Suppression of tumor growth in H-ras12V liver cancer mice by delivery of programmed cell death protein 4 using galactosylated poly(ethylene glycol)-chitosan-graft-spermine

Biomaterials

Volumn 33, Issue 6, 2012, Pages 1894-1902

  Kim, Ji Hye ^a,b   Minai Tehrani, Arash ^a   Kim, You Kyoung ^a   Shin, Ji Young ^a   Hong, Seong Ho ^a   Kim, Hye Joon ^a   Lee, Hee Do ^a   Chang, Seung Hee ^a   Yu, Kyeong Nam ^a   Bang, Yong Bin ^b   Cho, Chong Su ^a   Yoon, Tae Jong ^c   Yu, Dae Yeul ^d   Jiang, Hu Lin ^a   Cho, Myung Haing ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c CHA University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Galactosylated poly(ethylene glycol) chitosan graft spermine; Gene therapy; Hepatocyte targeting; Non viral gene delivery

Indexed keywords

A549 CELLS; AMIDE BOND; ANGIOGENESIS; ENDOSOMES; GENE CARRIER; GENE DELIVERY; GFP EXPRESSION; HEPATOCYTES; INTRAVENOUS INJECTIONS; LIVER CANCERS; NAKED DNA; NANOSCALE SIZE; NON-TARGETED; NON-VIRAL GENE DELIVERY; PHYSICAL CHARACTERISTICS; PLASMID DNA; POLYETHYLENEIMINE; PROGRAMMED CELL DEATHS; SPHERICAL SHAPE; TUMOR GROWTH; TUMOR SUPPRESSION;

AMIDES; CELL CULTURE; CELL DEATH; CHITOSAN; COPOLYMERS; CYTOTOXICITY; DYNAMIC LIGHT SCATTERING; ETHYLENE; GENE THERAPY; GENE TRANSFER; GLYCOLS; GRAFTING (CHEMICAL); MAMMALS; POLYETHYLENES; TUMORS; ZETA POTENTIAL;

POLYETHYLENE GLYCOLS;

AMIDE; CHITOSAN; COPOLYMER; MACROGOL; NAKED DNA; NANOPARTICLE; PLASMID DNA; POLYETHYLENEIMINE; PROGRAMMED CELL DEATH PROTEIN 4; SPERMINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HEPG2; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; GENE DELIVERY SYSTEM; GENE TARGETING; HELA CELL; HEPATITIS; HUMAN; HUMAN CELL; LIGHT SCATTERING; LIPIDOSIS; LIVER CANCER; LIVER CELL; LIVER FIBROSIS; LIVER NECROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; ZETA POTENTIAL;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHITOSAN; DRUG DELIVERY SYSTEMS; ENDOSOMES; GENE TRANSFER TECHNIQUES; GENES, RAS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MICE; NEOVASCULARIZATION, PATHOLOGIC; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; PROTONS; RAS PROTEINS; SPERMINE;

MUS;

EID: 83555179059     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.024     Document Type: Article

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