (Pubitemid 34670576)
12. Soto D, Comes N, Ferrer E, Morales M, Escalada A, Pales J, Solsona C, Gual A, Gasull X: Modulation of aqueous humor outflow by ionic mechanisms involved in trabecular meshwork cell volume regulation. Invest Ophthalmol Vis Sci 2004;45:3650-3661. (Pubitemid 39298583)
13. Srinivas SP, Maertens C, Goon LH, Goon L, Satpathy M, Yue BY, Droogmans G, Nilius B: Cell volume response to hyposmotic shock and elevated cAMP in bovine trabecular meshwork cells. Exp Eye Res 2004;78:15-26. (Pubitemid 37518241)
14. Dismuke WM, Mbadugha CC, Ellis DZ: NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel. Am J Physiol Cell Physiol 2008;294:C1378-C1386.
15. Ellis DZ, Sharif NA, Dismuke WM: Endogenous Regulation of Human Schlemm's Canal Cell Volume by Nitric Oxide Signaling. Invest Ophthalmol Vis Sci 2010;51:5817-5824.
16. Wiederholt M: Direct involvement of trabecular meshwork in the regulation of aqueous humor outflow. Curr Opin Ophthalmol 1998;9:46-49. (Pubitemid 28284573)
17. Llobet A, Gual A, Pales J, Barraquer R, Tobias E, Nicolas JM: Bradykinin decreases outflow facility in perfused anterior segments and induces shape changes in passaged BTM cells in vitro. Invest Ophthalmol Vis Sci 1999;40:113-125. (Pubitemid 29029579)
18. Wiederholt M, Thieme H, Stumpff F: The regulation of trabecular meshwork and ciliary muscle contractility. Prog Retin Eye Res 2000;19:271-295. (Pubitemid 30122724)
19. Rao PV, Deng PF, Kumar J, Epstein DL: Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci 2001;42:1029-1037. (Pubitemid 32289800)
20. Stumpff F, Wiederholt M: Regulation of trabecular meshwork contractility. Ophthalmologica 2000;214:33-53. (Pubitemid 30084879)
21. Bradley JM, Vranka J, Colvis CM, Conger DM, Alexander JP, Fisk AS, Samples JR, Acott TS: Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci 1998;39:2649-2658. (Pubitemid 28558223)
22. Grierson I, Johnson NF: The postmortem vacuoles of Schlemm's canal. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1981;215:249-264.
23. Fuchshofer R, Welge-Lussen U, Lutjen-Drecoll E, Birke M: Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2006;47:794-801. (Pubitemid 46768308)
24. Coroneo MT, Korbmacher C, Flugel C, Stiemer B, Lutjen-Drecoll E, Wiederholt M: Electrical and morphological evidence for heterogeneous populations of cultured bovine trabecular meshwork cells. Exp Eye Res 1991;52:375-388.
25. Thomas DD, Liu X, Kantrow SP, Lancaster JR Jr: The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci USA 2001;98:355-360.
26. Murad F: Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone Recent Prog Horm Res 1998;53:43-59.
27. Bkaily G, Orleans-Juste P, Jacques D: A new paradigm: calcium independent and caveolae internalization dependent release of nitric oxide by the endothelial nitric oxide synthase. Circ Res 2006;99:793-794. (Pubitemid 44556376)
28. Nathanson JA, McKee M: Identification of an extensive system of nitric oxideproducing cells in the ciliary muscle and outflow pathway of the human eye. Invest Ophthalmol Vis Sci 1995;36:1765-1773.
29. Boissel JP, Schwarz PM, Forstermann U: Neuronal-type NO synthase: transcript diversity and expressional regulation. Nitric Oxide 1998;2:337-349. (Pubitemid 29133218)
30. Selbach JM, Gottanka J, Wittmann M, Lutjen-Drecoll E: Efferent and afferent innervation of primate trabecular meshwork and scleral spur. Invest Ophthalmol Vis Sci 2000;41:2184-2191. (Pubitemid 30450991)
31. Matsuo T: Basal nitric oxide production is enhanced by hydraulic pressure in cultured human trabecular cells. Br J Ophthalmol 2000;84:631-635. (Pubitemid 30339317)
32. Schneemann A, Leusink-Muis A, van den BT, Hoyng PF, Kamphuis W: Elevation of nitric oxide production in human trabecular meshwork by increased pressure. Graefes Arch Clin Exp Ophthalmol 2003;241:321-326. (Pubitemid 36748563)
33. Russell-Randall KR, Dortch-Carnes J: Kappa opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber. Invest Ophthalmol Vis Sci 2011;52:5233-5239.
