Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 1-2, 2012, Pages 101-109

  Telbisz, Ágnes ^a   Hegedüs, Csilla ^a   Özvegy Laczka, Csilla ^a   Goda, Katalin ^b   Várady, György ^a   Takáts, Zoltán ^a   Szabó, Eszter ^a   Sorrentino, Brian P ^c   Váradi, András ^d   Sarkadi, Balázs ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

Anti ABCG2 monoclonal antibody; Drug interactions with ABCG2; High throughput antibody shift assay; Human ABCG2 multidrug transporter; Inhibitors of ABCG2

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; ADENOSINE TRIPHOSPHATASE; ANTIBODY; BREAST CANCER RESISTANCE PROTEIN; ELACRIDAR; FUMITREMORGIN C; GEFITINIB; HOE 33342; IMATINIB; METHOTREXATE; MITOXANTRONE; NILOTINIB; PRAZOSIN; QUERCETIN; TARIQUIDAR; TOPOTECAN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG RESISTANCE, NEOPLASM; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MEMBRANE TRANSPORT MODULATORS; MUTANT PROTEINS; NEOPLASM PROTEINS; OSMOLAR CONCENTRATION; RECOMBINANT PROTEINS;

EID: 83655163966     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.10.021     Document Type: Article

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