Bacterial plasminogen activators and receptors

FEMS Microbiology Reviews

Volumn 25, Issue 5, 2001, Pages 531-552

  Lähteenmäki, Kaarina ^a   Kuusela, Pentti ^a,b   Korhonen, Timo K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Bacterial metastasis; Plasmin; Plasminogen; Plasminogen activation; Plasminogen receptor

Indexed keywords

BACTERIAL PROTEIN; FIBRIN; PLASMIN; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR; PROCOLLAGENASE; PROTEINASE; SERINE PROTEINASE; STAPHYLOKINASE; STREPTOKINASE;

ARTICLE; ENZYME DEGRADATION; ENZYME RELEASE; EXTRACELLULAR MATRIX; FIMBRIA; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE TYPE A; NONHUMAN; PLASMINOGEN ACTIVATION; PROTEIN DEGRADATION; SALMONELLA TYPHIMURIUM; STREPTOCOCCUS PNEUMONIAE; TISSUE INJURY; YERSINIA PESTIS;

BACTERIA (MICROORGANISMS); BORRELIA; BORRELIA BURGDORFERI; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; MAMMALIA; NEGIBACTERIA; POSIBACTERIA; PROKARYOTA; SALMONELLA TYPHIMURIUM; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS SP. 'GROUP A'; YERSINIA; YERSINIA PESTIS;

EID: 0035666854     PISSN: 01686445     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-6445(01)00067-5     Document Type: Review

References (250)

