TTF-1 action on the transcriptional regulation of Cyclooxygenase-2 gene in the rat brain

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Yun, Chang Ho ^a   Kim, Jae Geun ^a   Park, Byong Seo ^a   Lee, Hye Myeong ^a   Kim, Dong Hee ^a   Kim, Eun Ok ^a   Park, Joong Jean ^b   Park, Jeong Woo ^a   Damante, Giuseppe ^c   Kim, Young Il ^d   Lee, Byung Ju ^a  

^a University of Ulsan   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c UNIVERSITY OF UDINE   (Italy)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CYCLOOXYGENASE 2; THYROID TRANSCRIPTION FACTOR 1; VON WILLEBRAND FACTOR; ANTISENSE OLIGONUCLEOTIDE; NUCLEAR PROTEIN; PTGS2 PROTEIN, RAT; THYROID NUCLEAR FACTOR 1; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; ASTROCYTE; BINDING SITE; BRAIN; BRAIN NERVE CELL; CONTROLLED STUDY; ENDOTHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HYPERTHERMIA; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; RAT; THERMOREGULATION; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NERVE CELL; NUCLEOTIDE MOTIF; PREOPTIC AREA; PROTEIN BINDING; SPRAGUE DAWLEY RAT;

ANIMALS; BINDING SITES; BODY TEMPERATURE REGULATION; BRAIN; CHROMATIN IMMUNOPRECIPITATION; CYCLOOXYGENASE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INJECTIONS, INTRAVENTRICULAR; MALE; NEURONS; NUCLEAR PROTEINS; NUCLEOTIDE MOTIFS; OLIGONUCLEOTIDES, ANTISENSE; PREOPTIC AREA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE DELETION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 83255193007     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028959     Document Type: Article

References (44)

