The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Girard, Emmanuelle ^a,b   Paul, Jean Louis ^a,b   Fournier, Natalie ^a,b   Beaune, Philippe ^a   Johannes, Ludger ^c,d   Lamaze, Christophe ^c,d   Védie, Benoît ^a  

^a HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^b EA 4529   (France)

^c INSTITUT CURIE   (France)

^d INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CHOLESTEROL; CHOLESTEROL ESTER; DYNAMIN; DYNASORE; ENZYME INHIBITOR; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG; 3 BETA (2 (DIETHYLAMINO)ETHOXY)ANDROST 5 EN 17 ONE; 3-BETA-(2-(DIETHYLAMINO)ETHOXY)ANDROST-5-EN-17-ONE; ANDROSTANE DERIVATIVE; HYDRAZONE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N' (3,4 DIHYDROXYBENZYLIDENE) 3 HYDROXY 2 NAPHTHAHYDRAZIDE; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE; SOMATOMEDIN B RECEPTOR;

ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; HELA CELL; HUMAN; HUMAN CELL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE GENE; LOW DENSITY LIPOPROTEIN RECEPTOR GENE; LYSOSOME; MACROPHAGE; MEMBRANE TRANSPORT; PROTEIN TRANSPORT; STEROL METABOLISM; STEROL REGULATORY ELEMENT BINDING PROTEIN 2 GENE; TRANSCRIPTION REGULATION; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; ESTERIFICATION; GENETIC TRANSCRIPTION; GENETICS; HOMEOSTASIS; METABOLISM; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ANDROSTENES; BIOLOGICAL TRANSPORT; CHOLESTEROL; CHOLESTEROL, LDL; DOWN-REGULATION; DYNAMINS; ENDOSOMES; ENZYME INHIBITORS; ESTERIFICATION; HELA CELLS; HOMEOSTASIS; HUMANS; HYDRAZONES; MACROPHAGES; RECEPTOR, IGF TYPE 2; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 83655212383     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029042     Document Type: Article

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