Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia

British Journal of Anaesthesia

Volumn 102, Issue 1, 2009, Pages 117-122

  Lin, T F ^a   Yeh, Y C ^a   Lin, F S ^a   Wang, Y P ^a   Lin, C J ^a   Sun, W Z ^a   Fan, S Z ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Analgesia, patient controlled; Analgesia, postoperative; Analgesics opioid, morphine; Pharmacology, dexmedetomidine

Indexed keywords

CISATRACURIUM; DEXMEDETOMIDINE; FENTANYL; ISOFLURANE; MORPHINE; NITROUS OXIDE PLUS OXYGEN; THIOPENTAL;

ABDOMINAL HYSTERECTOMY; ADULT; AGED; ARTICLE; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART RATE; HUMAN; HYPOTENSION; INCIDENCE; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; NAUSEA; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; SIDE EFFECT; SOMNOLENCE; VOMITING;

EID: 57349146913     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aen320     Document Type: Article

References (23)

1. Joshi GP. Multimodal analgesia techniques and postoperative rehabilitation. Anesthesiol Clin North America 2005; 23: 185-202
2. Lin TF, Yeh YC, Yen YH, Wang YP, Lin CJ, Sun WZ. Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia. Br J Anaesth 2005; 94: 835-9
3. Chen JY, Wu GJ, Mok MS, et al. Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients - a prospective, randomized, double-blind study. Acta Anaesthesiol Scand 2005; 49: 546-51
4. Cepeda MS, Alvarez H, Morales O, Carr DB. Addition of ultralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 2004; 107: 41-6
5. Yeh Y-C, Lin T-F, Lin F-S, Wang Y-P, Lin C-J, Sun W-Z. Combination of opioid agonist and agonist-antagonist: patient-controlled analgesia requirement and adverse events among different-ratio morphine and nalbuphine admixtures for postoperative pain. Br J Anaesth 2008; 101: 542-8
6. Michelet P, Guervilly C, Helaine A, et al. Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. Br J Anaesth 2007; 99: 396-403
7. Khan ZP, Ferguson CN, Jones RM. Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia 1999; 54: 146-65
8. Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL. Alpha(2C)-adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther 2002; 300: 282-90
9. Lakhlani PP, MacMillan LB, Guo TZ, et al. Substitution of a mutant alpha2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997; 94: 9950-5
10. Kauppila T, Kemppainen P, Tanila H, Pertovaara A. Effect of systemic medetomidine, an alpha 2 adrenoceptor agonist, on experimental pain in humans. Anesthesiology 1991; 74: 3-8
11. Gan TJ, Coop A, Philip BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondansetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesth Analg 2005; 101: 1323-9
12. Malviya S, Voepel-Lewis T, Ludomirsky A, Marshall J, Tait AR. Can we improve the assessment of discharge readiness?: a comparative study of observational and objective measures of depth of sedation in children. Anesthesiology 2004; 100: 218-24
13. Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 2004; 98: 153-8
14. Unlugenc H, Gunduz M, Guler T, Yagmur O, Isik G. The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine. Eur J Anaesthesiol 2005; 22: 386-91
15. Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. Br J Anaesth 2002; 88: 669-75
16. Angst MS, Ramaswamy B, Davies MF, Maze M. Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology 2004; 101: 744-52
17. Ossipov MH, Suarez LJ, Spaulding TC. Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents. Anesth Analg 1989; 68: 194-200
18. Abdelmalak B, Makary L, Hoban J, Doyle DJ. Dexmedetomidine as sole sedative for awake intubation in management of the critical airway. J Clin Anesth 2007; 19: 370-3
19. Ickeringill M, Shehabi Y, Adamson H, Ruettimann U. Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: haemodynamic effects and efficacy. Anaesth Intensive Care 2004; 32: 741-5
20. Glass PS, Reves JG. Drug delivery system to improve the perioperative administration of intravenous drugs: computer assisted continuous infusion (CACI). Anesth Analg 1995; 81: 665-7
21. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93: 382-94
22. Samuel IO, Unni VK, Dundee JW. Peripheral vascular effects of morphine in patients without pre-existing cardiac disease. Br J Anaesth 1977; 49: 935-9
23. Stockall CA. Postoperative nausea and vomiting - when will it stop? Can J Anaesth 1999; 46: 715-6