A factorial trial of six interventions for the prevention of postoperative nausea and vomiting

New England Journal of Medicine

Volumn 350, Issue 24, 2004, Pages 2441-2451+2534

  Apfel, Christian C ^a,b,l   Korttila, Kari ^c   Abdalla, Mona ^d   Kerger, Heinz ^e   Turan, Alparslan ^f   Vedder, Ina ^g   Zernak, Carmen ^h   Danner, Klaus ⁱ   Jokela, Ritva ^c   Pocock, Stuart J ^d   Trenkler, Stefan ^j   Kredel, Markus ^a   Biedler, Andreas ^k   Sessler, Daniel I ^b   Roewer, Norbert ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f TRAKYA UNIVERSITY   (Turkey)

^g Von Bodelschwinghsche Anst Bethel   (Germany)

^h Klinikum Garmisch Partenkirchen   (Germany)

ⁱ Westpfalz Klinikum GmbH   (Germany)

^j FNsP J A Reimanna   (Slovakia)

^k SAARLAND UNIVERSITY   (Germany)

^l Outcomes Research Institute   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; BENZODIAZEPINE; DEXAMETHASONE; DROPERIDOL; FENTANYL; NITROGEN; NITROUS OXIDE; ONDANSETRON; PROPOFOL; REMIFENTANIL; ROCURONIUM; INTRAVENOUS ANESTHETIC AGENT; PIPERIDINE DERIVATIVE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; FACTORIAL ANALYSIS; FEMALE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOMES RESEARCH; POSTOPERATIVE CARE; POSTOPERATIVE NAUSEA; POSTOPERATIVE VOMITING; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SURGICAL PATIENT; DRUG COMBINATION; GENERAL ANESTHESIA; INTRAVENOUS ANESTHESIA; LOCAL ANESTHESIA; MULTIVARIATE ANALYSIS; POSTOPERATIVE NAUSEA AND VOMITING; PREMEDICATION; SINGLE BLIND PROCEDURE; STATISTICAL MODEL;

ANESTHESIA, GENERAL; ANESTHESIA, INTRAVENOUS; ANESTHESIA, LOCAL; ANESTHETICS, INTRAVENOUS; ANTIEMETICS; DEXAMETHASONE; DROPERIDOL; DRUG THERAPY, COMBINATION; FACTOR ANALYSIS, STATISTICAL; FEMALE; FENTANYL; HUMANS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; NITROGEN; NITROUS OXIDE; ONDANSETRON; PIPERIDINES; POSTOPERATIVE NAUSEA AND VOMITING; PREMEDICATION; PROPOFOL; SINGLE-BLIND METHOD;

EID: 2942532387     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa032196     Document Type: Article

References (35)

