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Volumn 7, Issue 1, 2012, Pages 118-131

Insights into angiogenesis in non-small cell lung cancer: Molecular mechanisms, polymorphic genes, and targeted therapies

Author keywords

Angiogenesis; Antineoplastic drug combination; Biological markers; Neovascularization; Non small cell lung cancer; Pathology; Polymorphism; Vascular endothelial growth factor

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR; GEFITINIB; GEMCITABINE; MOTESANIB; NOTCH DELTA LIKE LIGAND 4; PACLITAXEL; PANITUMUMAB; PLACEBO; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN RET; REGULATOR PROTEIN; RILOTUMUMAB; SORAFENIB; SUNITINIB; TIVANTINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; XL 184;

EID: 83455233831     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489212798357994     Document Type: Review
Times cited : (22)

References (117)
  • 1
    • 77954982964 scopus 로고    scopus 로고
    • Non Small Cell Lung Cancer
    • In: DeVita V, Lawrence T, Rosenberg S, Weinberg R, DePinho R, editors, 8thed. Philadelphia: Lippincott Williams & Wilkins
    • Schrump D, Giaccone G, Kelsey K, Marks L. Non Small Cell Lung Cancer. In: DeVita V, Lawrence T, Rosenberg S, Weinberg R, DePinho R, editors. DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 8thed. Philadelphia: Lippincott Williams & Wilkins 2008: 896-939.
    • (2008) DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology , pp. 896-939
    • Schrump, D.1    Giaccone, G.2    Kelsey, K.3    Marks, L.4
  • 3
    • 65249113902 scopus 로고    scopus 로고
    • Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer
    • Guo X, Chen Y, Xu Z, Qian Y, Yu X. Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. Acta Biochim Biophys Sin (Shanghai) 2009; 41(3): 217-22.
    • (2009) Acta Biochim Biophys Sin (Shanghai) , vol.41 , Issue.3 , pp. 217-222
    • Guo, X.1    Chen, Y.2    Xu, Z.3    Qian, Y.4    Yu, X.5
  • 4
    • 52649131951 scopus 로고    scopus 로고
    • Molecular origins of cancer
    • Herbst R, Heymach J, Lippman S. Molecular origins of cancer. N Engl J Med 2008; 359 (13): 1367-80.
    • (2008) N Engl J Med , vol.359 , Issue.13 , pp. 1367-1380
    • Herbst, R.1    Heymach, J.2    Lippman, S.3
  • 6
    • 19844373387 scopus 로고    scopus 로고
    • Epidemiology of lung cancer: Looking to the future
    • Alberg A, Brock M, Samet J. Epidemiology of lung cancer: looking to the future. J Clin Oncol 2005; 23(14): 3175-85.
    • (2005) J Clin Oncol , vol.23 , Issue.14 , pp. 3175-3185
    • Alberg, A.1    Brock, M.2    Samet, J.3
  • 7
    • 43049111064 scopus 로고    scopus 로고
    • The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th Edition of the TNM Classification of Malignant Tumors and the proposals for the 7th Edition
    • [Sculier J, Chansky K, Crowley J, Van Meerbeeck J, Goldstraw P. The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th Edition of the TNM Classification of Malignant Tumors and the proposals for the 7th Edition. J Thorac Oncol 2008; 3(5): 457-66.
    • (2008) J Thorac Oncol , vol.3 , Issue.5 , pp. 457-466
    • Sculier, J.1    Chansky, K.2    Crowley, J.3    van Meerbeeck, J.4    Goldstraw, P.5
  • 8
    • 0036198731 scopus 로고    scopus 로고
    • Molecular biology of lung cancer: Clinical implications
    • Fong K, Minna J. Molecular biology of lung cancer: Clinical implications. Clin Chest Med 2002; 23(1): 83-101.
    • (2002) Clin Chest Med , vol.23 , Issue.1 , pp. 83-101
    • Fong, K.1    Minna, J.2
  • 9
    • 73149124713 scopus 로고    scopus 로고
    • Efficacy of plasma vascular endothelial growth factor in monitoring firstline chemotherapy in patients with advanced non-small cell lung cancer
    • Kumar S, Guleria R, Singh V, Bharti A, Mohan A, Das B. Efficacy of plasma vascular endothelial growth factor in monitoring firstline chemotherapy in patients with advanced non-small cell lung cancer. BMC cancer 2009; 9(1): 421.
    • (2009) BMC Cancer , vol.9 , Issue.1 , pp. 421
    • Kumar, S.1    Guleria, R.2    Singh, V.3    Bharti, A.4    Mohan, A.5    Das, B.6
  • 10
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • Bremnes R, Camps C, Sirera R. Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer. 2006; 51(2): 143-58.
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 143-158
    • Bremnes, R.1    Camps, C.2    Sirera, R.3
  • 11
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009; 27(8): 1227-34.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6
  • 12
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel R. Tumor angiogenesis. N Engl J Med 2008; 358(19): 2039-49.
