Expression of Cdx2 and the phenotype of advanced gastric cancers: Relationship with prognosis

Journal of Cancer Research and Clinical Oncology

Volumn 129, Issue 12, 2003, Pages 727-734

  Mizoshita, Tsutomu ^a   Tsukamoto, Tetsuya ^a   Nakanishi, Hayao ^a   Inada, Ken Ichi ^a   Ogasawara, Naotaka ^a,b   Joh, Takashi ^b   Itoh, Makoto ^b   Yamamura, Yoshitaka ^a   Tatematsu, Masae ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Cdx2; Gastric cancer; Phenotype; Prognosis

Indexed keywords

HOMEODOMAIN PROTEIN; MUCIN; MUCIN 2; MUCIN 5A; MUCIN 6; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

AGED; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM PROTEINS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TIME FACTORS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0346847596     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-003-0499-6     Document Type: Article

References (46)

1. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolos C, David L (2003) Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 199:36-40
2. Bai Y, Akiyama Y, Nagasaki H, Yagi OK, Kikuchi Y, Saito N, Takeshita K, Iwai T, Yuasa Y (2000) Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Mol Carcinog 28:184-188
3. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y (2002) Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47-55
4. Baldus SE, Zirbes TK, Engel S, Hanisch FG, Monig SP, Lorenzen J, Glossmann J, Fromm S, Thiele J, Pichlmaier H, Dienes HP (1998) Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas. Int J Cancer 79:133-138
5. Baldus SE, Monig SP, Arkenau V, Hanisch FG, Schneider PM, Thiele J, Holscher AH, Dienes HP (2002) Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma. Ann Surg Oncol 9:887-893
6. Bamba M, Sugihara H, Kushima R, Okada K, Tsukashita S, Horinouchi M, Hattori T (2001) Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach. Virchows Arch 438:49-56
7. Ee HC, Erler T, Bhathal PS, Young GP, James RJ (1995) Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol 147:586-592
8. Egashira Y, Shimoda T, Ikegami M (1999) Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol Int 49:55-61
9. Gurbuz Y, Kahlke V, Kloppel G (2002) How do gastric carcinoma classification systems relate to mucin expression patterns? An immunohistochemical analysis in a series of advanced gastric carcinomas. Virchows Arch 440:505-511
10. Ho SB, Shekels LL, Toribara NW, Kim YS, Lyftogt C, Cherwitz DL, Niehans GA (1995) Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res 55:2681-2690
11. Inada K, Nakanishi H, Fujimitsu Y, Shimizu N, Ichinose M, Miki K, Nakamura S, Tatematsu M (1997) Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach. Pathol Int 47:831-841
12. Inada K, Tanaka H, Nakanishi H, Tsukamoto T, Ikehara Y, Tatematsu K, Nakamura S, Porter EM, Tatematsu M (2001) Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach. Virchows Arch 439:14-20
13. Japanese Gastric Cancer Association (1998) Japanese Classification of Gastric Carcinoma - 2nd English Edition. Gastric Cancer 1:10-24
14. Kawachi H, Takizawa T, Eishi Y, Shimizu S, Kumagai J, Funata N, Koike M (2003) Absence of either gastric or intestinal phenotype in microscopic differentiated gastric carcinomas. J Pathol 199:436-446
15. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K (2000) Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 89:724-732
16. Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31-49
17. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH (2001) MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 92:1427-1434
18. Lee HS, Lee HK, Kim HS, Yang HK, Kim WH (2003) Tumour suppressor gene expression correlates with gastric cancer prognosis. J Pathol 200:39-46
19. Machado JC, Nogueira, AM, Carneiro F, Reis CA, Sobrinho-Simoes M (2000) Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6). J Pathol 190:437-443
20. Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL (1997) Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Downregulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74:35-44
21. Mallo GV, Soubeyran P, Lissitzky JC, Andre F, Farnarier C, Marvaldi J, Dagorn JC, lovanna JL (1998) Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 273:14030-14036
