메뉴 건너뛰기




Volumn 12, Issue 6, 2011, Pages 527-536

Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD + level, SIRT1 activity and replicative lifespan of human Hs68 cells

Author keywords

2 Deoxyglucose; Caloric restriction mimetic; Dehydroepiandrosterone; NAD +; Replicative lifespan; Sirtuin

Indexed keywords

BETA GALACTOSIDASE; DEOXYGLUCOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PRASTERONE; PROTEIN P53; SIRTUIN 1;

EID: 83555163590     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-011-9342-7     Document Type: Article
Times cited : (24)

References (40)
  • 1
    • 77957565881 scopus 로고    scopus 로고
    • Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications
    • 20872319 1:CAS:528:DC%2BC3cXhtlaktLzK
    • A Aljada L Dong SA Mousa 2010 Sirtuin-targeting drugs: mechanisms of action and potential therapeutic applications Curr Opin Investig Drugs 11 1158 1168 20872319 1:CAS:528:DC%2BC3cXhtlaktLzK
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1158-1168
    • Aljada, A.1    Dong, L.2    Mousa, S.A.3
  • 3
    • 60249098570 scopus 로고    scopus 로고
    • DHEA metabolism in prostate: For better or worse?
    • 10.1016/j.mce.2008.10.019 19013497 10.1016/j.mce.2008.10.019 1:CAS:528:DC%2BD1MXit1Ogsbw%3D
    • JT Arnold 2009 DHEA metabolism in prostate: for better or worse? Mol Cell Endocrinol 301 83 88 10.1016/j.mce.2008.10.019 19013497 10.1016/j.mce.2008.10. 019 1:CAS:528:DC%2BD1MXit1Ogsbw%3D
    • (2009) Mol Cell Endocrinol , vol.301 , pp. 83-88
    • Arnold, J.T.1
  • 4
    • 0142052858 scopus 로고    scopus 로고
    • Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans
    • 10.1152/ajpendo.00296.2003 14534077 1:CAS:528:DC%2BD3sXpt1Kjurg%3D
    • M Barbieri M Bonafè C Franceschi G Paolisso 2003 Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans Am J Physiol Endocrinol Metab 285 E1064 E1071 10.1152/ajpendo.00296.2003 14534077 1:CAS:528:DC%2BD3sXpt1Kjurg%3D
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barbieri, M.1    Bonafè, M.2    Franceschi, C.3    Paolisso, G.4
  • 5
    • 33646731782 scopus 로고    scopus 로고
    • Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    • 10.1073/pnas.0600161103 16682650 10.1073/pnas.0600161103 1:CAS:528:DC%2BD28XlsVGksbs%3D
    • MS Bonkowski JS Rocha MM Masternak KA Al Regaiey A Bartke 2006 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction Proc Natl Acad Sci USA 103 7901 7905 10.1073/pnas.0600161103 16682650 10.1073/pnas.0600161103 1:CAS:528:DC%2BD28XlsVGksbs%3D
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7901-7905
    • Bonkowski, M.S.1    Rocha, J.S.2    Masternak, M.M.3    Al Regaiey, K.A.4    Bartke, A.5
  • 6
    • 0035059672 scopus 로고    scopus 로고
    • From cells to organisms: Can we learn about aging from cells in culture?
