Acetylcholinesterase inhibition and antioxidant activity of the water extracts of several Hypericum species

Food Chemistry

Volumn 120, Issue 4, 2010, Pages 1076-1082

  Hernandez, Maria Filipa ^a   Falé, Pedro L V ^a   Araújo, Maria Eduarda M ^a   Serralheiro, Maria Luísa M ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

AChE inhibition; Antioxidant activity; Chlorogenic acid; Hypericum; Hyperoside; Isoquercitrin; Quercitrin; Rutin; Water extracts

Indexed keywords

ACETYLCHOLINESTERASE; CHLOROGENIC ACID; HYPERICUM EXTRACT; HYPERIN; ISOQUERCITRIN; QUERCETIN; QUERCITRIN; RUTOSIDE; WATER;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERICUM;

HYPERICUM; HYPERICUM ANDROSAEMUM; HYPERICUM PERFORATUM;

EID: 74849111056     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2009.11.055     Document Type: Article

References (33)

1. Brolis M., Gabetta B., Pace R., Panzeri F., and Peterlongo F. Identification by high-performance liquid chromatography-diode array detection-mass spectrometry and quantification by high-performance liquid chromatography-UV absorbance detection of active constituents of Hypericum perforatum. Journal of Chromatography A 825 (1998) 9-16
2. Cunha A.P., Silva A.P., and Roque O.R. Plantas e produtos vegetais em Fitoterapia (2003), Fundação Calouste Gulbenkian, Lisboa p. 380
3. Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., & Deacon, R.M.J., et al. (2008). Systematic inflammation induces acute behavioural and cognitive changes and accelerates neurodegenerative disease. doi:10.1016/j.biopsych.2008.07.024.
4. Eggelkraut-Gottanka S.G., Abed S.A., Muller W., and Schmidt P.C. Quantitative analysis of the active components and by-products of eight dry extracts of Hypericum perforatum L. (St. John's wort). Phytochemical Analysis 13 (2002) 170-176
5. Falé P.L., Borges C., Madeira P.J.A., Ascensão L., Araujo M.E.M., Florêncio M.H., et al. Rosmarinic acid, scutellarein 4′-methyl ether 7-O-glucoronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus ("falso boldo"). Food Chemistry 114 (2009) 798-805
6. Ferreira A., Proença C., Serralheiro M.L.M., and Araújo M.E.M. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology 108 (2006) 31-37
7. Frank B., and Gupta S. A review of antioxidants and Alzheimer's disease. Annals of Clinical Psychiatry 17 (2005) 269-286
8. Gioti E.M., Skalkos D.C., Fiamegos Y.C., and Stalikas C.D. Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography. Journal of Chromatography A 1093 (2005) 1-10
9. Gomes A., Fernandes E., Lima J.L.F.C., Mira L., and Corvo M.L. Molecular mechanism of anti-inflammatory activity mediated by flavonoids. Current Medicinal Chemistry 15 (2008) 1586-1605
10. Heinrich M., and Teoh H.L. Galanthamine from snowdrop - The development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethopharmacology 92 (2004) 147-162
11. Houghton P., Ren Y., and Howes M.-J. Acetylcholinesterase inhibitors from plants and fungi. Natural Products Report 23 (2006) 181-199
12. Kamer A.R., Craig R.G., Dasanayake A.P., Brys M., Glodzik-Sobanska L., and de Leon M.J. Inflammation and Alzheimer's disease: Possible role of periodontal disease. Alzheimer's and Dementia 4 (2008) 242-250
13. Kasper S., Gastpar M., Müller W.E., Volz H.P., Dienel A., Kieser M., et al. Efficacy of St. John's wort extract WS® 5570 in acute treatment of mild depression. A reanalysis of data from controlled clinical trials. European Archives of Psychiatry Clinical Neuroscience 258 (2008) 59-63
14. Latvala A., Onur M.A., Gozler T., Linden A., Kivçak B., and Hesse M. Alkaloids of Galanthus elwesii. Phytochemistry 39 (1995) 1229-1240
