Active site mutants of human secreted Group IIA Phospholipase A 2 lacking hydrolytic activity retain their bactericidal effect

Biochimie

Volumn 94, Issue 1, 2012, Pages 132-136

  Chioato, Lucimara ^a   Aragão, Elisangela Aparecida ^a   Ferreira, Tatiana Lopes ^a   Ward, Richard J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Active site mutant; Ca 2+ independent; Membrane damage

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM ION; ESTERASE; LIPOSOME; PHOSPHOLIPASE A2 GROUP IIA; UNCLASSIFIED DRUG;

ARTICLE; BACTERICIDAL ACTIVITY; CATALYSIS; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROLYSIS; IMMUNE RESPONSE; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MICROCOCCUS LUTEUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID MEMBRANE; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACTERIA; BASE SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; DNA PRIMERS; GROUP II PHOSPHOLIPASES A2; HUMANS; LIPOSOMES; MUTAGENESIS, SITE-DIRECTED; PROTEOLYSIS; SPECTROPHOTOMETRY, ULTRAVIOLET;

MICROCOCCUS LUTEUS;

EID: 83555174538     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.09.027     Document Type: Article

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