    • DOI 10.1016/S0531-5565(00)00230-8, PII S0531556500002308
    • J Campisi 2001 From cells to organisms: can we learn about aging from cells in culture? Exp Gerontol 36 607 618 10.1016/S0531-5565(00)00230-8 11295503 10.1016/S0531-5565(00)00230-8 1:STN:280:DC%2BD3Mris1erug%3D%3D (Pubitemid 32273407)
    • (2001) Experimental Gerontology , vol.36 , Issue.4-6 , pp. 607-618
    • Campisi, J.1
  • 7
    • 33846583673 scopus 로고    scopus 로고
    • SIR2: A potential target for calorie restriction mimetics
    • DOI 10.1016/j.molmed.2006.12.004, PII S1471491406002863
    • D Chen L Guarente 2007 SIR2: a potential target for calorie restriction mimetics Trends Mol Med 13 64 71 10.1016/j.molmed.2006.12.004 17207661 10.1016/j.molmed.2006.12.004 1:CAS:528:DC%2BD2sXhtlSnsro%3D (Pubitemid 46186153)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.2 , pp. 64-71
    • Chen, D.1    Guarente, L.2
  • 8
    • 77953257025 scopus 로고    scopus 로고
    • Aging and disease: Connections to sirtuins
    • 10.1111/j.1474-9726.2010.00548.x 20409078 10.1111/j.1474-9726.2010.00548. x 1:CAS:528:DC%2BC3cXktFOnsLw%3D
    • G Donmez L Guarente 2010 Aging and disease: connections to sirtuins Aging Cell 9 285 290 10.1111/j.1474-9726.2010.00548.x 20409078 10.1111/j.1474-9726. 2010.00548.x 1:CAS:528:DC%2BC3cXktFOnsLw%3D
    • (2010) Aging Cell , vol.9 , pp. 285-290
    • Donmez, G.1    Guarente, L.2
  • 9
    • 43049121395 scopus 로고    scopus 로고
    • Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
    • DOI 10.1016/j.devcel.2008.02.004, PII S1534580708000749
    • M Fulco Y Cen P Zhao EP Hoffman MW McBurney AA Sauve V Sartorelli 2008 Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt Dev Cell 14 661 673 10.1016/j.devcel.2008.02.004 18477450 10.1016/j.devcel.2008.02.004 1:CAS:528:DC%2BD1cXmtleju7g%3D (Pubitemid 351622608)
    • (2008) Developmental Cell , vol.14 , Issue.5 , pp. 661-673
    • Fulco, M.1    Cen, Y.2    Zhao, P.3    Hoffman, E.P.4    McBurney, M.W.5    Sauve, A.A.6    Sartorelli, V.7
  • 10
    • 53049092131 scopus 로고    scopus 로고
    • The anti-aging, metabolism potential of SIRT1
    • 18821472 1:CAS:528:DC%2BD1cXhtlSgtbrP
    • HS Ghosh 2008 The anti-aging, metabolism potential of SIRT1 Curr Opin Investig Drugs 9 1095 1102 18821472 1:CAS:528:DC%2BD1cXhtlSgtbrP
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 1095-1102
    • Ghosh, H.S.1
  • 11
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • 10.1146/annurev.pathol.4.110807.092250 20078221 10.1146/annurev.pathol.4. 110807.092250 1:CAS:528:DC%2BC3cXivFekt7c%3D
    • MC Haigis DA Sinclair 2010 Mammalian sirtuins: biological insights and disease relevance Annu Rev Pathol 5 253 295 10.1146/annurev.pathol.4.110807. 092250 20078221 10.1146/annurev.pathol.4.110807.092250 1:CAS:528: DC%2BC3cXivFekt7c%3D
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 12
    • 73449114300 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16
    • 10.1007/s10522-009-9225-3 19370397 10.1007/s10522-009-9225-3 1:CAS:528:DC%2BC3cXjtlGjsg%3D%3D
    • T Hashimoto M Horikawa T Nomura K Sakamoto 2010 Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 Biogerontology 11 31 43 10.1007/s10522-009-9225-3 19370397 10.1007/s10522-009-9225-3 1:CAS:528:DC%2BC3cXjtlGjsg%3D%3D
    • (2010) Biogerontology , vol.11 , pp. 31-43
    • Hashimoto, T.1    Horikawa, M.2    Nomura, T.3    Sakamoto, K.4
  • 13
