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Volumn 2, Issue 5, 2011, Pages 211-225

An endocrine perspective of nonalcoholic fatty liver disease (NAFLD)

Author keywords

diabetes; fatty liver; insulin resistance; nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis (NASH)

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; CYTOKERATIN 18; EXENDIN 4; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIRAGLUTIDE; METFORMIN; NICOTINIC ACID; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SIBUTRAMINE; SIMVASTATIN; TETRAHYDROLIPSTATIN;

EID: 83755196306     PISSN: 20420188     EISSN: 20420196     Source Type: Journal    
DOI: 10.1177/2042018811419157     Document Type: Review
Times cited : (32)

References (144)
  • 2
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
    • Adams L.A. Sanderson S. Lindor K.D. Angulo P. (2005 b) The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 42: 132–138.
    • (2005) J Hepatol , vol.42 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 3
    • 40749137040 scopus 로고    scopus 로고
    • Fatty liver, insulin resistance, and dyslipidemia
    • Adiels M. Taskinen M.-R. Boren J. (2008) Fatty liver, insulin resistance, and dyslipidemia. Curr Diab Rep 8: 60–64.
    • (2008) Curr Diab Rep , vol.8 , pp. 60-64
    • Adiels, M.1    Taskinen, M.-R.2    Boren, J.3
  • 5
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal G.P. Thomas J.A. Kaye P.V. Lawson A. Ryder S.D. Spendlove I. et al (2008) Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology 135: 1176–1184.
    • (2008) Gastroenterology , vol.135 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3    Lawson, A.4    Ryder, S.D.5    Spendlove, I.6
  • 6
    • 67649723378 scopus 로고    scopus 로고
    • New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD)
    • Ali R. Cusi K. (2009) New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD). Ann Med 41: 265–278.
    • (2009) Ann Med , vol.41 , pp. 265-278
    • Ali, R.1    Cusi, K.2
  • 7
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • Andersen T. Gluud C. Franzmann M.B. Christoffersen P. (1991) Hepatic effects of dietary weight loss in morbidly obese subjects. J Hepatol 12: 224–229.
    • (1991) J Hepatol , vol.12 , pp. 224-229
    • Andersen, T.1    Gluud, C.2    Franzmann, M.B.3    Christoffersen, P.4
  • 8
    • 34247384560 scopus 로고    scopus 로고
    • The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    • Angulo P. Hui J.M. Marchesini G. Bugianesi E. George J. Farrell G.C. et al (2007) The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 45: 846–854.
    • (2007) Hepatology , vol.45 , pp. 846-854
    • Angulo, P.1    Hui, J.M.2    Marchesini, G.3    Bugianesi, E.4    George, J.5    Farrell, G.C.6
  • 9
    • 49649106710 scopus 로고    scopus 로고
    • Statins in liver disease: a molehill, an iceberg, or neither?
    • Argo C.K. Loria P. Caldwell S.H. Lonardo A. (2008) Statins in liver disease: a molehill, an iceberg, or neither? Hepatology 48: 662–669.
    • (2008) Hepatology , vol.48 , pp. 662-669
    • Argo, C.K.1    Loria, P.2    Caldwell, S.H.3    Lonardo, A.4
  • 13
    • 76149092815 scopus 로고    scopus 로고
    • Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome
    • Belfort R. Berria R. Cornell J. Cusi K. (2010) Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome. J Clin Endocrinol Metab 95: 829–836.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 829-836
    • Belfort, R.1    Berria, R.2    Cornell, J.3    Cusi, K.4
  • 14
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R. Harrison S.A. Brown K. Darland C. Finch J. Hardies J. et al (2006) A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 355: 2297–2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 15
    • 4143071323 scopus 로고    scopus 로고
    • Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans
    • Bergman A.J. Murphy G. Burke J. Zhao J.J. Valesky R. Liu L. et al (2004) Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans. J Clin Pharmacol 44: 1054–1062.
    • (2004) J Clin Pharmacol , vol.44 , pp. 1054-1062
    • Bergman, A.J.1    Murphy, G.2    Burke, J.3    Zhao, J.J.4    Valesky, R.5    Liu, L.6
  • 16
    • 33747047274 scopus 로고    scopus 로고
    • Statins and hepatic steatosis: perspectives from the Dallas Heart Study
    • Browning J.D. (2006) Statins and hepatic steatosis: perspectives from the Dallas Heart Study. Hepatology 44: 466–471.
    • (2006) Hepatology , vol.44 , pp. 466-471
    • Browning, J.D.1
  • 18
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning J.D. Szczepaniak L.S. Dobbins R. Nuremberg P. Horton J.D. Cohen J.C. et al (2004b) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40: 1387–1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 19
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E. Gentilcore E. Manini R. Natale S. Vanni E. Villanova N. et al (2005) A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 100: 1082–1090.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3    Natale, S.4    Vanni, E.5    Villanova, N.6
  • 20
    • 34250732933 scopus 로고    scopus 로고
    • NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes
    • Bugianesi E. Vanni E. Marchesini G. (2007) NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes. Curr Diab Rep 7: 175–180.
    • (2007) Curr Diab Rep , vol.7 , pp. 175-180
    • Bugianesi, E.1    Vanni, E.2    Marchesini, G.3
  • 21
    • 77950859491 scopus 로고    scopus 로고
    • Cryptogenic cirrhosis: what are we missing?