34. Schneemann A, Dijkstra BG, van den Berg TJ, Kamphuis W, Hoyng PF: Nitric oxide/guanylate cyclase pathways and flow in anterior segment perfusion. Graefes Arch Clin Exp Ophthalmol 2002;240:936-941. (Pubitemid 36097118)
35. Nathanson JA: Nitrovasodilators as a new class of ocular hypotensive agents. J Pharmacol Exp Ther 1992;260:956-965.
36. Kotikoski H, Vapaatalo H, Oksala O: Nitric oxide and cyclic GMP enhance aqueous humor outflow facility in rabbits. Curr Eye Res 2003;26:119-123. (Pubitemid 36776119)
37. Behar-Cohen FF, Goureau O, d'Hermies F, Courtois Y: Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest Ophthalmol Vis Sci 1996;37:1711-1715.
38. Schuman JS, Erickson K, Nathanson JA: Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys. Exp Eye Res 1994;58:99-105. (Pubitemid 24071624)
39. Stamer W, Lei Y, Boussommier-Calleja A, Overby D, Ethier C: eNOS, a Pressure-Dependent Regulator of Intraocular Pressure. Invest Ophthalmol Vis Sci 2011; in press.
40. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA: Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev 2000;52:375-414.
41. Ford PC, Wink DA, Stanbury DM: Autoxidation kinetics of aqueous nitric oxide. FEBS Lett 7-12-1993;326:1-3.
42. Beckman JS, Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996;271:C1424-C1437.
43. Ellis DZ, Dismuke WM, Chokshi BM: Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork. Invest Ophthalmol Vis Sci 2009;50:1808-1813.
44. Kuno T, Andresen JW, Kamisaki Y, Waldman SA, Chang LY, Saheki S, Leitman DC, Nakane M, Murad F: Copurification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J Biol Chem 1986;261:5817-5823. (Pubitemid 17207410)
45. Paul AK, Marala RB, Jaiswal RK, Sharma RK: Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein. Science 1987;235:1224-1226.
46. Chang MS, Lowe DG, Lewis M, Hellmiss R, Chen E, Goeddel DV: Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Nature 1989;341:68-72. (Pubitemid 19220660)
47. Schulz S, Singh S, Bellet RA, Singh G, Tubb DJ, Chin H, Garbers DL: The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Cell 1989;58:1155-1162. (Pubitemid 19238191)
48. Chinkers M, Garbers DL, Chang MS, Lowe DG, Chin HM, Goeddel DV, Schulz S: A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature 1989;338:78-83. (Pubitemid 19076788)
49. Garbers DL: Purification of soluble guanylate cyclase from rat lung. J Biol Chem 1979;254:240-243.
50. Lewicki JA, Brandwein HJ, Waldman SA, Murad F: Purified guanylate cyclase: characterization, iodination and preparation of monoclonal antibodies. J Cyclic Nucleotide Res 1980;6:283-296. (Pubitemid 11154342)
51. Koesling D, Harteneck C, Humbert P, Bosserhoff A, Frank R, Schultz G, Bohme E: The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme. FEBS Lett 1990;266:128-132. (Pubitemid 20194190)
52. Kamisaki Y, Saheki S, Nakane M, Palmieri JA, Kuno T, Chang BY, Waldman SA, Murad F: Soluble guanylate cyclase from rat lung exists as a heterodimer. J Biol Chem 1986;261:7236-7241. (Pubitemid 17224718)
53. Yuen PS, Potter LR, Garbers DL: A new form of guanylyl cyclase is preferentially expressed in rat kidney. Biochemistry 1990;29:10872-10878.