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • 10.1016/0014-4827(61)90192-6
    • L Hayflick PS Moorehead 1961 The serial cultivation of human diploid cell strains Exp Cell Res 25 585 621 10.1016/0014-4827(61)90192-6
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorehead, P.S.2
  • 14
    • 0034661010 scopus 로고    scopus 로고
    • Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
    • 10.1016/S0891-5849(00)00331-2 10980404 10.1016/S0891-5849(00)00331-2 1:CAS:528:DC%2BD3cXmt1ajsb4%3D
    • HY Ho ML Cheng FJ Lu YH Chou A Stern CM Liang DT Chiu 2000 Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts Free Radic Biol Med 29 156 169 10.1016/S0891-5849(00)00331-2 10980404 10.1016/S0891-5849(00)00331-2 1:CAS:528:DC%2BD3cXmt1ajsb4%3D
    • (2000) Free Radic Biol Med , vol.29 , pp. 156-169
    • Ho, H.Y.1    Cheng, M.L.2    Lu, F.J.3    Chou, Y.H.4    Stern, A.5    Liang, C.M.6    Chiu, D.T.7
  • 15
    • 33646948539 scopus 로고    scopus 로고
    • Calorie restriction mimetics: An emerging research field
    • DOI 10.1111/j.1474-9726.2006.00202.x
    • DK Ingram M Zhu J Mamczarz S Zou MA Lane GS Roth R deCabo 2006 Calorie restriction mimetics: an emerging research field Aging Cell 5 97 108 10.1111/j.1474-9726.2006.00202.x 16626389 10.1111/j.1474-9726.2006.00202.x 1:CAS:528:DC%2BD28XktVOiu7k%3D (Pubitemid 44056501)
    • (2006) Aging Cell , vol.5 , Issue.2 , pp. 97-108
    • Ingram, D.K.1    Zhu, M.2    Mamczarz, J.3    Zou, S.4    Lane, M.A.5    Roth, G.S.6    DeCabo, R.7
  • 16
    • 32044448517 scopus 로고    scopus 로고
    • 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic
    • DOI 10.1016/j.lfs.2005.07.001, PII S0024320505006983
    • HT Kang ES Hwang 2006 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic Life Sci 78 1392 1399 10.1016/j.lfs.2005.07.001 16111712 10.1016/j.lfs.2005.07.001 1:CAS:528:DC%2BD28XhtlGmurw%3D (Pubitemid 43199960)
    • (2006) Life Sciences , vol.78 , Issue.12 , pp. 1392-1399
    • Kang, H.T.1    Hwang, E.S.2
  • 17
    • 77955608578 scopus 로고    scopus 로고
    • Sirtuin family: A link to metabolic signaling and senescence
    • 10.2174/092986710792065009 20858173 10.2174/092986710792065009 1:CAS:528:DC%2BC3cXhtFaisr3N
    • S Kyrylenko A Baniahmad 2010 Sirtuin family: a link to metabolic signaling and senescence Curr Med Chem 17 2921 2932 10.2174/092986710792065009 20858173 10.2174/092986710792065009 1:CAS:528:DC%2BC3cXhtFaisr3N
    • (2010) Curr Med Chem , vol.17 , pp. 2921-2932
    • Kyrylenko, S.1    Baniahmad, A.2
  • 18
    • 0000093948 scopus 로고    scopus 로고
    • 2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restriction
    • MA Lane J Mattison DK Ingram GS Roth 1998 2-Deoxyglucose feeding in rats mimics physiological effects of caloric restriction J Anti-Aging Med 1 327 337 10.1089/rej.1.1998.1.327 10.1089/rej.1.1998.1.327 1:CAS:528:DyaK1MXmslSrsr4%3D (Pubitemid 128538830)
    • (1998) Journal of Anti-Aging Medicine , vol.1 , Issue.4 , pp. 327-337
    • Lane, M.A.1    Ingram, D.K.2    Roth, G.S.3
  • 19
    • 34548714671 scopus 로고    scopus 로고
    • Caloric restriction mimetics: A novel approach for biogerontology
    • DOI 10.1385/1-59745-361-7:143, Biological Aging: Methods and Protocols
    • MA Lane GS Roth DK Ingram 2007 Caloric restriction mimetics: a novel approach for biogerontology Methods Mol Biol 371 143 149 10.1007/978-1-59745- 361-5-11 17634579 10.1007/978-1-59745-361-5-11 1:CAS:528:DC%2BD2sXls1Kmsr0%3D (Pubitemid 350183423)