1. Are bacterial proteinases pathogenic factors?
2. Proteases and bacterial virulence: A view from the trenches
3. Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease
4. The contact system: A proinflammatory pathway with antithrombotic activity
5. Activation of the contact-phase system on bacterial surfaces - A clue to serious complications in infectious diseases
6. Plasminogen activation and regulation of pericellular proteolysis
7. Plasminogen
8. Mechanisms of physiological fibrinolysis
9. Human plasminogen
10. Molecular mechanisms of plasminogen activation: Bacterial cofactors provide clues
11. Physico-chemical and proenzyme properties of NH2-terminal glutamic acid and NH2-terminal lysine human plasminogen. Influence of 6-aminohexanoic acid
12. Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic acid
13. Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-Å resolution
14. Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen
15. Crystal structure of the proenzyme domain of plasminogen
16. The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action
17. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation
18. Receptors for plasminogen and tPA: An update
19. Characterization of an extremely large, ligand-induced conformational change in plasminogen
20. Plasminogen activators, tissue degradation, and cancer
21. Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors
22. Plasminogen activators and plasminogen activator inhibitors: Biochemical aspects
23. The 2.3 Å crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator
24. The crystal structure of the catalytic domain of human urokinase-type plasminogen activator
25. The receptor-binding sequence of urokinase: A biological function for the growth-factor module of proteases
26. Common evolutionary origin of the fibrin-binding structures of fibronectin and tissue-type plasminogen activator
27. Involvement of finger domain and kringle 2 domain of tissue-type plasminogen activator in fibrin binding and stimulation of activity by fibrin
28. Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes
29. A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase
30. Human plasma proteinase inhibitors
31. Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins
32. The serpin-proteinase complex revealed
33. Cell-associated plasminogen activation: Regulation and physiological functions
34. On the mechanism of the reaction between human α2-antiplasmin and plasmin
35. On the specific interaction between the lysine-binding sites in plasmin and complementary sites in α2-antiplasmin and in fibrinogen
36. The cell biology of the plasminogen system
37. Role of cell-surface lysines in plasminogen binding to cells: Identification of α-enolase as a candidate plasminogen receptor
38. The role of an enolase-related molecule in plasminogen binding to cells
39. An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II
40. An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation
41. Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin
42. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides
43. Regulation of cell migration by amphoterin
44. Studies on the kinetics of plasminogen activation by tissue plasminogen activator
45. Binding of plasminogen to extracellular matrix
46. Laminin interacts with plasminogen and its tissue-type activator
47. Plasminogen and tissue-type plasminogen activator bind to immobilized fibronectin
48. Specific binding of plasminogen to vitronectin
49. Limited plasmin proteolysis of vitronectin
50. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
51. Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: A localized and regulated proteolytic system
52. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
53. Biology and biochemistry of proteinases in tumor invasion
54. Antibodies to plasminogen activator inhibit human tumor metastasis
55. Inhibition of urokinase-type plasminogen activator by antibodies: The effect on dissemination of a human tumor in the nude mouse
56. Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: Cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals
57. Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture
58. Induction of morphological differentiation of human neuroblastoma cells is accompanied by induction of tissue-type plasminogen activator
59. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction
60. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility
61. Plasminogen activator inhibitor-1 gene deficient mice. I. Generation by homologous recombination and characterization
62. Physiological consequences of loss of plasminogen activator gene function in mice
63. Generation and characterization of urokinase receptor-deficient mice
64. Plasminogen and cell migration in vivo
65. Binding of human plasminogen to basement-membrane (type IV) collagen
66. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane
67. Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator
68. Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator
69. Control of type IV collagenase activity by components of the urokinase-plasmin system: A regulatory mechanism with cell-bound reactants
70. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages
71. Borrelia burgdorferi induces secretion of pro-urokinase-type plasminogen activator by human monocytes
72. Staphylococcus aureus stimulates urokinase-type plasminogen activator expression by bovine mammary cells
73. A protease of Bacteroides gingivalis degrades cell surface and matrix glycoproteins of cultured gingival fibroblasts and induces secretion of collagenase and plasminogen activator