54. Harteneck C, Koesling D, Soling A, Schultz G, Bohme E: Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunits. FEBS Lett 1990;272:221-223. (Pubitemid 20349022)
55. Millar JC, Shahidullah M, Wilson WS: Atriopeptin lowers aqueous humor formation and intraocular pressure and elevates ciliary cyclic GMP but lacks uveal vascular effects in the bovine perfused eye. J Ocul Pharmacol Ther 1997;13:1-11. (Pubitemid 27130717)
56. Mittag TW, Tormay A, Ortega M, Severin C: Atrial natriuretic peptide (ANP), guanylate cyclase, and intraocular pressure in the rabbit eye. Curr Eye Res 1987;6:1189-1196. (Pubitemid 18043597)
57. Nathanson JA: Direct application of a guanylate cyclase activator lowers intraocular pressure. Eur J Pharmacol 1988;147:155-156. (Pubitemid 18058737)
58. Diestelhorst M, Krieglstein GK: [The intraocular pressure lowering effect of human atrial peptide]. Fortschr Ophthalmol 1989;86:89-91. (Pubitemid 19135233)
59. Fernandez-Durango R, Moya FJ, Ripodas A, de Juan JA, Fernandez-Cruz A, Bernal R: Type B and type C natriuretic peptide receptors modulate intraocular pressure in the rabbit eye. Eur J Pharmacol 1999;364:107-113. (Pubitemid 29065259)
60. Goldmann DB, Waubke N: [A pilot study on the effect of atrial natriuretic peptide on intraocular pressure in the human]. Fortschr Ophthalmol. 1989; 86: 494-496. (Pubitemid 19273708)
61. Korenfeld MS, Becker B: Atrial natriuretic peptides. Effects on intraocular pressure, cGMP, and aqueous flow. Invest Ophthalmol Vis Sci 1989;30:2385-2392. (Pubitemid 20004240)
62. Wolfensberger TJ, Singer DR, Freegard T, Markandu ND, Buckley MG, MacGregor GA: Evidence for a new role of natriuretic peptides: control of intraocular pressure. Br J Ophthalmol 1994;78:446-448. (Pubitemid 24186281)
63. Yang L, Guan J, Gao S: [An experimental study on effect of atrial natriuretic peptide on intraocular pressure of white rabbits]. Zhonghua Yan Ke Za Zhi 1997;33:149-151.
64. Davis KL, Martin E, Turko IV, Murad F: Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol 2001;41:203-236. (Pubitemid 32385888)
65. Murad F: The excitement and rewards of research with our discovery of some of the biological effects of nitric oxide. Circ Res 2003;92:339-341. (Pubitemid 36298190)
66. Bian K, Murad F: Nitric Oxide-Biogeneration, Regulation and Relevence to Human Diseases. Front Biosci 2003;8:264-278.
67. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B: Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Molec Pharmacol 1995;48:184-188.
68. Schrammel A, Behrends S, Schmidt K, Koesling D, Mayer B: Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 1996;50:1-5. (Pubitemid 26250067)
69. Brunner F, Schmidt K, Nielsen EB, Mayer B: Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery. J Pharmacol Exp Ther 1996;277:48-53. (Pubitemid 27169042)
70. Schlossmann J, Hofmann F: cGMPdependent protein kinase in drug discovery. Drug Discov Today 2005;10:627-634. (Pubitemid 40704770)
71. Ko FN, Wu CC, Kuo SC, Lee FY, Teng CM: YC-1, a novel activator of platelet guanylate cyclase. Blood 1994;84:4226-4233.
72. Kotikoski H, Alajuuma P, Moilanen E, Salmenpera P, Oksala O, Laippala P, Vapaatalo H: Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP. J Ocul Pharmacol Ther 2002;18:11-23. (Pubitemid 34132689)
73. Martin E, Lee YC, Murad F: YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components. Proc Natl Acad Sci USA 2001;98:12938-12942. (Pubitemid 33051298)
74. Mulsch A, Bauersachs J, Schafer A, Stasch JP, Kast R, Busse R: Effect of YC-1, an NO-independent, superoxidesensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. Br J Pharmacol 1997;120:681-689. (Pubitemid 27089418)
75. Nathanson JA, McKee M: Alterations of ocular nitric oxide synthase in human glaucoma. Invest Ophthalmol Vis Sci 1995;36:1774-1784.
76. Lamothe M, Chang FJ, Balashova N, Shirokov R, Beuve A: Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site Biochemistry 2004;43:3039-3048. (Pubitemid 38352254)
77. Stasch JP, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Minuth T, Perzborn E, Schramm M, Straub A: Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br J Pharmacol 2002;135:333-343. (Pubitemid 34151165)
78. Dismuke WM, Sharif NA, Ellis DZ: Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-2 and BAY-58-2667 involves the BKCa ion channel. Invest Ophthalmol Vis Sci 2009;50:3353-3359.