    • (2007) Methods in Molecular Biology , vol.371 , pp. 143-149
    • Lane, M.A.1    Roth, G.S.2    Ingram, D.K.3
  • 20
    • 33646133889 scopus 로고    scopus 로고
    • Nicotinamide extends the replicative life span of primary human cells
    • 10.1016/j.mad.2006.02.001 16545428 10.1016/j.mad.2006.02.001 1:CAS:528:DC%2BD28XktVGiu7k%3D
    • CS Lim M Potts RF Helm 2006 Nicotinamide extends the replicative life span of primary human cells Mech Ageing Dev 127 511 514 10.1016/j.mad.2006.02. 001 16545428 10.1016/j.mad.2006.02.001 1:CAS:528:DC%2BD28XktVGiu7k%3D
    • (2006) Mech Ageing Dev , vol.127 , pp. 511-514
    • Lim, C.S.1    Potts, M.2    Helm, R.F.3
  • 21
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • DOI 10.1101/gad.1164804
    • SJ Lin E Ford M Haigis G Liszt L Guarente 2004 Calorie restriction extends yeast life span by lowering the level of NADH Genes Dev 18 12 16 10.1101/gad.1164804 14724176 10.1101/gad.1164804 1:CAS:528: DC%2BD2cXotFOiuw%3D%3D (Pubitemid 38090683)
    • (2004) Genes and Development , vol.18 , Issue.1 , pp. 12-16
    • Lin, S.-J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 22
    • 77953288455 scopus 로고    scopus 로고
    • Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction
    • 10.1016/j.bbapap.2009.09.030 19818879 1:CAS:528:DC%2BC3cXntlaltLs%3D
    • SP Lu SJ Lin 2010 Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction Biochim Biophys Acta 1804 1567 1575 10.1016/j.bbapap.2009. 09.030 19818879 1:CAS:528:DC%2BC3cXntlaltLs%3D
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1567-1575
    • Lu, S.P.1    Lin, S.J.2
  • 23
    • 0035660250 scopus 로고    scopus 로고
    • Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation
    • K Matuoka KY Chen T Takenawa 2001 Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation Cell Mol Life Sci 58 2108 2116 10.1007/PL00000840 11814060 10.1007/PL00000840 1:CAS:528:DC%2BD38XptVek (Pubitemid 34016979)
    • (2001) Cellular and Molecular Life Sciences , vol.58 , Issue.14 , pp. 2108-2116
    • Matuoka, K.1    Chen, K.Y.2    Takenawa, T.3
  • 24
    • 0028235687 scopus 로고
    • Retardation of the senescence of cultured human diploid fibroblasts by carnosine
    • DOI 10.1006/excr.1994.1132
    • GA McFarland R Holliday 1994 Retardation of the senescence of cultured human diploid fibroblasts by carnosine Exp Cell Res 212 167 175 10.1006/excr.1994.1132 8187813 10.1006/excr.1994.1132 1:CAS:528: DyaK2cXktlWqs70%3D (Pubitemid 24216690)
    • (1994) Experimental Cell Research , vol.212 , Issue.2 , pp. 167-175
    • Mcfarland, G.A.1    Holliday, R.2
  • 27
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • DOI 10.1038/sj.onc.1209597, PII 1209597
    • H Pelicano DS Martin RH Xu P Huang 2006 Glycolysis inhibition for anticancer treatment Oncogene 25 4633 4646 10.1038/sj.onc.1209597 16892078 10.1038/sj.onc.1209597 1:CAS:528:DC%2BD28Xnsl2hs7Y%3D (Pubitemid 44187614)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.-H.3    Huang, P.4
  • 28
    • 0033119046 scopus 로고    scopus 로고
    • Dietary intervention at middle age: Caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice
    • DP Pugh TD Oberley R Weindruch 1999 Dietary intervention at middle age: caloric restriction but no dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice Cancer Res 59 1642 1648 10197641 1:CAS:528:DyaK1MXisVWku7k%3D (Pubitemid 29160138)
    • (1999) Cancer Research , vol.59 , Issue.7 , pp. 1642-1648
