Gluten sensitivity: Problems of an emerging condition separate from celiac disease

Expert Review of Gastroenterology and Hepatology

Volumn 6, Issue 1, 2012, Pages 43-55

  Brown, Amy C ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

celiac disease; gluten sensitivity; intolerance; nonceliac gluten sensitivity

Indexed keywords

GLUTEN; STARCH;

CELIAC DISEASE; CLINICAL FEATURE; DELAYED DIAGNOSIS; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA MODIFICATION; ENVIRONMENTAL FACTOR; FOOD CONTAMINATION; GENETIC ASSOCIATION; GENETIC SCREENING; GLUTEN FREE DIET; GLUTEN SENSITIVITY; HORMONAL REGULATION; HUMAN; INTESTINE BIOPSY; INTESTINE INFECTION; MOLECULAR PATHOLOGY; NONHUMAN; NUTRITIONAL INTOLERANCE; PLANT BREEDING; PREVALENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEROLOGY;

AUTOIMMUNE DISEASES; BREEDING; CELIAC DISEASE; DIAGNOSIS, DIFFERENTIAL; DIET, GLUTEN-FREE; FOOD HYPERSENSITIVITY; GLUTENS; HUMANS; TRITICUM; WHEAT HYPERSENSITIVITY;

EID: 83455236257     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/egh.11.79     Document Type: Review

References (114)

