Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: Correlation with variation in VEGF protein production

Cytokine

Volumn 12, Issue 8, 2000, Pages 1232-1235

  Watson, Carolyn J ^a   Webb, Nicholas J A ^b   Bottomley, Martyn J ^a   Brenchley, Paul E C ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Genotype; LPS; PBMCs; Polymorphism; VEGF

Indexed keywords

LIPOPOLYSACCHARIDE; PROTEIN; VASCULOTROPIN;

ARTICLE; CIS TRANS ISOMERISM; DELETION MUTANT; ETIOLOGY; EXON; FEMALE; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; NORMAL HUMAN; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0033865580     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0692     Document Type: Article

References (15)

1. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 77:1999;527-543.
2. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13:1999;9-22.
3. Watson CJ, Webb NJA, Bottomley MJ, Brenchley PEC. Peripheral mononuclear cells express VEGF and the VEGF receptor flt-1. J Amer Soc Nephrol. 7:1996;A2390.
4. Claffey KP, Robinson GS. Regulation of VEGF/VPF expression in tumour cells: consequences for tumour growth and metastasis. Cancer Metastasis Rev. 15:1996;165-176.
5. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol. 152:1994;4149-4156.
6. Miller JW, Adamis AP, Aiello LP. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev. 13:1997;37-50.
7. Schultz A, Lavie L, Hochberg I, Beyar R, Stone T, Skorecki K, Lavie P, Roguin A, Levy AP. Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of coronary artery collateral circulation. Circulation. 100:1999;547-552.
8. Webb NJA, Bottomley MJ, Watson CJ, Brenchley PEC. Vascular endothelial growth factor (VEGF) is released from platelets during clotting : implications for measurement of circulating levels in clinical disease. Clin Sci. 94:1998;395-404.
9. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor: multiple protein forms are encoded through alternative exon splicing. J Biol Chem. 266:1991;11947-11954.
10. Webb NJA, Watson CJ, Roberts ISD, Bottomley MJ, Jones CA, Lewis MA, Postlethwaite RJ, Brenchley PEC. Circulating vascular endothelial growth factor is not increased during relapses of steroid-sensitive nephrotic syndrome. Kidney Int. 55:1999;1063-1071.
11. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, Kel OV, Ignatieva EV, Ananko EA, Podkolodnaya OA, Kolpakov FA, Podkolodny NL, Kolchanov NA. Databases on transcription regulation: TRANSFAC, TRRD and COMPEL. Nucl Acids Res. 26:1998;364-370.
12. Lenny N, Westendorf JJ, Hiebert SW. Transcriptional regulation of myelopoiesis. Mol Biol Rep. 24:1997;157-168.
13. Hromas R, Davis B, Rauscher FJ III, Klemsz M, Tenen D, Hoffman S, Xu D, Morris JF. Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1. Curr Top Microbiol Immunol. 211:1996;159-164.
14. Watson CJ, Webb NJA, Bottomley MJ, Brenchley PEC. Polymorphisms in the vascular endothelial growth factor gene (VEGF) promoter are not associated with the development of proteinuria in minimal change nephrotic syndrome (MCNS) and focal segmental glomerular sclerosis (FSGS). J Amer Soc Nephrol. 9:1998;A2497.
15. Bottomley MJ, Webb NJA, Watson CJ, Holt L, Bukhari M, Denton J, Freemont AJ, Brenchley PEC. Placenta growth factor (PlGF) induces vascular endothelial growth factor (VEGF) secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid. Clin Exp Immunol. 119:2000;182-188.