The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; Correlations with clinicopathologic parameters

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 12, 2011, Pages 1749-1762

  Oz Puyan, Fulya ^a   Can, Nuray ^b   Ozyilmaz, Filiz ^a   Usta, Ufuk ^a   Sut, Necdet ^a   Tastekin, Ebru ^a   Altaner, Semsi ^a  

^a TRAKYA UNIVERSITY   (Turkey)

^b Sanliurfa Education and Research Hospital ^*  (Turkey)

Author keywords

Carcinogenesis; CDX2; Gastric carcinoma; Mucins; PDX1

Indexed keywords

KI 67 ANTIGEN; MUCIN; MUCIN 2; MUCIN 5AC; MUCIN 6; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR PDX 1;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GASTRECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METAPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROSPECTIVE STUDY; STOMACH CARCINOMA; UNDIFFERENTIATED CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; MUCIN 5AC; MUCIN-2; MUCIN-6; MUCINS; PHENOTYPE; STOMACH NEOPLASMS; TRANS-ACTIVATORS;

EID: 82955233664     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1044-7     Document Type: Article

References (57)

1. N Akyürek G Akyol A Dursun, et al. 2002 Expression of MUC1 and MUC2 mucins in gastric carcinomas: their relationship with clinicopathologic parameters and prognosis Pathol Res Pract 198 10 665 674 12498221 10.1078/0344-0338-00318 (Pubitemid 35452874)
2. S Alappat ZY Zhang YP Chen 2003 Msx homeobox gene family and craniofacial development Cell Res 13 429 442 14728799 10.1038/sj.cr.7290185 1:CAS:528:DC%2BD2cXivVSisbo%3D (Pubitemid 43231836)
3. R Almeida E Silva F Santos-Silva, et al. 2003 Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas J Pathol 199 36 40 12474224 10.1002/path.1246 (Pubitemid 36054727)
4. Y Bai Y Akiyama H Nagasaki, et al. 2000 Distinct expression of CDX2 and GATA4/5, development-related genes in human gastric cancer cell lines Mol Carcinog 28 3 184 188 10942535 10.1002/1098-2744(200007)28:3<184::AID- MC7>3.0.CO;2-6 1:CAS:528:DC%2BD3cXmtVWhu74%3D (Pubitemid 30612998)
5. YQ Bai H Yamamoto Y Akiyama, et al. 2002 Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach Cancer Lett 176 47 55 11790453 10.1016/S0304-3835(01)00753-4 1:CAS:528:DC%2BD38XktFarsw%3D%3D (Pubitemid 34085069)
6. V Barresi E Vitarelli M Grosso G Tuccari G Barresi 2006 Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren's histologic subtypes of gastric carcinomas Eur J Histochem 50 4 301 309 17213039 1:STN:280:DC%2BD2s%2FhslSjsw%3D%3D (Pubitemid 351480092)
7. R Barros LT da Costa J Pinto-de-Sousa, et al. 2011 CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype Gut 60 3 290 298 21148572 10.1136/gut.2010.222323 1:CAS:528: DC%2BC3MXjslGis7k%3D
8. NM Brooke J Garcia-Fernandez PW Holland 1998 The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster Nature 392 920 922 9582071 10.1038/31933 1:CAS:528:DyaK1cXjtV2ju7w%3D (Pubitemid 28232062)
9. M Buettner A Dimmler A Magener, et al. 2004 Gastric PDX-1 expression in pancreatic metaplasia and endocrine cell hyperplasia in atrophic corpus gastritis Mod Pathol 17 56 61 14631368 10.1038/modpathol.3800015 1:CAS:528:DC%2BD2cXmtlGru7k%3D (Pubitemid 41656453)
10. C Carrato C Balague C Bolos, et al. 1994 Differential apomucin expression in normal and neoplastic human gastrointestinal tissues Gastroenterology 107 160 172 8020658 1:CAS:528:DyaK2cXlslKgu7s%3D (Pubitemid 24195358)
