Characterization of IgG monoclonal anti-cardiolipin/anti-β2GP1 antibodies from two patients with antiphospholipid syndrome reveals three species of antibodies

British Journal of Haematology

Volumn 105, Issue 1, 1999, Pages 102-109

  Zhu, Mln ^a   Olee, Tsaiwei ^a   Dzung, T L E ^a,b   Roubey, Robert A S ^b   Hahn, Devra H ^c   Woods Jr , Vlrgil L ^d   Chen, Pojen P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Medicine ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

2 glycoprotein 1; Anti cardiolipin antibody; Antiphospholipid antibody; Antiphospholipid syndrome; Lupus anticoagulant

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ADOLESCENT; ADULT; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTIGEN BINDING; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CASE REPORT; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTIBODIES; ANTIBODIES, ANTICARDIOLIPIN; ANTICOAGULANTS; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN G; LUPUS COAGULATION INHIBITOR; MALE;

EID: 0032892020     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1999.01292.x     Document Type: Article

References (42)

1. Amengual, O., Atsumi. T., Khamashta, M.A. & Hughes, G.R.V. (1998) The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thrombosis and Haemostasis, 79, 276-281.
2. Arvieux. J., Darnige, L., Hachulla, E., Roussel, B., Bensa, J.C. & Colomb, M.G. (1996) Species specificity of anti-b2 glycoprotein I autoantibodies and its relevance to anticardiolipin antibody quantitation. Thrombosis and Haemostasis, 75. 725-730.
3. Borrell, M., Sala, N., de Castellanau. C., Lopez, S., Gari, M. & Foncuberta, J. (1992) Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent the inactivation of factor Va by activated protein C on human cndothelial cells. Thrombosis and Haemostasis, 68, 268-272.
4. Cariou. R., Tobelem. G., Bellucci. S., Soria, J., Soria, C., Maclouf, J. & Caen, J. (1988) Effect of lupus anticoagulant on antithrombogenic properties of cndothelial cells: inhibition of thrombomodulin-dependent protein C activation. Thrombosis and Haemostasis, 60, 54-58.
5. Cuadrado, M.J., Löpez-Pedrera, C., Khamashta, M.A., Camps, M.T., Tinahones, F., Torres. A., Hughes, G.R.V. & Velasco, F. (1997) Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis and Rheumatism, 40, 834-841.
6. 2-gIycoprotein I and induce endothelial activation. Arthritis ami Rheumatism, 40, 551-561.
7. Exner, T., Rickard, K.A. & Kronenberg, H. (1978) A sensitive test demonstrating lupus anticoagulant .and its behavioural patterns. British Journal of Haematologij, 40, 143-151.
8. Galli, M., Ruggeri, L & Barbui, T. (1998) Differential effects of anti-b2-glycoprotein I and antiprothrombin antibodies on the anticoagulant activity of activated protein C. Blood, 91, 1999-2004.
9. Harmer, I.J., Loizou, S., Thompson, K.M., So, A.K.L., Walport, M.J. & Mackworth-Young, C. (1995) A human monoclonal anti-phospholipid antibody that is representative of serum antibodies and is gcrmline encoded. Arthritis and Rheumatism. 38, 1068-1076.
10. Harris, E.N., Gharavi, A.E., Boey, M.L., Patel, B.M., Mackworth-Young, G.G., Loizou, S. & Hughes. G.R. (1983) Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet, ii, 1211-1214.
11. Harris, E.N. & Pierangeli, S.S. (1994) Antiphospholipkl antibodies and the antiphospholipid syndrome. Springer Seminars in Imimmopathology, 16, 223-245.
12. Harris, E.N., Pierangeli, S.S. & Birch. D.J. (1994) Anticardiolipin Wet Workshop report: Vth International Symposium on Antiphospholipid Antibodies. American Journal of Clinical Pathology, 101, 616-624.
13. Hasegawa, I., Suzuki, T., Ishii, S., Takakuwa, K. & Tanaka, K. (1994) Estubübhment of two distinct anti-cardiolipin antibody-producing cell lines from the same individual by Epstein-Barr virus transformation. Thrombosis Research, 74, 77-84.
14. Hughes, G.R.V. (1993) The antiphospholipid syndrome: ten years on. Lancet, 342, 341-344.
15. Ichikawa. K., Khamashta, M.A., Koike, T., Matsuura, E. & Hughes, G.R.V. (1994) 02-Glycoprotein I reactivity of monoclonal anti-cardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis and Rheumatism. 37, 1453-1461.
16. Kato, H. & Enjyoji, K. (1991) Amino acid sequence and location of the disulfide bonds in bovine β2 glycoprotein I: the presence of five Sushi domains. Biochemistry 30, 11687-11694.
17. Khamashta, M.A. & Asherson, R.A. (1995) Hughes syndrome: antiphospholipid antibodies move closer to thrombosis in 1994. British Journal of Rheumatology, 34. 493-497.
18. Khamashta, M.A. & Hughes, G.R.V. (1994) Antiphospholipid antibodies: a marker for thrombosis and recurrent abortion. Clinical Reviews in Allergy. 12, 287-296.