15. Leuner K., Kazanski V., Muller M., Essin K., Henke B., Gollasch M., et al. Hyperforin - A key constituent of St. John's wort specifically activates TRPC6 channels. The FASEB Journal 21 (2007) 4101-4111
16. Liu F., Pan C., Drumm P., and Ang C.Y.W. Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: Active constituents and their transformation. Journal of Phramaceutical and Biomedical Analysis 37 (2005) 303-312
17. Mata A.T., Proença C., Ferreira A.R., Serralheiro M.L.M., Nogueira J.M.F., and Araújo M.E.M. Antioxidant and antiacetylcholinesterase activities of five plants used as Portuguese food spices. Food Chemistry 103 (2007) 778-786
18. Menegazzi M., Novelli M., Beffy P., D'Aleo V., Tedeschi E., Lupi R., et al. Protective effects of St. Johns's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic β-cell line. The International Journal of Biochemistry and Cell Biology 40 (2008) 1509-1521
19. Nishida Y., Yokota T., Takahashi T., Uchihara T., Jishage K.-I., and Mizusawa H. Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse. Biochemical and Biophysical Research Communications 350 (2006) 530-536
20. Paulke A., Noldner M., Scubert-Zsilavecz M., and Wurglics M. St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses. Pharmazie 63 (2008) 296-302
21. Pilkington K., Boshnakova A., and Richardson J. St Johńs wort for depression: Time for a different perspective. Complementary Therapies in Medicine 14 (2006) 268-281
22. Resende R., Moreira P.I., Proença T., Deshpande A., Busciglio J., Pereira C., et al. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radical Biology and Medicine 44 (2008) 2051-2057
23. 2+ channels in cardiac myocytes. Journal Natural Products 70 (2007) 510-514
24. Silva B.A., Malva J.O., and Dias A.C.P. St. John's wort (Hypericum perforatum) extracts and isolated phenolic compounds are effective antioxidants in several in vitro models of oxidative stress. Food Chemistry 110 (2008) 611-619
25. Smelcerovic A., Zuehlke S., Spiteller M., Raabe N., and Ozen T. Phenolic constituents of 17 Hypericum species from Turkey. Biochemical Systematics and Ecology 36 (2008) 316-319
26. Tatsis E., Boeren S., Exarchou V., Troganis A.N., Vervoort J., and Gerothanassis I.P. Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS. Phytochemistry 68 (2007) 383-393
27. Teeling, J. L., & Perry, V. H. (2008). Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms. doi:10.1016/j.neuroscience.2008.07.031.
28. Tsai T.-H., Tsai T.-H., Chien Y.-C., Lee C.-W., and Tsai P.-J. In vitro antimicrobial activities against cariogenic streptococci and their antioxidant capacities: A comparative study of green tea versus different herbs. Food Chemistry 110 (2008) 859-864
29. Valentão P., Fernandes E., Carvalho F., Andrade P.B., Seabra R.M., and Bastos M.L. Antioxidant activity of Hypericum androsaemum infusion: Scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid. Biological and Pharmaceutical Bulletin 25 (2002) 1320-1323
30. Verotta L. Hypericum perforatum, a source of neuroprotective lead structures. Current Topics in Medicinal Chemistry 3 (2003) 187-201
31. Williams F.B., Sander L.C., Wise S.A., and Girard J. Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort. Journal of Chromatography A 1115 (2006) 93-102
32. Wurglics M., and Schubert-Zsilavecz M. Hypericum perforatum: A "Modern" herbal antidepressant. Clinical Pharmacokinetics 45 (2006) 449-468
33. Zhou C., Tabb M., Sadatrafieii A., Grun F., Sun A., and Blumberg B. Hyperforin, the active component of St. John's wort, induces IL-8 expresssion in human intestinal epithelial cells via a MAPK-dependent, NF-kB-independent pathway. Journal of Clinical Immunology 24 (2004) 623-636