    • (2008) N Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.1
  • 13
    • 84873096158 scopus 로고    scopus 로고
    • Tumor Angiogenesis: From Bench to Bedside
    • In: Marmé D, Fusenig N, editors, Berlin: Springer, 8thed
    • Folkman J. Tumor Angiogenesis: From Bench to Bedside. In: Marmé D, Fusenig N, editors. Tumor Angiogenesis: Basic concepts and cancer therapy. 8thed. Berlin: Springer 2008: 3-28.
    • (2008) Tumor Angiogenesis: Basic Concepts and Cancer Therapy , pp. 3-28
    • Folkman, J.1
  • 14
    • 19844364244 scopus 로고    scopus 로고
    • Angiogenesis and lung cancer: Prognostic and therapeutic implications
    • Herbst R, Onn A, Sandler A. Angiogenesis and lung cancer: Prognostic and therapeutic implications. J Clin Oncol 2005; 23(14): 3243-46.
    • (2005) J Clin Oncol , vol.23 , Issue.14 , pp. 3243-3246
    • Herbst, R.1    Onn, A.2    Sandler, A.3
  • 15
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971; 285: 1182-86.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 16
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20(21): 4368-80.
    • (2002) J Clin Oncol , vol.20 , Issue.21 , pp. 4368-4680
    • Dvorak, H.1
  • 17
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel W. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161(2): 851-58.
    • (1989) Biochem Biophys Res Commun , vol.161 , Issue.2 , pp. 851-858
    • Ferrara, N.1    Henzel, W.2
  • 18
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza G. Hydroxylation of HIF-1: Oxygen sensing at the molecular level. Physiology (Bethesda) 2004; 19: 176-82.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.1
  • 20
    • 33644825389 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma
    • Juttner S, Wissmann C, Jons T, Vieth M, Hertel J, Gretschel S, et al. Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma. J Clin Oncol 2006; 24(2): 228-40.
    • (2006) J Clin Oncol , vol.24 , Issue.2 , pp. 228-240
    • Juttner, S.1    Wissmann, C.2    Jons, T.3    Vieth, M.4    Hertel, J.5    Gretschel, S.6
  • 21
    • 74549223368 scopus 로고    scopus 로고
    • Método para estudo in vivo da angiogênese: Indução de neovascularização na córnea de coelho
    • González R, Leyva A, Melo R, Moreira R, Pessoa C, Farias R, et al. Método para estudo in vivo da angiogênese: Indução de neovascularização na córnea de coelho. Acta Cir Bras 2000; 15(3): 168-73.
    • (2000) Acta Cir Bras , vol.15 , Issue.3 , pp. 168-173
    • González, R.1    Leyva, A.2    Melo, R.3    Moreira, R.4    Pessoa, C.5    Farias, R.6
  • 22
    • 34748921698 scopus 로고    scopus 로고
    • Antiangiogenics: The potential role of integrating this novel treatment modality with chemoradiation for solid cancers
    • Duda D, Jain R, Willett C. Antiangiogenics: The potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 2007; 25(26): 4033-42.
    • (2007) J Clin Oncol , vol.25 , Issue.26 , pp. 4033-4042
    • Duda, D.1    Jain, R.2    Willett, C.3
  • 23
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos N, Coetzee S, Boland P, Gale N, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444(7122): 1032-37.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.3    Coetzee, S.4    Boland, P.5    Gale, N.6
  • 24
    • 34548535783 scopus 로고    scopus 로고
    • Anti-Dll4 therapy: Can we block tumour growth by increasing angiogenesis?
    • Sainson R, Harris A. Anti-Dll4 therapy: Can we block tumour growth by increasing angiogenesis? Trends Mol Med 2007; 13(9): 389-95.
    • (2007) Trends Mol Med , vol.13 , Issue.9 , pp. 389-395
    • Sainson, R.1    Harris, A.2
  • 25
    • 70449130019 scopus 로고    scopus 로고
    • Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non-small cell lung cancer patients: Relation to prognosis
    • Bonnesen B, Pappot H, Holmstav J, Skov BG. Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non-small cell lung cancer patients: Relation to prognosis. Lung Cancer 2009; 66(3): 314-8.
    • (2009) Lung Cancer , vol.66 , Issue.3 , pp. 314-318
    • Bonnesen, B.1    Pappot, H.2    Holmstav, J.3    Skov, B.G.4
  • 26
    • 0033739211 scopus 로고    scopus 로고
    • Quantification of VEGF mRNA expression in non-small cell lung cancer using a real-time quantitative reverse transcription-PCR assay and a comparison with quantitative competitive reverse transcription- PCR
    • Yuan A, Yu C, Luh K, Chen W, Lin F, Kuo S, et al. Quantification of VEGF mRNA expression in non-small cell lung cancer using a real-time quantitative reverse transcription-PCR assay and a comparison with quantitative competitive reverse transcription- PCR. Lab Invest 2000; 80(11): 1671-80.