19. Kornberg, A., Blank, M., Kaufman, S. & Shoenfeld. Y. (1994) Induction of tissue factor-like activity in monocytes by anticardiolipin antibodies. Journal of Immunology. 153, 1328-1332.
20. Lu. E.W., Deftos, M., Olee, T., Huang, D.-F, Soto-Gil. R.W., Carson. D.A. & Chen, P.P. (1993) Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis and Rheumatism. 36, 927-937.
21. Malia, R.G., Kitchen, S., Greaves, M. & Preston. F.E. (1990) Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. British Journal of Haematology, 76, 101-107.
22. Marciniak, E. & Romond, E.H. (1989) Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant. Blood. 74, 2426-2432.
23. Olee, T.W., Pierangeli. S.S., Handley. H.H., Le, D.T., U'ei. X., Lai, C.J., En, J., Novotny, W. Harris, E.N., Woods. V.L., Jr & Chen, P.P. (1996) A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice. Proceedings of the National Academy of Sciences of the United States of America, 93, 8606-8611.
24. Gosling, J.D., Derksen, R.H.W.M., Bobbink, I.W.G., Hackeng. T.M., Bouimi, B.N. & de Groot, P.G. (1993) Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? Blood, 81, 2618-2625.
25. Pierangeli, S.S., Barker, J.H., Stikovac, D., Ackerman, D., Anderson, G., Barquinero. J., Acland, R. & Harris, E.N. (1994) Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thrombosis and Haenwstasis, 71, 670-674.
26. Pierangeli, S.S., Liu, X., Barker, J.H., Anderson, G. & Harris, E.N. (1995) Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome. Thrombosis and Haemostasis, 74, 1361-1367.
27. Pierangeli, S.S., Stewart, M., Suva, L.K. & Harris, E.N. (1998) An Antiphospholipid Wet Workshop: 7th International Symposium on Antiphospholipid Antibodies. Journal of Rheumatology, 25, 156-160.
28. Rand, J.H., Wu, X.X., "Andree, U.A.M., Lockwood. C.J., Culler, S., Scher, J. & Harpel, P.C. (1997) Pregnancy loss in the antiphospholipid-antibody syndrome: a possible thrombogenic mechanism. New England Journal of Medicine, 337, 154-160.
29. Rao, L.V.M., Hoang, A.D. & Rapaport, S.I. (1996) Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid. Blood. 88. 4173-4182.
30. Roubey, R.A.S. (1994) Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other 'antiphospholipid1 autoantibodies. Blood, 84, 2854-2867.
31. Roubey, R.A.S. (1996) Immunology of the antiphospholipid antibody syndrome. Arthritis and Rheumatism, 39, 1444-1454.
32. Roubey, R.A.S., Eisenberg, R.A., Harper, M.F. & Winfield, J.B. (1995) 'Anticardiolipin' autoantibodies recognize fo-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. Journal of Immunology. 154, 954-960.
33. Roubey, R.A.S. & Huffman. M. (1997) From antiphospholipid syndrome to antibody-mediated thrombosis. Lancet, 350, 14911493.
34. Sammaritano, L.R., Lockshin, M.D. & Gharavi. A.E. (1992) Antiphospholipid antibodies differ in aPL cofactor requirement. Lupus, 1, 83-90.
35. Santoro, S.A. (1994) Antiphospholipid antibodies and thrombotic predisposition: underlying pathogenetic mechanisms. Blood, 83, 2389-2391.
36. Simantov, R., LaSala, J.M., Lo, S.K., Gharavi, A.E., Sammaritano, L.R., Salmon, J.E. & Silverstein, R.L. (1995) Activation of cultured vascular endothelial cells by antiphospholipid antibodies. Journal of Clinical Investigation, 96, 2211-2219.
37. Smirnov, M.D., Triplett, D.T., Comp, P.C., Esmon, N.L. & Esmon, C.T. (1995) On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies. Journal of Clinical Investigation, 95, 309-316.
38. Takeya, H., Mori, T., Gabaeza, E.C., Kuroda, K., Deguchi, H., Matsuura, E., Ichikawa, K., Koike, T. & Suzuki, K. (1997) Anti-β2-glycoprotein I (02GP1) monoclonal antibodies with lupus anticoagulant-like activity enhance the β2GPI binding to phospholipids. Journal of Clinical Investigation, 99, 2260-2268.
39. Tan, E.M., Cohcn. A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N. & Winchester, R.J. (1982) The 1982 revised criteria for the classification of SLE. Arthritis and Rheumatism, 25, 1271-1277.
40. Tincani. A., Spatola. L., Prati, E., Allegri. F., Ferremi. P., Cattaneo, R., Meroni, P. & Balestrieri. G. (1996) The anti-β2-clycoprotein I activity in human antiphospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native β2-glycoprotcin I and preserved during species evolution. Journal of Immunology. 157. 5732-5738.
41. Triplett, D.A. (1993) Antiphospholipid antibodies and thrombosis: a consequence, coincidence, or cause? Archives in Pathology and Laboratory Medicine, 117, 78-88.
42. Willems, G.M., Janssen. M.P., Pelsers, M.M.A.L., Comfurius, P., Galli, M., Zu-aal. R.F.A. & Bevcrs. E.M. (1996) Role of divalency in the high-affinity binding of anticardiolipin antibody-β2-glycoprotein I complexes to lipid membranes. Biochemistry. 35, 13833-13842.