    • Caldwell S. (2010) Cryptogenic cirrhosis: what are we missing? Curr Gastroenterol Rep 12: 40–48.
    • (2010) Curr Gastroenterol Rep , vol.12 , pp. 40-48
    • Caldwell, S.1
  • 23
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: focus on patients with fatty liver
    • Chalasani N. (2005) Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology 41: 690–695.
    • (2005) Hepatology , vol.41 , pp. 690-695
    • Chalasani, N.1
  • 25
    • 78650774076 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground
    • Chitturi S. Wong V.W. Farrell G. (2011) Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground. J Gastroenterol Hepatol 26(Suppl. 1): 163–172.
    • (2011) J Gastroenterol Hepatol , vol.26 , Issue.Suppl. 1 , pp. 163-172
    • Chitturi, S.1    Wong, V.W.2    Farrell, G.3
  • 27
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • Clark J.M. Brancati F.L. Diehl A.M. (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98: 960–967.
    • (2003) Am J Gastroenterol , vol.98 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 28
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • Cohen D.E. Anania F.A. Chalasani N. (2006) An assessment of statin safety by hepatologists. Am J Cardiol 97(8A): 77C–81C.
    • (2006) Am J Cardiol , vol.97 , Issue.8A , pp. 77C-81C
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 30
    • 33646861774 scopus 로고    scopus 로고
    • Histological findings in the liver before and after gastric bypass
    • Csendes A. Smok G. Burgos A.M. (2006) Histological findings in the liver before and after gastric bypass. Obes Surg 16(5): 607–611.
    • (2006) Obes Surg , vol.16 , Issue.5 , pp. 607-611
    • Csendes, A.1    Smok, G.2    Burgos, A.M.3
  • 31
    • 66149088144 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in type 2 diabetes mellitus
    • Cusi K. (2009a) Nonalcoholic fatty liver disease in type 2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 16: 141–149.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 141-149
    • Cusi, K.1
  • 32
    • 70349764468 scopus 로고    scopus 로고
    • Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis
    • Cusi K. (2009b) Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis. Clin Liver Dis 13: 545–563.
    • (2009) Clin Liver Dis , vol.13 , pp. 545-563
    • Cusi, K.1
  • 34
    • 77956395533 scopus 로고    scopus 로고
    • The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes
    • Cusi K. (2010) The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr Diab Rep 10: 306–315.
    • (2010) Curr Diab Rep , vol.10 , pp. 306-315
    • Cusi, K.1
  • 35
    • 84993731585 scopus 로고    scopus 로고
    • Clinical implications of obesity and lipotoxicity for the treatment of nonalcoholic steatohepatitis (NASH)
    • in press
    • Cusi K. (2011) Clinical implications of obesity and lipotoxicity for the treatment of nonalcoholic steatohepatitis (NASH). Gastroenterology in press.
    • (2011) Gastroenterology
    • Cusi, K.1
  • 36
    • 84993825459 scopus 로고    scopus 로고
    • Relationship of cytokeratin-18 with clinical, metabolic and histological parameters in patients with nonalcoholic steatohepatitis (NASH)
    • in press
    • Cusi K. Chang Z. Harrison S. Lomonaco R. Ortiz-Lopez C. Feldstein A. et al (2011) Relationship of cytokeratin-18 with clinical, metabolic and histological parameters in patients with nonalcoholic steatohepatitis (NASH). Hepatology in press.
    • (2011) Hepatology
    • Cusi, K.1    Chang, Z.2    Harrison, S.3    Lomonaco, R.4    Ortiz-Lopez, C.5    Feldstein, A.6
  • 37
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
    • Cusi K. Consoli A. DeFronzo R.A. (1996) Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81: 4059–4067.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4059-4067
    • Cusi, K.1    Consoli, A.2    DeFronzo, R.A.3
  • 38
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: a review of its metabolic effects
    • Cusi K. DeFronzo R. (1998) Metformin: a review of its metabolic effects. Diabetes Reviews 6: 89–131.
    • (1998) Diabetes Reviews , vol.6 , pp. 89-131
    • Cusi, K.1    DeFronzo, R.2
  • 40
    • 55149102644 scopus 로고    scopus 로고
    • Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    • Diab D.L. Yerian L. Schauer P. Kashyap S.R. Lopez R. Hazen S.L. et al (2008) Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin Gastroenterol Hepatol 6: 1249–1254.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1249-1254
    • Diab, D.L.1    Yerian, L.2    Schauer, P.3    Kashyap, S.R.4    Lopez, R.5    Hazen, S.L.6
  • 41
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X. Saxena N.K. Lin S. Gupta N.A. Anania F.A. (2006) Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43: 173–181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 42
    • 79251524594 scopus 로고    scopus 로고
    • Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • Dowman J.K. Tomlinson J.W. Newsome P.N. (2011) Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 33: 525–540.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 525-540
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 43
    • 79955475454 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in India - a lot done, yet more required!
    • Duseja A. (2010) Nonalcoholic fatty liver disease in India - a lot done, yet more required!. Indian J Gastroenterol 29: 217–225.
    • (2010) Indian J Gastroenterol , vol.29 , pp. 217-225
    • Duseja, A.1
  • 44
    • 37549047166 scopus 로고    scopus 로고
    • Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions
    • Duseja A. Das A. Dhiman R.K. Chawla Y.K. Thumburu K.T. Bhadada S. et al (2007) Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions. Ann Hepatol 6: 222–226.