    • (2000) Lab Invest , vol.80 , Issue.11 , pp. 1671-1680
    • Yuan, A.1    Yu, C.2    Luh, K.3    Chen, W.4    Lin, F.5    Kuo, S.6
  • 28
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from anti-angiogenic agents in malignancy
    • Jubb A, Oates A, Holden S, Koeppen H. Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 2006; 6(8): 626-35.
    • (2006) Nat Rev Cancer , vol.6 , Issue.8 , pp. 626-635
    • Jubb, A.1    Oates, A.2    Holden, S.3    Koeppen, H.4
  • 29
    • 0036809005 scopus 로고    scopus 로고
    • Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in nonsmall- cell lung cancer
    • Laack E, Kohler A, Kugler C, Dierlamm T, Knuffmann C, Vohwinkel G, et al. Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in nonsmall- cell lung cancer. Ann Oncol 2002; 13(10): 1550-7.
    • (2002) Ann Oncol , vol.13 , Issue.10 , pp. 1550-1557
    • Laack, E.1    Kohler, A.2    Kugler, C.3    Dierlamm, T.4    Knuffmann, C.5    Vohwinkel, G.6
  • 30
    • 77950243445 scopus 로고    scopus 로고
    • Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib
    • Nikolinakos P, Altorki N, Yankelevitz D, Tran H, Yan S, Rajagopalan D, et al. Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib. Cancer Res 2010; 70(6): 2171-9.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2171-2179
    • Nikolinakos, P.1    Altorki, N.2    Yankelevitz, D.3    Tran, H.4    Yan, S.5    Rajagopalan, D.6
  • 31
    • 40949111793 scopus 로고    scopus 로고
    • Cell Adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab: An Eastern Cooperative Oncology Group Study
    • Dowlati A, Gray R, Sandler A, Schiller J, Johnson D. Cell Adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab: An Eastern Cooperative Oncology Group Study. Clin Cancer Res 2008; 14(5): 1407-12.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.3    Schiller, J.4    Johnson, D.5
  • 32
    • 65349189877 scopus 로고    scopus 로고
    • Angiogenesis in the treatment of non-small cell lung cancer
    • Horn L, Sandler AB. Angiogenesis in the treatment of non-small cell lung cancer. Proc Am Thorac Soc 2009; 6(2): 206-17.
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.2 , pp. 206-217
    • Horn, L.1    Sandler, A.B.2
  • 33
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for nonsmall- cell lung cancer
    • Sandler A, Gray R, Perry M, Brahmer J, Schiller J, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for nonsmall- cell lung cancer. N Engl J Med 2006; 355(24): 2542-50.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.3    Brahmer, J.4    Schiller, J.5    Dowlati, A.6
  • 34
    • 74949088883 scopus 로고    scopus 로고
    • Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer
    • Blumenschein G, Reckamp K, Stephenson G, O'Rourke T, Gladish G, McGreivy J, et al. Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer. Clin Cancer Res 2010; 16(1): 279-90.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 279-290
    • Blumenschein, G.1    Reckamp, K.2    Stephenson, G.3    O'Rourke, T.4    Gladish, G.5    McGreivy, J.6
  • 35
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
    • Socinski M, Novello S, Brahmer J, Rosell R, Sanchez J, Belani C, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008; 26(4): 650-6.
    • (2008) J Clin Oncol , vol.26 , Issue.4 , pp. 650-656
    • Socinski, M.1    Novello, S.2    Brahmer, J.3    Rosell, R.4    Sanchez, J.5    Belani, C.6
  • 36
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with nonsmall- cell lung cancer
    • Hanrahan E, Lin H, Kim E, Yan S, Du D, McKee K, et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with nonsmall- cell lung cancer. J Clin Oncol 2010; 28(2): 193-201.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 193-201
    • Hanrahan, E.1    Lin, H.2    Kim, E.3    Yan, S.4    Du, D.5    McKee, K.6
  • 38
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang A, Massague J. Molecular basis of metastasis. N Engl J Med 2008; 359(26): 2814-23.
    • (2008) N Engl J Med , vol.359 , Issue.26 , pp. 2814-2823
    • Chiang, A.1    Massague, J.2
  • 40
    • 63549123584 scopus 로고    scopus 로고
    • Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from a randomized phase III trial (ESCAPE)
    • Hanna N, Von Pawel J, Reck M, Scagliotti G. Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from a randomized phase III trial (ESCAPE). J Thorac Oncol 2008; 3: S268.
    • (2008) J Thorac Oncol , vol.3
    • Hanna, N.1    von Pawel, J.2    Reck, M.3    Scagliotti, G.4
  • 41
    • 54249138858 scopus 로고    scopus 로고
    • Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from the phase III, randomized, double-blind, placebo-controlled, ESCAPE (Evaluation of Sorafenib, Carboplatin, and Paclitaxel Efficacy in NSCLC) trial
    • Scagliotti G, von Pawel J, Reck M, Cupit L, Cihon F, DiMatteo S, et al. Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (IA) results from the phase III, randomized, double-blind, placebo-controlled, ESCAPE (Evaluation of Sorafenib, Carboplatin, and Paclitaxel Efficacy in NSCLC) trial. J Thor Oncol 2008; 3: S97-S98.