1. Gan TJ. Postoperative nausea and vomiting - can it be eliminated? JAMA 2002; 287:1233-6.
2. Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs 2000;59:213-43.
3. Watcha MF. Postoperative nausea and emesis. Anesthesiol Clin North Am 2002; 20:709-22.
4. Koivuranta M, Laara E, Snare L, Alahuhta S. A survey of postoperative nausea and vomiting. Anaesthesia 1997;52:443-9.
5. Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg 1999;89:652-8.
6. Darkow T, Gora-Harper ML, Goulson DT, Record KE. Impact of antiemetic selection on postoperative nausea and vomiting and patient satisfaction. Pharmacotherapy 2001;21:540-8.
7. Schumann R, Polaner DM. Massive subcutaneous emphysema and sudden airway compromise after postoperative vomiting. Anesth Analg 1999;89:796-7.
8. Bremner WG, Kumar CM. Delayed surgical emphysema, pneumomediastinum and bilateral pneumothoraces after postoperative vomiting. Br J Anaesth 1993;71:296-7.
9. Gold BS, Kitz DS, Lecky JH, Neuhaus JM. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989; 262:3008-10.
10. Hill KP, Lubarsky DA, Phillips-Bute B, et al. Cost-effectiveness of prophylactic antiemetic therapy with ondansetron, droperidol, or placebo. Anesthesiology 2000;92; 958-67.
11. Watcha MF. The cost-effective management of postoperative nausea and vomiting. Anesthesiology 2000;92;931-3.
12. Apfel CC, Kranke P, Katz MH, et al. Volatile anaesthetics may be the main cause for early but not delayed postoperative nausea and vomiting: a randomized controlled trial of factorial design. Br J Anaesth 2002;88:659-68.
13. Divatia JV, Vaidya JS, Badwe RA, Hawaldar RW. Omission of nitrous oxide during anesthesia reduces the incidence of postoperative nausea and vomiting: a meta-analysis. Anesthesiology 1996;85:1055-62.
14. Tramer MR. A rational approach to the control of postoperative nausea and vomiting: evidence from systematic reviews. I. Efficacy and harm of antiemetic interventions, and methodological issues. Acta Anaesthesiol Scand 2001;45;4-13.
15. Scuderi PE, James RL, Harris L, Mims GR III. Multimodal antiemetic management prevents early postoperative vomiting after outpatient laparoscopy. Anesth Analg 2000; 91:1408-14.
16. Gan TJ, Meyer T, Apfel CC, et al. Consensus guidelines for management of postoperative nausea and vomiting. Anesth Analg 2003;97:62-71.
17. Apfel CC, Laara E, Koivuranta M, Greim CA, Koewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology 1999;91:693-700.
18. Pierre S, Benais H, Pouymayou J. Apfel's simplified score may favourably predict the risk of postoperative nausea and vomiting. Can J Anaesth 2002;49:237-42.
19. Apfel CC, Kranke P, Eberhart LHJ, Roos A, Roewer N. Comparison of predictive models for postoperative nausea and vomiting. Br J Anaesth 2002;88:234-40.
20. Apfel CC, Korttila K, Abdalla M, et al. An international multicenter protocol to assess the single and combined benefits of antiemetic interventions in a controlled clinical trial of a 2×2×2×2×2×2 factorial design (IMPACT). Control Clin Trials 2003;24:736-51.
21. Sneyd JR, Carr A, Byrom WD, Bilski AJ. A meta-analysis of nausea and vomiting following maintenance of anaesthesia with propofol or inhalational agents. Eur J Anaesthesiol 1998;15:433-45.
22. Greif R, Laciny S, Rapf B, Hickle RS, Sessler DI. Supplemental oxygen reduces the incidence of postoperative nausea and vomiting. Anesthesiology 1999;91:1246-52.
23. Goll V, Akca O, Greif R, et al. Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting. Anesth Analg 2001;92:112-7.
24. Purhonen S, Turunen M, Ruohoaho U-M, Niskanen M, Hynynen M. Supplemental oxygen does not reduce the incidence of postoperative nausea and vomiting after ambulatory gynecologic laparoscopy. Anesth Analg 2003;96:91-6.
25. Joris JL, Poth NJ, Djamadar AM, et al. Supplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy. Br J Anaesth 2003;91:857-61.
26. Liu K, Hsu CC, Chia YY. The effect of dose of dexamethasone for antiemesis after major gynecological surgery. Anesth Analg 1999;89:1316-8.
27. Tang J, Wang B, White PF, Watcha MF, Qi J, Wender RH. The effect of timing of ondansetron administration on its efficacy, cost-effectiveness, and cost-benefit as a prophylactic antiemetic in the ambulatory setting. Anesth Analg 1998;86:274-82.
28. Melnick B, Sawyer R, Karambelkar D, Phitayakorn P, Uy NT, Patel R. Delayed side effects of droperidol after ambulatory general anesthesia. Anesth Analg 1989;69:748-51.
29. Lim BS, Pavy TJ, Lumsden G. The antiemetic and dysphoric effects of droperidol in the day surgery patient. Anaesth Intensive Care 1999;27:371-4.
30. Gan TJ, White PF, Scuderi PE, Watcha MF, Kovac A. FDA "black box" warning regarding use of droperidol for postoperative nausea and vomiting: is it justified? Anesthesiology 2002;97:287.
31. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000;90:186-94.
32. Sinclair DR, Chung F, Mezei G. Can postoperative nausea and vomiting be predicted? Anesthesiology 1999;91:109-18.
33. Apfel CC, Roewer N, Korttila K. How to study postoperative nausea and vomiting. Acta Anaesthesiol Scand 2002;46:921-8.
34. Wang JJ, Ho ST, Tzeng JI, Tang CS. The effect of timing of dexamethasone administration on its efficacy as a prophylactic antiemetic for postoperative nausea and vomiting. Anesth Analg 2000;91:136-9.
35. Kovac AL, O'Connor TA, Pearman MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth 1999;11:453-9.