Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs

NeuroImmunoModulation

Volumn 9, Issue 5, 2001, Pages 263-275

  Steiner, Alexandre A ^a   Li, Shuxin ^a   Llanos Q , Jose ^a   Blatteis, Clark M ^a,b  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Antipyretics; Cyclooxygenase; Fever; Indomethacin; Lipopolysaccharide; Nimesulide; Prostaglandin E2; SC 560

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; NIMESULIDE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; CORE TEMPERATURE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; FEVER; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; BRAIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEVER; GUINEA PIGS; INDOMETHACIN; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; ISOENZYMES; LIPOPOLYSACCHARIDES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES;

EID: 0035570008     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054289     Document Type: Article

References (55)

1. 2: A putative fever mediator
2. Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells
3. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: A possible site of prostaglandin synthesis responsible for fever
4. Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: Light and electron microscopic immunocytochemical studies
5. Coexpression of microsomal type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever
6. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
7. 2
8. Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis
9. 2s and cyclooxygenases in immediate and delayed prostaglandin biosynthetic pathways
10. 2 biosynthesis
11. Cyclooxygenase-1 and -2 isoenzymes
12. Pharmacological analysis of cyclooxygenase-1 in inflammation
13. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
14. Prostaglandin synthase 2
15. Cyclooxygenase 2: Molecular biology, pharmacology, and neurobiology
16. Cyclooxygenase-2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide
17. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
18. Cyclooxygenase systems in the mammalian brain
19. -/- mice
20. 2 in microvasculature and in neurons of rat brain after administration of bacterial endotoxin
21. Pyrogen sensing and signaling: Old views and new concepts
22. Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1β
23. Quantitative aspects of the fever response elicited by intracerebral injection of endotoxin in the guinea pigs
24. Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits
25. Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation
26. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
27. Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans
28. Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide
29. 2 during lipopolysaccharide-induced fever in guinea pigs
30. Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury
31. Relation between complement and the febrile response of guinea pigs to systemic endotoxin
32. 2 in the preoptic area of conscious guinea pigs
33. Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor
34. 2 entry into the brain
35. 2 enzymes
36. Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells
37. 1 macrophage-like cells
38. Expression of mRNAs for vasopressin, oxytocin and corticotrophin releasing hormone in the hypothalamus, and of cyclooxygenases-1 and -2 in the cerebral vasculature of endotoxin-challenged pigs
39. Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors
40. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: An overview
41. Nimesulide in the treatment of fever: A double-blind crossover clinical trial
42. Activity of nimesulide on constitutive and inducible cyclooxygenases
43. Fever: Role of pyrogens and cryogens
44. Fever: How may circulating pyrogens signal the brain?
45. Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever
46. Temporal profiles of interleukin-1β, interleukin-6, and tumor necrosis factor-α in the plasma and hypothalamic paraventricular nucleus after intravenous and intraperitoneal administration of lipopolysaccharide in the rat: Estimation by push-pull perfusion
47. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1β and TNF-α
48. 2 and TNF-α production by rat glial brain culture: Influence of COX and cytokine inhibitors
49. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroidal antiinflammatory drugs
50. Nonsteroidal antiinflammatory drugs acetaminophen, cyclooxygenase 2, and fever
51. Mechanism of action of acetaminophen: Is there a cyclooxygenase 3?
52. Inflammatory response: Pathway across the blood-brain barrier
53. Interleukin-1 receptors on rat brain endothelial cells: A role in neuroimmune interaction?
54. Delineation of the proinflammatory cytokine cascade in fever induction