Morphologic features suggestive of gluten sensitivity in architecturally normal duodenal biopsy specimens

American Journal of Clinical Pathology

Volumn 116, Issue 1, 2001, Pages 63-71

  Goldstein, Ned S ^a   Underhill, Jeanette ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

Biopsy; Celiac; Gluten; Intraepithelial lymphocytes; Latent; Pathology; Sprue

Indexed keywords

IMMUNOGLOBULIN A;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CRYPT CELL; DUODENUM BIOPSY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINE VILLUS; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MITOSIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BIOPSY; CELIAC DISEASE; CELL COUNT; DUODENUM; ENTEROCYTES; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICROVILLI; REFERENCE VALUES;

EID: 0034950651     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/5PRJ-CM0U-6KLD-6KCM     Document Type: Article

References (89)

1. Gostout CJ. Enteroscopy for unexplained iron-deficiency anemia: identifying the patient with sprue. Gastrointest Endosc. 1993;39:76-79.
2. Corazza GR, Frisoni M, Treggiari EA, et al. Subclinical celiac sprue: increasing occurrence and clues to its diagnosis. J Clin Gastroenterol. 1993;16:16-21.
3. Halsted CH. The many faces of celiac disease. N Engl J Med. 1996;334:1190-1191.
4. Corazza GR, Brusco G, Andreani ML, et al. Previous misdiagnosis and diagnostic delay in adult celiac sprue. J Clin Gastroenterol. 1996;22:324-325.
5. Fasano A. Where have all the American celiacs gone? Acta Paediatr Suppl. 1996;412:20-24.
6. Ferguson A, Arranz E, O'Mahony S. Definitions and diagnostic criteria of latent and potential celiac disease. Dyn Nutr Res. 1992;12:119-127.
7. Vitoria JC, Arrieta A, Arranz C, et al. Antibodies to gliadin, endomysium, and tissue transglutaminase for the diagnosis of celiac disease. J Pediatr Gastroenterol Nutr. 1999;29:571-574.
8. Bhattacharyya A, Patel MK, Tymms DJ. Celiac disease in adults: variations on a theme. J R Soc Med. 1999;92:286-289.
9. Hovdenak N, Hovlid E, Aksnes L, et al. High prevalence of asymptomatic celiac disease in Norway: a study of blood donors. Eur J Gastroenterol Hepatol. 1999;11:185-187.
10. Ivarsson A, Persson LA, Juto P, et al. High prevalence of undiagnosed celiac disease in adults: a Swedish population-based study. J Intern Med. 1999;245:63-68.
11. Bottaro G, Cataldo F, Rotolo N, et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol. 1999;94:691-696.
12. Murray JA. The widening spectrum of celiac disease. Am J Clin Nutr. 1999;69:354-365.
13. Korponay-Szabo IR, Kovacs JB, Czinner A, et al. High prevalence of silent celiac disease in preschool children screened with IgA/IgG antiendomysium antibodies. J Pediatr Gastroenterol Nutr. 1999;28:26-30.
14. Johnston SD, Watson RG, McMillan SA, et al. Celiac disease detected by screening is not silent: simply unrecognized. QJM. 1998;91:853-860.
15. Beaumont DM, Mian MS. Coeliac disease in old age: "a catch in the rye." Age Ageing. 1998;27:535-538.
16. Collin P, Reunala T, Rasmussen M, et al. High incidence and prevalence of adult celiac disease: augmented diagnostic approach. Scand J Gastroenterol 1997;32:1129-1133.
17. Marsh MN. Gluten sensitivity and latency: can patterns of intestinal antibody secretion define the great "silent majority"? Gastroenterology. 1993;104:1550-1553.
18. Bardella MT, Minoli G, Ravizza D, et al. Increased prevalence of celiac disease in patients with dyspepsia. Arch Intern Med. 2000;160:1489-1491.
19. Green PH, Shane E, Rotterdam H, et al. Significance of unsuspected celiac disease detected at endoscopy. Gastrointest Endosc. 2000;51:60-65.