1. Guandalini S, Newland C. differentiating food allergies from food intolerances. Curr. Gastroenterol. Rep. 13(5), 426-434 (2011)
2. Bizzaro N, Tozzoli R, Villalta D, Fabris M, Tonutti E. Cutting-edge issues in celiac disease and in gluten intolerance. Clin. Rev. Allergy Immunol. doi:10.1007/s12016-010-8223-1 (2010) (Epub ahead of print)
3. Newnham ED. Does gluten cause gastrointestinal symptoms in subjects without coeliac disease? J. Gastroenterol. Hepatol. Suppl. 3, 132-134 (2011)
4. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am. J. Gastroenterol. 106(3), 508-514 (2011)
5. Carroccio A, Brusca I, Mansueto P, et al. A cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 8(3), 254-260 (2010)
6. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology 102, 330-354 (1992)
7. Collin P, Wahab PJ, Murray JA. Intraepithelial lymphocytes and coeliac disease. Best Pract. Res. Clin. Gastroenterol. 19, 341-350 (2005)
8. Ferguson A, Arranz E, OMahony S. Spectrum of expression of intestinal cellular immunity: proposal for a change in diagnostic criteria of celiac disease. Ann. Allergy 71, 29-32 (1993)
9. Arranz E, Ferguson A. Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. Gastroenterology 104, 1263-1272 (1993)
10. Kakar S, Nehra V, Murray JA, et al. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am. J. Gastroenterol. 98, 2027-2033 (2003)
11. Goldstein NS, Underhill J. Morphologic features suggestive of gluten sensitivity in architecturally normal duodenal biopsy specimens. Am. J. Clin. Pathol. 116, 63-71 (2001)
12. Ferguson A, Arranz E, OMahony S. Spectrum of expression of intestinal cellular immunity: proposal for a change in diagnostic criteria of celiac disease. Ann. Allergy 71, 29-32 (1993)
13. Ferguson A, Blackwell JN, Barnetson RS. Effects of additional dietary gluten on the small-intestinal mucosa of volunteers and of patients with dermatitis herpetiformis. Scand. J. Gastroenterol. 22, 543-549 (1987)
14. Reunala T. Dermatitis herpetiformis: coeliac disease of the skin. Ann. Med. 30, 416-418 (1998)
15. Tortora R, Russo I, De Palma GD, et al. In vitro gliadin challenge: diagnostic accuracy and utility for the difficult diagnosis of celiac disease. Am. J. Gastroenterol. doi:10.1038/ajg.2011.311 (2011) (Epub ahead of print)
16. Ribes-Koninckx C, Mearin M, Korponay-Szabó I, et al. The ESPGHAN working group on coeliac disease diagnosis. Coeliac disease diagnosis: ESPGHAN 1990 criteria or need for a change? Results of a questionnaire. J. Pediatr. Gastroenterol. Nutr. doi:10.1097/ MPG.0b013e31822a00bb (2011) (Epub ahead of print)
17. Anderson RP. Coeliac disease is on the rise. Med. J. Aust. 194(6), 278-279 (2011)
18. Parakkal D, Du H, Semer R, Ehrenpreis ED, Guandalini S. Do gastroenterologists adhere to diagnostic and treatment guidelines for celiac disease? J. Clin. Gastroenterol. doi:10.1097/ MCG.0b013e31822f0da0 (2011) (Epub ahead of print)
19. Sapone A, Lammers KM, Casolaro V, et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med. 9, 23 (2011)
20. Hill ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 128, S25-S32 (2005)
21. Rostom A, Dube C, Cranney A, et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 128, S38-S46 (2005)
22. Dickey W, Hughes D. Disappointing sensitivity of endoscopic markers for villous atrophy in a high-risk population: implications for celiac disease diagnosis during routine endoscopy. Am. J. Gastroenterol. 96, 2126-2128 (2001)
23. Anderson RP. Coeliac disease: current approach and future prospects. Intern. Med. J. 38(10), 790-799 (2008)
24. Catassi C, Fasano A. Celiac disease. In: Gluten-Free Cereal Products and Beverages. Arendt E, Dal Bello F (Eds). Elsevier Inc., Amsterdam, The Netherlands, 1-28 (2008)
25. Wu J, Xia B, von Blomberg BME, et al. Coeliac disease: emerging in China? Gut 59, 418-419 (2010)
26. Rubio-Tapia A, Kyle RA, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 137(1), 88-93 (2009)
27. Murray JA, Van Dyke C, Plevak MF, Dierkhising RA, Zinsmeister AR, Melton LJ III. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin. Gastroenterol. Hepatol. 1(1), 19-27 (2003)
28. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann. Med. 42(7), 530-538 (2010)
29. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch. Intern. Med. 163(3), 286-292 (2003)
30. Catassi C. [The global village of celiac disease]. Recenti. Prog. Med. 92 (7-8), 446-450 (2001)
31. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment. Pharmacol. Ther. 26(9), 1217-1225 (2007)
32. Mustalahti K, Catassi C, Reunanen A, et al. Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann. Med. 42(8), 587-595 (2010)
33. Vilppula A, Collin P, Mäki M, et al. Undetected coeliac disease in the elderly: a biopsy-proven population-based study. Dig. Liver Dis. 40(10), 809-813 (2008)
34. Rashtak S, Murray JA. Celiac disease in the elderly. Gastroenterol. Clin. North Am. 38(3), 433-446 (2009)
35. Trynka G, Wijmenga C, van Heel DA. A genetic perspective on coeliac disease. Trends Mol. Med. 16(11), 537-550 (2010)
36. van den Broeck HC, de Jong HC, Salentijn EM, et al. Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease. Theor. Appl. Genet. 121(8), 1527-1539 (2010)
37. Shan L, Molberg Ø, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. 297(5590), 2275-2279 (2002)
38. Tye-Din JA, Stewart JA, Dromey JA, et al. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci. Transl. Med. 2(41), 41ra51 (2010)
39. Colgrave ML, Goswami H, Howitt CA, Tanner GJ. What is in a beer? Proteomic characterization and relative quantification of hordein (gluten) in beer. J. Proteome Res. doi:10.1021/pr2008434 (2011) (Epub ahead of print)
40. Shewry PR, Tatham AS. The prolamin storage proteins of cereal seeds: structure and evolution. Biochem. J. 267(1), 1-12 (1990)
41. Shewry PR. Plant storage proteins. Biol. Rev. Camb. Philos. Soc. 70(3), 375-426 (1995)
42. Hausch F, Shan L, Santiago NA, Gray GM, Khosla C. Intestinal digestive resistance of immunodominant gliadin peptides. Am. J. Physiol. Gastrointest. Liver Physiol. 283(4), G996-G1003 (2002)
43. Skovbjerg H, Koch C, Anthonsen D, Sjöström H. Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim. Biophys. Acta 1690(3), 220-230 (2004)
44. Anderson RP, Degano P, Godkin AJ, Jewell DP, Hill AV. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat. Med. 6(3), 337-342 (2000)
45. Mitea C, Salentijn EM, van Veelen P, et al. A universal approach to eliminate antigenic properties of alpha-gliadin peptides in celiac disease. PLoS One 5(12), e15637 (2010)
46. Salentijn EM, Goryunova SV, Bas N, et al. Tetraploid and hexaploid wheat varieties reveal large differences in expression of alpha-gliadins from homoeologous Gli-2 loci. BMC Genomics 10, 48 (2009)
47. Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, et al. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology 129(3), 797-806 (2005)
48. Molberg O, Uhlen AK, Jensen T, et al. Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. Gastroenterology 128(2), 393-401 (2005)
49. Frisoni M, Corazza GR, Lafiandra D, et al. Wheat deficient in gliadins: promising tool for treatment of coeliac disease. Gut 36(3), 375-378 (1995)
50. Filer LJ Jr. Modified food starch-an update. J. Am. Diet. Assoc. 88(3), 342-344 (1988)
51. Lebenthal-Bendor Y, Theuer RC, Lebenthal A, Tabi I, Lebenthal E. Malabsorption of modified food starch (acetylated distarch phosphate) in normal infants and in 8-24-month-old toddlers with non-specific diarrhea, as influenced by sorbitol and fructose. Acta Paediatr. 90(12), 1368-1372 (2001)
52. Anjum FM, Khan MR, Din A, Saeed M, Pasha I, Arshad MU. Wheat gluten: high molecular weight glutenin subunits-structure, genetics, and relation to dough elasticity. J. Food Sci. 72(3), R56-R63 (2007)
53. Kasim S, Moriarty KJ, Liston R. Nonresponsive celiac disease due to inhaled gluten. N. Engl. J. Med. 356(24), 2548-2549 (2007)
54. Myléus A, Ivarsson A, Webb C, et al. Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic. J. Pediatr. Gastroenterol. Nutr. 49(2), 170-176 (2009)
55. Ivarsson A, Persson LA, Nyström L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 89(2), 165-171 (2000)
56. Norris JM, Barriga K, Hoffenberg EJ, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 293(19), 2343-2351 (2005)
57. Moore JC, Lipp M, Griffiths JC. Preventing the adulteration of food protein. Food Tech. 65(2), 46-50 (2011)