    • (2008) J Thor Oncol , vol.3
    • Scagliotti, G.1    von Pawel, J.2    Reck, M.3    Cupit, L.4    Cihon, F.5    Dimatteo, S.6
  • 42
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced nonsmall- cell lung cancer: Results from a two-part, double-blind, randomized phase II study
    • Natale R, Bodkin D, Govindan R, Sleckman B, Rizvi N, Capo A, et al. Vandetanib versus gefitinib in patients with advanced nonsmall- cell lung cancer: Results from a two-part, double-blind, randomized phase II study. J Clin Oncol 2009; 27(15): 2523-9.
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2523-2529
    • Natale, R.1    Bodkin, D.2    Govindan, R.3    Sleckman, B.4    Rizvi, N.5    Capo, A.6
  • 44
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst R, Sun Y, Eberhardt W, Germonpré P, Saijo N, Zhou C, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial. Lancet Oncol 2010; 11(7): 619-26.
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.1    Sun, Y.2    Eberhardt, W.3    Germonpré, P.4    Saijo, N.5    Zhou, C.6
  • 45
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of singleagent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein Jr G, Gatzemeier U, Fossella F, Stewart D, Cupit L, Cihon F, et al. Phase II, multicenter, uncontrolled trial of singleagent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 2009; 27(26): 4274-80.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4274-4280
    • Blumenschein, G.1    Gatzemeier, U.2    Fossella, F.3    Stewart, D.4    Cupit, L.5    Cihon, F.6
  • 47
    • 34249093653 scopus 로고    scopus 로고
    • Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer
    • Adjei A, Molina J, Mandrekar S, Marks R, Reid J, Croghan G, et al. Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer. Clin Cancer Res 2007; 13(9): 2684-91.
    • (2007) Clin Cancer Res , vol.13 , Issue.9 , pp. 2684-2691
    • Adjei, A.1    Molina, J.2    Mandrekar, S.3    Marks, R.4    Reid, J.5    Croghan, G.6
  • 51
    • 76749101884 scopus 로고    scopus 로고
    • Antiangiogenic therapy in lung cancer: Focus on vascular endothelial growth factor pathway
    • Korpanty G, Smyth E, Sullivan L, Brekken R, Carney D. Antiangiogenic therapy in lung cancer: Focus on vascular endothelial growth factor pathway. Exp Biol Med 2010; 235(1): 3-9.
    • (2010) Exp Biol Med , vol.235 , Issue.1 , pp. 3-9
    • Korpanty, G.1    Smyth, E.2    Sullivan, L.3    Brekken, R.4    Carney, D.5
  • 52
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib in patients with advanced non-smallcell lung cancer: Results from a phase II study
    • Schiller J, Larson T, Ou S, Limentani S, Sandler A, Vokes E, et al. Efficacy and safety of axitinib in patients with advanced non-smallcell lung cancer: Results from a phase II study. J Clin Oncol 2009; 27(23): 3836-41.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3836-3841
    • Schiller, J.1    Larson, T.2    Ou, S.3    Limentani, S.4    Sandler, A.5    Vokes, E.6
  • 54
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • doi: 10.1093/annonc/mdq618
    • Reck M, Kaiser R, Eschbach C, Stefanic M, Love J, Gatzemeier U, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol 2011; doi: 10.1093/annonc/mdq618.
    • (2011) Ann Oncol
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3    Stefanic, M.4    Love, J.5    Gatzemeier, U.6
  • 55
    • 33847056277 scopus 로고    scopus 로고
    • Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer: A review of the literature
    • Araujo A, Ribeiro R, Azevedo I, Coelho A, Soares M, Sousa B, et al. Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer: A review of the literature. Oncologist 2007; 12(2): 201-10.
    • (2007) Oncologist , vol.12 , Issue.2 , pp. 201-210
    • Araujo, A.1    Ribeiro, R.2    Azevedo, I.3    Coelho, A.4    Soares, M.5    Sousa, B.6
  • 56
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21
    • Zhu C, da Cunha Santos G, Ding K, Sakurada A, Cutz J, Liu N, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21. J Clin Oncol 2008; 26(26): 4268-75.
    • (2008) J Clin Oncol , vol.26 , Issue.26 , pp. 4268-4275
    • Zhu, C.1    da Cunha Santos, G.2    Ding, K.3    Sakurada, A.4    Cutz, J.5    Liu, N.6
  • 57
    • 41149097557 scopus 로고    scopus 로고
    • Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib
    • Miller V, Riely G, Zakowski M, Li A, Patel J, Heelan R, et al. Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J Clin Oncol 2008; 26(9): 1472-8.