20. Ferguson A. Celiac disease research and clinical practice: maintaining momentum into the twenty-first century. Baillieres Clin Gastroenterol. 1995;9:395-412.
21. Johnston SD, Watson RG, McMillan SA, et al. Preliminary results from follow-up of a large-scale population survey of antibodies to gliadin, reticulin and endomysium. Acta Paediatr Suppl. 1996;412:61-64.
22. Kelly CP, Feighery CF, Gallagher RB, et al. Diagnosis and treatment of gluten-sensitive enteropathy. Adv Intern Med. 1990;35:341-363.
23. Frazzoni M, Lonardo A, Grisendi A, et al. Are routine duodenal and antral biopsies useful in the management of "functional" dyspepsia? J Clin Gastroenterol. 1993;17:101-108.
24. Ackerman A, Eliakim R, Stalnikowicz R, et al. Role of small bowel biopsy in the endoscopic evaluation of adults with iron deficiency anemia. Am J Gastroenterol. 1996;91:2099-2102.
25. Rostami K, Mulder CJ, Werre JM, et al. High prevalence of celiac disease in apparently healthy blood donors suggests a high prevalence of undiagnosed celiac disease in the Dutch population. Scand J Gastroenterol. 1999;34:276-279.
26. Ferguson A. Celiac disease, an eminently treatable condition, may be underdiagnosed in the United States. Am J Gastroenterol. 1997;92:1252-1254.
27. Corazza GR, Brochhi E, Caletti G, et al. Loss of duodenal folds allows diagnosis of unsuspected celiac disease. Gut. 1990;31:1080-1081.
28. Bardella MT, Minoli G, Radaelli F, et al. Reevaluation of duodenal endoscopic markers in the diagnosis of celiac disease. Gastrointest Endosc. 2000;51:714-716.
29. Marsh MN. Screening for latent gluten sensitivity: questions many, but answers few [editorial]. Eur J Gastroenterol Hepatol. 1996;8:3-6.
30. Marsh MN. The natural history of gluten sensitivity: defining, refining and re-defining. QJM. 1995;88:9-13.
31. Marsh MN, Crowe PT. Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin Gastroenterol. 1995;9:273-293.
32. Marsh MN. Clinical and pathological spectrum of coeliac disease [letter]. Gut. 1993;34:1740-1741.
33. Yardley JH. Malabsorptive disorders. In: Ming S-C, Goldman H, eds. Pathobgy of the Gastrointestinal Tract. Philadelphia, PA: William & Wilkins; 1998:755-800.
34. Petras R. Nonneoplastic intestinal diseases. In: Sternberg SS, Antonioli DA, Carter D, et al, eds. Diagnostic Surgical Pathobgy. Philadelphia, PA: Lippincott Williams & Wilkins; 1999:1349-1412.
35. Rosai J. Gastrointestinal tract. In: Ackerman's Surgical Pathology. New York, NY: Mosby; 1996:589-815.
36. Valdimarsson T, Franzen L, Grodzinsky E, et al. Is small biopsy necessary in adults with suspected celiac disease and IgA antiendomysium antibodies? 100% positive predictive value for celiac disease in adults. Dig Dis Sci. 1996;41:83-87.
37. Arranz E, Ferguson A. Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology. Gastroenterology. 1993;104:1263-1272.
38. Jenkins D, Goodall A, Gillet FR, et al. Defining duodenitis: quantitative histological study of mucosal responses and their correlations. J Clin Pathol 1985;38:1119-1126.
39. Marsh MN. Studies of intestinal lymphoid tissue, XIII: immunopathology of the evolving celiac sprue lesion. Pathol Res Pract. 1989;185:774-777.
40. Marsh MN. Studies of intestinal lymphoid tissue, XI: the immunopathology of cell-mediated reactions in gluten sensitivity and other enteropathies. Scanning Microsc. 1988;2:1663-1684.
41. Marsh MN, Leigh RJ, Loft DE, et al. Studies of intestinal lymphoid tissue, X: observations on granular epithelial lymphocytes (gEL) in normal and diseased human jejunum. Virchows Arch A Pathol Anat Histopathol. 1988;412:365-370.