    • (2007) Ann Hepatol , vol.6 , pp. 222-226
    • Duseja, A.1    Das, A.2    Dhiman, R.K.3    Chawla, Y.K.4    Thumburu, K.T.5    Bhadada, S.6
  • 45
    • 34249342305 scopus 로고    scopus 로고
    • Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study
    • Ekstedt M. Franzen L.E. Mathiesen U.L. Holmqvist M. Bodemar G. Kechagias S. (2007) Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study. J Hepatol 47: 135–141.
    • (2007) J Hepatol , vol.47 , pp. 135-141
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3    Holmqvist, M.4    Bodemar, G.5    Kechagias, S.6
  • 47
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies
    • Fassio E. Alvarez E. Dominguez N. Landeira G. Longo C. (2004) Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40: 820–826.
    • (2004) Hepatology , vol.40 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 48
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    • Feldstein A.E. Wieckowska A. Lopez A.R. Liu Y.C. Zein N.N. McCullough A.J. (2009) Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology 50: 1072–1078.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3    Liu, Y.C.4    Zein, N.N.5    McCullough, A.J.6
  • 50
    • 77649130285 scopus 로고    scopus 로고
    • Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review
    • Fogelholm M. (2010) Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review. Obes Rev 11: 202–221.
    • (2010) Obes Rev , vol.11 , pp. 202-221
    • Fogelholm, M.1
  • 51
    • 51349083814 scopus 로고    scopus 로고
    • Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    • Fracanzani A.L. Valenti L. Bugianesi E. Andreoletti M. Colli A. Vanni E. et al (2008) Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 48: 792–798.
    • (2008) Hepatology , vol.48 , pp. 792-798
    • Fracanzani, A.L.1    Valenti, L.2    Bugianesi, E.3    Andreoletti, M.4    Colli, A.5    Vanni, E.6
  • 52
    • 73349096617 scopus 로고    scopus 로고
    • Alanine aminotransferase, gamma-glutamyltransferase (GGT) and all-cause mortality: results from a population-based Danish twins study alanine aminotransferase, GGT and mortality in elderly twins
    • Fraser A. Thinggaard M. Christensen K. Lawlor D.A. (2009) Alanine aminotransferase, gamma-glutamyltransferase (GGT) and all-cause mortality: results from a population-based Danish twins study alanine aminotransferase, GGT and mortality in elderly twins. Liver Int 29: 1494–1499.
    • (2009) Liver Int , vol.29 , pp. 1494-1499
    • Fraser, A.1    Thinggaard, M.2    Christensen, K.3    Lawlor, D.A.4
  • 54
    • 78649630014 scopus 로고    scopus 로고
    • Reliability of transient elastography for the detection of fibrosis in non-alcoholic fatty liver disease and chronic viral hepatitis
    • Gaia S. Carenzi S. Barilli A.L. Bugianesi E. Smedile A. Brunello F. et al (2011) Reliability of transient elastography for the detection of fibrosis in non-alcoholic fatty liver disease and chronic viral hepatitis. J Hepatol 54: 64–71.
    • (2011) J Hepatol , vol.54 , pp. 64-71
    • Gaia, S.1    Carenzi, S.2    Barilli, A.L.3    Bugianesi, E.4    Smedile, A.5    Brunello, F.6
  • 57
    • 34548419344 scopus 로고    scopus 로고
    • Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
    • Gregor M. Hotamisligil G. (2007) Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 48: 1905–1914.
    • (2007) J Lipid Res , vol.48 , pp. 1905-1914
    • Gregor, M.1    Hotamisligil, G.2
  • 58
    • 33644888156 scopus 로고    scopus 로고
    • Liver disease in patients with diabetes mellitus
    • Harrison S.A. (2006) Liver disease in patients with diabetes mellitus. J Clin Gastroenterol 40: 68–76.
    • (2006) J Clin Gastroenterol , vol.40 , pp. 68-76
    • Harrison, S.A.1
  • 59
    • 58949102847 scopus 로고    scopus 로고
    • Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
    • Harrison S.A. Fecht W. Brunt E.M. Neuschwander-Tetri B.A. (2009) Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial. Hepatology 49: 80–86.
    • (2009) Hepatology , vol.49 , pp. 80-86
    • Harrison, S.A.1    Fecht, W.2    Brunt, E.M.3    Neuschwander-Tetri, B.A.4
  • 60
    • 0141510580 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a clinical histopathological study
    • Harrison S.A. Torgerson S. Hayashi P.H. (2003) The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol 98: 2042–2047.
    • (2003) Am J Gastroenterol , vol.98 , pp. 2042-2047
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.H.3
  • 61
    • 79955107467 scopus 로고    scopus 로고
    • Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
    • Haufe S. Engeli S. Kast P. Bohnke J. Utz W. Haas V. et al (2011) Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology 53: 1504–1514.
    • (2011) Hepatology , vol.53 , pp. 1504-1514
    • Haufe, S.1    Engeli, S.2    Kast, P.3    Bohnke, J.4    Utz, W.5    Haas, V.6
  • 63
    • 1242340436 scopus 로고    scopus 로고
    • Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
    • Hickman I.J. Jonsson J.R. Prins J.B. Ash S. Purdie D.M. Clouston A.D. et al (2004) Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut 53: 413–419.
