Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: Critical contribution of kringle-4 revealed by the mutagenesis approaches

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1824, Issue 2, 2012, Pages 326-333

  Joshi, Kishore K ^a   Nanda, Jagpreet S ^a   Kumar, Prakash ^a   Sahni, Girish ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

Catalysis; Fibrinolytic system; Pichia pastoris; Plasminogen; Plasminogen activator; Streptokinase

Indexed keywords

KRINGLE 5 PROTEIN; PEPTIDE; PLASMA PROTEIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; PROTEIN K1K5CD; PROTEIN K2K5CD; PROTEIN K3K5CD; PROTEIN K4K5CD; PROTEIN K5CD; SCISSILE PEPTIDE; STREPTOKINASE; TETRANECTIN; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; EUKARYOTE; GENETIC VARIABILITY; KRINGLE DOMAIN; MEDIATOR; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROKARYOTE; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BIOCATALYSIS; CATALYTIC DOMAIN; ENZYME ACTIVATION; FIBRINOLYSIN; HUMANS; KRINGLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PICHIA; PLASMINOGEN; PLASMINOGEN ACTIVATORS; PROTEIN BINDING; RECOMBINANT PROTEINS; STREPTOKINASE; SUBSTRATE SPECIFICITY;

EUKARYOTA; PICHIA PASTORIS; PROKARYOTA;

EID: 83455178215     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2011.10.010     Document Type: Article

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