42. Marsh MN. Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology. 1992;102:330-354.
43. Marsh MN, Loft DE. Celiac sprue: a centennial overview 1888-1988. Dig Dis. 1988;6:216-228.
44. Marsh MN. Studies of intestinal lymphoid tissue, XV: histopathologic features suggestive of cell-mediated reactivity in jejunal mucosae of patients with dermatitis herpetiformis. Virchows Arch A Pathol Anat Histopathol. 1989;416:125-132.
45. Marsh MN, Bjarnason I, Shaw J, et al. Studies of intestinal lymphoid tissue, XIV: HLA status, mucosal morphology, permeability and epithelial lymphocyte populations in first degree relatives of patients with celiac disease. Gut. 1990;31:32-36.
46. Marsh MN. Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge. Gut. 1990;31:111-114.
47. Troncone R, Greco L, Mayer M, et al. Latent and potential coeliac disease. Acta Paediatr Suppl. 1996;412:10-14.
48. Corazza GR, Andreani ML, Biagi F, et al. Clinical, pathological, and antibody pattern of latent celiac disease: report of three adult cases. Am J Gastroenterol. 1996;91:2203-2207.
49. Picarelli A, Maiuri L, Mazzilli MC, et al. Gluten-sensitive disease with mild enteropathy. Gastroenterology. 1996; 111:608-616.
50. Maki M, Holm K, Collin P, et al. Increase in gamma-delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent celiac disease. Gut. 1991;32:1412-1414.
51. Maki M, Collin P. Celiac disease. Lancet. 1997;349:1755-1759.
52. Arranz E, Bode J, Kingstone K, et al. Intestinal antibody pattern of celiac disease: association with gamma/delta T cell receptor expression by intraepithelial lymphocytes, and other indices of potential celiac disease. Gut. 1994;35:476-482.
53. Marsh MN. Studies of intestinal lymphoid tissue, III: quantitative analysis of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue. Gastroenterobgy. 1980;79:481-492.
54. Ferguson A, Murray D. Qualification of intraepithelial lymphocytes in human jejunum. Gut. 1971;12:988-994.
55. Maki M, Visakorpi JK. Normal small bowel histology does not exclude celiac disease [abstract]. Pediatr Res. 1988;24:411.
56. Fry L, Seah RMH, Hoffbrand AV. Lymphocytic infiltration of epithelium in diagnosis of gluten-sensitivity enteropathy. Br Med J. 1972;3:371-374.
57. Marsh MN. The immunopathology of the small intestinal reaction in gluten-sensitivity. Immunol Invest. 1989;18:509-531.
58. Fric P, Lojda Z, Malis F. Analysis of perioral jejunal biopsies in clinically asymptomatic parents of children with celiac sprue. Digestion. 1969;2:35-42.
59. Feighery C, Weir DG, Whelan A, et al. Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate? Eur J Gastroenterol Hepatol. 1998;10:919-925.
60. Loft DE, Nwokolo CU, Ciclitira PJ. The diagnosis of gluten sensitivity and celiac disease: the two are not mutually inclusive. Eur J Gastroenterol Hepatol. 1998;10:911-913.
61. Leonard NL, Feighery CF, Hourihane DO. Peptic duodenitis: does it exist in the second part of the duodenum? J Clin Pathol. 1997;50:54-58.
62. Niveloni S, Pedreira S, Sugai E, et al. The natural history of gluten sensitivity: report of two new celiac disease patients resulting from a long-term follow-up of nonatrophic, first-degree relatives. Am J Gastroenterol. 2000;95:463-468.
63. Leigh RJ, Marsh MN, Crowe P, et al. Studies of intestinal lymphoid tissue, IX: dose-dependent, gluten-induced lymphoid infiltration of celiac jejunal epithelium. Scand J Gastroenterol. 1985;20:715-719.
64. Geboes K, Ectors N, Desmet VJ. Celiac disease "anatomic pathology." Acta Gastroenterol Belg. 1992;55:190-199.