    • (2004) Gut , vol.53 , pp. 413-419
    • Hickman, I.J.1    Jonsson, J.R.2    Prins, J.B.3    Ash, S.4    Purdie, D.M.5    Clouston, A.D.6
  • 64
    • 33751546348 scopus 로고    scopus 로고
    • Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    • Kankaanpaa M. Lehto H.-R. Parkka J. Komu M. Viljanen A. (2006) Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol 91: 4689–4695.
    • (2006) J Clin Endocrinol , vol.91 , pp. 4689-4695
    • Kankaanpaa, M.1    Lehto, H.-R.2    Parkka, J.3    Komu, M.4    Viljanen, A.5
  • 65
    • 68849104744 scopus 로고    scopus 로고
    • High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
    • Kantartzis K. Thamer C. Peter A. Machann J. Schick F. Schraml C. et al (2009) High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 58: 1281–1288.
    • (2009) Gut , vol.58 , pp. 1281-1288
    • Kantartzis, K.1    Thamer, C.2    Peter, A.3    Machann, J.4    Schick, F.5    Schraml, C.6
  • 66
    • 58249083549 scopus 로고    scopus 로고
    • Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects
    • Kashyap R. Belfort Cersosimo E. Lee S. Cusi K. (2008) Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects. J Cardiometabol Syndrome 3: 141–146.
    • (2008) J Cardiometabol Syndrome , vol.3 , pp. 141-146
    • Kashyap, R.B.1    Cersosimo, E.2    Lee, S.3    Cusi, K.4
  • 67
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    • Keech A. Simes R.J. Barter P. Best J. Scott R. Taskinen M.R. et al (2005) Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366: 1849–1861.
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3    Best, J.4    Scott, R.5    Taskinen, M.R.6
  • 68
  • 69
    • 65249179010 scopus 로고    scopus 로고
    • Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
    • Kirk E. Reeds D.N. Finck B.N. Mayurranjan S.M. Patterson B.W. Klein S. (2009) Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 136: 1552–1560.
    • (2009) Gastroenterology , vol.136 , pp. 1552-1560
    • Kirk, E.1    Reeds, D.N.2    Finck, B.N.3    Mayurranjan, S.M.4    Patterson, B.W.5    Klein, S.6
  • 70
    • 38149030206 scopus 로고    scopus 로고
    • Liver fat Is Increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
    • Kotronen A. Juurinen L. Hakkarainen A. Westerbacka J. Corner A. Bergholm R. et al (2008) Liver fat Is Increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 31: 165–169.
    • (2008) Diabetes Care , vol.31 , pp. 165-169
    • Kotronen, A.1    Juurinen, L.2    Hakkarainen, A.3    Westerbacka, J.4    Corner, A.5    Bergholm, R.6
  • 71
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    • Kugelmas M. Hill D.B. Vivian B. Marsano L. McClain C.J. (2003) Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38: 413–419.
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3    Marsano, L.4    McClain, C.J.5
  • 72
    • 33746419647 scopus 로고    scopus 로고
    • Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects
    • Larson-Meyer D.E. Heilbronn L.K. Redman L.M. Newcomer B.R. Frisard M.I. Anton S. et al (2006) Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 29: 1337–1344.
    • (2006) Diabetes Care , vol.29 , pp. 1337-1344
    • Larson-Meyer, D.E.1    Heilbronn, L.K.2    Redman, L.M.3    Newcomer, B.R.4    Frisard, M.I.5    Anton, S.6
  • 74
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • Lavine J.E. Schwimmer J.B. Van Natta M.L. Molleston J.P. Murray K.F. Rosenthal P. et al (2011) Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305: 1659–1668.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6
  • 75
    • 78149283488 scopus 로고    scopus 로고
    • Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes
    • Lazo M. Solga S.F. Horska A. Bonekamp S. Diehl A.M. Brancati F.L. et al (2010) Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care 33: 2156–2163.
    • (2010) Diabetes Care , vol.33 , pp. 2156-2163
    • Lazo, M.1    Solga, S.F.2    Horska, A.3    Bonekamp, S.4    Diehl, A.M.5    Brancati, F.L.6
  • 76
    • 79953321393 scopus 로고    scopus 로고
    • Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors
    • Leite N.C. Villela-Nogueira C.A. Pannain V.L. Bottino A.C. Rezende G.F. Cardoso C.R. et al (2011) Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int 31: 700–706.
    • (2011) Liver Int , vol.31 , pp. 700-706
    • Leite, N.C.1    Villela-Nogueira, C.A.2    Pannain, V.L.3    Bottino, A.C.4    Rezende, G.F.5    Cardoso, C.R.6
  • 77
    • 36348987648 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial
    • Lewis J.H. Mortensen M.E. Zweig S. Fusco M.J. Medoff J.R. Belder R. (2007) Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Hepatology 46: 1453–1463.
    • (2007) Hepatology , vol.46 , pp. 1453-1463
    • Lewis, J.H.1    Mortensen, M.E.2    Zweig, S.3    Fusco, M.J.4    Medoff, J.R.5    Belder, R.6
  • 78
    • 34047173534 scopus 로고    scopus 로고
    • Diagnostic value of ultrasonographic examination for nonalcoholic steatohepatitis in morbidly obese patients undergoing laparoscopic bariatric surgery
    • Liang R.J. Wang H.H. Lee W.J. Liew P.L. Lin J.T. Wu M.S. (2007) Diagnostic value of ultrasonographic examination for nonalcoholic steatohepatitis in morbidly obese patients undergoing laparoscopic bariatric surgery. Obes Surg 17: 45–56.