    • (2008) J Clin Oncol , vol.26 , Issue.9 , pp. 1472-1478
    • Miller, V.1    Riely, G.2    Zakowski, M.3    Li, A.4    Patel, J.5    Heelan, R.6
  • 58
    • 34147178125 scopus 로고    scopus 로고
    • Key signaling pathways and targets in lung cancer therapy
    • Choong N, Salgia R, Vokes E. Key signaling pathways and targets in lung cancer therapy. Clin Lung Cancer 2008; 8(suppl 2): 52-60.
    • (2008) Clin Lung Cancer , vol.8 , Issue.SUPPL. 2 , pp. 52-60
    • Choong, N.1    Salgia, R.2    Vokes, E.3
  • 59
    • 23944515326 scopus 로고    scopus 로고
    • Intracellular signal transduction pathway proteins as targets for cancer therapy
    • Adjei A, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol 2005; 23(23): 5386-403.
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5386-5403
    • Adjei, A.1    Hidalgo, M.2
  • 60
    • 33847068819 scopus 로고    scopus 로고
    • Understanding the new genetics of responsiveness to epidermal growth factor receptor tyrosine kinase inhibitors
    • Toschi L, Cappuzzo F. Understanding the new genetics of responsiveness to epidermal growth factor receptor tyrosine kinase inhibitors. Oncologist 2007; 12(2): 211-20.
    • (2007) Oncologist , vol.12 , Issue.2 , pp. 211-220
    • Toschi, L.1    Cappuzzo, F.2
  • 62
    • 77953000554 scopus 로고    scopus 로고
    • EGFR Mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry
    • Sholl L, Xiao Y, Joshi V, Yeap B, Cioffredi L, Jackman D, et al. EGFR Mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. Am J Clin Pathol 2010; 133(6): 922-34.
    • (2010) Am J Clin Pathol , vol.133 , Issue.6 , pp. 922-934
    • Sholl, L.1    Xiao, Y.2    Joshi, V.3    Yeap, B.4    Cioffredi, L.5    Jackman, D.6
  • 63
    • 79958020132 scopus 로고    scopus 로고
    • EGFRmutated lung cancer: A paradigm of molecular oncology
    • Zhang Z, Stiegler A, Boggon T, Kobayashi S, Halmos B. EGFRmutated lung cancer: A paradigm of molecular oncology. Oncotarget 2010; 1(7): 497-514.
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 497-514
    • Zhang, Z.1    Stiegler, A.2    Boggon, T.3    Kobayashi, S.4    Halmos, B.5
  • 65
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T, Bell D, Sordella R, Gurubhagavatula S, Okimoto R, Brannigan B, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350(21): 2129-39.
    • (2004) N Engl J Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.1    Bell, D.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.5    Brannigan, B.6
  • 66
    • 33846994719 scopus 로고    scopus 로고
    • The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-smallcell lung cancer
    • Ichihara S, Toyooka S, Fujiwara Y, Hotta K, Shigematsu H, Tokumo M, et al. The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-smallcell lung cancer. Int J Cancer 2007; 120(6): 1239-47.
    • (2007) Int J Cancer , vol.120 , Issue.6 , pp. 1239-1247
    • Ichihara, S.1    Toyooka, S.2    Fujiwara, Y.3    Hotta, K.4    Shigematsu, H.5    Tokumo, M.6
  • 67
    • 77953114837 scopus 로고    scopus 로고
    • A Multicenter Phase II study of erlotinib and sorafenib in chemotherapy-naïve patients with advanced non-small cell lung cancer
    • Lind J, Dingemans A, Groen H, Thunnissen F, Bekers O, Heideman D, et al. A Multicenter Phase II study of erlotinib and sorafenib in chemotherapy-naïve patients with advanced non-small cell lung cancer. Clin Cancer Res 2010; 16(11): 3078-87.
    • (2010) Clin Cancer Res , vol.16 , Issue.11 , pp. 3078-3087
    • Lind, J.1    Dingemans, A.2    Groen, H.3    Thunnissen, F.4    Bekers, O.5    Heideman, D.6
  • 68
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005; 23(28): 6829-37.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3    Tsuta, K.4    Matsuno, Y.5    Tateishi, U.6
  • 69
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch F, Varella-Garcia M, McCoy J, West H, Xavier A, Gumerlock P, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study. J Clin Oncol 2005; 23(28): 6838-85.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6838-6885
    • Hirsch, F.1    Varella-Garcia, M.2    McCoy, J.3    West, H.4    Xavier, A.5    Gumerlock, P.6
  • 70
    • 5644293135 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255
    • Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson B, Jänne P. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res 2004; 64(20): 7241-4.
    • (2004) Cancer Res , vol.64 , Issue.20 , pp. 7241-7244
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3    Meyerson, M.4    Johnson, B.5    Jänne, P.6
  • 71
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause D, Van Etten R. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005; 353(2): 172-87.
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 172-187
    • Krause, D.1    van Etten, R.2
  • 72
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok T, Wu Y, Thongprasert S, Yang C, Chu D, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361(10): 947-57.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.1    Wu, Y.2    Thongprasert, S.3    Yang, C.4    Chu, D.5    Saijo, N.6
  • 73
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010; 362(25): 2380-8.