74. Plasminogen activator inhibitor 1 and 2, alpha-2-antiplasmin, plasminogen, and endotoxin levels in systemic meningococcal disease
75. Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects
76. Endotoxin stimulates expression of the murine urokinase receptor gene in vivo
77. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia
78. Borrelia burgdorferi and other bacterial products induce expression and release of the urokinase receptor (CD87)
79. Mediators of inflammation and the treatment of bacterial meningitis
80. Cytokine responses during mucosal infections: Role in disease pathogenesis and host defence
81. Expression of and cytokine activation by Escherichia coli curli fibers in human sepsis
82. Intracellular localization of human monocyte associated interleukin (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin
83. Interleukin-1 beta up-regulates the plasminogen activator/plasmin system in human mesangial cells
84. Dexamethasone attenuation of cytokine-mediated articular cartilage degradation in experimental lapine Haemophilus arthritis
85. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential
86. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase
87. Polymorphism of the streptokinase gene: Implications for the pathogenesis of post-streptococcal glomerulonephritis
88. Genetics and pathogenicity factors of group C and G streptococci
89. Plasminogen activation by streptokinase via a unique mechanism
90. 2-antiplasmin
91. 2-antiplasmin
92. A characterization of native streptokinase and altered streptokinase isolated from a human plasminogen activator complex
93. Streptokinases produced by pathogenic group C streptococci demonstrate species-specific plasminogen activation
94. Analysis of plasminogen-binding M proteins of Streptococcus pyogenes
95. Mechanism of activation of human plasminogen by streptokinase. Presence of active center in streptokinase-plasminogen complex
96. Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity
97. Function of streptokinase fragments in plasminogen activation
98. Asp41-His48 region of streptokinase is important in binding a substrate plasminogen
99. Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis
100. Staphylokinase: A potent, uniquely fibrin-selective thrombolytic agent
101. Extracellular enzymes from Staphylococcus aureus
102. Primary structure and gene structure of staphylokinase
103. Cloning and expression of the staphylokinase gene of Staphylococcus aureus in Escherichia coli
104. Cloning and expression in Escherichia coli, Bacillus subtilis, and Streptococcus sanguis of a gene for staphylokinase - A bacterial plasminogen activator
105. Isolation and characterization of natural and recombinant staphylokinase
106. A novel variant of staphylokinase gene from Staphylococcus aureus ATCC 29213
107. Production of staphylokinase and hemolysin by coagulase-negative Staphylococcus
108. Characterization of the interaction between plasminogen and staphylokinase
109. 2-terminal structural motifs in staphylokinase required for plasminogen activation
110. Effects of fibrin and alpha2-antiplasmin on plasminogen activation by staphylokinase
111. Interactions between staphylokinase, plasmin(ogen), and fibrin. Staphylokinase discriminates between free plasminogen and plasminogen bound to partially degraded fibrin
112. Structural and functional basis of plasminogen activation by staphylokinase
113. Structure-function relationships in staphylokinase as revealed by 'clustered charge to alanine' mutagenesis
114. Role of staphylokinase in the acquisition of plasmin(ogen)-dependent enzymatic activity by staphylococci
115. A surface protease and the invasive character of plague
116. Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis
117. Nucleotide sequence of the plasminogen activator gene of Yersinia pestis: Relationship to ompT of Escherichia coli and gene E of Salmonella typhimurium
118. A PhoP-regulated outer membrane protease of Salmonella enterica serovar Typhimurium promotes resistance to alpha-helical antimicrobial peptides
119. Activation of plasminogen to plasmin by a protease associated with the outer membrane of Escherichia coli
120. Prevalence of ompT among Escherichia coli isolates of human origin
121. Enhancement of tissue plasminogen activator-catalyzed plasminogen activation by Escherichia coli S fimbriae associated with neonatal septicaemia and meningitis
122. Bacterial plasminogen receptors: In vitro evidence for a role in degradation of the mammalian extracellular matrix
123. 2-antiplasmin in the surface protease Pla of Yersinia pestis
124. A novel activity of OmpT. Proteolysis under extreme denaturing conditions
125. OmpT in Escherichia coli correlates with severity of disease in urinary tract infections
126. Identification of OmpT as the protease that hydrolyzes the antimicrobial peptide protamine before it enters growing cells of Escherichia coli
127. SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri
128. Omptin: An Escherichia coli outer membrane proteinase that activates plasminogen
129. In vitro folding, purification and characterization of Escherichia coli outer membrane protease OmpT
130. Identification of active site serine and histidine residues in Escherichia coli outer membrane protease OmpT
131. Expression of the plague plasminogen activator in Yersinia pseudotuberculosis and Escherichia coli
132. Yersinia pestis - Etiologic agent of plague
133. Adhesive properties conferred by the plasminogen activator of Yersinia pestis