    • (2007) Obes Surg , vol.17 , pp. 45-56
    • Liang, R.J.1    Wang, H.H.2    Lee, W.J.3    Liew, P.L.4    Lin, J.T.5    Wu, M.S.6
  • 79
    • 80052032690 scopus 로고    scopus 로고
    • Role of ethnicity in overweight and obese subjects with nonalcoholic steatohepatitis (NASH)
    • in press doi: 10.1002/hep.24483
    • Lomonaco R. Ortiz-Lopez C. Orsak B. Finch J. Webb A. Bril F. et al (2011a) Role of ethnicity in overweight and obese subjects with nonalcoholic steatohepatitis (NASH). Hepatology in press doi: 10.1002/hep.24483.
    • (2011) Hepatology
    • Lomonaco, R.1    Ortiz-Lopez, C.2    Orsak, B.3    Finch, J.4    Webb, A.5    Bril, F.6
  • 80
    • 83755215879 scopus 로고    scopus 로고
    • Effect of liver fat accumulation on insulin resistance and severity of NASH in obese patients with T2DM
    • Lomonaco R. Orsak B. Ortiz-Lopez C. Chen J. Webb A. Cusi K. (2011b) Effect of liver fat accumulation on insulin resistance and severity of NASH in obese patients with T2DM. Diabetes 60: A1668–A1668.
    • (2011) Diabetes , vol.60 , pp. A1668-A1668
    • Lomonaco, R.1    Orsak, B.2    Ortiz-Lopez, C.3    Chen, J.4    Webb, A.5    Cusi, K.6
  • 81
    • 0029300637 scopus 로고
    • Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis
    • Longo R. Pollesello P. Ricci C. Masutti F. Kvam B.J. Bercich L. et al (1995) Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 5: 281–285.
    • (1995) J Magn Reson Imaging , vol.5 , pp. 281-285
    • Longo, R.1    Pollesello, P.2    Ricci, C.3    Masutti, F.4    Kvam, B.J.5    Bercich, L.6
  • 82
    • 57649229536 scopus 로고    scopus 로고
    • Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis
    • Loomba R. Lutchman G. Kleiner D.E. Ricks M. Feld J.J. Borg B.B. et al (2009) Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis. Aliment Pharmacol Ther 29: 172–182.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 172-182
    • Loomba, R.1    Lutchman, G.2    Kleiner, D.E.3    Ricks, M.4    Feld, J.J.5    Borg, B.B.6
  • 85
    • 77949433612 scopus 로고    scopus 로고
    • Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
    • Mathew M. Tay E. Cusi K. (2010) Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects. Cardiovasc Diabetol 9: 9–9.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 9
    • Mathew, M.1    Tay, E.2    Cusi, K.3
  • 86
    • 67650951419 scopus 로고    scopus 로고
    • Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease
    • Mathurin P. Hollebecque A. Arnalsteen L. Buob D. Leteurtre E. Caiazzo R. et al (2009) Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 137: 532–540.
    • (2009) Gastroenterology , vol.137 , pp. 532-540
    • Mathurin, P.1    Hollebecque, A.2    Arnalsteen, L.3    Buob, D.4    Leteurtre, E.5    Caiazzo, R.6
  • 89
    • 33645889332 scopus 로고    scopus 로고
    • Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force
    • McKenney J.M. Davidson M.H. Jacobson T.A. Guyton J.R. (2006) Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol 97(8A): 89C–94C.
    • (2006) Am J Cardiol , vol.97 , Issue.8A , pp. 89C-94C
    • McKenney, J.M.1    Davidson, M.H.2    Jacobson, T.A.3    Guyton, J.R.4
  • 91
    • 0037566201 scopus 로고    scopus 로고
    • Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values
    • Mofrad P. Contos M.J. Haque M. Sargeant C. Fisher R.A. Luketic V.A. et al (2003) Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 37: 1286–1292.
    • (2003) Hepatology , vol.37 , pp. 1286-1292
    • Mofrad, P.1    Contos, M.J.2    Haque, M.3    Sargeant, C.4    Fisher, R.A.5    Luketic, V.A.6
  • 92
    • 61749092425 scopus 로고    scopus 로고
    • Influence of ethnicity on histological differences in non-alcoholic fatty liver disease
    • Mohanty S.R. Troy T.N. Huo D. O'Brien B.L. Jensen D.M. Hart J. (2009) Influence of ethnicity on histological differences in non-alcoholic fatty liver disease. J Hepatol 50: 797–804.
    • (2009) J Hepatol , vol.50 , pp. 797-804
    • Mohanty, S.R.1    Troy, T.N.2    Huo, D.3    O'Brien, B.L.4    Jensen, D.M.5    Hart, J.6
  • 93
    • 63749129833 scopus 로고    scopus 로고
    • Early-life origins of metabolic dysfunction: role of the adipocyte
    • Muhlhausler B. Smith S.R. (2009) Early-life origins of metabolic dysfunction: role of the adipocyte. Trends Endocrinol Metab 20: 51–57.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 51-57
    • Muhlhausler, B.1    Smith, S.R.2
  • 94
    • 79251496078 scopus 로고    scopus 로고
    • Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • in press
    • Musso G. Gambino R. Cassader M. Pagano G. (2010) Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med in press.