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 74
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 2010; 11(2): 121-28.
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 75
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebocontrolled phase 3 study
    • Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczésna A, Juhász E, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebocontrolled phase 3 study. Lancet Oncol 2010; 11(6): 521-9.
    • (2010) Lancet Oncol , vol.11 , Issue.6 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3    Cicenas, S.4    Szczésna, A.5    Juhász, E.6
  • 76
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller V, Politi K, Ricly G, Somwar R, Zakowski M, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PloS Med 2005; 2(3): 225-35.
    • (2005) PloS Med , vol.2 , Issue.3 , pp. 225-235
    • Pao, W.1    Miller, V.2    Politi, K.3    Ricly, G.4    Somwar, R.5    Zakowski, M.6
  • 77
    • 77952519096 scopus 로고    scopus 로고
    • Clinical implications of MET gene copy number in lung cancer
    • Toschi L, Cappuzzo F. Clinical implications of MET gene copy number in lung cancer. Future Oncol 2010; 6(2): 239-47.
    • (2010) Future Oncol , vol.6 , Issue.2 , pp. 239-247
    • Toschi, L.1    Cappuzzo, F.2
  • 79
    • 77957031745 scopus 로고    scopus 로고
    • Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitornaive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • Eds., Chicago, USA
    • th annual meeting, Chicago, USA, (2010).
    • (2010) th Annual Meeting
    • Schiller, J.1    Akerley, W.2    Brugger, W.3    Ferrari, D.4    Garmey, E.5    Gerber, D.6
  • 83
    • 41749097667 scopus 로고    scopus 로고
    • A randomized, double-blind, phase IIa dose-finding study of vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
    • Kiura K, Nakagawa K, Shinkai T, Eguchi K, Ohe Y, Yamamoto N, et al. A randomized, double-blind, phase IIa dose-finding study of vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. J Thorac Oncol 2008;3(4):386-93.
    • (2008) J Thorac Oncol , vol.3 , Issue.4 , pp. 386-393
    • Kiura, K.1    Nakagawa, K.2    Shinkai, T.3    Eguchi, K.4    Ohe, Y.5    Yamamoto, N.6
  • 84
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach J, Johnson B, Prager D, Csada E, Roubec J, Pesek M, et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 2007; 25(27): 4270-7.
    • (2007) J Clin Oncol , vol.25 , Issue.27 , pp. 4270-4277
    • Heymach, J.1    Johnson, B.2    Prager, D.3    Csada, E.4    Roubec, J.5    Pesek, M.6
  • 85
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach JV, Paz-Ares L, De Braud F, Sebastian M, Stewart DJ, Eberhardt WEE, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008; 26(33): 5407-15.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    de Braud, F.3    Sebastian, M.4    Stewart, D.J.5    Eberhardt, W.E.E.6
  • 86
    • 0242637170 scopus 로고    scopus 로고
    • Targeting angiogenesis: A review of angiogenesis inhibitors in the treatment of lung cancer
    • Sridhar S, Shepherd F. Targeting angiogenesis: A review of angiogenesis inhibitors in the treatment of lung cancer. Lung Cancer 2003; 42(2): 81-91.
    • (2003) Lung Cancer , vol.42 , Issue.2 , pp. 81-91
    • Sridhar, S.1    Shepherd, F.2
  • 87
    • 68249146507 scopus 로고    scopus 로고
    • Anti-angiogenic therapy using thalidomide combined with chemotherapy in small cell lung cancer: A randomized, doubleblind, placebo-controlled trial
    • Lee S, Woll P, Rudd R, Ferry D, O'Brien M, Middleton G, et al. Anti-angiogenic therapy using thalidomide combined with chemotherapy in small cell lung cancer: A randomized, doubleblind, placebo-controlled trial. J Nat Cancer Inst 2009; 101(15): 1049-57.
    • (2009) J Nat Cancer Inst , vol.101 , Issue.15 , pp. 1049-1057
    • Lee, S.1    Woll, P.2    Rudd, R.3    Ferry, D.4    O'Brien, M.5    Middleton, G.6
  • 88
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous nonsmall- cell lung cancer: Results from a randomised phase III trial (AVAiL)
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous nonsmall- cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol 2010; 21(9): 1804-9.
    • (2010) Ann Oncol , vol.21 , Issue.9 , pp. 1804-1809
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6
  • 89
    • 77955279664 scopus 로고    scopus 로고
    • Bevacizumab in lung cancer: Hurdles in clinical development
    • Pirker R. Bevacizumab in lung cancer: Hurdles in clinical development. Lancet Oncol 2010; 11(8): 703-4.
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 703-704
    • Pirker, R.1
  • 90
    • 70349477817 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • Chicago, USA
    • th annual meeting, Chicago, USA (2009).