11. T Chiba 2002 Key molecules in metaplastic gastritis: sequential analysis of CDX1/2 homeobox gene expression J Gastroenterol 37 94 100 10.1007/s005350200013 (Pubitemid 34223751)
12. AG Cole F Rizzo P Martinez M Fernandez-Serra MI Arnone 2009 Two ParaHox genes, SpLox and SpCdx, interact to partition the posterior endoderm in the formation of a functional gut Development 136 4 541 549 19144720 10.1242/dev.029959 1:CAS:528:DC%2BD1MXjsFKgtL8%3D
13. P Correa 1992 Human gastric carcinogenesis: a multistep and multifactorial process. First American cancer society award lecture on cancer epidemiology and prevention Cancer Res 52 6735 6740 1458460 1:CAS:528: DyaK3sXjs1Orsw%3D%3D (Pubitemid 23006271)
14. AC de Vries NC van Grieken CW Looman, et al. 2008 Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands Gastroenterology 134 945 952 18395075 10.1053/j.gastro.2008.01.071 (Pubitemid 351451990)
15. Fenoglio-Preiser C, Munoz N, Carneiro F et al (2000) Gastric carcinoma. In: Hamilton SR, Aaltonen LA (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, Lyon, pp 39-52
16. JR Goldenring KT Nam 2010 Oxyntic atrophy, metaplasia, and gastric cancer Prog Mol Biol Transl Sci 96 117 131 21075342 10.1016/B978-0-12-381280-3.00005-1 1:CAS:528:DC%2BC3MXovFSjuw%3D%3D
17. JR Goldenring S Nomura 2006 Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia Am J Physiol Gastointest Liver Physiol 291 999 1004 10.1152/ajpgi.00187.2006 (Pubitemid 44904153)
18. Goldenring JR, Nam KT, Wang TC, Mills JC, Wright NA (2010) Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology 138(7):2207-10, 2210.e1
19. S Grainger JG Savory D Lohnes 2010 Cdx2 regulates patterning of the intestinal epithelium Dev Biol 339 1 155 165 20043902 10.1016/j.ydbio.2009.12. 025 1:CAS:528:DC%2BC3cXitVarurg%3D
20. J Guarner A Mohar J Parsonnet, et al. 1993 The association of helicobacter pylori with gastric cancer and preneoplastic gastric lesions in Chiapas, Mexico Cancer 71 297 301 8422620 10.1002/1097-0142(19930115)71: 2<297::AID-CNCR2820710205>3.0.CO;2-9 1:STN:280:DyaK3s7jslWksg%3D%3D (Pubitemid 23021211)
21. NM Hassan J Hamada T Murai, et al. 2006 Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues Oncol Res 16 217 224 17294802 1:CAS:528:DC%2BD2sXhvVOhur8%3D (Pubitemid 46211725)
22. SB Ho LL Shekels NW Toribara, et al. 1995 Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium Cancer Res 55 2681 2690 7780985 1:CAS:528:DyaK2MXmtlWrt7k%3D
23. Ö İlhan Ü Han B Önal SY Çelik 2010 Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma Turk J Gastroenterol 21 4 345 352 21331986
24. Japanese Gastric Cancer Association 1998 Japanese classification of gastric carcinoma. 2nd English edn Gastric Cancer 1 10 24 11957040 10.1007/PL00011681
25. P Laure'n 1965 The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification Acta Pathol Microbiol Scand 64 31 49
26. HS Lee HK Lee HS Kim, et al. 2001 MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators Cancer 92 6 1427 1434 11745219 10.1002/1097-0142(20010915)92:6<1427::AID- CNCR1466>3.0.CO;2-L 1:CAS:528:DC%2BD3MXnvVyhu7c%3D (Pubitemid 32947826)
27. E Leteurtre F Zerimech G Piessen, et al. 2006 Relationships between mucinous gastric carcinoma, MUC2 expression and survival World J Gastroenterol 12 21 3324 3331 16733847 1:CAS:528:DC%2BD28XnsFWkt70%3D (Pubitemid 43933775)