    • (2010) Ann Med
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 95
    • 3142670354 scopus 로고    scopus 로고
    • Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial
    • Nair S. Diehl A.M. Wiseman M. Farr G.H. Jr Perrillo R.P. (2004) Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial. Aliment Pharmacol Ther 20: 23–28.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 23-28
    • Nair, S.1    Diehl, A.M.2    Wiseman, M.3    Farr, G.H.4    Perrillo, R.P.5
  • 97
    • 0034935888 scopus 로고    scopus 로고
    • Effect of a moderately energy-restricted diet on obese patients with fatty liver
    • Okita M. Hayashi M. Sasagawa T. Takagi K. Suzuki K. Kinoyama S. et al (2001) Effect of a moderately energy-restricted diet on obese patients with fatty liver. Nutrition 17: 542–547.
    • (2001) Nutrition , vol.17 , pp. 542-547
    • Okita, M.1    Hayashi, M.2    Sasagawa, T.3    Takagi, K.4    Suzuki, K.5    Kinoyama, S.6
  • 98
    • 83755193494 scopus 로고    scopus 로고
    • Adding exenatide to bedtime insulin detemir promotes weight loss and improves hepatic steatosis in insulin-treated patients with T2DM
    • Orsi C. Matthew M. Chen J. Darland J. Gastaldelli A. Ali R. et al (2009) Adding exenatide to bedtime insulin detemir promotes weight loss and improves hepatic steatosis in insulin-treated patients with T2DM. Diabetologia 52(Suppl. 1): A248–A248.
    • (2009) Diabetologia , vol.52 , Issue.Suppl. 1 , pp. A248-A248
    • Orsi, C.1    Matthew, M.2    Chen, J.3    Darland, J.4    Gastaldelli, A.5    Ali, R.6
  • 99
    • 83755230568 scopus 로고    scopus 로고
    • Abnormal glucose metabolism is common in NASH patients and associated with more severe hepatic and adipose tissue insulin resistance and hepatocyte necroinflammation
    • Ortiz-Lopez C. Orsak B. Darland C. Finch J. Lomonaco R. Cusi K. (2010) Abnormal glucose metabolism is common in NASH patients and associated with more severe hepatic and adipose tissue insulin resistance and hepatocyte necroinflammation. Diabetes 59(Suppl. 1): A88–A88.
    • (2010) Diabetes , vol.59 , Issue.Suppl. 1 , pp. A88-A88
    • Ortiz-Lopez, C.1    Orsak, B.2    Darland, C.3    Finch, J.4    Lomonaco, R.5    Cusi, K.6
  • 100
    • 83755215881 scopus 로고    scopus 로고
    • Insulin resistance but not hyperglycemia, plays a key role in the severity of NAFLD in T2DM patients
    • Ortiz-Lopez C. Orsak B. Lomonaco R. Finch J. Darland C. Cusi K. (2011) Insulin resistance but not hyperglycemia, plays a key role in the severity of NAFLD in T2DM patients. Diabetes 60(Suppl. 1): A1665–A1665.
    • (2011) Diabetes , vol.60 , Issue.Suppl. 1 , pp. A1665-A1665
    • Ortiz-Lopez, C.1    Orsak, B.2    Lomonaco, R.3    Finch, J.4    Darland, C.5    Cusi, K.6
  • 101
    • 70349974666 scopus 로고    scopus 로고
    • Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease
    • Pagadala M. Zein C.O. McCullough A.J. (2009) Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease. Clin Liver Dis 13: 591–606.
    • (2009) Clin Liver Dis , vol.13 , pp. 591-606
    • Pagadala, M.1    Zein, C.O.2    McCullough, A.J.3
  • 102
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer M. Schaffner F. (1990) Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 99: 1408–1413.
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 103
    • 38649091680 scopus 로고    scopus 로고
    • Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
    • Perseghin G. Lattuada G. De Cobelli F. Esposito A. Belloni E. Ntali G. et al (2008) Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver. Hepatology 47: 51–58.
    • (2008) Hepatology , vol.47 , pp. 51-58
    • Perseghin, G.1    Lattuada, G.2    De Cobelli, F.3    Esposito, A.4    Belloni, E.5    Ntali, G.6
  • 104
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen K.F. Dufour S. Befroy D. Lehrke M. Hendler R.E. Shulman G.I. (2005) Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54: 603–608.
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 105
    • 70349771924 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: is bariatric surgery the answer?
    • Pillai A.A. Rinella M.E. (2009) Non-alcoholic fatty liver disease: is bariatric surgery the answer? Clin Liver Dis 13: 689–710.
    • (2009) Clin Liver Dis , vol.13 , pp. 689-710
    • Pillai, A.A.1    Rinella, M.E.2
  • 106
    • 33845207096 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease
    • Poynard T. Ratziu V. Charlotte F. Messous D. Munteanu M. Imbert-Bismut F. et al (2006) Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 6: 34–34.
    • (2006) BMC Gastroenterol , vol.6 , pp. 34
    • Poynard, T.1    Ratziu, V.2    Charlotte, F.3    Messous, D.4    Munteanu, M.5    Imbert-Bismut, F.6
  • 107
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
    • Ratziu V. Charlotte F. Bernhardt C. Giral P. Halbron M. Lenaour G. et al (2010) Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial. Hepatology 51: 445–453.