    • (2009) th Annual Meeting
    • Miller, V.1    O'Connor, P.2    Soh, C.3    Kabbinavar, F.4
  • 94
    • 77951760333 scopus 로고    scopus 로고
    • A Phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors
    • Rosen P, Sweeney C, Park D, Beaupre D, Deng H, Leitch I, et al. A Phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors. Clin Cancer Res 2010; 16(9): 2677-87.
    • (2010) Clin Cancer Res , vol.16 , Issue.9 , pp. 2677-2687
    • Rosen, P.1    Sweeney, C.2    Park, D.3    Beaupre, D.4    Deng, H.5    Leitch, I.6
  • 95
    • 78549238592 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study of MetMAb, a monovalent antagonist antibody to the receptor MET, in combination with bevacizumab in patients with locally advanced or metastatic solid tumors
    • Chicago, USA
    • Moss R, Bothos J, Filvaroff E, Merchant M, Eppler S, Yu W, et al. Phase Ib dose-escalation study of MetMAb, a monovalent antagonist antibody to the receptor MET, in combination with bevacizumab in patients with locally advanced or metastatic solid tumors. American Society of Clinical Oncology - 10th annual meeting, Chicago, USA, (2010).
    • (2010) American Society of Clinical Oncology - 10th Annual Meeting
    • Moss, R.1    Bothos, J.2    Filvaroff, E.3    Merchant, M.4    Eppler, S.5    Yu, W.6
  • 98
    • 83455199570 scopus 로고    scopus 로고
    • NSCLC: MetMAb+ erlotinib extends survival in subset of lung cancer patients
    • Laino C. NSCLC: MetMAb+ erlotinib extends survival in subset of lung cancer patients. Oncology Times 2010; 32(24): 38-39.
    • (2010) Oncology Times , vol.32 , Issue.24 , pp. 38-39
    • Laino, C.1
  • 99
    • 78650431570 scopus 로고    scopus 로고
    • New insights on personalized cancer treatments: A report from the ESMO Congress
    • Ciardiello F, Jezdic S. New insights on personalized cancer treatments: A report from the ESMO Congress. Expert Rev Anticancer Ther 2011; 11(1): 21-23.
    • (2011) Expert Rev Anticancer Ther , vol.11 , Issue.1 , pp. 21-23
    • Ciardiello, F.1    Jezdic, S.2
  • 100
    • 0036645063 scopus 로고    scopus 로고
    • Novel targets for lung cancer therapy: Part I
    • Dy G, Adjei A. Novel targets for lung cancer therapy: Part I. J ClinOncol 2002; 20(12): 2881-94.
    • (2002) J ClinOncol , vol.20 , Issue.12 , pp. 2881-2894
    • Dy, G.1    Adjei, A.2
  • 101
    • 70349499022 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors
    • Jain L, Vargo CA, Danesi R, Sissung TM, Price DK, Venzon D, et al. The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors. Mol Cancer Ther 2009; 8(9): 2496-508.
    • (2009) Mol Cancer Ther , vol.8 , Issue.9 , pp. 2496-2508
    • Jain, L.1    Vargo, C.A.2    Danesi, R.3    Sissung, T.M.4    Price, D.K.5    Venzon, D.6
  • 103
    • 38949126951 scopus 로고    scopus 로고
    • Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer
    • Zhai R, Liu G, Zhou W, Su L, Heist R, Lynch T, et al. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008; 14(2): 612-7.
    • (2008) Clin Cancer Res , vol.14 , Issue.2 , pp. 612-617
    • Zhai, R.1    Liu, G.2    Zhou, W.3    Su, L.4    Heist, R.5    Lynch, T.6
  • 104
    • 18744409046 scopus 로고    scopus 로고
    • Role of genetic polymorphisms in tumour angiogenesis
    • Balasubramanian S, Brown N, Reed M. Role of genetic polymorphisms in tumour angiogenesis. Br J Cancer 2002; 87(10): 1057-65.
    • (2002) Br J Cancer , vol.87 , Issue.10 , pp. 1057-1065
    • Balasubramanian, S.1    Brown, N.2    Reed, M.3
  • 105
    • 3242717786 scopus 로고    scopus 로고
    • Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma
    • Howell W, Bateman A, Turner S, Collins A, Theaker J. Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma. Genes Immun 2002; 3(4): 229-32.
    • (2002) Genes Immun , vol.3 , Issue.4 , pp. 229-232
    • Howell, W.1    Bateman, A.2    Turner, S.3    Collins, A.4    Theaker, J.5
  • 106
    • 0037096738 scopus 로고    scopus 로고
    • Influence of cytokine gene polymorphisms on the development of prostate cancer
    • McCarron S, Edwards S, Evans P, Gibbs R, Dearnaley D, Dowe A, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res 2002; 62(12): 3369-72.
    • (2002) Cancer Res , vol.62 , Issue.12 , pp. 3369-3372
    • McCarron, S.1    Edwards, S.2    Evans, P.3    Gibbs, R.4    Dearnaley, D.5    Dowe, A.6
  • 107
    • 8444239305 scopus 로고    scopus 로고
    • VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
    • Koukourakis M, Papazoglou D, Giatromanolaki A, Bougioukas G, Maltezos E, Siviridis E. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer 2004; 46(3): 293-98.
