Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells

BMC Neuroscience

Volumn 12, Issue , 2011, Pages

  Zhu, Feiqi ^a,b   Wu, Fujun ^c   Ma, Ying ^a   Liu, Guangjian ^b   Li, Zhong ^d   Sun, Yong'an ^e   Pei, Zhong ^d  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

^c ANHUI AGRICULTURAL UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Alzheimer's disease; Berberine; Beta amyloid40 42; Beta secretase; Extracellular signal regulated kinase1 2

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BERBERINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; 1,3 BUTADIENE DERIVATIVE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; NEUROPROTECTIVE AGENT; NITRILE; PEPTIDE FRAGMENT; SECRETASE;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVATION; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RHIZOME; STABLE TRANSFECTION; ALZHEIMER DISEASE; BIOSYNTHESIS; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; TIME;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BERBERINE; BUTADIENES; DOWN-REGULATION; HEK293 CELLS; HUMANS; NEUROPROTECTIVE AGENTS; NITRILES; PEPTIDE FRAGMENTS; TIME FACTORS;

EID: 83155191087     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-12-125     Document Type: Article

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