1. Morrison SF, Nakamura K, Madden CJ, (2008) Central control of thermogenesis in mammals. Exp Physiol 93: 773-797.
2. Boulant JA, (2000) Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin Infect Dis 31 (Suppl 5): S157-161.
3. Conti B, Tabarean I, Andrei C, Bartfai T, (2004) Cytokines and fever. Front Biosci 9: 1433-1449.
4. Li S, Wang Y, Matsumura K, Ballou LR, Morham SG, et al. (1999) The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2 (-/-), but not in cyclooxygenase-1 (-/-) mice. Brain Res 825: 86-94.
5. Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, et al. (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395: 281-284.
6. Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL, (1991) Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci U S A 88: 2692-2696.
7. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, et al. (1998) Cyclooxygenase in biology and disease. FASEB J 12: 1063-1073.
8. Williams CS, Mann M, DuBois RN, (1999) The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 18: 7908-7916.
9. DeWitt DL, (1991) Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1083: 121-134.
10. Smith WL, Garavito RM, DeWitt DL, (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and-2. J Biol Chem 271: 33157-33160.
11. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, et al. (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47: 55-59.
12. Cao C, Matsumura K, Yamagata K, Watanabe Y, (1997) Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain. Am J Physiol 272: R1712-1725.
13. Cao C, Matsumura K, Yamagata K, Watanabe Y, (1998) Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor. Brain Res Mol Brain Res 56: 45-56.
14. Lindstrom T, Bennett P, (2004) Transcriptional regulation of genes for enzymes of the prostaglandin biosynthetic pathway. Prostaglandins Leukot Essent Fatty Acids 70: 115-135.
15. Kaufmann WE, Andreasson KI, Isakson PC, Worley PF, (1997) Cyclooxygenases and the central nervous system. Prostaglandins 54: 601-624.
16. Nadjar A, Tridon V, May MJ, Ghosh S, Dantzer R, et al. (2005) NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain. J Cereb Blood Flow Metab 25: 1047-1059.
17. Civitareale D, Lonigro R, Sinclair AJ, Di Lauro R, (1989) A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J 8: 2537-2542.
18. Kimura S, (1996) Thyroid-specific enhancer-binding protein Role in thyroid function and organogenesis. Trends Endocrinol Metab 7: 247-252.
19. Lee BJ, Cho GJ, Norgren RB Jr, Junier MP, Hill DF, et al. (2001) TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci 17: 107-126.
20. Kim MS, Hur MK, Son YJ, Park JI, Chun SY, et al. (2002) Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J Biol Chem 277: 36863-36871.
21. Kim JG, Park BS, Yun CH, Kim HJ, Kang SS, et al. (2011) Thyroid Transcription Factor 1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus. Diabetes 60: 710-719.
22. Son YJ, Hur MK, Ryu BJ, Park SK, Damante G, et al. (2003) TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ. J Biol Chem 278: 27043-27052.
23. Kim JG, Son YJ, Yun CH, Kim YI, Nam-Goong IS, et al. (2007) Thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain. J Biol Chem 282: 14923-14931.
24. Tzeng SF, Hsiao HY, Mak OT, (2005) Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 4: 335-340.
25. Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P, (1996) COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci U S A 93: 2317-2321.
26. Matsumura K, Cao C, Ozaki M, Morii H, Nakadate K, et al. (1998) Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J Neurosci 18: 6279-6289.
27. Magno L, Catanzariti V, Nitsch R, Krude H, Naumann T, (2009) Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans? Brain Res 1304: 164-186.
28. Ray MK, Chen CY, Schwartz RJ, DeMayo FJ, (1996) Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transcription factor 1 and cardiac muscle-specific homeobox protein (CSX). Mol Cell Biol 16: 2056-2064.
29. Kramer SG, Jinks TM, Schedl P, Gergen JP, (1999) Direct activation of Sex-lethal transcription by the Drosophila runt protein. Development 126: 191-200.
30. Kumbrink J, Gerlinger M, Johnson JP, (2005) Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop. J Biol Chem 280: 42785-42793.
31. Roser K, Bohn W, Giese G, Mannweiler K, (1991) Subclones of C6 rat glioma cells differing in intermediate filament protein expression. Exp Cell Res 197: 200-206.
32. Trentin AG, Alvarez-Silva M, (1998) Thyroid hormone regulates protein expression in C6 glioma cells. Braz J Med Biol Res 31: 1281-1284.
33. Benda P, Lightbody J, Sato G, Levine L, Sweet W, (1968) Differentiated rat glial cell strain in tissue culture. Science 161: 370-371.
34. Otey CA, Boukhelifa M, Maness P, (2003) B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neurons. Methods Cell Biol 71: 287-304.
35. Steiner AA, Li S, Llanos QJ, Blatteis CM, (2001) Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. Neuroimmunomodulation 9: 263-275.
36. Steiner AA, Rudaya AY, Robbins JR, Dragic AS, Langenbach R, et al. (2005) Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses. Am J Physiol Regul Integr Comp Physiol 289: R1253-1257.
37. Scammell TE, Elmquist JK, Griffin JD, Saper CB, (1996) Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J Neurosci 16: 6246-6254.
38. Scammell TE, Griffin JD, Elmquist JK, Saper CB, (1998) Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol 274: R783-789.
39. Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ, (1999) Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A 96: 7047-7052.
40. Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, et al. (2004) Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287: E1107-1113.
41. Inoue W, Poole S, Bristow AF, Luheshi GN, (2006) Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain. Eur J Neurosci 24: 2233-2245.
42. Ohmori M, Harii N, Endo T, Onaya T, (1999) Tumor necrosis factor-alpha regulation of thyroid transcription factor-1 and Pax-8 in rat thyroid FRTL-5 cells. Endocrinology 140: 4651-4658.
43. Damante G, Pellizzari L, Esposito G, Fogolari F, Viglino P, et al. (1996) A molecular code dictates sequence-specific DNA recognition by homeodomains. EMBO J 15: 4992-5000.
44. Pellizzari L, Tell G, Damante G, (1999) Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter. Biochem J 337 (Pt 2): 253-262.