    • Pugh, T.D.1    Oberley, T.D.2    Weindruch, R.3
  • 29
    • 55549137715 scopus 로고    scopus 로고
    • Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity
    • 10.1016/j.jnutbio.2007.10.005 18482832 10.1016/j.jnutbio.2007.10.005
    • J Sánchez F Pérez-Heredia T Priego MP Portillo S Zamora M Garaulet A Palou 2008 Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity J Nutr Biochem 19 809 818 10.1016/j.jnutbio.2007.10.005 18482832 10.1016/j.jnutbio.2007.10.005
    • (2008) J Nutr Biochem , vol.19 , pp. 809-818
    • Sánchez, J.1    Pérez-Heredia, F.2    Priego, T.3    Portillo, M.P.4    Zamora, S.5    Garaulet, M.6    Palou, A.7
  • 30
    • 4544243684 scopus 로고    scopus 로고
    • Coenzyme specificity of Sir2 protein deacetylases. Implications for physiological regulation
    • DOI 10.1074/jbc.M407484200
    • MT Schmidt BC Smith MD Jackson JM Denu 2004 Coenzyme specificity of sir2 protein deacetylases: implications for physiological regulation J Biol Chem 279 40122 40129 10.1074/jbc.M407484200 15269219 10.1074/jbc.M407484200 1:CAS:528:DC%2BD2cXnsVKrs7c%3D (Pubitemid 39258287)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 40122-40129
    • Schmidt, M.T.1    Smith, B.C.2    Jackson, M.D.3    Denu, J.M.4
  • 31
    • 23044507635 scopus 로고    scopus 로고
    • Optimizing cancer radiotherapy with 2-deoxy-D-glucose: Dose escalation studies in patients with glioblastoma multiforme
    • DOI 10.1007/s00066-005-1320-z
    • D Singh AK Banerji BS Dwarakanath RP Tripathi JP Gupta TL Mathew T Ravindranath V Jain 2005 Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme Strahlenther Onkol 181 507 514 10.1007/s00066-005-1320-z 16044218 10.1007/s00066-005-1320-z (Pubitemid 41059520)
    • (2005) Strahlentherapie und Onkologie , vol.181 , Issue.8 , pp. 507-514
    • Singh, D.1    Banerji, A.K.2    Dwarakanath, B.S.3    Tripathi, R.P.4    Gupta, J.P.5    Mathew, T.L.6    Ravindranath, T.7    Jain, V.8
  • 32
    • 0023081730 scopus 로고
    • Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell
    • 3297086 10.1146/annurev.bb.16.060187.001135 1:CAS:528:DyaL2sXkvFagt7g%3D
    • DK Srivastava SA Bernhard 1987 Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell Annu Rev Biophys Biophys Chem 16 175 204 3297086 10.1146/annurev.bb.16.060187.001135 1:CAS:528:DyaL2sXkvFagt7g%3D
    • (1987) Annu Rev Biophys Biophys Chem , vol.16 , pp. 175-204
    • Srivastava, D.K.1    Bernhard, S.A.2
  • 33
    • 0035019204 scopus 로고    scopus 로고
    • Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding
    • 11787951
    • J Swierczyński E Słomińska RT Smoleński D Mayer 2001 Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding Pol J Pharmacol 53 125 130 11787951
    • (2001) Pol J Pharmacol , vol.53 , pp. 125-130
    • Swierczyński, J.1    Słomińska, E.2    Smoleński, R.T.3    Mayer, D.4
  • 34
    • 0034036174 scopus 로고    scopus 로고
    • The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging
    • JR Williams 2000 The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system and aging Lipids 35 325 331 10.1007/s11745-000-0529- 7 10783010 10.1007/s11745-000-0529-7 1:CAS:528:DC%2BD3cXisVeqtbc%3D (Pubitemid 30198778)
    • (2000) Lipids , vol.35 , Issue.3 , pp. 325-331
    • Williams, J.R.1
  • 35
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • DOI 10.1038/nature02789
