Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity

Journal of Lipid Research

Volumn 51, Issue 6, 2010, Pages 1263-1272

  Sakashita, Naomi ^a,b   Chang, Catherine C Y ^b   Lei, Xiaofeng ^a   Fujiwara, Yukio ^a   Takeya, Motohiro ^a   Chang, Ta Yuan ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Foam cells; Low density lipoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BINDING IMMUNOGLOBULIN PROTEIN; BINDING PROTEIN; CALNEXIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SYNTAXIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CELL GROWTH; CELL VACUOLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; TRANS GOLGI NETWORK;

EID: 77952738926     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900288-JLR200     Document Type: Article

References (22)

1. Maxfield, F. R., and I. Tabas. 2005. Role of cholesterol and lipid organization in disease. Nature. 438: 612-621. (Pubitemid 41740565)
2. Ikonen, E. 2008. Cellular cholesterol trafficking and compartmentalization. Nat. Rev. Mol. Cell Biol. 9: 125-138.
3. Buhman, K. F., M. Accada, and R. V. Farese, Jr. 2000. Mammalian acyl-CoA:cholesterol acyltransferases. Biochim. Biophys. Acta. 1529: 142-154.
4. Rudel, L. L., R. Lee, and T. Cockman. 2001. Structure, function, and regulation of ACAT. Curr. Opin. Lipidol. 12: 121-127.
5. Chang, T. Y., B. L. Li, C. C. Chang, and Y. Urano. 2009. Acylcoenzyme A:cholesterol acyltransferases. Am. J. Physiol. Endocrinol. Metab. 297: E1-E9.
6. Parini, P., M. Davis, A. T. Lada, S. K. Erickson, T. L. Wright, U. Gustafsson, S. Sahlin, C. Einarsson, M. Eriksson, B. Angelin, et al. 2004. ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation. 110: 2017-2023. (Pubitemid 39331916)
7. Song, B. L., C. H. Wang, X. M. Yao, L. Yang, W. J. Zhang, Z. Z. Wang, X. N. Zhao, J. B. Yang, W. Qi, X. Y. Yang, et al. 2006. Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Biochem. J. 394: 617-626.
8. Miyazaki, A., N. Sakashita, O. Lee, K. Takahashi, S. Horiuchi, H. Hakamata, P. M. Morganelli, C. C. Chang, and T. Y. Chang. 1998. Expression of ACAT1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages. Arterioscler. Thromb. Vasc. Biol. 18: 1568-1574. (Pubitemid 28465408)
9. Warner, G. J., G. Stoudt, M. Bamberger, W. J. Johnson, and G. H. Rothblat. 1995. Cell toxicity induced by inhibition of acyl coenzyme A:cholessterol acyltransferase and accumulation of unesterified cholesterol. J. Biol. Chem. 270: 5772-5778.
10. Tabas, I. 2002. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 110: 905-911.
11. Chang, T. Y., C. C. Y. Chang, and D. Cheng. 1997. Acylcoenzyme A:cholesterol acyltransferase. Annu. Rev. Biochem. 66: 613-638.
12. Khelef, N., T. T. Soe, O. Quehenberger, N. Beatini, I. Tabas, and F. R. Maxfield. 2000. Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. Arterioscler. Thromb. Vasc. Biol. 20: 1769-1776. (Pubitemid 30470592)
13. Sakashita, N., A. Miyazaki, M. Takeya, S. Horiuchi, C. C. Y. Chang, T. Y. Chang, and K. Takahashi. 2000. Localization of human acylcoenzyme A:cholesterol acyltransferase-1 in macrophages and in various tissues. Am. J. Pathol. 156: 227-236. (Pubitemid 30644456)
14. Chang, C. C. Y., J. Chen, M. A. Thomas, D. Cheng, V. A. Del Priore, R. S. Newton, M. E. Pape, and T. Y. Chang. 1995. Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies. J. Biol. Chem. 270: 29532-29540.
15. Chang, C. C., C. Y. Lee, E. T. Chang, J. C. Cruz, M. C. Levesque, and T. Y. Chang. 1998. Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner. J. Biol. Chem. 273: 35132-35141.
16. Ikenoya, M., Y. Yoshinaka, H. Kobayashi, K. Kawamine, K. Shibuya, F. Sato, K. Sawanobori, T. Watanabe, and A. Miyazaki. 2007. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 191: 290-297. (Pubitemid 46400712)
17. Huang, W., I. Ishii, W-Y. Zhang, M. Sonobe, and H. S. Kruth. 2002. PMA activation of macrophages alters macrophage metabolism of aggregated LDL. J. Lipid Res. 43: 1275-1282. (Pubitemid 34988175)
18. Cadigan, K. M., and T. Y. Chang. 1988. A simple method for reconstitution of CHO cell and human fibroblast ACAT activity into liposomes. J. Lipid Res. 29: 1683-1692.
19. Bock, J. B., J. Klumperman, S. Davanger, and R. H. Scheller. 1997. Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol. Biol. Cell. 8: 1261-1271.
20. Sakashita, N., A. Miyazaki, C. C. Y. Chang, P. Morganelli, T. Y. Chang, O. Nakamura, E. Kiyota, H. Hakamata, M. Satoh, H. Tamagawa, et al. 2003. The presence of ACAT2 in human and mouse macrophages: in vivo and in vitro studies. Lab. Invest. 83: 1569-1581.
21. Baumann, O., and B. Walz. 2001. Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int. Rev. Cytol. 205: 149-214. (Pubitemid 32390830)
22. Shibata, Y., G. K. Voeltz, and T. A. Rapoport. 2006. Rough sheets and smooth tubules. Cell. 126: 435-439.