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1    Charlotte, F.2    Bernhardt, C.3    Giral, P.4    Halbron, M.5    Lenaour, G.6
  • 108
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V. Giral P. Jacqueminet S. Charlotte F. Hartemann-Heurtier A. Serfaty L. et al (2008) Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 135: 100–110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3    Charlotte, F.4    Hartemann-Heurtier, A.5    Serfaty, L.6
  • 109
    • 33644607568 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    • Ratziu V. Massard J. Charlotte F. Messous D. Imbert-Bismut F. Bonyhay L. et al (2006) Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 6: 6–6.
    • (2006) BMC Gastroenterol , vol.6 , pp. 6
    • Ratziu, V.1    Massard, J.2    Charlotte, F.3    Messous, D.4    Imbert-Bismut, F.5    Bonyhay, L.6
  • 110
    • 27144543513 scopus 로고    scopus 로고
    • Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method
    • Reingold J.S. McGavock J.M. Kaka S. Tillery T. Victor R.G. Szczepaniak L.S. (2005) Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method. Am J Physiol Endocrinol Metab 289: E935–E939.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , pp. E935-E939
    • Reingold, J.S.1    McGavock, J.M.2    Kaka, S.3    Tillery, T.4    Victor, R.G.5    Szczepaniak, L.S.6
  • 111
    • 38849148319 scopus 로고    scopus 로고
    • Weight loss, dietary advice and statin therapy in non-alcoholic fatty liver disease: a retrospective study
    • Riley P. Sudarshi D. Johal M. Benedict A. Panteli J. Crook M. et al (2008) Weight loss, dietary advice and statin therapy in non-alcoholic fatty liver disease: a retrospective study. Int J Clin Pract 62: 374–381.
    • (2008) Int J Clin Pract , vol.62 , pp. 374-381
    • Riley, P.1    Sudarshi, D.2    Johal, M.3    Benedict, A.4    Panteli, J.5    Crook, M.6
  • 112
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • Ryysy L. Hakkinen A.M. Goto T. Vehkavaara S. Westerbacka J. Halavaara J. et al (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49: 749–758.
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1    Hakkinen, A.M.2    Goto, T.3    Vehkavaara, S.4    Westerbacka, J.5    Halavaara, J.6
  • 115
    • 7044274423 scopus 로고    scopus 로고
    • Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study
    • Sattar N. Scherbakova O. Ford I. O'Reilly D.S. Stanley A. Forrest E. et al (2004) Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study. Diabetes 53: 2855–2860.
    • (2004) Diabetes , vol.53 , pp. 2855-2860
    • Sattar, N.1    Scherbakova, O.2    Ford, I.3    O'Reilly, D.S.4    Stanley, A.5    Forrest, E.6
  • 116
  • 118
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson S. Lee J. Goldfine A. (2006) Inflammation and insulin resistance. J Clin Invest 116: 1793–1801.
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.1    Lee, J.2    Goldfine, A.3
  • 120
    • 33645225309 scopus 로고    scopus 로고
    • Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis
    • Sreenivasa Baba C. Alexander G. Kalyani B. Pandey R. Rastogi S. Pandey A. et al (2006) Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol 21(1 Pt 1): 191–198.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.1 Pt 1 , pp. 191-198
    • Sreenivasa Baba, C.1    Alexander, G.2    Kalyani, B.3    Pandey, R.4    Rastogi, S.5    Pandey, A.6
  • 121
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A. Lindor K. St Saver J. Lymp J. Mendes F. Muto A. et al (2005) Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 43: 1060–1066.
    • (2005) J Hepatol , vol.43 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3    Lymp, J.4    Mendes, F.5    Muto, A.6
  • 122
    • 0033007207 scopus 로고    scopus 로고
    • Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo
    • Szczepaniak L.S. Babcock E.E. Schick F. Dobbins R.L. Garg A. Burns D.K. et al (1999) Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276(5 Pt 1): E977–E989.
    • (1999) Am J Physiol , vol.276 , Issue.5 Pt 1 , pp. E977-E989
    • Szczepaniak, L.S.1    Babcock, E.E.2    Schick, F.3    Dobbins, R.L.4    Garg, A.5    Burns, D.K.6
  • 123
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    • Szczepaniak L.S. Nurenberg P. Leonard D. Browning J.D. Reingold J.S. Grundy S. et al (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288: E462–E468.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3    Browning, J.D.4    Reingold, J.S.5    Grundy, S.6
  • 124
    • 21244490885 scopus 로고    scopus 로고
    • Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients
    • Tamura Y. Tanaka Y. Sato F. Choi J.B. Watada H. Niwa M. et al (2005) Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 90: 3191–3196.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3191-3196
    • Tamura, Y.1    Tanaka, Y.2    Sato, F.3    Choi, J.B.4    Watada, H.5    Niwa, M.6
  • 125
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G. Day C.P. Bonora E. (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363: 1341–1350.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 126
    • 66149085898 scopus 로고    scopus 로고
    • A 2-day lipid or combined lipid-glucose infusion reproduce in healthy subjects the metabolic abnormalities seen in the metabolic syndrome
    • Tay C. Belfort R. Mathew M. Cusi K. (2006) A 2-day lipid or combined lipid-glucose infusion reproduce in healthy subjects the metabolic abnormalities seen in the metabolic syndrome. Diabetes 55(Suppl. 1): A66–A66.
    • (2006) Diabetes , vol.55 , Issue.Suppl. 1 , pp. A66-A66
    • Tay, C.1    Belfort, R.2    Mathew, M.3    Cusi, K.4
  • 127
    • 19344375593 scopus 로고    scopus 로고
    • Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome
    • Tenenbaum A. Motro M. Fisman E.Z. Tanne D. Boyko V. Behar S. (2005) Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. Arch Intern Med 165: 1154–1160.