28. CM Leys S Nomura E Rudzinski, et al. 2006 Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma Hum Pathol 37 9 1162 1168 16938521 10.1016/j.humpath.2006.04.011 1:CAS:528:DC%2BD28XovVWrt74%3D (Pubitemid 44286981)
29. Q Liu M Teh K Ito, et al. 2007 CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer Mod Pathol 20 12 1286 1297 17906616 10.1038/modpathol.3800968 1:CAS:528:DC%2BD2sXhtlSmtbnE (Pubitemid 350126854)
30. J Ma M Chen J Wang, et al. 2008 Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer Carcinogenesis 29 1327 1333 18477649 10.1093/carcin/bgn112 1:CAS:528:DC%2BD1cXpslarsLo%3D
31. JC Machado AM Nogueira F Carneiro, et al. 2000 Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6) J Pathol 190 437 443 10699992 10.1002/(SICI)1096-9896(200003)190:4<437::AID-PATH547>3. 0.CO;2-1 1:CAS:528:DC%2BD3cXisF2rtrg%3D (Pubitemid 30163583)
32. DA Melton 1991 Pattern formation during animal development Science 252 234 241 1672778 10.1126/science.1672778 1:STN:280:DyaK3M7ovVaqsA%3D%3D (Pubitemid 21916957)
33. T Mizoshita T Tsukamoto H Nakanishi, et al. 2003 Expression of Cdx2 and the phenotype of advanced gastric cancers: Relationship with prognosis J Cancer Res Clin Oncol 129 727 734 14557879 10.1007/s00432-003-0499-6 1:CAS:528:DC%2BD3sXptlekuro%3D (Pubitemid 38002304)
34. T Mizoshita T Tsukamoto H Tanaka, et al. 2005 Colonic and small-intestinal phenotypes in gastric cancers: relationships with clinicopathological findings Pathol Int 55 10 611 618 16185290 10.1111/j.1440-1827.2005.01878.x 1:CAS:528:DC%2BD2MXht1Cls7nL (Pubitemid 41726944)
35. DP Mortlock JW Innis 1997 Mutation of HOXA13 in hand-foot-genital syndrome Nat Genet 15 179 180 9020844 10.1038/ng0297-179 1:CAS:528: DyaK2sXhtVOltLo%3D (Pubitemid 27061638)
36. H Mutoh S Sakurai K Satoh, et al. 2004 Development of gastric carcinoma from intestinal metaplasia in Cdx2- transgenic mice Cancer Res 64 7740 7747 15520178 10.1158/0008-5472.CAN-04-1617 1:CAS:528:DC%2BD2cXptFemurk%3D (Pubitemid 39446905)
37. KT Nam HJ Lee H Mok J Romero-Gallo JE Crowe Jr RM Peek Jr JR Goldenring 2009 Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia Gastroenterology 136 4 1288 1296 19230855 10.1053/j.gastro.2008.12.037 1:CAS:528:DC%2BD1MXkslWgtr4%3D
38. H Naora YQ Yang FJ Montz, et al. 2001 A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells Proc Natl Acad Sci USA 98 4060 4065 11274429 10.1073/pnas.071594398 1:CAS:528:DC%2BD3MXis1Khtrc%3D (Pubitemid 32249898)
39. AM Nogueira JC Machado F Carneiro, et al. 1999 Patterns of expression of trefoil peptides and mucins in gastric polyps with and without malignant transformation J Pathol 187 541 548 10398119 10.1002/(SICI)1096-9896(199904)187: 5<541::AID-PATH283>3.0.CO;2-9 1:STN:280:DyaK1MzlvFGnuw%3D%3D (Pubitemid 29151995)
40. MF Offield TL Jetton PA Labosky, et al. 1996 PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum Development 122 983 995 8631275 1:CAS:528:DyaK28XhvVOruro%3D (Pubitemid 26096002)
41. JE Pitera VV Smith P Thorogood PJ Milla 1999 Coordinated expression of 3' Hox genes during murine embryonal gut development: an enteric Hox code Gastroenterology 117 1339 1351 10579975 10.1016/S0016-5085(99)70284-2 1:STN:280:DC%2BD3c%2Fkslyluw%3D%3D