79. Schmidt PM, Schramm M, Schroder H, Wunder F, Stasch JP: Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase. J Biol Chem 2004;279:3025-3032. (Pubitemid 38114295)
80. Schmidt P, Schramm M, Schroder H, Stasch JP: Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase. Eur J Pharmacol 2003;468:167-174. (Pubitemid 36712896)
81. Stasch JP, Schmidt P, onso-Alija C, Apeler H, Dembowsky K, Haerter M, Heil M, Minuth T, Perzborn E, Pleiss U, Schramm M, Schroeder W, Schroder H, Stahl E, Steinke W, Wunder F: NO-and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br J Pharmacol 2002;136:773-783. (Pubitemid 34785720)
82. Benham CD, Bolton TB, Lang RJ, Takewaki T: Calcium-activated potassium channels in single smooth muscle cells of rabbit jejunum and guineapig mesenteric artery. J Physiol 1986;371:45-67. (Pubitemid 16139405)
83. Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Lederer WJ: Relaxation of arterial smooth muscle by calcium sparks. Science 1995;270:633-637.
84. Singer JJ, Walsh JV, Jr.: Characterization of calcium-activated potassium channels in single smooth muscle cells using the patch-clamp technique. Pflugers Arch 1987;408:98-111. (Pubitemid 17036557)
85. Robertson BE, Schubert R, Hescheler J, Nelson MT: cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol 1993;265:C299-C303. (Pubitemid 23224681)
86. Sausbier M, Schubert R, Voigt V, Hirneiss C, Pfeifer A, Korth M, Kleppisch T, Ruth P, Hofmann F: Mechanisms of NO/cGMP-dependent vasorelaxation. Circ Res 2000;87:825-830.
87. Stumpff F, Strauss O, Boxberger M, Wiederholt M: Characterization of maxi-K-channels in bovine trabecular meshwork and their activation by cyclic guanosine monophosphate. Invest Ophthalmol Vis Sci 1997;38:1883-1892. (Pubitemid 27382356)
88. Wiederholt M, Sturm A, Lepple-Wienhues A: Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide. Invest Ophthalmol Vis Sci 1994;35:2515-2520. (Pubitemid 24137048)
89. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ, Garcia ML: Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem 1990;265:11083-11090.
90. Olesen SP, Munch E, Moldt P, Drejer J: Selective activation of Ca2+-dependent K+ channels by novel benzimidazolone. Eur J Pharmacol 1994;251:53-59.
91. Dismuke WM, Ellis DZ: Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume. J Ocul Pharmacol Ther 2009;25:309-314.
92. Alioua A, Tanaka Y, Wallner M, Hofmann F, Ruth P, Meera P, Toro L: The large conductance, voltagedependent, and calcium-sensitive K+ channel, Hslo, is a target of cGMPdependent protein kinase phosphorylation in vivo. J Biol Chem 1998;273:32950-32956. (Pubitemid 28557688)
93. Holland M, Langton PD, Standen NB, Boyle JP: Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle. Br J Pharmacol 1996;117:119-129.
94. Gasull X, Ferrer E, Llobet A, Castellano A, Nicolas JM, Pales J, Gual A: Cell membrane stretch modulates the highconductance Ca2+-activated K+ channel in bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci 2003;44:706-714. (Pubitemid 36159718)
95. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S: Receptormediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 2001;532:3-16. (Pubitemid 32303268)
96. Mitchell CH, Fleischhauer JC, Stamer WD, Peterson-Yantorno K, Civan MM: Human trabecular meshwork cell volume regulation. Am J Physiol 2002;283:C315-C326. (Pubitemid 34670576)
97. Ziyadeh FN, Mills JW, Kleinzeller A: Hypotonicity and cell volume regulation in shark rectal gland: role of organic osmolytes and F-actin. Am J Physiol 1992;262:F468-F479.
98. Henson JH, Roesener CD, Gaetano CJ, Mendola RJ, Forrest JN Jr, Holy J, Kleinzeller A: Confocal microscopic observation of cytoskeletal reorganizations in cultured shark rectal gland cells following treatment with hypotonic shock and high external K+. J Exp Zool 1997;279:415-424. (Pubitemid 27523401)
99. Tian B, Geiger B, Epstein DL, Kaufman PL: Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest Ophthalmol Vis Sci 2000;41:619-623. (Pubitemid 30158867)