134. Expression of plasminogen activator Pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix
135. Pesticins. III. Expression of coagulase and mechanism of fibrinolysis
136. Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice
137. A Yersinia pestis-specific DNA fragment encodes temperature-dependent coagulase and fibrinolysin-associated phenotypes
138. Mutation in the pla gene of Yersinia pestis alters the course of the plague bacillus-flea (Siphonaptera: Ceratophyllidae) interaction
139. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins
140. Activation of bovine plasminogen by Streptococcus uberis
141. Purification of a plasminogen activator from Streptococcus uberis
142. Streptococcus uberis acquires plasmin activity following growth in the presence of bovine plasminogen through the action of its specific plasminogen activator
143. PauA: A novel plasminogen activator from Streptococcus uberis
144. The auxotrophic nature of Streptococcus uberis: The acquisition of essential amino acids from plasmin derived casein peptides
145. Binding and activation of human plasminogen by Mycobacterium tuberculosis
146. Degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from Porphyromonas gingivalis and Treponema denticola
147. Identification of two laminin-binding fimbriae, the type-1 fimbria of Salmonella enterica serovar typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors
148. Binding of human urokinase type plasminogen activator and plasminogen to Borrelia species
149. Analysis of plasmin(ogen) acquisition by clinical isolates of group A streptococci incubated in human plasma
150. Binding of plasminogen to Neisseria meningitidis and Neisseria gonorrhoeae and formation of surface-associated plasmin
151. Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases
152. Identification of a plasminogen-binding motif in PAM, a bacterial surface protein
153. Identification of a specific receptor for plasmin on a group A streptococcus
154. Characterization of the interaction of human plasmin with its specific receptor on a group A streptococcus
155. Group A streptococci bind human plasmin but not other structurally related proteins
156. Mapping of the human plasmin domain recognized by the unique plasmin receptor of group A streptococci
157. New receptor for human plasminogen on gram positive cocci
158. Two types of receptors for human plasminogen on group G streptococci
159. Tissue-type plasminogen activator-mediated activation of plasminogen on the surface of group A, C, and G streptococci
160. PAM, a novel plasminogen-binding protein from Streptococcus pyogenes
161. Binding and activation of plasminogen at the surface of Staphylococcus aureus: Increase in affinity after conversion to the Lys form of the ligand
162. Surface-associated activation of plasminogen on gram-positive bacteria: Effect of plasmin on the adherence of Staphylococcus aureus
163. Binding of plasminogen to Escherichia coli adhesion proteins
164. Enhancement of tissue plasminogen activator-catalyzed plasminogen activation by Escherichia coli S fimbriae associated with neonatal septicaemia and meningitis
165. Immobilization of plasminogen on Escherichia coli flagella
166. Plasminogen, absorbed by Escherichia coli expressing curli or by Salmonella enteritidis expressing thin aggregative fimbriae, can be activated by simultaneously captured tissue-type plasminogen activator (tPA)
167. Receptors for human plasminogen on Gram-negative bacteria
168. Binding of human plasminogen and urokinase-type plasminogen activator to the Lyme disease spirochete, Borrelia burgdorferi
169. Binding of human plasminogen to Borrelia burgdorferi
170. Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers
171. Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment
172. Binding of vitronectin and plasminogen to Helicobacter pylori
173. Binding of human plasminogen and lactoferrin by Helicobacter pylori coccoid forms
174. Plasminogen binding and activation at the surface of Helicobacter pylori CCUG 17874
175. Mycoplasma cells stimulate in vitro activation of plasminogen by purified tissue-type plasminogen activator
176. Plasminogen binding and activation by Mycoplasma fermentans
177. Acquisition of plasmin activity by Fusobacterium nucleatum subsp. nucleatum and potential contribution to tissue destruction during periodontitis
178. Isolation of a prokaryotic plasmin receptor: Relationship to a plasminogen activator produced by the same micro-organism
179. Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptor
180. The plasmin-binding protein Plr of group A streptococci is identified as glyceraldehyde-3-phosphate dehydrogenase
181. 334 as essential for plasmin binding, but mutation of the plr gene does not reduce plasmin binding to group A streptococci
182. Cloning, sequencing and functional overexpression of the Streptococcus equisimilis H46A gapC gene encoding a glyceraldehyde-3-phosphate dehydrogenase that also functions as a plasmin(ogen)-binding protein
183. A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity
184. Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes
185. Kringle 2 mediates high affinity binding of plasminogen to an internal sequence in streptococcal surface protein PAM
186. Streptokinase activates plasminogen bound to human group C and G streptococci through M-like proteins
187. Streptococcal M protein: Molecular design and biological behaviour
188. A role for the fibrinogen-binding regions of streptococcal M proteins in phagocytosis resistance
189. α-Enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci
190. Basement membrane carbohydrate as a target for bacterial adhesion: Binding of type 1 fimbriae of Salmonella enterica and Escherichia coli to laminin
191. Sialyloligosaccharide chains of laminin as an extracellular matrix target for S fimbriae of Escherichia coli
192. The GafD protein of the G (F17) fimbrial complex confers adhesiveness of Escherichia coli to laminin
193. Amino-acid residue Ala-62 in the FimH fimbrial adhesin is critical for the adhesiveness of meningitis-associated Escherichia coli to collagens
194. Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli
195. Purification and characterisation of a plasminogen-binding protein from Haemophilus influenzae. Sequence determination reveals identity with aspartase
196. The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor
197. Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi
198. Cell-to-cell signalling between group A streptococci and pharyngeal cells. Role of streptococcal surface dehydrogenase (SDH)
199. Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: Signal transduction between streptococci and pharyngeal cells
200. Purification of the plasmin receptor from human carcinoma cells and comparison to alpha-enolase
201. Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane
202. Autoantibodies to the centrosome (centriole) react with determinants present in the glycolytic enzyme enolase
203. Antibodies to streptococcal surface enolase react with human alpha-enolase: Implications in poststreptococcal sequelae
204. Selective distribution of a high-affinity plasminogen-binding site among group A streptococci associated with impetigo
205. Different alleles of the fcrA/mrp gene of Streptococcus pyogenes encode M-related proteins exhibiting an identical immunoglobulin-binding pattern
206. Interaction of group A streptococci with human plasmin(ogen) under physiological conditions
207. Bacterial pili: Molecular mechanisms of pathogenesis
208. Bacterial adhesins: Function and structure
209. Bacterial proteins binding to the mammalian extracellular matrix
210. The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding protein
211. Binding of bacterial adhesins to rat glomerular mesangium in vivo
212. Microbial adhesins recognizing extracellular matrix macromolecules
213. Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin
214. Penetration of fimbriate enteric bacteria through basement membranes: A hypothesis
215. Capturing host plasmin(ogen): A common mechanism for invasive pathogens?
216. Plasminogen activation by invasive human pathogens
217. Use of the plasminogen activation system by microorganisms
218. Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice
219. Plasmin-coated Borrelia burgdorferi degrades soluble and insoluble components of the mammalian extracellular matrix
220. The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis
221. Interaction of Haemophilus influenzae with the mammalian extracellular matrix
222. Interaction between group A streptococci and the plasmin(ogen) system promotes virulence in a mouse skin infection model
223. Species specificity of plasminogen activation and acquisition of surface-associated proteolytic activity by group C streptococci grown in plasma
224. The potential role for nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis
225. Biochemical interactions of tumor cells with the basement membrane
226. Metastatic infection secondary to genitourinary tract sepsis
227. Plasminogen activation in degradation and penetration of extracellular matrices and basement membranes by invasive bacteria
228. Surface bound plasmin promotes migration of Streptococcus pneumoniae through reconstituted basement membranes
229. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma
230. Basement membrane complexes with biological activity
231. Basement membrane structure in situ: Evidence for lateral associations in the type IV collagen network
232. A rapid in vitro assay for quantitating the invasive potential of tumor cells
233. A new in vitro assay for quantitating tumor cell invasion
234. Hydrophobic domains affect the collagen-binding specificity and surface polymerization as well as the virulence potential of the YadA protein of Yersinia enterocolitica
235. Identification of the 72-kDa (MMP-2) and 92-kDa (MMP-9) gelatinase/type IV collagenase in preparations of laminin and Matrigel
236. Identification of plasminogen in Matrigel and its activation by reconstitution of this basement membrane extract
237. Activation of interstitial collagenase, MMP-1, by Staphylococcus aureus cells having surface-bound plasmin: A novel role of plasminogen receptors of bacteria
238. Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase 1 (MMP-1) in human cells
239. Vaccination with the plasminogen activator from Streptococcus uberis induces an inhibitory response and protects against experimental infection in the dairy cow
240. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases
241. Activation of latent collagenase by microbial plaque
242. Degradation of the human proteinase inhibitors alpha-1-antitrypsin and alpha-2-macroglobulin by Bacteroides gingivalis
243. Induction of MMP-9 mediated gelatinolytic activity in human monocytic cells by cell wall components of Mycobacterium tuberculosis
244. Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae
245. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis
246. Differential expression of matrix metalloproteinases in bacterial meningitis
247. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
248. Pathogenic potentials of bacterial proteases
249. 1-proteinase inhibitor by selected bacterial proteinases