58. Burns K. Researchers examine contaminants in food, deaths of pets. J. Am. Vet. Med. Assoc. 231(11), 1636-1638 (2007)
59. Panfeng S, Hong C, Zhongjin Y, et al. Management of pediatric urolithiasis induced by melamine-contaminated powdered formula (report of 619 cases). Pediatr. Urol. 78(2), 411-416 (2011)
60. Qiao G, Guo T, Klein KK. Melamine in Chinese milk products and consumer confidence. Appetite 55(2), 190-195 (2010)
61. American Academy of Pediatrics. Council on Environmental Health Chemical-Management Policy: prioritizing childrens health. Pediatrics 127(5), 983-990 (2011)
62. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347(12), 911-920 (2002)
63. Lane EA, Austin EJ, Crowe MA. Oestrous synchronisation in cattle-current options following the EU regulations restricting use of oestrogenic compounds in food-producing animals: a review. Anim. Reprod. Sci. 109(1-4), 1-16 (2008)
64. Rewers M. Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease? Gastroenterology 128(4 Suppl. 1), S47-S51 (2005)
65. Jacobson-Dickman E, Lee MM. The influence of endocrine disruptors on pubertal timing. Curr. Opin. Endocrinol. Diabetes Obes. 16, 25-30 (2009)
66. Verdu EF, Mauro M, Bourgeois J, Armstrong D. Clinical onset of celiac disease after an episode of Campylobacter jejuni enteritis. Can. J. Gastroenterol. (7), 453-455 (2007)
67. Naim HY. Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. Histol. Histopathol. 16(2), 553-561 (2001)
68. Ojetti V, Nucera G, Migneco A, et al. High prevalence of celiac disease in patients with lactose intolerance. Digestion 71(2), 106-110 (2005)
69. Stene LC, Honeyman MC, Hoffenberg EJ, et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am. J. Gastroenterol. 101(10), 2333-2340 (2006)
70. Carroccio A, Cavataio F, Montalto G, Paparo F, Troncone R, Iacono G. Treatment of giardiasis reverses active coeliac disease to latent coeliac disease. Eur. J. Gastroenterol. Hepatol. 13(9), 1101-1105 (2001)
71. Corazza GR, Ginaldi L, Furia N, Marani-Toro G, Di Giammartino D, Quaglino D. The impact of HIV infection on lactose absorptive capacity. J. Infect. 35(1), 31-35 (1997)
72. Taylor C, Hodgson K, Sharpstone D, et al. The prevalence and severity of intestinal disaccharidase deficiency in human immunodeficiency virus-infected subjects. Scand. J. Gastroenterol. 35(6), 599-606 (2000)
73. Nellen H, Flores G, Wacher N. Treatment of human immunodeficiency virus enteropathy with a gluten-free diet. Arch. Intern. Med. 160(2), 244 (2000)
74. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the no mans land of gluten sensitivity. Am. J. Gastroenterol. 104(6), 1587-1594 (2009)
75. Verdu EF. Editorial: can gluten contribute to irritable bowel syndrome? Am. J. Gastroenterol. 106(3), 516-518 (2011)
76. Sanders DS, Patel D, Stephenson TJ, et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur. J. Gastroenterol. Hepatol. 15, 407-413 (2003)
77. Sanders DS, Carter MJ, Hurlstone DP, et al. Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 358, 1504-1508 (2001)
78. Shahbazkhani B, Forootan M, Merat S. Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment. Pharmacol. Ther. 18, 231-235 (2003)
79. Stepniak D, Koning F. Celiac disease-sandwiched between innate and adaptive immunity. Hum. Immunol. 67(6), 460-468 (2006)
80. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol. Rev. 91(1), 151-175 (2011)
81. Bach JF. Infections and autoimmune diseases. J. Autoimmun. 25(Suppl.), 74-80 (2005)
82. Sabayan B, Foroughinia F, Imanieh MH. Can Campylobacter jejuni play a role in development of celiac disease? A hypothesis. World J. Gastroenterol. 13(35), 4784-4785 (2007)
83. Gaboriau-Routhiau V, Rakotobe S, Lécuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31(4), 677-689 (2009)
84. Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc. Natl Acad. Sci. USA 108(28), 11548-11553 (2011)
85. Sanz Y, Pama GD, Laparra M. Unraveling the ties between celiac disease and intestinal microbiota. Int. Rev. Immunol. 30(4), 207-218 (2011)
86. Savidge TC, Urvil P, Oezguen N, et al. Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat. Med. 17(9), 1136-1141 (2011)
87. Ferner RE. Drug-induced diabetes. Baillieres Clin. Endocrinol. Metab. 6(4), 849-866 (1992)