    • (2004) Lung Cancer , vol.46 , Issue.3 , pp. 293-298
    • Koukourakis, M.1    Papazoglou, D.2    Giatromanolaki, A.3    Bougioukas, G.4    Maltezos, E.5    Siviridis, E.6
  • 108
    • 39749096242 scopus 로고    scopus 로고
    • VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
    • Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, et al. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008; 26(6): 856-62.
    • (2008) J Clin Oncol , vol.26 , Issue.6 , pp. 856-862
    • Heist, R.S.1    Zhai, R.2    Liu, G.3    Zhou, W.4    Lin, X.5    Su, L.6
  • 109
    • 70350622991 scopus 로고    scopus 로고
    • The positive correlation between gene expression of the two angiogenic factors: VEGF and BMP-2 in lung cancer patients
    • Bieniasz M, Oszajca K, Eusebio M, Kordiak J, Bartkowiak J, Szemraj J. The positive correlation between gene expression of the two angiogenic factors: VEGF and BMP-2 in lung cancer patients. Lung Cancer. 2009; 66(3): 319-26.
    • (2009) Lung Cancer , vol.66 , Issue.3 , pp. 319-326
    • Bieniasz, M.1    Oszajca, K.2    Eusebio, M.3    Kordiak, J.4    Bartkowiak, J.5    Szemraj, J.6
  • 110
    • 77953937410 scopus 로고    scopus 로고
    • Polymorphisms in EGFR and VEGF contribute to non-small cell lung cancer survival in a Chinese Population
    • Dong J, Dai J, Shu Y, Pan S, Xu L, Chen W, et al. Polymorphisms in EGFR and VEGF contribute to non-small cell lung cancer survival in a Chinese Population. Carcinogenesis 2010; 31(6): 1080-6.
    • (2010) Carcinogenesis , vol.31 , Issue.6 , pp. 1080-1086
    • Dong, J.1    Dai, J.2    Shu, Y.3    Pan, S.4    Xu, L.5    Chen, W.6
  • 112
    • 70349585443 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor polymorphisms on survival in advanced stage non small cell lung cancer
    • Masago K, Fujita S, Kim Y, Hatachi Y, Fukuhara A, Nagai H, et al. Effect of vascular endothelial growth factor polymorphisms on survival in advanced stage non small cell lung cancer. Cancer Sci 2009; 100(10): 1917-22.
    • (2009) Cancer Sci , vol.100 , Issue.10 , pp. 1917-1922
    • Masago, K.1    Fujita, S.2    Kim, Y.3    Hatachi, Y.4    Fukuhara, A.5    Nagai, H.6
  • 113
    • 0033865580 scopus 로고    scopus 로고
    • Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: Correlation with variation in VEGF protein production
    • Watson C, Webb N, Bottomley M, Brenchley P. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: Correlation with variation in VEGF protein production. Cytokine 2000; 12(8): 1232-35.
    • (2000) Cytokine , vol.12 , Issue.8 , pp. 1232-1235
    • Watson, C.1    Webb, N.2    Bottomley, M.3    Brenchley, P.4
  • 114
    • 0036138599 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection
    • Shahbazi M, Fryer A, Pravica V, Brogan I, Ramsay H, Hutchinson I, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 2002; 13(1): 260-4.
    • (2002) J Am Soc Nephrol , vol.13 , Issue.1 , pp. 260-264
    • Shahbazi, M.1    Fryer, A.2    Pravica, V.3    Brogan, I.4    Ramsay, H.5    Hutchinson, I.6
  • 115
    • 0037442985 scopus 로고    scopus 로고
    • Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
    • Stevens A, Soden J, Brenchley P, Ralph S, Ray D. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 2003; 63(4): 812-6.
    • (2003) Cancer Res , vol.63 , Issue.4 , pp. 812-816
    • Stevens, A.1    Soden, J.2    Brenchley, P.3    Ralph, S.4    Ray, D.5
  • 116
    • 63049132774 scopus 로고    scopus 로고
    • First-line gefitinib for patients with advanced non-smallcell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
    • Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, et al. First-line gefitinib for patients with advanced non-smallcell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol 2009; 27(9): 1394-400.
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1394-1400
    • Inoue, A.1    Kobayashi, K.2    Usui, K.3    Maemondo, M.4    Okinaga, S.5    Mikami, I.6
  • 117
    • 0036384579 scopus 로고    scopus 로고
    • Prognostic factors in nonsmall cell lung cancer
    • Brundage M, Davies D, Mackillop W. Prognostic factors in nonsmall cell lung cancer. Chest 2002; 122(3): 1037-57.
    • (2002) Chest , vol.122 , Issue.3 , pp. 1037-1057
    • Brundage, M.1    Davies, D.2    Mackillop, W.3


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