22. Matsukuma A, Mori M, Enjoji M (1990) Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa: an association with intestinal-type gastric carcinoma. Cancer 66:689-694
23. Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu, M (2001) Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa - with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 4:185-191
24. Nakamura K, Sugano H, Takagi K (1968) Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 59:251-258
25. Pinto-de-Sousa J, David L, Reis CA, Gomes R, Silva L, Pimenta A (2002) Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma. Virchows Arch 440:304-310
26. Reis CA, David L, Carvalho F, Mandel U, de Bolos C, Mirgorodskaya E, Clausen H, Sobrinho-Simoes M (2000) Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. J Histochem Cytochem 48:377-388
27. Seno H, Oshima M, Taniguchi MA, Usami K, Ishikawa TO, Chiba T, Taketo MM (2002) CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. Int J Oncol 21:769-774
28. Silberg DG, Swain GP, Suh ER, Traber PG (2000) Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119:961-971
29. Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH (2002) Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 122:689-696
30. Sugano H, Nakamura K, Kato Y (1982) Pathological studies of human gastric cancer. Acta Pathol Jpn 32 [Suppl 2]: 329-347
31. Tajima Y, Shimoda T, Nakanishi Y, Yokoyama N, Tanaka T, Shimizu K, Saito T, Kawamura M, Kusano M, Kumagai K (2001) Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions. Oncology 61:212-220
32. Tanaka M, Kitajima Y, Sato S, Miyazaki K (2003) Combined evaluation of mucin antigen and E-cadherin expression may help select patients with gastric cancer suitable for minimally invasive therapy. Br J Surg 90:95-101
33. Tatematsu M, Furihata C, Katsuyama T, Hasegawa R, Nakanowatari J, Saito D, Takahashi M, Matsushima T, Ito N (1983) Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N′-nitro-N- nitrosoguanidine. Cancer Res 43:1335-1341
34. Tatematsu M, Katsuyama T, Furihata C, Tsuda H, Ito N (1984) Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N′-nitro-N-nitrosoguanidine or methylnitrosourea in rats. Gann 75:957-965
35. Tatematsu M, Furihata C, Katsuyama T, Miki K, Honda H, Konishi Y, Ito N (1986) Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res 46:4866-4872
36. Tatematsu M, Ichinose M, Miki K, Hasegawa R, Kato T, Ito N (1990) Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn 40:494-504
37. Tatematsu M, Hasegawa R, Ogawa K, Kato T, Ichinose M, Miki K, Ito N (1992) Histogenesis of human stomach cancers based on assessment of differentiation. J Clin Gastroenterol 14 [Suppl 1]: S1-7
38. Tatematsu M, Fukami H, Yamamoto M, Nakanishi H, Masui T, Kusakabe N, Sakakura T (1994) Clonal analysis of glandular stomach carcinogenesis in C3H/HeN⇔BALB/c chimeric mice treated with N-methyl-N-nitro-N-nitrosourea. Cancer Lett 83:37-42
39. Tatematsu M, Tsukamoto T, Inada K (2003) Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 94:135-141
40. Tsuchiya A, Kikuchi Y, Ando Y, Abe R (1995) Correlation between expression of sialosyl-T antigen and survival in patients with gastric cancer. Br J Surg 82:960-962
41. Utsunomiya T, Yonezawa S, Sakamoto H, Kitamura H, Hokita S, Aiko T, Tanaka S, Irimura T, Kim YS, Sato E (1998) Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 4:2605-2614
42. Vider BZ, Zimber A, Hirsch D, Estlein D, Chastre E, Prevot S, Gespach C, Yaniv A, Gazit A (1997) Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. Biochem Biophys Res Commun 232:742-748
43. Werling RW, Yaziji H, Bacchi CE, Gown AM (2003) CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27:303-310
44. Yamachika T, Inada K, Fujimitsu Y, Nakamura S, Yamamura Y, Kitou T, Itzkowitz SH, Werther JL, Miki K, Tatematsu M (1997) Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch 431:103-110
45. Yoshikawa A, Inada Ki K, Yamachika T, Shimizu N, Kaminishi M, Tatematsu M (1998) Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression. Gastric Cancer 1:134-141
46. Yuasa H, Inada K, Watanabe H, Tatematsu M (2002) A phenotypic shift from gastric-intestinal to solely intestinal cell types in intestinal metaplasia in rat stomach following treatment with X-rays. J Toxicol Pathol 15:85-93