42. H Sakai Y Eishi XL Li, et al. 2004 PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas Gut 53 323 330 14960508 10.1136/gut.2003.026609 1:CAS:528:DC%2BD2cXitlersL8%3D (Pubitemid 38241323)
43. PH Schmidt JR Lee V Joshi, et al. 1999 Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma Lab Invest 79 639 646 10378506 1:STN:280:DyaK1MzgsVymsw%3D%3D (Pubitemid 29283417)
44. MP Scott JW Tamkun GW Hartzell 1989 The structure and function of the homeodomain Biochim Biophys Acta 989 25 48 2568852 1:CAS:528:DyaL1MXltV2ktbo%3D (Pubitemid 19180349)
45. H Seno M Oshima MA Taniguchi, et al. 2002 CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications Int J Oncol 21 4 769 774 12239615 1:STN:280:DC%2BD38vnslemug%3D%3D
46. DG Silberg GP Swain ER Suh, et al. 2000 Cdx1 and Cdx2 expression during intestinal development Gastroenterology 119 961 971 11040183 10.1053/gast.2000.18142 1:CAS:528:DC%2BD3cXnvV2gsr0%3D
47. DA Stoffers RS Heller CP Miller, et al. 1999 Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter Endocrinology 140 5374 5381 10537169 10.1210/en.140.11.5374 1:CAS:528:DyaK1MXmvFemtbk%3D
48. Y Tajima T Shimoda Y Nakanishi, et al. 2001 Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions Oncology 61 212 220 11574777 10.1159/000055377 1:STN:280:DC%2BD3MrivVKntg%3D%3D (Pubitemid 34701536)
49. M Tatematsu T Tsukamoto K Inada 2003 Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia Cancer Sci 94 135 141 12708487 10.1111/j.1349-7006.2003.tb01409.x 1:CAS:528:DC%2BD3sXjtFGjsbw%3D (Pubitemid 36575871)
50. T Tsukamoto T Mizoshita M Tatematsu 2006 Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of transcription factors and stem cell intestinalization Gastric Cancer 9 156 166 16952033 10.1007/s10120-006-0375-6 1:CAS:528:DC%2BD28XptVeqsro%3D (Pubitemid 44426888)
51. N Uemura S Okamoto S Yamamoto, et al. 2001 Helicobacter pylori infection and the development of gastric cancer N Engl J Med 345 784 789 11556297 10.1056/NEJMoa001999 1:STN:280:DC%2BD3MrgslCqtA%3D%3D
52. XP Wang ZJ Li J Magnusson FC Brunicardi 2005 Tissue Micro Array analyses of pancreatic duodenal homeobox-1 in human cancers World J Surg 29 3 334 338 15706433 10.1007/s00268-004-7823-4 (Pubitemid 40768046)
53. VG Weis JR Goldenring 2009 Current understanding of SPEM and its standing in the preneoplastic process Gastric Cancer 12 4 189 197 20047123 10.1007/s10120-009-0527-6
54. H Yamamoto YQ Bai Y Yuasa 2003 Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression Biochem Biophys Res Commun 300 4 813 818 12559945 10.1016/S0006-291X(02)02935-2 1:CAS:528:DC%2BD3sXmsVCgsg%3D%3D (Pubitemid 36259834)
55. N Yoshizawa Y Takenaka Y Yamaguchi T Tetsuya H Tanaka M Tatematsu S Nomura JR Goldenring M Kaminishi 2007 Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori Lab Invest 87 1265 1276 18004396 10.1038/labinvest.3700682 1:CAS:528:DC%2BD2sXhtlWjt7nP (Pubitemid 350126706)
56. Y Yuasa 2003 Control of gut differentiation and intestinal-type gastric carcinogenesis Nat Rev Cancer 3 592 600 12894247 10.1038/nrc1141 1:CAS:528:DC%2BD3sXlvV2iu74%3D (Pubitemid 37328831)
57. S Zhu HH Xia Y Yang, et al. 2009 Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia Dig Dis Sci 54 5 996 1002 18754095 10.1007/s10620-008- 0459-8 1:CAS:528:DC%2BD1MXjvVWjtL4%3D