    • JG Wood B Rogina S Lavu K Howitz SL Helfand M Tatar D Sinclair 2004 Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 686 689 10.1038/nature02789 15254550 10.1038/nature02789 1:CAS:528:DC%2BD2cXmt1Gisb4%3D (Pubitemid 39061685)
    • (2004) Nature , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Regina, B.2    Lavu, S.3    Hewitz, K.4    Helfand, S.L.5    Tatar, M.6    Sinclair, D.7
  • 36
    • 1642497603 scopus 로고    scopus 로고
    • A fluorimetric method using fluorescein di-β-D-galactopyranoside for quantifying the senescence-associated β-galactosidase activity in human foreskin fibroblast Hs68 cells
    • DOI 10.1016/j.ab.2003.11.012
    • NC Yang ML Hu 2004 A fluorimetric method using fluorescein di-beta-D-galactopyranoside for quantifying the senescence-associated beta-galactosidase activity in human foreskin fibroblast Hs68 cells Anal Biochem 325 337 343 10.1016/j.ab.2003.11.012 14751269 10.1016/j.ab.2003.11.012 1:CAS:528:DC%2BD2cXmvFKqug%3D%3D (Pubitemid 38134371)
    • (2004) Analytical Biochemistry , vol.325 , Issue.2 , pp. 337-343
    • Yang, N.-C.1    Hu, M.-L.2
  • 37
    • 26244445013 scopus 로고    scopus 로고
    • The limitations and validities of senescence associated-β- galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells
    • DOI 10.1016/j.exger.2005.07.011, PII S0531556505001567
    • NC Yang ML Hu 2005 The limitations and validities of senescence associated-beta-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells Exp Gerontol 40 813 819 10.1016/j.exger.2005.07.011 16154306 10.1016/j.exger.2005.07.011 1:CAS:528:DC%2BD2MXhtVyms7zK (Pubitemid 41416544)
    • (2005) Experimental Gerontology , vol.40 , Issue.10 , pp. 813-819
    • Yang, N.-C.1    Hu, M.-L.2
  • 38
    • 0034671008 scopus 로고    scopus 로고
    • DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium
    • DOI 10.1016/S0960-0760(00)00180-1, PII S0960076000001801
    • NC Yang KC Jeng WM Ho SJ Chou ML Hu 2000 DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium J Steroid Biochem Mol Biol 75 159 166 10.1016/S0960-0760(00)00180-1 11226832 10.1016/S0960-0760(00)00180-1 1:CAS:528:DC%2BD3MXit1aktL8%3D (Pubitemid 32168141)
    • (2000) Journal of Steroid Biochemistry and Molecular Biology , vol.75 , Issue.2-3 , pp. 159-166
    • Yang, N.-C.1    Jeng, K.-C.G.2    Ho, W.-M.3    Chou, S.-J.4    Hu, M.-L.5
  • 39
    • 0037087239 scopus 로고    scopus 로고
    • ATP depletion is an important factor in DHEA-induced growth inhibition and apoptosis in BV-2 cells
    • DOI 10.1016/S0024-3205(01)01542-9, PII S0024320501015429
    • NC Yang KC Jeng WM Ho ML Hu 2002 ATP depletion is an important factor in DHEA-induced growth inhibition and apoptosis in BV-2 cells Life Sci 70 1979 1988 10.1016/S0024-3205(01)01542-9 12148690 10.1016/S0024-3205(01)01542-9 1:CAS:528:DC%2BD38XjsFarurw%3D (Pubitemid 34215123)
    • (2002) Life Sciences , vol.70 , Issue.17 , pp. 1979-1988
    • Yang, N.-C.1    Jeng, K.-C.G.2    Ho, W.-M.3    Hu, M.-L.4
  • 40
    • 0023221206 scopus 로고
    • Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure
    • CR Zerez SJ Lee KR Tanaka 1987 Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure Anal Biochem 164 367 373 10.1016/0003-2697(87)90506-9 3674385 10.1016/0003-2697(87)90506-9 1:CAS:528:DyaL2sXltlSitLc%3D (Pubitemid 17123608)
    • (1987) Analytical Biochemistry , vol.164 , Issue.2 , pp. 367-373
    • Zerez, C.R.1    Lee, S.J.2    Tanaka, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.