88. Cosnes J, Cellier C, Viola S, et al. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin. Gastroenterol. Hepatol. 6(7), 753-758 (2008)
89. Massari S, Liso M, De Santis L, et al. Occurrence of nonceliac gluten sensitivity in patients with allergic disease. Int. Arch. Allergy Immunol. 155(4), 389-394 (2011)
90. Joneja JV. Dealing with Food Allergies. Bull Publishing Company, Boulder, Colorado, USA (2003)
91. Ford RP. The gluten syndrome: a neurological disease. Med. Hypotheses 73(3), 438-440 (2009)
92. NIH consensus development conference on celiac disease. NIH Consens. State Sci. Statements 21(1), 1-23 (2004)
93. Hill ID, Dirks MH, Liptak GS, et al. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 40(1), 1-19 (2005)
94. Karell K, Louka AS, Moodie SJ, et al. European genetics cluster on celiac disease. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum. Immunol. 64(4), 469-477 (2003)
95. Sapone A, Lammers KM, Mazzarella G, et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int. Arch. Allergy Immunol. 152(1), 75-80 (2010)
96. Volta U, De Giorgio R. Gluten sensitivity: an emerging issue behind neurological impairment? Lancet Neurol. 9(3), 233-235 (2010)
97. Crenn P, Vahedi K, Lavergne-Slove A, Cynober L, Matuchansky C, Messing B. Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124(5), 1210-1219 (2003)
98. Högberg L, Webb C, Fälth-Magnusson K, et al. Children with screening-detected coeliac disease show increased levels of nitric oxide products in urine. Acta Paediatr. 100(7), 1023-1027 (2011)
99. Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 9(3), 318-330 (2010)
100. Rashid M, Zarkadas M, Anca A, Limeback H. Oral manifestations of celiac disease: a clinical guide for dentists. J. Can. Dent. Assoc. 77, b39 (2011)
101. Benito Conejero S, Díaz Espejo C, López Domínguez JM, Pujol de la Llave E. [Cerebral calcifications: a clue for a diagnostic process in a nonspecific clinical case]. An. Med. Interna. 23 (3), 127-129 (2006)
102. Collin P. Should adults be screened for celiac disease? What are the benefits and harms of screening? Gastroenterology 128(4 Suppl. 1), S104-S108 (2005)
103. Wright DH. The major complications of coeliac disease. Baillieres Clin. Gastroenterol. 9(2), 351-369 (1995)
104. Fichna M, Fichna P, Gryczyska M, Walkowiak J, Zurawek M, Sowiski J. Screening for associated autoimmune disorders in Polish patients with Addisons disease. Endocrine 37(2), 349-360 (2010)
105. Thompson JS, Lebwohl B, Reilly NR, Talley NJ, Bhagat G, Green PH. Increased incidence of eosinophilic esophagitis in children and adults with celiac disease. J. Clin. Gastroenterol. doi:10.1097/ MCG.0b013e318221aefd (2011) (Epub ahead of print)
106. Choi JM, Lebwohl B, Wang J, et al. Increased prevalence of celiac disease in patients with unexplained infertility in the United States. J. Reprod. Med. 56(5-6), 199-203 (2011)
107. Ludvigsson JF, Lindelöf B, Zingone F, Ciacci C. Psoriasis in a nationwide cohort study of patients with celiac disease. J. Invest. Dermatol. 131(10), 2010-2016 (2011)
108. Dohan F, Grassberger J, Lowell F, Johnson H, Arbegast A. Relapsed schizophrenics: more rapid improvement on a milk-and cereal-free diet. Br. J. Psychiatry 115(522), 595-596 (1969)
109. Lidén M, Kristjánsson G, Valtýsdóttir S, Hällgren R. Gluten sensitivity in patients with primary Sjögrens syndrome. Scand. J. Gastroenterol. 42(8), 962-967 (2007)
110. Hadjivassiliou M, Sanders DS, Grünewald RA, Akil M. Gluten sensitivity masquerading as systemic lupus erythematosus. Ann. Rheum. Dis. 63, 1501-1503 (2004)
111. Aetna. Clinical policy bulletin: celiac disease laboratory testing. www.aetna.com/cpb/medical/ data/500-599/0561.html (Accessed 26 April 2011)
112. American Dietetic Association. Nutrition Care Manual. www.nutritioncaremanual.org/auth. cfm?p=%2Findex%2Ecfm%3F&err= NotLoggedIn. (Accessed 1 August 2011)
113. US driving gluten-free market growth. www.foodproductdesign.com/ news/2010/07/us-driving-gluten-free-product-growth.aspx (Accessed 26 April 2011)
114. Associated Press. Gluten-free market goes mainstream. www.msnbc.msn.com/id/8729169/ns/ business-consumer-news/ (Accessed 26 April 2011)