65. Kaukinen K, Collin P, Holm K, et al. Small-bowel mucosal inflammation in reticulin or gliadin antibody-positive patients without villus atrophy. Scand J Gastroenterol. 1998;33:944-949.
66. Cooper BT, Holmes GK, Ferguson R, et al. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology. 1980;79:801-806.
67. Corazza GR, Valentini RA, Frisoni M, et al. Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients. Gastroenterology. 1992;103:1517-1522.
68. Corazza GR, Frazzoni M, Gasbarrini G. Jejunal intraepithelial lymphocytes in celiac disease: are they increased or decreased? Gut. 1984;25:158-162.
69. Ferguson A. Intraepithelial lymphocytes of the small intestine. Gut. 1977;18:921-937.
70. Anand BS, Piris J, Jerrome DW, et al. The timing of histological damage following a single challenge with gluten in treated coeliac disease. Q J Med. 1981;50:83-94.
71. Savilahti E, Ormala T, Arato A, et al. Density of gamma/delta+ T cells in the jejunal epithelium of patients with celiac disease and dermatitis herpetiformis is increased with age. Clin Exp Immunol. 1997;109:464-467.
72. Patinen P, Savilahti E, Hietanen J, et al. Intraepithelial lymphocytes bearing the gamma/delta receptor in the oral and jejunal mucosa in patients with dermatitis herpetiformis. Eur J Oral Sci. 1997;105:130-135.
73. Weinstein WM. Latent celiac sprue. Gastroenterology. 1974;66:489-493.
74. Pittschieler K, Ladinser B. Coeliac disease: screened by a new strategy. Acta Paediatr Suppl. 1996;412:42-45.
75. Del Rosario MA, Fitzgerald JF, Chong SK, et al. Further studies of anti-endomysium and anti-gliadin antibodies in patients with suspected celiac disease. J Pediatr Gastroenterol Nutr. 1998;27:191-195.
76. Volta U, Molinaro N, De Franchis R, et al. Correlation between IgA antiendomysial antibodies and subtotal villus atrophy in dermatitis herpetiformis. J Clin Gastroenterol. 1992;14:298-301.
77. Rostami K, Kerckhaert J, Tiemessen R, et al. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am J Gastroenterol. 1999;94:888-894.
78. Mulder CJ, Rostami K, Marsh MN. When is a celiac a celiac [letter]? Gut. 1998;42:594.
79. Dickey W, Hughes DF, McMillan SA. Reliance on serum endomysial antibody testing underestimates the true prevalence of celiac disease by one fifth. Scand J Gastroenterol. 2000;35:181-183.
80. Usselmann B, Loft DE. An easy test for celiac disease using human umbilical vein endothelial cells. Eur J Gastroenterol Hepatol. 1996;8:947-950.
81. Ladinser B, Rossipal E, Pittschieler K. Endomysium antibodies in celiac disease: an improved method. Gut. 1994;35:776-778.
82. Rostami K, Kerckhaert J, Tiemessen R, et al. The relationship between anti-endomysium antibodies and villus atrophy in celiac disease using both monkey and human substrate. Eur J Gastroenterol Hepatol. 1999;11:439-442.
83. Murray JA, Green PH. Biopsy is the gold standard of diagnosis of celiac sprue [letter]. Gastroenterology. 1999;116:1273-1274.
84. Murray JA. It's not time to put away the biopsy forceps [editorial]. Am J Gastroenterol. 1999;94:869-871.
85. Yuce A, Demir H, Kocak N, et al. Antiendomysium and antigliadin antibodies for the diagnosis of celiac disease [letter]. Am J Gastroenterol. 2000;95:1366-1367.
86. Trier JS. Diagnosis of celiac sprue. Gastroenterology. 1998;115:211-216.
87. Kolho KL, Farkkila MA, Savilahti E. Undiagnosed celiac disease is common in Finnish adults. Scand J Gastroenterol. 1998;33:1280-1283.
88. Corazza GR, Andreani ML, Biagi F, et al. The smaller size of the "celiac iceberg" in adults. Scand J Gastroenterol. 1997;32:917-919.
89. Korn ER, Foroozan P. Endoscopic biopsies of normal duodenal mucosa. Gastrointest Endosc. 1974;21:51-54.