Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg 253, Lys 256 and Lys 257 in the streptokinase β-domain and kringle 5 of the substrate

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19511-19521

  Tharp, Anthony C ^a   Laha, Malabika ^a   Panizzi, Peter ^a,c   Thompson, Michael W ^a,d   Fuentes Prior, Pablo ^b   Bock, Paul E ^a,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MIDDLE TENNESSEE STATE UNIVERSITY   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIMOLECULAR RATE CONSTANTS; CATALYTIC COMPLEXES; CHARGED RESIDUES; COOH-TERMINAL; DOUBLE MUTANTS; KINETIC STUDY; LYSINE-BINDING SITES; MOLECULAR MODELS; STRUCTURAL ELEMENTS; SUBSTRATE RECOGNITION; TERNARY COMPLEX;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; LABELS; RATE CONSTANTS;

SUBSTRATES;

ALANINE; ARGININE; ENZYME PRECURSOR; FLUORESCENT DYE; LYSINE; PLASMIN; PLASMINOGEN; STREPTOKINASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; COW; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; FIBRINOLYSIS; HUMAN; HUMAN CELL; KRINGLE DOMAIN; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION;

ALGORITHMS; ANIMALS; ARGININE; BINDING SITES; CATALYSIS; CATTLE; DRUG COMBINATIONS; HUMANS; KINETICS; KRINGLES; LYSINE; MODELS, MOLECULAR; MUTATION; PLASMINOGEN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STREPTOKINASE; SUBSTRATE SPECIFICITY;

BOVINAE;

EID: 67749114693     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005512     Document Type: Article

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