    • (2005) Arch Intern Med , vol.165 , pp. 1154-1160
    • Tenenbaum, A.1    Motro, M.2    Fisman, E.Z.3    Tanne, D.4    Boyko, V.5    Behar, S.6
  • 128
    • 33947153419 scopus 로고    scopus 로고
    • High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
    • Thamer C. Machann J. Stefan N. Haap M. Schafer S. Brenner S. et al (2007) High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring) 15: 531–538.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 531-538
    • Thamer, C.1    Machann, J.2    Stefan, N.3    Haap, M.4    Schafer, S.5    Brenner, S.6
  • 129
    • 23644443235 scopus 로고    scopus 로고
    • The Diabetes Prevention Program Research Group
    • Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the Diabetes Prevention Program: effects of lifestyle intervention and metformin
    • The Diabetes Prevention Program Research Group (2005) Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the Diabetes Prevention Program: effects of lifestyle intervention and metformin. Diabetes 54: 2404–2414.
    • (2005) Diabetes , vol.54 , pp. 2404-2414
  • 130
    • 33748748206 scopus 로고    scopus 로고
    • Trial Investigators (2006) Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
    • The DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication)
    • The DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication). Trial Investigators (2006) Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. The Lancet 368: 1096–1105.
    • The Lancet , vol.368 , pp. 1096-1105
  • 131
    • 33750122264 scopus 로고    scopus 로고
    • Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
    • Thomas E.L. Brynes A.E. Hamilton G. Patel N. Spong A. Goldin R.D. et al (2006) Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World J Gastroenterol 12: 5813–5819.
    • (2006) World J Gastroenterol , vol.12 , pp. 5813-5819
    • Thomas, E.L.1    Brynes, A.E.2    Hamilton, G.3    Patel, N.4    Spong, A.5    Goldin, R.D.6
  • 132
    • 0037342842 scopus 로고    scopus 로고
    • Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content
    • Tiikkainen M. Bergholm R. Vehkavaara S. Rissanen A. Hakkinen A.M. Tamminen M. et al (2003) Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 52: 701–707.
    • (2003) Diabetes , vol.52 , pp. 701-707
    • Tiikkainen, M.1    Bergholm, R.2    Vehkavaara, S.3    Rissanen, A.4    Hakkinen, A.M.5    Tamminen, M.6
  • 133
    • 0030740659 scopus 로고    scopus 로고
    • Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
    • Ueno T. Sugawara H. Sujaku K. Hashimoto O. Tsuji R. Tamaki S. et al (1997) Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol 27: 103–107.
    • (1997) J Hepatol , vol.27 , pp. 103-107
    • Ueno, T.1    Sugawara, H.2    Sujaku, K.3    Hashimoto, O.4    Tsuji, R.5    Tamaki, S.6
  • 136
    • 58949094415 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    • Vuppalanchi R. Chalasani N. (2009) Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 49: 306–317.
    • (2009) Hepatology , vol.49 , pp. 306-317
    • Vuppalanchi, R.1    Chalasani, N.2
  • 138
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    • Wieckowska A. McCullough A.J. Feldstein A.E. (2007) Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 46: 582–589.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 139
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    • Williams C.D. Stengel J. Asike M.I. Torres D.M. Shaw J. Contreras M. et al (2011) Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140: 124–131.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3    Torres, D.M.4    Shaw, J.5    Contreras, M.6
  • 140
    • 75449091784 scopus 로고    scopus 로고
    • Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
    • Wong V.W. Vergniol J. Wong G.L. Foucher J. Chan H.L. Le Bail B. et al (2010) Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 51: 454–462.
    • (2010) Hepatology , vol.51 , pp. 454-462
    • Wong, V.W.1    Vergniol, J.2    Wong, G.L.3    Foucher, J.4    Chan, H.L.5    Le Bail, B.6
  • 141
    • 72049105082 scopus 로고    scopus 로고
    • Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis
    • Yilmaz Y. Kedrah A.E. Ozdogan O. (2009) Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis. World J Gastroenterol 15: 4387–4391.
    • (2009) World J Gastroenterol , vol.15 , pp. 4387-4391
    • Yilmaz, Y.1    Kedrah, A.E.2    Ozdogan, O.3
  • 142
    • 53849114643 scopus 로고    scopus 로고
    • A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH)
    • Younossi Z.M. Jarrar M. Nugent C. Randhawa M. Afendy M. Stepanova M. et al (2008) A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). Obes Surg 18: 1430–1437.
    • (2008) Obes Surg , vol.18 , pp. 1430-1437
    • Younossi, Z.M.1    Jarrar, M.2    Nugent, C.3    Randhawa, M.4    Afendy, M.5    Stepanova, M.6
  • 143
    • 79958865915 scopus 로고    scopus 로고
    • Liver function tests and statins
    • Zamor P.J. Russo M.W. (2011) Liver function tests and statins. Curr Opin Cardiol 4: 338–341.
    • (2011) Curr Opin Cardiol , vol.4 , pp. 338-341
    • Zamor, P.J.1    Russo, M.W.2
  • 144
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi S. Kessler A. Brazowsky E. Webb M. Lurie Y. Santo M. et al (2006) A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 4: 639–644.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 639-644
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3    Webb, M.4    Lurie, Y.5    Santo, M.6


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